Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Vestibular function tests are essential tests in otorhinolaryngology examination, especially examination of ear.
This presentation explains about all the important vestibular function tests.
A detailed description of benign paroxysmal positional vertigo (BPPV): the symptoms, causes, diagnosis, and treatment methods.For more information, please visit www.everydayhearing.com
Vestibular function tests are essential tests in otorhinolaryngology examination, especially examination of ear.
This presentation explains about all the important vestibular function tests.
A detailed description of benign paroxysmal positional vertigo (BPPV): the symptoms, causes, diagnosis, and treatment methods.For more information, please visit www.everydayhearing.com
Vertigo –the dizzy patient an evidence-based diagnosis and treatment strategySachin Verma
Vertigo is a symptom of illusory movement and not a diagnosis .It is due to asymmetry of vestibular system due to damage or dysfunction of the
Labyrinth and vestibular nerve, or
Central vestibular structures in the brainstem
A concise presentation about BPPV and Ménière's disease and other causes of vertigo, the difference between central and peripheral vertigo, symptoms and etiology and approach to physical examination and treatment.
The cerebellum is a structure that is located at the back of the brain.
Although the cerebellum accounts for approximately 10% of the brain’s volume, it contains over 50% of the total number of neurons in the brain.
Similar to Assessment of vestibular function test (20)
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. Balance in humans is maintained by the
integration within the central nervous
system (CNS) of information from the
vestibular labyrinths, the eyes and the
proprioceptive systems. Damage to any of
these three systems may lead to
dyscquilibrium.
Assessment of dizziness must include
evaluation of each of these three peripheral
systems and of the ‘central processing unit
it self.
3.
4. ANATOMY OF THE VESTIBULAR
APPARATUS
THE INTERNAL EAR OF THE LABYRINTH
1) Bony labyrinth
A) Vestibule
B) Semicirular Canals Lateral, Posterior &
Superior
C) Cochlea
2) Membranous Labyrinth
10. CENTRALVESTIBULAR CONNECTIONS
Afferents
1. Peripheral vestibular receptors (scc, utricle and
saccule)
2. Cerebellum
3. Reticular formation
4. Spiral Cord
5. Contralateral vestibular nuclei
Efferents
1. Nuclei of CN III IV VI (Vestibulo ocular reflexes)
2. Motor part of spinal cord (vestibulo spinal fibres)
3. Cerebellum (Vestibulo cerebellar fibres)
4. Autonomic nervous system
5. Vestibular nuclei of opposite side.
6. Cerebral Cortex (temporal lobe.)
11. PHYSIOLOGY (VESTIBULAR SYSTEM)
A) Peripheral SCC, utricle & saccule
B) Central made up of nuclei and fibre tracts in CNS to
integrate vestibular impulses with other systems to
maintain body balance.
Semi circular Canals :
Respond to angular acceleration and deceleration
Three canals lie at right angles to each other
One which lies at right angles to the axis rotation is
stimulated the most.
Stimulus to SCC is flow of endolymp which displaces
the cupula.
The quick component is always opposite to the
direction of flow of endolymph.
12.
13. UTRICLE AND SACCULE
Utricle stimulated by linear acceleration and
deceleration or gravitational pull during head
tilts.
Sensory hair cells of macula in different planes
are stimulated during head tilts.
Function of saccule is similar
Cerebellum further coordinates muscle
movements in their rate,range,
force duration and thus helps in
maintenance of balance.
14. ASSESSMENT OF VESTIBULAR FUNCTIONS
1) Clinical History A full general medical
history, cardiovascular & neurological. Specific
aspects of the digginess or imbalance should
be sought.
a) Character of Symptoms (vertigo or digginess)
b) Time, course of dysequilibrium
c) Associated Symptoms hearing loss, tinnitus
palpitation
d) Precipitating factors Head, body and eye
movements
e) Drug history Gentamicin, PCM, Diuretics,
Cisplatinum etc.
2) Clinical Test
3) Laboratory Test
15. CLINICAL TEST
1) Spontaneous nystagmus it is an important sign
Defn Invountary rhythimical, oscillatroy movement
of eyes.
Horizontal, vertical, rotatory
Slow and a fast component
Direction indicated by direction of fast component
Intensity indicated by degree
Degree of nystagmus
1st degree Nystagmus in direction of fast component
2nd degree When patient looks straight ahead.
3rd degree In the direction of slow component.
Vestibular or peripheral, hystagmus due to lestion
of labyrinth or VIIIth nv.
Central nystagmus lesion in central pathways
vestubular nuclei, brainstem, cerebellum.
16. 2) FISTULA TEST
Induction of nystagmus by pressure changes in
the external canal.
Stimulation of labyrinth results in nystagmus
and vertigo.
Performed by intermittent pressure on tragus
or by siegel’s speculum.
Normally test is negative.
Positive test implies labyrinth is functioning
False negative cholesteatoma covers site of
fistula.
False positive congenital syphilis and
Meniere’s disease (Hennebert’s sign)
17. 3) ROMBERG TEST
Stands with feet together, arms by side with eyes first
open and then closed.
Peripheral lesions sways to side of lesion.
Central lesions Shows instability.
Sharpened Rombery test if patient performs above test
without sway. Inability to perform indicates vestibular
impairment.
4) GAIT
Asked to walk along a straight line to a fixed point first
with eyes open and then closed.
Uncomplensated lesion of peripheral vestibular system
with eyes closed, deviates to affected side.
5) Past pointing and falling
Acute vestibular failure right side.
Nystagmus to left, past pointing and falling to right
side.
19. Peripheral Central
1. Latency 2-20 Seconds No Latency
2. Duration Less than 1 min More than 1 min
3. Direction of
nystamus
Fixed to the
undermost ear
Changing
4. Fatiguability Fatiguable Non- fatiguable
5. Accompanying
Symptoms
Servere vertigo Non or slight
20. TEST OF CEREBELLAR DYSFUCTION
Cerebellar Hemisphere
Asysnergia (Abnormal finger nose test)
Dysmetria (unable to control range of motion)
Adiadokokinesia
Rebound phenomenon (unable to control movement of
extremity when opposing force, suddenly released)
Cerebellar midline disease
I. Wide base gait
II. Falling in any direction
III. Inability to make sudden turns
IV. Truncal ataxia
Nystagmus gaze evoked, rebound and opto kinetic.
21. LABORATORY TESTS
Caloric test
Induction of nystagmus by thermal stimulation of
vestibular system
Advantage, each labyrinth tested separately
Ladyrinthine origin of vertigo if qualitatively similar to
the type experienced, during episodes of vertigo
a. Modified kobrak tests
b. Fitzgerald hallpike test (bithermal caloric test)
22.
23. Canal paresis
L30 +L44 X 100
Response from Left ear =L30+L44 + R30+R44
R30 +R44 X 100
Response from Right ear =L30+L44 + R30+R44
Seen in Meniere’s ds, Acoustic neuroma,
Post Labyrinthectomy or Vestibular nv section
24. Directional Preponderance
Takes into consideration the duration of nystagmus to the
right or left irrespective of whether it is elicited from rt or
left labyrinth
If nystagmus is 25-30% or more on oneside than other it is directional pre
ponderance
25. COLD AIR CALORIC TEST
Done if peforated tympanic membrane
Dundas grant tube used
Only a rough qualitative test.
ELECTRONYSTAGMOGRAPHY
Corneo retinal potentials recorded by electrodes
placed around eyes
Detects nystagmus not seen with naked eye
Keeps permanent record of nystagmus.
26.
27. OPTOKINETIC TEST
Normally produes nystamus with slow component in
the direction of moving stripes
Optokintic abnormality seen in brain stem and
cerebral hemisphere lesion.
ROTATION TEST
Barany’s chair, 10 turns in 20 secs.
Normally there is nystagmus for 25-40 secs.
Can be done in congenital abnormality of external ear
canal where caloric best not possible
Disadvantage, both labyrinths are simultaneously
stimulated
28. GALVANIC TEST
Only test to differentiate end organ lesion from that of
vestibular nv.
Normally person sways towards the side of anodal
current
POSTUROGRAPHY
Measures postural stability
Maintenace of posture depends on 3 sensory inputs
visual, vestibular and somatosensory
AUDITORY FUNCTION TEST
Close relationship, both anatomically and
physiologically, between the vestibular and auditory
divisions of VIII the nv.
Precise site of lesions causing vestibular disturbance.