This document summarizes efforts to address the opioid epidemic in West Virginia through multi-level collaboration. It describes rising overdose rates, community health needs, and how substance use disorder often co-occurs with other conditions. It then outlines examples of local and regional response efforts like the "Bridges" program, which brings together public health, public safety, and other partners using a harm reduction approach. These efforts aim to improve prevention, treatment, overdose reversal, family support, and recovery through initiatives like expanding peer recovery coaching, integrating behavioral health into harm reduction, and launching rural outreach teams.