The document describes the key stages of human development from fertilization through the embryonic period (first 8 weeks). It explains that fertilization involves the merging of sperm and egg nuclei. The zygote then undergoes cell division and develops into a blastocyst that implants in the uterus. Major events of the embryonic period include gastrulation, formation of the three germ layers and organs, and development of the heart and placenta to support growth.
Introduction to female reproductive physiology (the guyton and hall physiology)Maryam Fida
Introduction to female reproductive physiology
Formation of female gametes, ova
Reception of male gametes, spermatozoa
Provision of suitable environments for fertilization of the ovum by spermatozoa and development of the resultant fetus
Parturition (childbirth)
Lactation, the production of breast milk, which provides complete nourishment for the baby in its early life
Onset of adult sexual life
Developing of female glands
Enlargement of breasts and erection of nipples
Growth of body hair, most prominently underarm and pubic hair
Greater development of thigh muscles behind the femur, rather than in front of it
Widening of hips
lower waist to hip ratio than adult males
Smaller hands and feet than men
Rounder face
Smaller waist than men
Changed distribution in weight and fat; more subcutaneous fat and fat deposits, mainly around the buttocks, thighs, and hips
Effect of Estrogens on the Uterus and External Female Sex Organs
Enlargement of external genitalia due to fat deposition
Change of Vaginal epithelium from cuboidal to stratified
Increased size of uterus after puberty
Proliferation of endometrial stroma
Effect of Estrogens on the Fallopian Tubes
Glandular tissue proliferation
Number of ciliated epithelial cells increase
Effect of Estrogens on the Breasts
development of the stromal tissues of the breasts
Growth of an extensive ductile system
Deposition of fat in the breasts.
Effect of Estrogens on the Skeleton
Estrogens inhibit osteoclastic activity in the bones stimulating bone growth
uniting of the epiphyses with the shafts of the long bones
Osteoporosis of the Bones Caused by Estrogen deficiency in Old Age
increased osteoclastic activity in the bones
decreased bone matrix
decreased deposition of bone calcium and phosphate
Effect of Estrogens on Protein Deposition
Slight increase in total body protein
BMR increased only1/3rd as compared to testosterone
Increased deposition of fate in:
Subcutaneous tissue
Breasts, buttocks and thighs
Effect of Estrogens on Hair Distribution
No effect
Effect of Estrogens on the Skin
Makes skin soft and smooth
Increased skin vascularity
Effect of Estrogens on Electrolyte Balance
Slight sodium and water reabsorption
Introduction to female reproductive physiology (the guyton and hall physiology)Maryam Fida
Introduction to female reproductive physiology
Formation of female gametes, ova
Reception of male gametes, spermatozoa
Provision of suitable environments for fertilization of the ovum by spermatozoa and development of the resultant fetus
Parturition (childbirth)
Lactation, the production of breast milk, which provides complete nourishment for the baby in its early life
Onset of adult sexual life
Developing of female glands
Enlargement of breasts and erection of nipples
Growth of body hair, most prominently underarm and pubic hair
Greater development of thigh muscles behind the femur, rather than in front of it
Widening of hips
lower waist to hip ratio than adult males
Smaller hands and feet than men
Rounder face
Smaller waist than men
Changed distribution in weight and fat; more subcutaneous fat and fat deposits, mainly around the buttocks, thighs, and hips
Effect of Estrogens on the Uterus and External Female Sex Organs
Enlargement of external genitalia due to fat deposition
Change of Vaginal epithelium from cuboidal to stratified
Increased size of uterus after puberty
Proliferation of endometrial stroma
Effect of Estrogens on the Fallopian Tubes
Glandular tissue proliferation
Number of ciliated epithelial cells increase
Effect of Estrogens on the Breasts
development of the stromal tissues of the breasts
Growth of an extensive ductile system
Deposition of fat in the breasts.
Effect of Estrogens on the Skeleton
Estrogens inhibit osteoclastic activity in the bones stimulating bone growth
uniting of the epiphyses with the shafts of the long bones
Osteoporosis of the Bones Caused by Estrogen deficiency in Old Age
increased osteoclastic activity in the bones
decreased bone matrix
decreased deposition of bone calcium and phosphate
Effect of Estrogens on Protein Deposition
Slight increase in total body protein
BMR increased only1/3rd as compared to testosterone
Increased deposition of fate in:
Subcutaneous tissue
Breasts, buttocks and thighs
Effect of Estrogens on Hair Distribution
No effect
Effect of Estrogens on the Skin
Makes skin soft and smooth
Increased skin vascularity
Effect of Estrogens on Electrolyte Balance
Slight sodium and water reabsorption
Embryology is the branch of biology that studies the prenatal development of gametes (sex cells), fertilization, and development of embryos and fetuses. Additionally, embryology encompasses the study of congenital disorders that occur before birth. Here's a breakdown of the major areas within embryology:
Gametogenesis: This is the process by which male and female sex cells are formed. In males, it’s called spermatogenesis and involves the formation of sperm cells. In females, it’s called oogenesis and involves the formation of egg cells.
Fertilization: This is the process where the sperm cell joins with an egg cell, leading to the formation of a zygote. This marks the beginning of the embryo's development.
Embryonic Development: Post fertilization, the zygote begins a series of rapid divisions called cleavage, leading to the formation of a multicellular stage known as a blastocyst. The blastocyst then implants in the uterine wall, where it develops into an embryo. During this stage, the basic body plan and primary tissue layers (endoderm, mesoderm, and ectoderm) are established.
Fetal Development: After the initial stages of embryonic development, the developing organism is referred to as a fetus. This period is characterized by the rapid growth and maturation of tissues and organs that were formed during the embryonic period.
Teratology: This is the study of abnormalities of physiological development. It often focuses on congenital birth defects, their causes, and their prevention.
The physiological processes that regulate parturition and the onset of labor continue to be defined. It is clear, however, that labor onset represents the culmination of a series of biochemical changes in the uterus and cervix. These result from endocrine and paracrine signals emanating from both mother and fetus.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.