This was prepared by Drs during Medical school lecture on ENT at St. Francis university college of health and allied sciences-Ifakara, Tanzania.
Cc Dr. Rajabu Jumanne Mlaluko (MD), Dr. Swaumu Shein (MD) and Dr. Stephano Phabian (MD).
Tonsillitis slideshare for medical students NehaNupur8
complete and detail information about tonsillits , that is the inflammation of the tonsils ,present in the oral cavity , disease of oral cavity contains introduction, definition, types, causes, risk factors,pathophysiology , treatment , medical management, nursing management, nurses role, patient teaching sign and symptoms , drug therapy, diet management,
Tonsillitis slideshare for medical students NehaNupur8
complete and detail information about tonsillits , that is the inflammation of the tonsils ,present in the oral cavity , disease of oral cavity contains introduction, definition, types, causes, risk factors,pathophysiology , treatment , medical management, nursing management, nurses role, patient teaching sign and symptoms , drug therapy, diet management,
A female patient of age 9 yrs was admitted in VBGH at ENT male ward with chief complaints of :
Difficulty in swallowing
Pain during swallowing since few days and is diagnosed as Chronic tonsillitis
A female patient of age 9 yrs was admitted in VBGH at ENT male ward with chief complaints of :
Difficulty in swallowing
Pain during swallowing since few days and is diagnosed as Chronic tonsillitis
Questions to ask to elicit a diagnosis.
Give your differential diagnosis.
Give management plan of most probable diagnosis.
Differentiate between viral upper respiratory tract infection from bacterial pharyngitis / tonsillitis.
Discuss the criteria to prescribe antibiotics for URTI.
Write prescription for viral URTI.
A sore throat is pain or irritation of the throat that often worsens when you swallow.
Fever is the temporary increase in the body's temperature in response to a disease or illness.
There are many clinical scenarios where sore throat is associated with fever. E.g. pharyngitis, tonsilitis, influenza, laryngitis.
.
Homeopathy medicines for throat infection are selected based on signs and symptoms; each case is taken after a thorough history, extracting the causative factors, modalities as well as characteristic symptoms. Homeopathy treatments are very safe and side effect free. So it cures the disease in a very smooth and holistic way. It is given to all age groups from 1-day infant to 80 years old person.
Know more: https://www.multicarehomeopathy.com/online-consultation
The ciliary ganglion is one of four parasympathetic ganglia of the head and neck. It receives preganglionic parasympathetic fibers from the EWN via the CN III.
It supplies the eye via short ciliary nerves not only with parasympathetic fibers, but also with sensory and sympathetic fibers that pass through the ganglion.
Gross anatomy
Shape: Flat/lenticular
Size: 2 mm*1mm (smallest)
Location: posterolaterally in the intra-conal space of the orbit between the optic nerve and the LR muscle. 10 mm from Zinn, 15-20 mm from posterior pole
It is just lateral to the ophthalmic artery as it crosses the optic nerve from lateral to medial
Sympathetic root
from the ICA (from the superior cervical ganglion) via the nasociliary nerve, a branch of the trigeminal nerve
fibers pass through the ganglion without synapsing.
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Sensory root
via the small communicating branch of the ciliary ganglion (from CN V1)
fibers pass through the ganglion without synapsing
Uvea tract and their presentations. They are so important for blood supply to the retina as well as preventing infection to the retina.
This is important topic for undergraduates as well as masters students.
I dedicate this work to all ophthalmology students across the globe.
Retinitis pigmentosa is rare heritable diseases which affect photoreceptor and make the patient unable to see normally in dimlight then loss of vision.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Outline
Anatomy of tonsils
Physiology of tonsils
Definition of acute tonsillitis
Etiology of acute tonsillitis
Types of acute tonsillitis
Diagnosis
Treatment
Complications
3. Anatomy of Tonsils
Tonsils are the lymphoid tissue mass which are
found in the pharynx. They form part of waldeyer’s
ring and opens into respiratory and digestive
system.
Lateral part is formed by palatine tonsils and tubal
tonsils which found around auditory tube opening
Upper part by pharyngeal tonsil (on the roof of
nasopharynx)
Lower part by Lingual tonsil ( on posterior 1/3 of
tongue)
5. Palatine tonsil
Lateral surface of tonsil presents a well defined
fibrous capsule and Loose areolar tissue lies
between the tonsillar bed and the capsule, it is
the site for collection of pus in peritonsillar
abscess (Quinsy)
Upper pole of tonsil extends into soft palate, its
medial surface is covered by semilunar fold plica
semilunaris
Lower pole of tonsil is attached to the tongue,
triangular fold of mucous membrane extends from
anterior pillar to antero-inferior part of tonsil
enclosing plica triangularis
Tonsil is separated from the tongue by
10. Physiology/Function of tonsils
It is the component of inner waldeyer’s ring
It has a protective role and acts as a sentinel at
portal of air and food passage
Crypts increase the surface area for contact with
foreign substances
NB: As the person grow tonsils tend to decrease in
size and become fibrosed. That’s why Tonsillitis
unlikely to occur in elder otherwise there other risk
factor for infection.
11. Acute tonsillitis
It is the inflammation of tonsils. It can be of
palatine, pharyngeal or lingual tonsils.
It is mostly common caused by virus but
sometimes by bacteria.
12. Etiology of acute tonsillitis
Viral tonsillitis (70-80%)
In children less than 5 years and young adults.
Mostly self limiting in 3-4 days. Influenza, Para
influenza, coxsackies A, rhinovirus etc.
Bacterial tonsillitis(15-30%)
In children 5-15 years and rarely in less than 2
years. It is also called streptococcal tonsillitis. Since
the most common bacteria is Group A streptococcal
(GAS). Others organisms are staphylococci and
anaerobes.
17. Cont..
Acute membranous ;follows stage of acute
follicular tonsillitis where exudates coalesce to
form membrane on the surface
18. Diagnosis
Through History and physical exam
S/S Fever, sore throat, painful swallowing.
Supportive investigations
FBP (Leukocytosis), increased CRP and ESR (not
specific), ASO- titer (risk for RF)
MODIFIED CENTOR SCORE for diagnosis of
bacterial tonsillitis
C-cough
E-Exudates
N-Nodes
T-Temp
OR- young or old
19. CENTOR cont…
Criteria
Signs and symptoms
No cough (1 point)
Tender anterior cervical adenopathy ( 1point)
Fever (1 point)
Tonsillar exudates (1 point)
Age
3-14 years (1 point)
15-44 years ( 0 point)
More than 45 ( -1 point)
20. Cont…
Approach from CENTOR score
Score less or equal to 1 means no further
diagnostic testing or abx is indicated
Score 2-3 means rapid antigen detection testing
(RADT)/ throat culture indicated
Score more than 4 means needs empirical abx
21. Treatment
Conservative tx
Rest, fluid intake, analgesics, salt water gargles
Avoid Aspirin in children
Abx if GAS confirmed. Pen V if allergic give
Macrolides
22. Cont..
Surgery tx ( tonsillectomy)
Types
1) Subtotal. Capsule is spared. No bleeding. Risk
of relapse
2) Total. Tonsil + capsule. Risk of bleeding. No
relapse
Indications
1. Recurrent and chronic
2. Extreme hypertrophy of tonsils
3. Hx of peritonsillar abscess
4. Tonsillitis that resist abx
23. Cont…
Post Op Management
NPO till gag reflex returns
First 48 hours Cold foods
Soft non-spicy food for one week after the first 48
hours
Following GA- Tonsillar position is given
Following LA- Semi-sitting position is given
Condy’s gargles (1:4000 Potassium Permanganate)
or diluted Hydrogen peroxide gargles for 8-10 days
Ask patient to blow balloons to stretch and strenghens
the palate (Nasal speech tx)
25. Cont…
Non suppurative comps
1. Rheumatic fever
2. Scarlet fever (fever, flushed cheek, strawberry
tongue)
3. Post streptococcal glomerulonephritis. Occurs
mostly at age of 10-30 years following Impetigo/
tonsillopharyngitis
4. Sub acute bacterial endocarditis