This document defines atherosclerosis as the hardening and loss of elasticity of arteries due to plaque buildup. It also defines myocardial infarction as irreversible necrosis of heart muscle due to prolonged ischemia. It then proceeds to explain the process of atherosclerosis, from initial endothelial injury to formation of plaque and potential blockage. For myocardial infarction, it notes that ischemia beyond a critical threshold can cause heart muscle cell death. Causes discussed include presence of atherosclerosis and high lipoprotein(a) levels.