This document discusses the pathogenesis and clinical features of tuberculosis. It describes the various fates tuberculosis can take, from primary infection to disseminated or miliary forms. The clinical features of different types of extrapulmonary TB are outlined, including pleural, genitourinary, skeletal, tuberculous meningitis, gastrointestinal, and pericardial TB. Miliary TB is described as presenting with yellowish granulomas resembling millet seeds and can cause hepatomegaly, splenomegaly, and lymphadenopathy. The role of the NRAMP1 polymorphism in TB pathogenesis is to influence the generation of anti-microbial oxygen radicals in lysosomes.