Allopurinol is a xanthine oxidase inhibitor used to treat gout and hyperuricemia. It works by decreasing uric acid production. Common brands include Zyloric, Allgoric, and Ciploric. Allopurinol is generally well tolerated but can cause rare severe hypersensitivity reactions. It interacts with several other drugs like azathioprine and increases risk of toxicity. Patients on allopurinol require monitoring of uric acid levels and kidney and liver function.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Hypolipidemic agents, also known as cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are also called lipid-lowering drugs.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Hypolipidemic agents, also known as cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are also called lipid-lowering drugs.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Esomeprazole works by binding irreversibly to the H+/K+ ATPase in the proton pump.
Inhibition dramatically decrease the secretion of hydrochloric acid into the stomach
Allopurinol 300mg tablets smpc taj pharmaceuticalsTaj Pharma
Allopurinol 100mg, 300mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Allopurinol Dosage & Rx Info | Allopurinol Uses, Side Effects -, Allopurinol : Indications, Side Effects, Warnings, Allopurinol - Drug Information - Taj Pharma, Allopurinol dose Taj pharmaceuticals Allopurinol interactions, Taj Pharmaceutical Allopurinol contraindications, Allopurinol price, Allopurinol Taj Pharma Gout Kidney stone Cancer Allopurinol 100mg, 300mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Allopurinol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Non-steroidal anti-inflammatory drugs is a class of analgesic medication that reduces pain, fever and inflammation. Since most episodes of back pain involve inflammation, NSAIDs such as ibuprofen and naproxen are often an effective treatment option.
Sean Kelly is an Emergency Physician and Intensivist who's the director at Gosford ICU in New South Wales. He's also the medical director at ICCMU. He gave this great talk at Bedside Critical Care 2012 on Daydream Island. He'll be at SMACC. Check out the ICCMU website.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Chemical Structure
Allopurinol is known chemically as 1,5 Dihydro-4Hpyrazolo[3,4-d ]pyrimidin-4-one.
Category: Uricosuric agent(Antigout, Xanthine Oxidase
Inhibitor)
History:
Allopurinol was first synthesized and reported in 1956 by Roland K.
Robins (1926-1992), in a search for antineoplasitic agents.
Allopurinol has been marketed in the United States since August 19,
1966, when it was first approved by FDA under the trade name of
Zyloprim. Allopurinol was marketed at the time by BurroughsWellcome.
4. Mechanism Of
Action
Allopurinol and its metabolite, oxypurinol (alloxanthine),
decrease the production of uric acid by inhibiting the
action of xanthine oxidase, the enzyme that converts
hypoxanthine to xanthine and xanthine to uric acid.
Allopurinol also increases reutilization of hypoxanthine and
xanthine for nucleotide and nucleic acid synthesis; the
resultant increase in nucleotide concentration leads to
feedback inhibition of de novo purine synthesis.
10. Dosage &Route Of
Administration
ADULT DOSING
Calcium renal calculus, recurrent: 200 to 300 mg Orally
as a single or divided dose (2-3 times daily); maximum
dose: 800 mg/day
Gout: (mild) 100-300 mg/day Orally as a single or divided
dose (2-3 times daily)
11. Gout: (moderate to severe) 400-600 mg/day Orally as a
single or divided dose (2-3 times daily); maximum dose 800
mg/day
Hyperuricemia - Tumor lysis syndrome: 600 to 800
mg/day Orally for 2 or 3 days; MAX daily dose, 800 mg ,
12 hours to 3 days prior to initiation of chemotherapy
12. Pediatric Dosing
Cancer - Hyperuricemia: (under 6 y) 150 mg PO daily,
evaluate response after 48 hour and dose adjust accordingly
Cancer - Hyperuricemia: (6 to 10 y) 300 mg PO daily,
evaluate response after 48 hour and dose adjust
accordingly
Hyperuricemia - Tumor lysis syndrome: (under 6 years) 150
mg Orally once daily for 2 to 3 days
Hyperuricemia - Tumor lysis syndrome: (6 to 10 years) 300
mg Orally once daily for 2 to 3 days
13. Dose Adjustments
Maintenance dose should be based on serum uric acid
determinations performed 48 hours after initial dose
Renal impairment: CrCL 10 to 20 mL/min, 200 mg daily
Renal impairment: CrCL 3 to 10 mL/min, 100 mg daily
Renal impairment: CrCL less than 3 mL/min, 100 mg at
extended intervals greater than every 24 hours
14. Pharmacokinetics
Absorption
Tmax, Oral: 1.5 hours (allopurinol), 4.5 hours
(oxipurinol)
Bioavailability, Oral: 80% to 90%
Onset: Initial effect: 2-3 d, peak effect: 7-14 days
Distribution
Vd: 1.6 L/kg (allopurinol)
Protein Bound: <1%
Metabolism
Liver: 70%
Oxypurinol: active
15. Excretion
Renal clearance: approx GFR (allopurinol) ; 16.5
mL/minute (oxipurinol)
Renal: approximately 80%, Feces: 20%
Total body clearance: 15.7 mL/min/kg .
Elimination Half Life
Allopurinol: 1 to 2 hours ; Oxipurinol: 15 h (range 12
to 30 h)
Administration
Oral - better tolerated if administered following meals
16. Contraindications &
Precautions
Contraindications
Concomitant use with didanosine
Hypersensitivity to allopurinol
Precautions
Allergic reaction may occur; discontinue at first sign
Liver disease; monitoring recommended
Renal function, decreased; risk of worsening condition;
monitoring and dosage adjustment recommended
17. Pregnancy Category & Breast
Feeding
Pregnancy Category
Category -C
Breast Feeding
Compatible with breastfeeding
18. Adverse drug reactions
(ADRS)
Common
Dermatologic: Maculopapular eruption, Pruritus (less
than 1% )
Serious
Dermatologic: Rash (less than 1% ), Stevens-Johnson
syndrome (less than 1% ), Toxic epidermal necrolysis (less
than 1% )
Hematologic: Agranulocytosis,
Aplastic
anemia,
Eosinophilia, Myelosuppression, Thrombocytopenia (0.6%
)
19. Hepatic: Granulomatous hepatitis (less than 1% ),
Hepatic necrosis (less than 1% ), Hepatotoxicity
Immunologic: Immune hypersensitivity reaction
Renal: Renal failure (less than 1% )
20. Drug-Drug Interactions
DRUGS
SEVERIT
Y
SUMMARY
ALLOPURINOL -DIDANOSINE
Contraindicated
result in increased serum concentrations
of didanosine. (Decre M)
AZATHIOPRINE -ALLOPURINOL
Major
result in azathioprine toxicity by decre M
(nausea, vomiting, leukopenia, anemia).
MERCAPTOPURINE -ALLOPURINOL
Major
result in mercaptopurine toxicity by decre
M (bone marrow suppression, nausea,
vomiting). Management: reduce dose to
25-35% during concurrent admin.
21. ALUMINUM
HYDROXIDE -ALLOPURINOL
Moderate
may result in decreased
allopurinol
effectiveness(Separate by 2
hours) decre A
CYCLOSPORINE -ALLOPURINOL
Moderate
result in an increased risk of
cyclosporine toxicity (renal
dysfunction, cholestasis,
paresthesias). unknown mechanism
WARFARIN
POTASSIUM -ALLOPURINOL
Moderate
result in an increased risk of
bleeding. (Decre M)
Management: consider monitoring
CT, aPTT, INR and administer vitk accordingly
22. Monitoring
Serum uric acid levels; goal of serum uric acid level in adults
is 6 mg/dL or less
Hyperuricosuria: 24-hour urinary urate excretion to
determine best dose and frequency for efficacy
Pain relief is indicative of efficacy
Liver function tests; periodically with preexisting liver disease,
or if anorexia, weight loss, or pruritus develop in any patient
renal function tests; periodically if renal impairment is present
or if concomitant conditions affecting renal function (eg,
hypertension, diabetes mellitus) are present
23. Treatment In Allopurinol
Toxicity
Support:
Management Of Mild To Moderate Toxicity : Treatment
is symptomatic and supportive.
Management Of Severe Toxicity: Treatment is
symptomatic and supportive. In patients with acute allergic
reaction, oxygen therapy, bronchodilators, diphenhydramine,
corticosteroids, vasopressors and epinephrine may be required.
Decontamination:
Airway management: Ensure adequate ventilation and
perform endotracheal intubation early in patients with severe
allergic reactions.
Antidote: None.
24. Myelosuppression:
(leukocytosis,
leukopenia,
eosinophilia,
thrombocytopenia, granulocytopenia, and fatal bone marrow
suppression); these effects may be the result of concomitant use of other
myelosuppressive drugs.
Treat severe neutropenia with filgrastim 5 mcg/kg/day IV infused over 4
hours. Monitor serial CBC with differential.
Hypersensitivity reaction:
Mild/Moderate: Antihistamines with or without inhaled beta agonists,
corticosteroids or epinephrine.
Severe: Oxygen, aggressive airway management, antihistamines, epinephrine
(Adult: 0.3 to 0.5 mL of a 1:1000 solution subcutaneously;
Child: 0.01 mL/kg, 0.5 mL max; may repeat in 20 to 30 min),
corticosteroids, ECG monitoring, and IV fluids.
25. Monitoring of patient: Monitor renal function and liver enzymes in
symptomatic patients. Monitor CBC after significant overdose. Monitor
serum electrolytes in patients with significant vomiting and/or diarrhea.
Enhanced elimination procedure: Allopurinol and oxypurinol are
removed during hemodialysis.
26. Allopurinol – black box warning
THIS IS NOT AN INNOCUOUS DRUG. IT IS NOT
RECOMMENDED FOR THE TREATMENT OF
ASYMPTOMATIC HYPERURICEMIA
ALLOPURINOL SHOULD BE DISCONTINUED AT
THE FIRST APPEARANCE OF SKIN RASH OR
OTHER SIGNS OF AN ALLERGIC REACTION
27. Patient Education
Warn patient to immediately report a skin rash or signs/symptoms of an allergic
reaction (painful urination, blood in the urine, irritation of the eyes, or swelling of the
lips or mouth) as drug may cause severe, sometimes fatal, hypersensitivity reactions.
Drug may cause diarrhea, nausea.
Instruct patient to report signs/symptoms of hepatotoxicity (anorexia, weight loss, or
pruritus).
Advise patient that optimal benefit may be delayed for 2 to 6 weeks.
Counsel patient to take drug after meals to reduce gastric irritation.
Encourage patient to maintain adequate hydration during therapy to prevent renal
stones
Take the missed dose as soon as you remember. If it is almost time for your next dose,
skip the missed dose and take the medicine at your next regularly scheduled time. Do
not take extra medicine to make up the missed dose.