This document provides information on the approach to hypotension and shock, including definitions, categories, pathogenesis, assessment, and resuscitation. It discusses the definitions of related terms like stroke volume, cardiac output, blood pressures. It describes the three major categories of shock - cardiogenic, hypovolemic, and distributive - as well as others. It outlines the pathogenesis of shock in terms of cardiac output and vascular resistance. It provides steps for rapid initial assessment and the goals of resuscitation to reestablish tissue perfusion.
Edema is defined and its mechanism explained with reference to the Starling's forces. The causes of localized edema and anasarca discussed.
In history taking, the site and distribution of edema, its duration, association with pain, variability, systemic illness, drug intake, trauma, radiation discussed.
The local and systemic examination described. The approach to investigation including lab tests and imaging explained.
Finally, management is discussed in short.
Edema is defined and its mechanism explained with reference to the Starling's forces. The causes of localized edema and anasarca discussed.
In history taking, the site and distribution of edema, its duration, association with pain, variability, systemic illness, drug intake, trauma, radiation discussed.
The local and systemic examination described. The approach to investigation including lab tests and imaging explained.
Finally, management is discussed in short.
Cardiovascular physiology. Cardiac enzymes and their effects in the body system. Cardiac output and effects increasing and decreasing it. Calculations if Ejected fraction and other cardiac parameters.
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A member on Docplexus had a query on hirsuitism.
I have uploaded simple under graduate level lecture on Hirsuitism and Cong Adr Hyperplasia, which should give a simple and lucid overview of the distressing condition.
Several treatment options are available. Never forget to tell the patient that benefits will begin in 3 months time or so, otherwise they will run from clinic to clinic without relief.
Congenital Adr Hyperplasia (CAH) can appear at any age from birth to puberty where it can lead to ambiguous genitalia. It is due to absolute or relative deficiency of 17 Hydroxylase or 21 Hydroxylase enzyme.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
1. Approach to a case of
Hypotension and Shock
Introductory Lecture Series
Department of Medicine
Dr C Khati
2. Shock is an Emergency
Assessment and resuscitation go hand in hand
because time is critical
3. Learning Objectives
• To learn definition and meanings of related
terms
• To be able to list the steps in pathogenesis of
shock
• To be able to list the 3 major categories of
shock, and 3 others
• To be able to enumerate common causes of
shock in each of the 3 major categories
4. Learning Objectives
• To comprehend that more than one
mechanisms may operate in a given patient
• To list steps in rapid initial assessment
• To enumerate broad steps in resuscitation of
shock
5. Definitions and Meanings
• Stroke Volume (SV): Amount of blood
pumped out with each systole. Pulse pressure
correlates well with SV
• Heart Rate (HR): Number of ventricular
contractions per minute
• Cardiac Output(CO): Amount of blood
pumped out in each minute.
CO = SV X HR
6. Definitions and Meanings
• Stroke Volume (SV): Amount of blood
pumped out with each systole. Pulse pressure
correlates well with SV
• Heart Rate (HR): Number of ventricular
contractions per minute
• Cardiac Output(CO): Amount of blood
pumped out in each minute.
CO = SV X HR
7. Definitions and Meanings
• Stroke Volume (SV): Amount of blood
pumped out with each systole. Pulse pressure
correlates well with SV
• Heart Rate (HR): Number of ventricular
contractions per minute
• Cardiac Output(CO): Amount of blood
pumped out in each minute.
CO = SV X HR
8. Definitions and Meanings
• Stroke Volume (SV): Amount of blood
pumped out with each systole. Pulse pressure
correlates well with SV
• Heart Rate (HR): Number of ventricular
contractions per minute
• Cardiac Output(CO): Amount of blood
pumped out in each minute.
CO = SV X HR
10. Definitions and Meanings
Pulse Pressure (PP): SBP – DBP correlates well
with Stroke Volume .
Mean Arterial Pressure (MAP): DBP + 1/3 PP
11. Definition and Meanings
• Hypotension is diagnosed if blood pressure falls
below 90/50 mmHg in adults.
• Hypotension may also be diagnosed if an individual
has a sudden drop in SBP of 30 - 40 mmHg or more
from their baseline, or
• An orthostatic (postural) drop in DBP of 15 mm Hg
12. Definition and Meanings
• Hypotension is diagnosed if blood pressure falls
below 90/50 mmHg in adults.
• Hypotension may also be diagnosed if an individual
has a sudden drop in SBP of 30 - 40 mmHg or more
from their baseline, or
• An orthostatic (postural) drop in DBP of 15 mm Hg
13. Definition and Meanings
• Hypotension is diagnosed if blood pressure falls
below 90/50 mmHg in adults.
• Hypotension may also be diagnosed if an individual
has a sudden drop in SBP of 30 - 40 mmHg or more
from their baseline, or
• An orthostatic (postural) drop in DBP of 15 mm Hg
15. Definitions and Meanings
• The Jugular Venous Pressure (JVP) is an
observed pressure over the jugular veins
• The Central Venous Pressure (CVP) is a
measured pressure in the right atrium by
means of a catheter attached to a manometer
16. Definitions and Meanings
• The Jugular Venous Pressure (JVP) is an
observed pressure over the jugular veins
• The Central Venous Pressure (CVP) is a
measured pressure in the right atrium by
means of a catheter attached to a manometer
17. Definitions and Meanings
• The Jugular Venous Pressure (JVP) is an
observed pressure over the jugular veins
• The Central Venous Pressure (CVP) is a
measured pressure in the right atrium by
means of a catheter attached to a manometer
18. Definitions and Meanings
Capillary Nail Refill Test
• Pressure is applied to the nail bed until it turns white
(blanching). Then pressure is removed.
• Time taken for return of pink colour to the nail is
considered (capillary refill).
• Blanch time > 2 seconds is a delayed response.
–Dehydration
–Shock
– Peripheral vascular disease (PVD)
– Hypothermia
19. Definitions and Meanings
Capillary Nail Refill Test
• Pressure is applied to the nail bed until it turns
white (blanching). Then pressure is removed.
• Time taken for return of pink colour to the nail is
considered (capillary refill).
• Blanch time > 2 seconds is a delayed response.
–Dehydration
–Shock
–Peripheral vascular disease (PVD)
–Hypothermia
20. Definitions and Meanings
Shock or circulatory failure is the clinical syndrome that
results from generalized inadequate tissue perfusion
lasting for some time. Where oxygen delivery fails to
meet metabolic requirements of the tissues.
It is defined by the presence of multisystem, end organ
hypo perfusion causing cellular injury.
Cellular injury further compromises perfusion through
functional and structural changes in the
microvasculature through mediators
Thus, setting up a vicious cycle.
21. Definitions and Meanings
Shock or circulatory failure is the clinical syndrome that
results from generalized inadequate tissue perfusion
lasting for some time. Where oxygen delivery fails to
meet metabolic requirements of the tissues.
It is defined by the presence of multisystem, end organ
hypo perfusion causing cellular injury.
Cellular injury further compromises perfusion through
functional and structural changes in the
microvasculature through mediators
Thus, setting up a vicious cycle.
22. Definitions and Meanings
Shock or circulatory failure is the clinical syndrome that
results from generalized inadequate tissue perfusion
lasting for some time. Where oxygen delivery fails to
meet metabolic requirements of the tissues.
It is defined by the presence of multisystem, end organ
hypo perfusion causing cellular injury.
Cellular injury further compromises perfusion through
functional and structural changes in the
microvasculature through mediators
Thus, setting up a vicious cycle.
27. Definition and Meanings
• Early Shock
• No significant organ failure
• Late Shock
• Multi-organ failure. > 80% mortality
28. Definition and Meanings
• Early Shock
• No significant organ failure
• Late Shock
• Multi-organ failure. > 80% mortality
29. Definition and Meanings
• Early Shock
• No significant organ failure
• Late Shock
• Multi-organ failure. > 80% mortality
30. Definitions and Meanings
• Systemic Vascular Resistance (SVR): An index
of arteriolar constriction throughout the body
• Calculated by dividing the blood pressure by
the cardiac output. MAP/ CO = SVR
• Pulmonary Vascular Resistance (PVR): An
index of arteriolar constriction in the
pulmonary circulation
31. Definitions and Meanings
• Systemic Vascular Resistance (SVR): An index
of arteriolar constriction throughout the body
• Calculated by dividing the blood pressure by
the cardiac output. MAP/ CO = SVR
• Pulmonary Vascular Resistance (PVR): An
index of arteriolar constriction in the
pulmonary circulation
32. Definitions and Meanings
• Systemic Vascular Resistance (SVR): An index
of arteriolar constriction throughout the body
• Calculated by dividing the blood pressure by
the cardiac output. MAP/ CO = SVR
• Pulmonary Vascular Resistance (PVR): An
index of arteriolar constriction in the
pulmonary circulation
33. Definitions and Meanings
• Systemic Vascular Resistance (SVR): An index
of arteriolar constriction throughout the body
• Calculated by dividing the blood pressure by
the cardiac output. MAP/ CO = SVR
• Pulmonary Vascular Resistance (PVR): An
index of arteriolar constriction in the
pulmonary circulation
45. Pathogenesis of Shock ( CO)
MAP = CO X SVR
or
MAP/ CO = SVR
• If an hypotensive patient has high CO, it can
be inferred that reduced BP is a result of
decreased SVR
46. Pathogenesis of Shock ( CO)
MAP = CO X SVR
or
MAP/ CO = SVR
• If a hypotensive patient has high CO, it can be
inferred that reduced BP is a result of
decreased SVR
47. Pathogenesis of Shock ( CO)
• Low Intravascular and Cardiac Volume
• Increased Intravascular and Cardiac Volume
49. Pathogenesis of Shock ( CO)
Low Intravascular and Cardiac Volume
• Hemorrhage
• Volume Losses (vomiting, diarrhea, Polyuria)
• JVP/ CVP is reduced
• What do you think the other findings will be?
50. Pathogenesis of Shock ( CO)
Low Intravascular and Cardiac Volume
• Hemorrhage
• Volume Losses (vomiting, diarrhea, Polyuria)
• JVP/ CVP is reduced
• What do you think the other findings will be?
51. Pathogenesis of Shock( CO)
Increased Intravascular and Cardiac Volume
• Increased JVP/ CVP
• Extremity edema
• S3/ S4 gallops
• Basal crepitations
• X Ray
– Cardiomegaly
– Widened vascular pedicles, Kerley B Lines
– Pulmonary edema
52. Common Categories of Shock
1. Cardiogenic
2. Hypovolemic
3. High CO with decreased SVR (Warm Shock)
4. Neurogenic- Major brain or spinal injury-
5. Hypoadrenal- Refractory Shock
6. Obstructive- Tamponade, Pulmonary
Embolism, Tension Pneumothorax
53. Common Categories of Shock
1. Cardiogenic
2. Hypovolemic
3. High CO with decreased SVR (Warm Shock)
4. Neurogenic- Major brain or spinal injury-
5. Hypoadrenal- Refractory Shock
6. Obstructive- Tamponade, Pulmonary
Embolism, Tension Pneumothorax
54. Basic Changes in Each Category
Cardiogenic Hypovolemic High CO with
decreased SVR
CO Low Low High
55. Basic Changes in Each Category
Cardiogenic Hypovolemic High CO with
decreased SVR
CO Low Low High
SVR High High Low/ High (late)
56. Basic Changes in Each Category
Cardiogenic Hypovolemic High CO with
decreased SVR
CO Low Low High
SVR High High Low/ High (late)
MAP Low Low Normal/ Low
57. Basic Changes in Each Category
Cardiogenic Hypovolemic High CO with
decreased SVR
CO Low Low High
SVR High High Low/ High (late)
MAP Low Low Normal/ Low
CVP High Low Low/ High (late)
58. Basic Changes in Each Category
Cardiogenic Hypovolemic High CO with
decreased SVR
CO Low Low High
SVR High High Low/ High (late)
MAP Low Low Normal/ Low
CVP High Low Low/ High (late)
Venous Oxygen
saturation
Low Low High
59. Common Causes of Shock
Cardiogenic Hypovolemic High CO with
decreased SVR
MI GI Losses SIRS
Arrhythmias Heat stroke Sepsis
Myocarditis Hemorrhage Pancreatitis
Anaphylaxis
Tamponade Trauma Thyrotoxicosis (storm)
Injuries Burns Burns
AV Shunts
Liver Failure
60. Steps in rapid initial assessment
• Confirm shock and assess severity
• Assess category of shock
• Low CO or high CO
(Heart empty or full)
• Start resuscitation simultaneously
61. Steps in rapid initial assessment
• Confirm shock and assess severity
• Assess category of shock
• Low CO or high CO
(Heart empty or full)
• Start resuscitation simultaneously
62. Steps in rapid initial assessment
• Confirm shock and assess severity
• Assess category of shock
• Low CO or high CO
(Heart empty or full)
• Start resuscitation simultaneously
63. Goal of Resuscitation ?
• Re establish adequate tissue perfusion to
prevent or minimize end- organ injury
64. Goal of Resuscitation
• Re establish adequate tissue perfusion to
prevent or minimize end- organ injury
65. Resuscitation is different in each category
Cardiogenic Hypovolemic High CO with decreased
SVR
Treatment for
Ischemia
IV Fluids Antibiotics
Ionotropes Colloids EGDT*
After load
reduction
Low dose steroids
Activated Protein C
66. Steps in rapid initial assessment
• Patient and clinical situation assessment
• Vitals and quick examination to assess category
of shock-
• Core temperature
• Cold or warm peripheries
• Pulse- bounding or low volume
• Capillary filling- slow/ rapid
• Raised JVP, S3 and basal crepts in cardiogenic
• Respiration
• Urine Output
67. Steps in rapid initial assessment
• Patient and clinical situation assessment
• Vitals and quick examination to assess
category of shock-
–Core temperature
–Cold or warm peripheries
–Pulse- bounding or low volume
–Capillary filling- slow/ rapid
–Raised JVP, S3 and basal crepts in
cardiogenic
–Respiration
–Urine Output
68. Terms in Assessment/ Treatment
• APACHE II Score- Acute Physiology and
Chronic Health Evaluation II (with points for
age and co-morbidity)
• Glasgow Coma Score
• ACLS- Advanced Cardiac Life Support
• Old acronym- ABC (still valid)
69. General Features of Shock
• Hypotension (SBP < 100)
• Tachycardia (>100)
• Cold clammy skin (Low CO)
• Rapid shallow respiration
• Drowsiness, confusion and irritability
• Oliguria (<30ml/hr)
• Elevated / reduced CVP
• Multi- organ failure
70. Steps in Resuscitation
• Airway and Respiration
• Circulation
• Early Goal Directed Therapy (EGDT)
• Multisystem organ support
71. 32 year old young lady, on NSAIDS
• Dyspepsia X 5 days
• Dark tarry stools X 2 days
• Profound weakness X 2 days
• Syncope this morning
• Cold clammy and sweating, Poor capp refill
• BP 70/50 mm Hg lying; 60/ 35 mm standing
• Pulse 140/ min, thready
• Resp- 36/ min
• Pallor
72. 40 year busy doctor, HT
• Chest Pain X 1 Hour
• Sweating, palpitations and breathlessness
• Restless, sweating, cold and clammy
• BP 100/76 mm, Pulse 110/ min, low volume
• Resp- 26/ min, prefers to be propped up
• Poor capillary refill
• JVP/ CVP raised
73. 45 year old diabetic male
• Fever, cough and rusty sputum X 2 days
• Weakness X 1 day
• No urine X12 hours
• Temp- 40 degrees C, warm extremities
• Pulse 120/ min, good volume
• BP 108/30 mm, Resp rate 40/ min
• Cyanosis +, JVP not raised
• Capp refill good
74. Take Home Messages
• Shock is an Emergency. Assessment and
resuscitation go hand in hand because time is
critical
• Hypotension is a late feature of shock. Do not
wait for hypotension before starting treatment
• Clinical setting and simple examination of MAP,
pulse pressure, heart rate, JVP and nail cappillary
bed refill can give vital clues. Tachypnea and
sweating should also make you alert.
75. Take Home Messages
• Urine output is a good indicator of renal (tissue)
perfusion
• Goal of resucitatation is to re establish adequate
tissue perfusion to prevent or minimize end-
organ injury