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Charles P. OʼBrien, MD, PhD"
            University of Pennsylvania"




DIAGNOSTIC & STATISTICAL MANUAL

 Edition"        Year"       Pages"       Categories"


    I"           1952"        132"           106"
    II"          1968"        119"           182"
   III"          1980"        494"           265"
  III-R"         1987"        567"           292"
   IV"           1994"        686"          ~300"
   V"            2013"         -"             -"
Criteria should be"

       •  For Clinicians

       •  Easy to Use

       •  Reliable & Valid

       •  Good Coverage




        PHILOSOPHY"

•  Decide Using Data
•  Change When Justified
•  Base Decision On:
            Value Added
            Cohesive Structure
            Coverage
Proposed DSM-5 "
                                            Clustering"
Neurodevelopment disorders"    Developmental impairments in cognition   Autism, Learning Disabilities,
                               or social cognition"                     Intellectual Disability"

Neurocognitive disorders"                                               Dementias, Delirium"

Schizophrenia and related      Schizotype with or without psychosis"    Schizophrenia, Schizotypal
disorders"                                                              personality disorders, some
                                                                        nonaffective psychoses"
Mood Disorders"                Predominant disturbance of mood          Depression, GAD, Bipolar disorder"
                               regulation"

Anxiety Disorders"             Predominent dysregulation of fear"       Panic disorder, social phobia, simple
                                                                        phobias, PTSD"
Obsessive Compulsive           Unwanted intrusive thoughts or motor     OCD, Touretteʼs, BCC, possibly
Disorders"                     behaviors: In OCD, compulsions to        trichotillomania, possibly
                               manage the resulting tension"            hypochondria"

Substance use, addiction and   Pathological reward-seeking. Imbalance   Substance addictions, compulsive
related disorders"             between reward circuitry and cognitive   gambling, possibly other compulsive
                               control (PFC)"                           behaviors"

Impulse Control Disorders"     Pathological failure to control          ADHD, CD, ODD, Intermittent
                               inappropriate cognitive, emotional, or   explosive disorder; perhaps
                               behavioral responses"                    paraphilias; perhaps binge eating"

Somatic Disorders"                                                      Eating, Sleep, Sexual, Somatic
                                                                        Disorders"
Personality Disorders"
Symptom Changes"
Craving"




               Gambling"

•  Move pathological gambling from ICD-
   not otherwise specified to a “substance
   use and related disorders” section."
•  Change the name of the disorder (e.g.,
   “disordered gambling”)."
•  Reduce the threshold to 4 of 9 criteria
   and eliminate the legal criterion item "
Other putative “addictions”
                                  !

 •  Internet Addiction (insufficient data) "
 •  Sexual (sexual use disorders committee is evaluating;
   not sufficient evidence that it is similar to other non-
   substance related addictions)"

 •  Eating (some overlap with substance use disorders and
   putative associations with eating disorders)"

 •  Shopping (some empirical data available)"
 •  Work (minimal data available)"
 •  Exercise (minimal data available)"




          Addiction: A Brain Disease


•  Genetic vulnerability, e.g. 40-80% heritability

•  Biological risk factors, e.g. anhedonia

•  Brain abnormalities, e.g. low DA density NcA

•  Effective neurobiological interventions
Comorbidity PG-SUD
Petry, 2007



•  >25% of treatment-seeking pathological gamblers also
   have a substance use disorder

•  5-20% of treatment-seeking substance abusers also
   have pathological gambling (LTPcommunity 0.4-2%)

•  General population studies also show high rates of
   PG-SUD comorbidity

•  US and non-US studies




Considerations for including new
      disorders in DSM-V  "

•  A clinical need"
•  Sufficiently distinct from other
   disorders"
•  Potential harm (to other patient or non-
   patient groups)"
•  Potential for treatment"
•  Meets criteria for a mental disorder"
Prevalence rates of “gaming” addiction
                                   *modified




     Proportion of adolescents reporting DSM-IV
   symptoms for Internet “addiction” (Ko et al., 2005)
Limitations
! Usually non-random convenience samples (school
  surveys or on-line respondents, with limited
  representation of middle or older aged adults).
! Response biases.
! Different instruments with limited psychometric
  testing (Buyn et al., 2009).
! Lack of a general agreement as to what constitutes
  Internet/gaming addiction.

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2010 Conference - Proposed Changes for DSM-V (O'Brien)

  • 1. Charles P. OʼBrien, MD, PhD" University of Pennsylvania" DIAGNOSTIC & STATISTICAL MANUAL Edition" Year" Pages" Categories" I" 1952" 132" 106" II" 1968" 119" 182" III" 1980" 494" 265" III-R" 1987" 567" 292" IV" 1994" 686" ~300" V" 2013" -" -"
  • 2. Criteria should be" •  For Clinicians •  Easy to Use •  Reliable & Valid •  Good Coverage PHILOSOPHY" •  Decide Using Data •  Change When Justified •  Base Decision On: Value Added Cohesive Structure Coverage
  • 3. Proposed DSM-5 " Clustering" Neurodevelopment disorders" Developmental impairments in cognition Autism, Learning Disabilities, or social cognition" Intellectual Disability" Neurocognitive disorders" Dementias, Delirium" Schizophrenia and related Schizotype with or without psychosis" Schizophrenia, Schizotypal disorders" personality disorders, some nonaffective psychoses" Mood Disorders" Predominant disturbance of mood Depression, GAD, Bipolar disorder" regulation" Anxiety Disorders" Predominent dysregulation of fear" Panic disorder, social phobia, simple phobias, PTSD" Obsessive Compulsive Unwanted intrusive thoughts or motor OCD, Touretteʼs, BCC, possibly Disorders" behaviors: In OCD, compulsions to trichotillomania, possibly manage the resulting tension" hypochondria" Substance use, addiction and Pathological reward-seeking. Imbalance Substance addictions, compulsive related disorders" between reward circuitry and cognitive gambling, possibly other compulsive control (PFC)" behaviors" Impulse Control Disorders" Pathological failure to control ADHD, CD, ODD, Intermittent inappropriate cognitive, emotional, or explosive disorder; perhaps behavioral responses" paraphilias; perhaps binge eating" Somatic Disorders" Eating, Sleep, Sexual, Somatic Disorders" Personality Disorders"
  • 4.
  • 5.
  • 7. Craving" Gambling" •  Move pathological gambling from ICD- not otherwise specified to a “substance use and related disorders” section." •  Change the name of the disorder (e.g., “disordered gambling”)." •  Reduce the threshold to 4 of 9 criteria and eliminate the legal criterion item "
  • 8. Other putative “addictions” ! •  Internet Addiction (insufficient data) " •  Sexual (sexual use disorders committee is evaluating; not sufficient evidence that it is similar to other non- substance related addictions)" •  Eating (some overlap with substance use disorders and putative associations with eating disorders)" •  Shopping (some empirical data available)" •  Work (minimal data available)" •  Exercise (minimal data available)" Addiction: A Brain Disease •  Genetic vulnerability, e.g. 40-80% heritability •  Biological risk factors, e.g. anhedonia •  Brain abnormalities, e.g. low DA density NcA •  Effective neurobiological interventions
  • 9. Comorbidity PG-SUD Petry, 2007 •  >25% of treatment-seeking pathological gamblers also have a substance use disorder •  5-20% of treatment-seeking substance abusers also have pathological gambling (LTPcommunity 0.4-2%) •  General population studies also show high rates of PG-SUD comorbidity •  US and non-US studies Considerations for including new disorders in DSM-V " •  A clinical need" •  Sufficiently distinct from other disorders" •  Potential harm (to other patient or non- patient groups)" •  Potential for treatment" •  Meets criteria for a mental disorder"
  • 10. Prevalence rates of “gaming” addiction *modified Proportion of adolescents reporting DSM-IV symptoms for Internet “addiction” (Ko et al., 2005)
  • 11. Limitations ! Usually non-random convenience samples (school surveys or on-line respondents, with limited representation of middle or older aged adults). ! Response biases. ! Different instruments with limited psychometric testing (Buyn et al., 2009). ! Lack of a general agreement as to what constitutes Internet/gaming addiction.