There are two types of lymphocytes namely B-cells and T-cells, which are critical for the immune system. In addition, several accessory cells and effector cells also participate. The site of development and maturation of B-cells occurs in bursa fabricius in birds, and bone marrow in mammals. During the course of immune response. B-cells mature into plasma cells and secrete antibodies (immunoglobulins). The B-cells possess the capability to specifically recognize each antigen and produce antibodies (i.e. immunoglobulins) against it.