This document discusses several case studies of interventions that targeted social determinants of health. It describes initiatives in Pennsylvania, Arkansas, Wisconsin, and England. The Pennsylvania Fresh Food Financing Initiative aimed to increase access to healthy foods in urban areas by providing funding for supermarkets. The Healthy Arkansas Initiative sought to improve health outcomes by creating incentives for healthy behaviors. Wisconsin's New Hope program offered employment services and benefits to reduce poverty. England's Neighborhood Improvement Project addressed environmental factors and increased community engagement to improve mental health. All of the initiatives aimed to demonstrate how addressing social and economic factors can positively impact health outcomes.