3. Basis Of Presentation
Sleisenger and Fordtran’s GI & Liver Diseases 10th
Edition
Yamada’s Textbook of Gastroenterology 6th Edition
Harrison textbook of Medicine 19th Edition
Strength of recommendation from ACG guidelines
2012
Some other Articles
4. Outline Of Presentation
Definitions
Introduction
Approach considerations
Risk stratification and Management of UGI bleed
5. Definitions
Upper GI Bleeding : always proximal to ligament of
Treitz
Hematemesis : Vomiting of red blood or coffee ground
vomitus, indicative of bleeding from the esophagus,
stomach or duodenum.
Malena: Black tarry stools resulting from degradation of
blood to hematin or other hemochromes by intestinal
bacteria.
Hematochezia : Bright red blood per rectum and
suggests active UGI or small bowel bleeding or distal
colonic or anorectal bleeding
6. Severe GI Bleeding?
Hematemesis ,melena, hematochezia or positive
nasogastric lavage
Accompanied by shock
Orthostatic hypotension
Decrease in the haematocrit value by atleast 6%
Decrease in Hb of atleast 2 grams/dl or transfusion of
two units of packed red blood cells.
7. Some Facts
Approximately 50% of admissions for GI bleeding are
for upper GI (UGI) bleeding (from the esophagus,
stomach, and duodenum).
Self limiting in 80%.
Remaining 20% have a mortality of 30-40%.
5-10% mortality despite advances
8. Causes
COMMON CAUSES
Duodenal ulceration
Gastric ulceration
Esophagitis, gastritis,
duodenitis
Varices
Mallory Weiss tear
LESS COMMON CAUSES
Gastro oesophageal
cancer
Leiomyoma
PHG
Dieulafoy lesion
12. History
Suspected source /cause History
Esophagus erosion GERD/heartburn/alcohol/odynophagia
/ pill ingestion/NG tube placement
Peptic ulcer Epigastric discomfort/asprin/NSAID
use/ history of PUD
Mallory weiss tear Alcohol binge
Retching/vomiting
Cameron lesion Large hiatal hernia
Gastric angiodysplasia CKD
Variceal bleed CLD/cirrhosis/heavy alcohol use
Malignancies Dysphagia/wt loss/early satitation
Nasopharynx Radiation/recurrent epistaxis/
malignancy
Lungs Hemoptysis
13. Physical Examination
SEVERE BLEED (SR)
Tachycardia
Systolic blood pressure of less than 90 mm Hg
Cool extremities
Syncope
Ongoing brisk hematemesis or the occurrence of
maroon or bright-red stools, which requires rapid
blood transfusion.
18. Variceal Non variceal
History
CLD, Jaundice,decompesation
Alcohol consumption
Drugs,pain abdomen
,heartburn,retrosternal discomfort
NCPF recurrent bacterial
infection,umbilical sepsis
Examination
Jaundice,abd.distention.signs of liver
cell failue
No such signs .look for
rheumatological,petechial signs
Epigastric tenderness
Painless bleeding Painful bleeding
Large amount ,FRESH BLEED Mild to moderate, COFFEE
GROUND
Decompensates rapidly
19. Clues From Initial Investigation
Parameter Implications
Hb /HCT 24-72hrs
Need of transfusuion
MCV Less than 80
Less than 80 with negative SOB
Platelets CLD
Hematological disorder
PT/INR Coagulopathy
Disproportionate rise of
BUN
20. Points To Decide Line Of
Management
Severe or non severe
Overt/ hidden
Etiology
Co-morbid conditions
Availability of resources
21. Where To Manage
Severe UGI bleed in ICU. (SR)
Acute GI bleed with hemodynamic stability in ward.
Mild Acute GI bleed with hemodynamic stability and
routine investigations normal, on OPD basis.(CR)
SBP>110, pulse<100
Hb13/12. BUN <18.2
No malena, syncope, cardiac failure , liver disease
Chronic bleed OPD basis.
22. How to Manage
Resuscitation
Initial medical therapy
Endoscopy
Endoscopic hemosatasis
Post endoscopic considerations
Imaging and surgery
24. Monitoring
Vitals
Hct levels 4-6 hrly till stablise
Urinary catheter
ET intubation
MI evaluation
25. Initial Medical Therapy
Depends on cause
PUD – high dose PPI(CR)
Reduce endoscopic stigmata of bleed
Reduced need of endoscopy
No improvement in transfusion reqmt/ rebleed
rate/surgery/survival
Portal htn/variceal bleed
Octreotide infusion
26. Endoscopy
Requirement
Stable hemodynamic condition
Intubation if required
Correction of coagulopathy and thromboctopenia
Gastric lavage (CR)
IV erthromycin/metoclopramide 30-90 min before (CR)
Timing
Cirrohosis/aorto enteric fistula /rebleed in hosp---6hrs
(CR)
Stable with no ongong bleed – 12 hrs (CR)
31. Post Endoscopy Scoring System
(SR)
Complete Rockall score : Clinical Rockall score +
endoscopic stigmata of recent bleeding and
endoscopic diagnosis.
• Score 0-2: very less risk of rebleeding
• Score 9 and above: high risk of rebleeding and mortality.
• Correlates well with mortality but not as well with
rebleeding.
32.
33. FORREST Classification for Peptic
Ulcers
CLASSIFICATION ENDOSCOPIC PIC RISK OF REBLEEDING
FORREST IA ACTIVE SPURTING
AND BLEEDING
85 TO 100%
FORREST IB OOZING BLEEDING 10- 25%
FORREST 2A PIGMENTED
PROTRUBERANCE OR
NBVV
50%
FORRSET 2B ADHERENT CLOT 30 -35%
FORRSET 2C FLAT PIGMENTED
SPOT
<8%
FORRSET 3 CLEAN BASED ULCER <3%
34. Risk For Bleed
The most important predictor of hemorrhage is the
size of varices, with the highest risk of first
hemorrhage (15% per year) occurring in patients with
large varices.
Other predictors of hemorrhage are decompensated
cirrhosis (Child B ,C).
The endoscopic presence of red wale marks.
35. Red Wale Signs Of A Varix In
Endoscopy
Suggests recent haemorrhage
Longitudinal streak located on
esophageal varix
Cherry red spot (circular and
red)
36. Endoscopic Hemostasis
Thermal probe
multipolar electrocoagulation probe(MPEC)
Non contact argon plasma coagulation
Injection therapy
Epinephrine 1:10000, submucosal
N-butyl-2-cyanoacrylate, which is recommended as a first-
line endoscopic therapy
Sclerosant like Ethanolamine or alcohol
Hemoclips
Band ligation
Hemostatic spray
37. Endoscopic Therapy Rec.
Oozing /spurting or NBVV (SR)
Adherent clot with comorbidities increasing risk of
bleed (CR)
Not to clean base ulcer or flat pigmented spot (SR)
Epinephrine should not be used alone, if used then in
combination of other therapy(SR)
Use of IV PPI after hemostasis in ulcer with Oozing
/spurting or NBVV (SR)
Oral PPI clean base ulcer or flat pigmented spot (SR)
38. Relook endoscopy for rebleed or high stigmata of
rebleed in initial endoscopy (SR)
40. Post Endoscopy Considerations
PUD
PPI
H Pylori eradication (SR)
Iron replacement
Aspirin (CR)
Primary prevention : avoid
Secondary prevention : start in 1-3 days
NSAID (SR)
Not if possible
Cox2 inhibitors plus PPI
42. Second Look Endoscopy
Routine second look endoscopy is not
recommended for most patients with peptic ulcer
bleeding, except in those in whom the initial
endoscopic examination was suboptimal.
43. Rebleeding After Endoscopic
Treatment
An urgent repeat endoscopy should be performed
within 6 hrs of rebleeding.
75% of patients achieve endoscopic hemostasis &
donot require surgery.
High dose PPI for more than 72 hrs should be
considered.
Factors predicting failure of endoscopic retreatment
include ulcer >2cm & hypotension on initial
presentation.
44. ACTIVELY BLEEDING VARICES
TIPS OR SURGERY(PC SHUNT OR
ESO.TRANSECTION)
REPEAT BAND LIGATION OR
SCLEROSIS
BLEEDING CONTINUES
PERIPHERAL VENOUS VASOPRESSIN
ENDOSCOPIC BAND LIGATION OR
SCLEROSIS
BALLOON TAMPONADE
TIPS
BLEEDING CONTINUES
BLEEDING
CONTROLLED
CHRONIC
MANAGEMENT
OF VARICES
THAT HAVE BLED
CONSIDER:COURSE
OF ENDOSCOPIC
BAND LIGATION OR
INJECTION
SCLEROSIS OR
PORTOCAVAL
SHUNT SURGERY
(or)
and /or
or
45. Imaging
Role only if both endoscopy and colonoscopy fails
Mesentric arteriography 0.5ml/min
Radionuclide scaning 0.04ml/min
46. Surgery
Indicated only for massive continuous hemorrhage
with failed endoscopy and colonoscopy
48. Case Scenario
43 year old male with hematemesis , HE
History: alcohol consumption, liver
OPD visits, risk factors alcohol and no
prophylaxis for bleed
Examination: CLD features, low BP,
tachycardia, cool extremities
Inv : initial raised Hct, raised BUN
Mgt: Octreotide infusion and late
endoscopy
Complete resuscitation
Editor's Notes
SR
CR
ONE DEF THEN OTHER DEF
Red indicate fresh bleed, cofee old bleed
Melena
can signify bleeding that originates from a UGI, small bowel,
or proximal colonic source and generally occurs when 50 to
100 mL or more of blood is delivered into the GI tract (usually
the upper tract), with passage of characteristic stool occurring
several hours after the bleeding event
HEADING FIRST.. LATER SLIDE
BEAUTIFY
California university study
BEAUTIFY
early satitation in gastric ca
BEAUTIFY
BEAUTIFY
BEAUTIFY
BEAUTIFY
NON VARICEAL CAUSE Peptic ulcer
Dieulafoy’s
Mallory weiss tear
Cameron’s lesions
Upper gi malignancy
GAVE
ONE BY ONE
ICU IN CIRCLE AFTER ARROW
WARD IN CIRCLE AFTER ARROW
OPD IN CIRCLE AFTER ARROW
Barcelona trial… rstrictive transfusion associated with better survival and less re bleed in CHILD A B but opposite for C
NICE guidelines for correction of coagulopathy during AUGIB6 Coagulopathy Threshold Management Platelets <50 x109/L Platelet transfusion INR >1.5 FFP PCC (if on warfarin) aPTTr >1.5 FFP Fibrinogen <1.5g/L FFP Cryoprecipitate (if low despite FFP
ET.. Altered sensorium with risk of aspiration
MI evluation .. Chest pain, old 60 yrs , history of cad, ecg and serial troponin
Dose of ppi 80 MG STAT THEN 8 MG PER HR INFUSION
Octreotide 50 mcg bolus then infusion of 50 mcg/hr for 2-5 days
ERTHROMYCIN 250 MG
Lavage not required as per guideline
Complete rockall is clinical plus endoscopic finding .. Corelate well with mortality but not with risk of rebleed
Inj therapy adv wider avl , less damage than probes, less perf, safe in coagulopathy