The document summarizes the key events leading up to the American Civil War from the 1850s. It discusses the Compromise of 1850, the publication of Uncle Tom's Cabin which increased anti-slavery sentiment, the Kansas-Nebraska Act of 1854 which allowed slavery in new territories via popular sovereignty and inflamed tensions, the founding of the Republican Party in opposition to expanding slavery, the Dred Scott decision of 1857, and Lincoln's election in 1860 which prompted Southern states to begin seceding, leading to the outbreak of war with the Confederate attack on Fort Sumter in 1861.