definition of heart failure, classification of heart failure, risk factors for heart failure, clinical features, general physical examination findings in heart failure
Definition of heart failure - causes and types of heart failure - pathophysiology and risky factors for heart failure - Diagnosis clinical manifestations and investigations and classification of heart failure- treatment of chronic heart failure
Also Acute heart failure causes - clinical picture and treatment
Definition of heart failure - causes and types of heart failure - pathophysiology and risky factors for heart failure - Diagnosis clinical manifestations and investigations and classification of heart failure- treatment of chronic heart failure
Also Acute heart failure causes - clinical picture and treatment
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Some of the slides, i hide it from my real presentations for my own reference. Download to see all of them.
These are cardiac anomalies arising as a result of a defect in the structure or function of the heart and great vessels which is present at birth
These lesions either obstruct blood flow in the heart or vessels near it, or alter the pathway of blood circulating through the heart
It includes emergency situations related to the cardiovascular aspect of humans. it focuses on the critical care aspect to manage certain emergencies. Nursing care is also included thus, fosters a better aspect of nursing individuals to manage a cardiovascular emergency.
Kindly leave your comment if you found this helpful ;)
Some of the slides, i hide it from my real presentations for my own reference. Download to see all of them.
These are cardiac anomalies arising as a result of a defect in the structure or function of the heart and great vessels which is present at birth
These lesions either obstruct blood flow in the heart or vessels near it, or alter the pathway of blood circulating through the heart
It includes emergency situations related to the cardiovascular aspect of humans. it focuses on the critical care aspect to manage certain emergencies. Nursing care is also included thus, fosters a better aspect of nursing individuals to manage a cardiovascular emergency.
a detailed description of pain and therpaeutic options available and clinical assessment of pain, approach to the patient with pain, assessment of intensity of pain, nsaids and opioids, tca. WHO pain ladder, chronic opioid therapy
A detailed discussion on embryogenesis of heart and ennumeration of all congenital diseases and description of cyanotic congenital heart disease , each disease in detail.
BROADMANN AREA 1,2,3 Grouped as primary somatosensory cortex. Location – Post-Central gyrus on lateral surface of brain. Tactile representation is orderly arranged (in an inverted fashion) from the toe (at the top of the cerebral hemisphere) to mouth (at the bottom)
Erythroderma is defined as the scaling erythematous dermatitis involving 90% or more of the cutaneous surface.
Also known as exfoliative dermatitis
Idiopathic exfoliative dermatitis – also known as the “red man syndrome”, is characterized by marked palmoplantar keratoderma, dermatopathic lymphadenopathy,increased IgE.
Increased skin perfusion leads to
Temperature dysregulation >
Resulting in skin loss and hypothermia >
High output state >
Cardiac failure
BMR raises to compensate for heat loss
Increased dehydration due to transpiration (similar to burns)
All lead to negative nitrogen balance and characterized by edema, hypoalbuminemia, loss of muscle mass.
Graft versus host disease (GVHD) is an immune mediated disease due to complex interaction between donor (lymphoid tissue) and recipient’s immunity occurring after transplantation.
Two types
Acute (less than 100 days)
Chronic (more than 100 days)
Erythroderma is defined as the scaling erythematous dermatitis involving 90% or more of the cutaneous surface.Also known as exfoliative dermatitis.
Idiopathic exfoliative dermatitis – also known as the “red man syndrome”, is characterized by marked palmoplantar keratoderma, dermatopathic lymphadenopathy,increased IgE.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. DEFNITION
• 2013 ACC/ AHA DEFNITION-
– Heart Failure is defined as “ a complex clinical
syndrome that results from any structural or
functional impairment of ventricular
filling(diastole) or ejection of blood. (systole) ”
3. CLASSIFICATION BY DEFNITION
• SYSTOLIC HEART FAILURE
– Characterized by reduced ejection fraction and
enlarged ventricle size. Clinically present with left
ventricular failure and marked cardiomegaly.
• DIASTOLIC HEART FAILURE
– Characterized by increased resistance to filling due
to increased filling pressures. Clinically present
with pulmonary congestion with normal or slightly
enlarged ventricles .
4. CLASSIFICATION BASED ON EJECTION
FRACTION
• Heart Failure with reserved Ejection Fraction
HFrEF – Ejection fraction ≤ 40% .
– These patients will have systolic dysfunction and
concomitant diastolic dysfunction. Coronary artery
disease is the major cause.
• Heart Failure with Preserved Ejection Fraction
HFpEF – Ejection Fraction 40 – 50%.
– These patients can be diagnosed by 1)clinical signs
and symptoms and 2)evidence of pEF or normal EF or
previously rEF 3)evidence of abnormal LV diastolic
dysfunction (echo / LV catheterisation)
5. CLASSIFICATION BASED ON CARDIAC
OUTPUT
• HIGH OUTPUT FAILURE-
– The normal heart fails to maintain normal or
increased output in conditions like anemia,
hyperthyroidism, pregnancy.
– Usually right sided failure occurs followed by left sided
failure with presence of shortened circulatory time.
• LOW OUTPUT FAILURE-
– Heart fails to generate adequate output in conditions
like cardiomyopathy, valvular heart disease,
tamponade and bradycardia.
6. RIGHT AND LEFT SIDED HEART FAILURE
• Right sided heart failure is characterised by the
presence of peripheral edema, raised JVP and
hypotension and congestive hepatomegaly.
• Left sided heart failure – pulmonary edema is the
striking feature. Other signs are tachypnea,
tachycardia, third heart sound, pulsus alternans,
cardiomegaly.
• Congestive Cardiac Failure – Characterised by
combination of both left and right sided heart
failure.
7.
8. FORWARD AND BACKWARD HEART
FAILURE
• FORWARD HEART FAILURE-
– This results from inadequate discharge of blood
into arterial system leading to poor tissue
perfusion and excess Na+ reabsorption through
RAAS.
• BACKWARD HEART FAILURE-
– This results from failure of one or both ventricles
to fill normally and discharge its contents, causing
back pressure on the atria and venous system.
9. ACCF/AHA FUNCTIONAL
CLASSIFICATION
• Stage A – At high risk of HF but witout
structural hear disease.
• Stage B – Structural heart disease without
signs or symptoms of HF.
• Stage C – Structural heart disease with prior
HF or current HF.
• Stage D – Refractory HF requiring special
interventions.
10. NYHA FUNCTIONAL CLASSIFICATION
• Stage 1 – no limitation of ordinary physical
activity.
• Stage 2 – slight limitation of ordinary physical
activity.
• Stage 3 – marked limitation of ordinary
physical activity, but comfortable at rest.
• Stage 4 – unable to carry out physical activity,
symptomatic at rest.
11. RISK FACTORS
• Epidemiology –
– Worldwide 2 crore people are affected by heart
failure. Approximate 2 % prevalence in developed
countries. Women have better survival than men.
– Coronary artery disease is the major cause for
heart failure. (60 – 75%)
• Etiology and Risk Factors –
– Any condition that leads to alteration of LV
structure and function can lead to heart failure
14. Etiologies of Heart Failure
• High output states
– Thyrotoxicosis
– Nutritional – Beriberi
– Anemia
15. LV Remodeling
• DEFNITION – It refers to change in LV Mass ,
Volume or Shape or the Composition of the heart
after Cardiac injury or index event.
• Progress of HF associated with changes in
geometry of remodeled LV
• Changes that occur include –
– LV dilatation
– LV thinning
– Increase in LV end diastolic volume
– Decrease in stroke volume
16. LV Remodeling
– Subendocardial hypoperfusion
– Increased oxidative stress and free radical
generation
– Stress activated hypertrophic signaling pathways
– Incompitence of mitral valve apparatus and
functional MR
17. CLINICAL FEATURES
• Important symptoms –
– Fatigue
– Exertional Breathlessness
• Cause of breathlessness is multifactorial
– Pulmonary congestion due to LVF
– Accumulation of interstitial and intra alveolar fluid
, stimulating juxta capillary J receptors, causing
Rapid Shallow breathing
– Decreased pulmonary compliance
– Increased airway resistance
– Respiratory fatigue and Anemia
18. CLINICAL FEATURES
• Orthopnea –
– Dyspnea in recumbent position
– Occurs due to redistribution of fluid from
splanchnic circulation and lower extremities
– Causes increase in pulmonary capillary pressure.
– Nocturnal cough is usually asociated with this
symptom
– Relieved by sitting upright .
– This symtom is more common in patients with co
morbid obesity or ascites
19. CLINICAL FEATURES
• Paroxysmal Nocturnal Dyspnea-
– Defnition – it refers to acute episode of shortness of
breath and coughing that generally occur at night and
awken patient from sleep usually 1 – 3 hours after
recline.
– Associated with coughing or wheeze
– Mechanism – increased pressure in bronchial arteries
leading to airway compression (+) interstitial
pulmonary edema = increased airway resistance.
– Orthopnea symptoms resolve after upright posture,
but symptoms of PND persist even after upright
posture.
20. CLINICAL FEATURES
• Cheyne stokes respiration
– Also called periodic / cyclic respiration
– It is present in nearly 40 % cases of HF
– It is caused by decreased sensitivity of
RESPIRATORY CENTRE to PaCO2.
– Due to transient fall in PaO2 , rise in PaCO2 there
is an apneustic phase. PaCO2 rises steadily till it
stimulates depressed respiratory centre and
causes hyperventilation and hypocapnia (low
PaCO2).
21. CLINICAL FEATURES
• Other symptoms like
– Anorexia
– Nausea
– Early satiety
– Abdominal pain
– Abdominal fullness
– Congestive hepatomegaly
– Confusion , disorientation, sleep disturbances,
– Nocturia
22. PHYSICAL EXAMINATION
• Patient will present with laboured breathing in an
acute LVF. He/she may not be able to finish the
sentence due to shortness of breath. He / she
may have difficulty to talk due to shortness of
breath.
• Blood pressure may be normal or high in early HF
, may decrease consequently and is usually low.
• Low pulse pressure (reduced stroke volume)
• Sinus tachycardia (increased sympathetic activity)
cool peripheries, cyanosis of tips of fingers and
nail bed.
23. PHYSICAL EXAMINATION
• Jugular venous pressure –
– Indicates right atrial pressure
– It is measured in terms of (cm of H2O)
– Normal < 8 cm of H2O
– Method – measure highest point of JVP vertically
from sternal angle and add 5 cm of H2O
– Positive Abdomino- Jugular reflex
24. PHYSICAL EXAMINATION
• Respiratory system
– Bilateral rales/crepitations may be present as a
result of transudate of fluid from intravascular
space to intraalveolar space.
– May be accompanied by expiratory wheeze
(cardiac asthma).
– Pleural effusion may/may not be present.
(common in CCF)
25. PHYSICAL EXAMINATION
• Cardiovascular system
– Apical impulse may shift inferiorly / laterally.
– Sustained apical impulse is felt in severe LVH.
– S3 gallop (protodiastolic gallop) can be heard.
– Left parasternal impulse in cases if severe RVH
– S4 gallop is usually present in diastolic dysfunction.
– MR or TR may be present additionally.
26. PHYSICAL EXAMINATION
• Per abdomen
– Hepatomegaly is present (tender / pulsatile)
– Pulsations in liver indicate tricuspid regurgitation
– Ascites , Jaundice , raised liver enzymes
– Peripheral edema can be pre tibial or pre sacral
edema
• Cardiac cachexia
– Cause for cachexia is multifactorial
• Elevation of BMR
• Elevated circulating cytokines like TNF
• Congestion of intestinal veins
27. Other Important Comorbidities in HF
• Atrial Fibrillation
• Anemia
• Depression
• Others
– Diabetes
– Arthritis
– CKD
– COPD