1) The document discusses aromatic nitro compounds, specifically nitrobenzene.
2) Nitrobenzene can be synthesized from benzene through nitration using a nitrating mixture of concentrated nitric and sulfuric acids.
3) Nitrobenzene undergoes reduction under different conditions (acidic, neutral, alkaline) to form compounds like aniline, phenylhydroxylamine, or hydrazobenzene. It can also be electrolytically reduced.
The NO2 group attached with organic chain is called as nitro functional group. All the compounds containing the nitro functional group are called as organic nitro compounds.
The NO2 group attached with organic chain is called as nitro functional group. All the compounds containing the nitro functional group are called as organic nitro compounds.
Introduction of poly-cyclic compounds, resonance, molecular orbital structure, physical properties, preparation, reaction and uses of napthalene, anthracene, phenanthrene, napthaquinone, napthol, napthylamine, 9,10 anthraquinone and phenanthrequinone.
REDUCTION AND REDUCING AGENTS. in this presentation we explain the
Definition
Identification
Position in periodic table
Examples etc
of reduction and reducing agents.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Introduction of poly-cyclic compounds, resonance, molecular orbital structure, physical properties, preparation, reaction and uses of napthalene, anthracene, phenanthrene, napthaquinone, napthol, napthylamine, 9,10 anthraquinone and phenanthrequinone.
REDUCTION AND REDUCING AGENTS. in this presentation we explain the
Definition
Identification
Position in periodic table
Examples etc
of reduction and reducing agents.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Aromatic amines:
Methods of Preparation, reaction, Basicity of Aromatic Amines, Effect of Substituents on Acidity of Aromatic amines, Aryl diazonium salt and Uses of Aromatic Amines.
An aliphatic amine has no aromatic ring attached directly to the nitrogen atom. Aromatic amines have the nitrogen atom connected to an aromatic ring as in the various anilines. The aromatic ring decreases the alkalinity of the amine, depending on its substituents. The presence of an amine group strongly increases the reactivity of the aromatic ring, due to an electron-donating effect.
Amines are organized into four subcategories:
Primary amines—Primary amines arise when one of three hydrogen atoms in ammonia is replaced by an alkyl or aromatic. Important primary alkyl amines include, methylamine, most amino acids, and the buffering agent tris, while primary aromatic amines include aniline.
Secondary amines—Secondary amines have two organic substituents (alkyl, aryl or both) bound to the nitrogen together with one hydrogen. Important representatives include dimethylamine, while an example of an aromatic amine would be diphenylamine.
Tertiary amines—In tertiary amines, nitrogen has three organic substituents. Examples include trimethylamine, which has a distinctively fishy smell, and EDTA.
Cyclic amines—Cyclic amines are either secondary or tertiary amines. Examples of cyclic amines include the 3-membered ring aziridine and the six-membered ring piperidine. N-methylpiperidine and N-phenylpiperidine are examples of cyclic tertiary amines.
It is also possible to have four organic substituents on the nitrogen. These species are not amines but are quaternary ammonium cations and have a charged nitrogen center. Quaternary ammonium salts exist with many kinds of anions.
What is a Heterocyclic Compound?
A heterocyclic compound has at least two different elements as a member of its ring.
The most common hetero atoms found on a cyclic ring are Oxygen (O), Nitrogen (N) and Sulphur (S).
Example:
Nucleic Acid that is present in the body responsible for storing and expressing genetic information, is an example of a Heterocyclic compound.
Essential micronutrient, Vitamins is also an example of a heterocyclic compound.
The majority of drugs, pesticides, dyes, and plastics are examples of heterocyclic compounds.
Classification of Heterocyclic Compounds
Based on the electronic arrangement, we can classify Heterocyclic compounds into two types:
Aliphatic Heterocyclic Compounds
Aromatic Heterocyclic Compounds
Aliphatic Heterocyclic Compounds
Aliphatic heterocyclic compounds are those cyclic heterocycles that do not contain any double bond.
The properties of aliphatic heterocyclic compounds are mainly affected due to ring strain.
Examples of aliphatic heterocyclic compounds are Aziridine, Ethylene Oxide, Thiirane, Oxetane, Azetidine, Thietane, Tetrahydrofuran (THF), Dioxane, Pyrrolidine, Piperidine, etc.
Aromatic Heterocyclic Compound
Aromatic heterocyclic compounds, as the name suggests, are cyclic aromatic compounds.
Aromatic Heterocyclic compounds obey Huckels Rule, i.e.
It should be cyclic.
It should be planar.
It should not contain any sp3 hybridised atoms.
It must have (4n+2) 𝛑 electrons.
Aromatic Heterocyclic compounds are analogous to Benzene.
Examples: Furan, Pyrrole, Thiophene, Indole, Benzofuran, Carbazole, Quinoline, Isoquinoline, Imidazole, Oxazole, Pyrazole, Pyridazine, Pyrimidine, Purine, etc.
Based on structure, we can classify Heterocyclic compounds into five types:
Three-Membered Heterocyclic Compounds
Four-Membered Heterocyclic Compounds
Five-Membered Heterocyclic Compounds
Six-Membered Heterocyclic Compounds
Condensed or Fused Heterocyclic Compounds
Three-Membered Heterocyclic Compounds
These heterocyclic compounds contain three atoms which may be saturated or unsaturated.
Based on the number of heteroatoms present, we can further classify them into two categories:
B. Sc. Part - I (Sem-II) Unit-IV (A) Phenols by Dr Pramod R Padolepramod padole
A) PHENOLS: Methods of formations a) from aniline & b) from cumene. Acidic character, Reaction of Phenols- a) Carboxylation (Kolbe’s reaction), b) Fries Rearrangement, c) Claisen Rearrengement and d) Reimer – Tiemann reaction.
B.Sc. Sem-II Unit-III (B) Aryl halides by Dr Pramod R Padolepramod padole
Aryl Halides: Synthesis chlorobenzene from benzene, phenol, and benzene diazonium chloride, Synthesis of benzyl chloride from toluene and benzyl alcohol, Reactions of both with aqueous KOH, NH3, and sodium ethoxide, Comparison of the reactivity of chlorobenzene and benzyl chloride. Benzyne intermediate mechanism.
B.Sc. (Sem-II) Unit-III (A) Alkenyl Halides by Dr Pramod R Padolepramod padole
Alkenyl Halides: Synthesis of vinyl chloride from acetylene and allyl chloride from propylene, Reactions of both with aqueous and alcoholic KOH, Comparison of the reactivity of vinyl and allyl chloride.
B. Sc. Sem - I Unit-IV (D) Orientation by Dr Pramod R Padolepramod padole
Orientation: Effect of substituent groups. Activating and deactivating groups. Theory of reactivity and orientation on the basis of inductive and resonance effects (-CH3, -OH, -NO2 and –Cl groups).
B.Sc. Sem-I Unit-IV Mechanism of electrophilic aromatic substitution by Dr P...pramod padole
Mechanism of Electrophilic Aromatic Substitution: Nitration, Friedal Craft Alkylation and Acylation.Nuclear and Side Chain
Halogination, Birch Reduction
Sem - I Unit-III C) Aliphatic Hydrocarbons By Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction & ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism),
ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols.
Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
c) Alkynes: Preparation from vicinal and germinal dihalides. Chemical reactions: Hydrogenation.
d) Alkadienes : Classification, 1,3-Butadiene: Preparation from cycolhexene, Reactions: Addition of H2, Br2 & HBr.
Dyes, Drugs & Pesticides by Dr Pramod R Padolepramod padole
A] Dyes: Classification on the basis of structure and mode of application, Preparation and uses of Methyl orange, Crystal violet, Phenolphthalein , Alizarin and Indigo.
B) DRUGS:
Analgesic and antipyretics: Synthesis and uses of phenylbutazone. Sulpha drugs: Synthesis and uses of sulphanilamide and sulphadiazine. Antimalarials: Synthesis of chloroquine from 4,7-dichloroquinoline and its uses.
C] Pesticides: Insecticides: Synthesis and uses of malathion. Herbicides: Synthesis and uses of 2,4-dichloro phenoxy acetic acid (2,4-D). Fungicides: Synthesis and uses of thiram (tetramethyl thiuram disulphide).
Semester - I C) Aliphatic Hydrocarbons by Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction & ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism),
ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols.
Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
Semester - I C) Aliphatic Hydrocarbons by Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction &
ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism), ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols. Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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4. Contents
A) Aromatic nitro compounds:
Nitrobenzene:1
Synthesis from benzene2
Reduction of nitrobenzene3
in acidic, neutral and
alkaline (Basic) medium
Electrolytic Reduction
of Nitrobenzene:
4
5. Introduction:
The nitro group (-NO2) is the most highly oxygenated
form of the nitrogen atom.
The nitro group can be introduced in the benzene ring
very easily by electrophilic substitution but it is rather
difficult to replace a hydrogen atom in an aliphatic
compound by a nitro group.
Hence the aromatic nitro compounds are much more
readily available than their aliphatic counterparts.
5
Ar N
O
O
Ar N
O
O
N
O
O
N
O
O
I II
N
O
O
Classical Polar
Resonance Form Resonance Hybrid
1
2
Resonating structure of -NO2
I II
1
2
11. Aromatic Nitro Compounds:
Nitro Arenes:
Aromatic nitro compounds are the substitution
products of aromatic hydrocarbons in which one
or more ring hydrogen atoms have been replaced
by –NO2 group.
{Note that: The nuclear nitro compounds are by far more important
because they can be conveniently prepared from the aromatic
hydrocarbons by direct nitration. They have been used as dyes,
pharmaceuticals and use as explosives is too well-known.}
NO2
- H
+ NO2
Benezene Nitrobenzene
(Nuclear nitro compound)
H
12. www.themegallery.com
Aromatic Nitro Compounds:
In modern view, aromatic nitro compounds are molecules
in which –NO2 group is directly bonded to an aromatic
ring.
They have general formula Ar-NO2. The -NO2 group may
be represented as…..
Ar N
O
O
Ar N
O
O
N
O
O
N
O
O
I II
N
O
O
Classical Polar
Resonance Form Resonance Hybrid
1
2
Resonating structure of -NO2
I II
1
2
It has been shown by bond length and dipole measurements that both N–O bonds are equivalent.
Therefore, the structure of nitro group is as one in which resonance gives it symmetry.
13. Laboratory preparation of Nitrobenzene:
Preparation or Synthesis of
Nitrobenzene from Benzene
(Nitration):
Q.1) How will you prepare Nitrobenzene from Benzene? (W-16, 2 Mark)
Q.2) How will you obtain Nitrobenzene from Benzene?
(S-17 & W-19, 2 Mark)
Q.3) What is nitration?
Q.4) What is nitrating mixture? How benzene is nitrated with nitrating
mixture? (S-18, 4 Mark)
Q.5) Complete the following reaction: (S-19, 2 Mark)
Conc. HNO3
Conc. H2SO4
?
14. Nitration of Benzene:
Defination: Replacement of hydrogen atom of benzene ring by
nitro (-NO2) group is called nitration.
When benzene is reacted with concentrated
nitric acid (con. HNO3) in presence of
concentrated sulphuric acid (nitrating
mixture) at 60o C (333 K); to form
nitrobenzene.
14
con.HNO3 + Con.H2SO4)Mixture of ( is known as nitrating mixture.
H
HO-NO2
con. HNO3
con. H2SO4
NO2
H2 O
Benzene
+
or
Heat at 60o
C
or at 333K
+
Nitrobenzene
HO---NO2
15. Formation of nitronium ion (NO2)+ :
Formation of electrophile, i.e., NO2
+ ion:
The active electrophile, nitronium ion, NO2
+ is
formed from nitrating mixture as follows.
15
Q.1) Explain the formation of nitronium ion (NO2)+ in the nitrating mixture. (W-12, 3 Mark)
Q.2) The compound or mixture of compounds which is used as a source of electrophilic ,
NO2
+ is referred as nitrating agents
The electrophile in the reaction is NO2
+, why not H3O+?
Though Oxygen atom in H3O+ has a positive charge it is not
an electrophilic centre, because the atom has a complete
octet in its outermost shell hence cannot accommodate any
more electrons.
18. Addition of hydrogen or removal of oxygen is termed
as reduction.
18
Conversion of nitro (-NO2) group to amino group (-NH2)
is termed as reduction.
19. Reduction of Nitrobenzene under
Different Conditions:
Electrolytic
Electrolytic reduction of nitrobenzene:
(a) Reduction by dil. H2SO4 (Weakly acidic medium)
Preparation of Aniline from Nitrobenzene:
(b) Reduction by con. H2SO4 (Strongly acidic medium)
Preparation of p-Amino Phenol from Nitrobenzene:
Hydrazobenzene
Reduction of nitrobenzene in Alkaline Medium (Basic Medium):
Or Preparation of Hydrazobenzene from Nitrobenzene:
Reducing Agents: Zn dust & NaOH
Phenyl hydroxyl amine
Reduction of nitrobenzene in Neutral Medium:
Or
Preparation of Phenyl hydroxyl amine from Nitrobenzene:
Reducing Agents: Zn dust and NH4Cl
Aniline
Reduction of nitrobenzene in Acidic Medium:
Or
Preparation of Aniline from Nitrobenzene:
Reducing Agents: Zn/HCl, Fe/HCl, ZnCl2/HCl, Sn/HCl
Aniline
p-Amino Phenol
20. (i) Reduction of nitrobenzene in
Acidic Medium:
Or Preparation of Aniline from Nitrobenzene:
Reduction of nitrobenzene in Acidic Medium:
Or Metal-Acid Reduction:
Reducing Agents: Zn/HCl, Fe/HCl, ZnCl2/HCl, Sn/HCl
Ans: When nitrobenzene is reduced by metal like Zn, Fe, Sn in
presence of HCl acid (i.e., in acidic medium); to form aniline.
20
NO2
Nitrobenzene
+ 6 [H] Zn or Fe or Sn in HCl
or Zn / HCl
NH2
Aniline
Acidic medium
+ 2 H2O
or Fe / HCl
21. (i) Reduction of nitrobenzene in
Acidic Medium:
21
NO2
Nitrobenzene
+ 6 [H] Zn or Fe or Sn in HCl
or Zn / HCl
NH2
Aniline
Acidic medium
+ 2 H2O
or Fe / HCl
22. LOGO(ii) Reduction of nitrobenzene in Neutral Medium:
Preparation of Phenyl hydroxyl amine
from Nitrobenzene:
Reduction of nitrobenzene in Neutral Medium:
Reducing Agents: Zn dust and boiling aq. ammonium chloride solution (NH4Cl).
Ans: When nitrobenzene is reduced by Zn dust and ammonium chloride solution
(i.e., in neutral medium); to form N-phenyl hydroxyl-amine or
Phenyl hydroxyl-amine.
Q.1) How will you convert Nitrobenzene to phenylhydroxyl amine? (W-14, 2 Mark)
Q.2) Complete the following reaction: (S-18, 2 Mark)
Q.3) Discuss the reduction of nitrobenzene in neutral medium. (W-18 & S-19, 2 Mark)
NO2
Nitrobenzene
+ 4 [H]
Zn-dust & NH4Cl solution NH-OH
Phenyl hydroxyl amineNeutral medium
+ H2Owarm
NO2
Zn/NH4Cl
2 [H] ?
23. 23
Q.1) Discuss the reduction of nitrobenzene to hydrazobenzene in alkaline medium. (S-12 & W-14, 2 Mark)
Q.2) Complete the following reaction. (S-14, 2 Mark)
Q.3) Complete the following reaction. (S-14, W-15 & W-16, 2 Mark)
Q.4) What are products of reduction of nitrobenzene in alkaline medium? (W-15, 2 Mark)
Q.5) Complete the following reaction. (W-17, 2 Mark)
Q.6) What is the product of reduction of nitrobenzene in basic medium? (Ans: hydrazobenzene)
(iii) Reduction of nitrobenzene in Alkaline
Medium (Basic Medium):
Or Preparation of Hydrazobenzene from
Nitrobenzene:
NO2
Zn / NaOH / CH3OH2 ?
NO2
Zn / NaOH
2 ?
NO2
Zn dust
?+ 6 [H]
NaOH/ H2O
24. 24
Reduction of nitrobenzene in Alkaline Medium:
i.e., Basic medium
Reducing Agents:
Zn dust & NaOH, SnCl2 & NaOH, aq. Sodium Arsenite. (Na3AsO3)
Ans:
When nitrobenzene is reduced straight way by
Zn dust and NaOH solution (i.e., in alkaline medium /
Basic medium); to form Hydrazobenzene.
NO2
Nitrobenzene
+ 6 [H] Zn-dust & NaOH solution
HN
Hydrazobenzene
Alkaline medium + 4 H2O+
O2N
Nitrobenzene
NH
NO2
6 [H]+
Zn dust
& NaOH / H2O
2 NH
hydrazobenzene
NH
C2H5OH
or
OR
26. Electrolytic reduction of nitrobenzene:
a) Reduction
by dil. H2SO4
(Weakly acidic
medium)
Preparation of
Aniline from
Nitrobenzene:
Electrolytic
reduction
(b) Reduction by
con. H2SO4
(Strongly acidic
medium)
Preparation of
Phenyl hydroxyl
amine &
p-Amino Phenol :
27. (a) Reduction by dil. H2SO4 (Weakly acidic medium)
Preparation of Aniline from Nitrobenzene:
Reduction of nitrobenzene in weakly Acidic Medium (dil. H2SO4):
Reducing Agents: dil. H2SO4
When nitrobenzene is reduced by dil. H2SO4
(i.e., in weakly acidic medium); to form aniline.
27
Q.1) Explain: Electrolytic reduction of nitrobenzene. (S-12, 2 Mark)
Q.2) How will you convert Nitrobenzene to Aniline? (S-13, 2 Mark)
Q.3) Main product in the electrolytic reduction of nitrobenzene in weakly acidic medium is:(W-13, ½ Mark)
(a) Hydrazobenzene (b) Aniline (c) Azobenzene (d) p-amino phenol
NO2
Nitrobenzene
+ 6 [H]
NH2
Aniline
Weakly Acidic medium
+ 2 H2O
dil. H2SO4
Electolytic Reduction
28. (b) Reduction by con. H2SO4 (Strongly acidic medium)
28
Preparation of Phenyl hydroxyl amine & p-Amino Phenol
from Nitrobenzene:
NO2
?
Conc acid
H2SO4
Rearrangement
?
Reduction of nitrobenzene in strongly Acidic Medium (con. H2SO4):
Reducing Agents: con. H2SO4
When nitrobenzene is reduced by con. H2SO4 (i.e., in strongly acidic
medium); to form p-Amino-phenol.
Nitrobenzene
NHOHNO2
NH2
OH
Strong Acid
conc. H2SO4
Phenyl hydroxyl amine p-Amino phenol
Rearrengment
Electrolytic
Reduction
H