Molybdenum is a component of enzymes like xanthine oxidase, aldehyde oxidase, and sulfite oxidase. Good dietary sources include liver, kidney, meat, milk, whole grains, legumes, and leafy vegetables. The recommended daily intake is 200 micrograms. Molybdenum is readily absorbed and incorporated into enzymes, where it serves as a cofactor. Deficiency is rare but causes xanthinuria and low uric acid levels, while excess molybdenum intake can impair growth and cause diarrhea or anemia.

1. Molybdenum Metabolism
Gandham.Rajeev

2. • Molybdenum is a component of xanthine
oxidase, aldehyde oxidase & sulfite oxidase.
• Sources:
• Rich sources of molybdenum are liver,
kidney, meat, milk, whole grains, legumes
and leafy vegetables.
• RDA:
• 200 micrograms/day.

3. • Absorption:
• Dietary molybdenum is readily absorbed by
the intestine and is excreted in urine and bile.
• Functions:
• Molybdenum serves as a cofactor for
metalloenzymes.
• Molybdenum is incorporated into:
• Xanthine oxidase
• Aldehyde oxidase
• Sulfite oxidase

4. Deficiency manifestations
• Molybdenum deficiency is rare in humans.
• Its deficiency causes xanthinuria with low
plasma and urinary uric acid concentrations.
• Molybdenosis is a rare disorder caused by
excessive consumption of molybdenum.
• Symptoms:
• Impairment in growth, diarrhea & anemia.

5. • Deficiency manifestations:
• Molybdenum deficiency is rare in humans.
• Its deficiency causes xanthinuria with low
plasma and urinary uric acid concentrations.
• Molybdenosis is a rare disorder caused by
excessive consumption of molybdenum.
• Symptoms:
• Impairment in growth, diarrhea & anemia.

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