SlideShare a Scribd company logo
1 of 6
For all student:
main source is (Regezi)
This outline not enough for exam

Lymphoid lesions
 Reactive lesions
•
•

Lymphoid hyperplasia
Angiolymphoid hyperplasia

•

Lymphoepithelial cyst

 Developmental lesions
 Neoplasms:


Lymphomas
• Hodgkin’s lymphomas
• Non-Hodgkin’s lymphoma
 Myeloma/plasmacytoma

Reactive lesions
*Lymphoid hyperplasia
Normal lymphoid tissue in/around the oral cavity:
Pharyngeal tonsils
Lingual tonsils
Oral tonsils
Regional lymph nods
and lymphoid tissue
1. LH: is a proliferation of lymphocytes without cytological atypia.
2. Mitotic figures often remain restricted to the germinal center.
3. Occasionally, it may mimic the “starry-sky” appearance
Follicular lymphoid hyperplasia:
is a reactive condition involving the soft tissue covering the hard palate
Lymphoproliferative disease of the palate:
Similar to follicular lymphoid hyperplasia but always associated with malignancy
*Angiolymphoid hyperplasia with eosinophilia
"Epithelioid or histiocytoid hemangioma"
 Nodular subcutaneous benign disease [Aggregates of lymphocytes and eosinophils]
 Regional lymphadenopathy
 Blood eosinophilia
ALHE Clinically
 Oral mucosal involvement is rare, however, it is common in the head & neck area
 If occur, labial mucosa is the common site
 Predominant in males
 Affect persons in all ages
 1-2cm. Solitary painless mobile lesion that enlarged gradually
ALHE Histopathology
 Well developed lymphoid follicles containing
 Proliferating and dilated capillaries

germinal centers
 Intensive infiltration of lymphocytes with eosinophils and fewer number of macrophages
Treatment:
Surgical excision
Intralesional steroid injections might be effective
*Kimura’s Disease
 Similar to ALHE but without the association with regional lymphadenopathy
 Different but related entity
Developmental
*Lymphoepithelial cyst
Neoplasm
Hodgkin’s Lymphomas
Non-Hodgkin’s Lymphomas
**Hodgkin’s Lymphomas
 Affect bone or soft tissues
 Painless enlargement of lymph nods or extra-nodal lymphoid tissue
 Rarely affect the oral cavity
 Malignant lymphoid cells
 Non-neoplastic inflammatory cells
 Reed-Sternberg cells
Lukes-Bulter histologic classification
1. Lymphocytic predominance
2. Nodular sclerosis
3. Mixed cellularity
4. Lymphocyte depletion
Ann Arbor classification
 Stage I:
=Involvement of single LN or single extralymphatic site
 Stage II:
= 2 or more LN chains
 Stage III:
=Positive disease in both sides of diaphragm
 Stage IV:
= bone marrow, liver or other extralymphatic organs
Treatment and prognosis:
•
External radiotherapy
•
Chemotherapy
**Non-Hodgkin’s Lymphomas
 Middle-age and elderly
 Gradual, asymptomatic, Focal enlargement of lymph node
 Ann Arbor classification
1-Nodular lymphoma
 3 subtypes:
• Poorly differentiated
• Mixed lymphocytic-histiocytic
• Histiocytic [least favorable prognosis]
2-Diffuse lymphoma
 Lymphocytic
•
•
 Histiocytic

Well-differentiated
Poorly-differentiated
 Mixed
Treatment
- Stage I: radiotherapy
- Other stages: chemotherapy or both
*Burkett's lymphoma
 Non-Hodgkin’s Lymphoma
 African children lymphoma
 Translocation of distal part of chromosome 8 to chr. 14.
• Translocation of long arm of chromosome 22 to Chr. 9. is called Philadelphia Chr. [seen in
leukemia]
 Highest proliferation rate in humans
Clinically
African
American
% of all childhood
malignancy
Mean age
Race
Jaw involvement

50%

6-10%

3-10 years
#100 blacks
Relatively common

11 years
#77% whites
R. uncommon

Association with EBV

90%

10%

Radiographically
 Poorly marginated radiolucency
 Cortex: expanded, eroded or perforated
Histopathologically
 B-cell proliferation
 Nodular or diffuse proliferation
 Proliferation of lymphocytes with numerous scattered macrophages [starry-sky]
Treatment and prognosis
 Chemotherapy
 2 years survival
Plasma cell neoplasms
1-Multiple myeloma
2-Solitary plasmacytoma of bone
*Multiple myeloma
 What is plasma cell?
 May present in soft tissue or in bone [solitary or
multiple]
 80% of bone plasmacytomas involve head and neck region
 Mean age 63 years
 May be asymptomatic. In symptomatic cases: pain, swelling, expansion, numbness or mobility of
teeth. Loss of weight and anemia in some cases.
 Immunoglobulin components [IgG, IgA] maybe
detected in serum and urine of 91% and 97%
Radiographically
 85% of patients have abnormal radiographic
skeletal survey
 Multiple well-defined radiolucent areas
Histopathology
 Proliferation of plasma cells
Treatment and prognosis
 Chemotherapy and steroids and local radiation
 Most patients die of infection or renal failure
 Mean survival is 2-5 years
*Solitary plasmacytoma of bone
 Mean age 50 years
 Rarely affect jaw [angle of the mandible]
 It may progress to multiple myeloma
Radiographically
 Well defined radiolucency
 It may penetrate the cortical bone to the adjacent soft tissue
 Peripheral blood picture is normal
 Bone biopsy reveals proliferation of plasma cells producing immunoglobulin components

Treatment
Local radiotherapy
Survival of patients is 10 years
Metabolic and Genetic jaw diseases







Paget’s disease
Hyperparathyroidism
Hyperthyroidism
Acromegaly
Cherubism
Osteopetrosis

Paget’s disease
Chronic progressive disease of unknown etiology
 3 stages:
1. Bone resorption
2. Vascular phase
3. Osteoblastic repair
Clinical Features
 ≈90% >55 years of age
 Rare <40 years of age
 Slightly more common in men (4:3)
 More common in Europe mainly in England
 Site: Femora, cranium, pelvis and sternum
HP:
according to it’s stage, activity of osteoclast and osteoblast,
diagnosable…Why?].

mosaic picture [is characteristic but not

Treatment:
symptomatic includes analgesics, calcitonin.

Hyperparathyroidism









Etiology: unknown, neoplasm or hereditary
Elevated levels of [PTH] and hypercalcimia
Bone demineralization
Treatment: management of the primary cause and treatment of associated problems as renal failure
Excessive amount of T3 and T4 hormones
Common in female between 10 to 14 years
Tremor, muscle weakness palpitation, diarrhea, anxiety and loss of weight
Treatment:
 thyroid-suppressive drugs [Thiocarbamides]
 Radioactive iodine administration
 Stress or epinephrine may precipitate
“thyroid storm”

Acromegaly
 Hypersecretion of pituitary growth hormone
 Common in 4th decade
 Muscle weakness, paresthesia, new periosteal bone formation, enlargement of maxilla and mandible
and paranasal sinuses, hypertension
 Treatment: Controlling levels of growth hormone

Cherubism





Children of 5 years
Hereditary
Bone expansion particularly the posterior region of the mandible
Cervical and submandibular lymphadenopathy are common
Osteopetrosis
 Hereditary bone condition
 Generalized symmetrical increase in skeletal density and bone abnormalities
 2 main types
 Infantile [malignant]
 Adult [benign]
 Prognosis is poor, in adults is less sever
 Treatment of complications

Most common lesions containing large number of multinucleated giant cells are:








cherubism
giant cell tumor (osteoclastoma)
fibro-osseous lesions
bone lesion of hyperparathyroidism
hereditary hyperparathyroidism
jaw tumors syndrome
aneurysmal bone cyst

More Related Content

What's hot

Exfoliative cytology for dental students
Exfoliative cytology for dental students Exfoliative cytology for dental students
Exfoliative cytology for dental students
Beeula A
 
Odontogenic tumors
Odontogenic tumorsOdontogenic tumors
Odontogenic tumors
Marwa Salama
 
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
Doctor Faris Alabeedi
 

What's hot (20)

Tumor of oral cavity
Tumor of oral cavityTumor of oral cavity
Tumor of oral cavity
 
Spindle cell lesions of oral cavity part I
Spindle cell lesions of oral cavity part ISpindle cell lesions of oral cavity part I
Spindle cell lesions of oral cavity part I
 
Odontogenic tumors part 2
Odontogenic tumors part 2Odontogenic tumors part 2
Odontogenic tumors part 2
 
Ameloblastoma
AmeloblastomaAmeloblastoma
Ameloblastoma
 
Red lesion of oral mucosa
Red lesion of oral mucosa Red lesion of oral mucosa
Red lesion of oral mucosa
 
Exfoliative cytology for dental students
Exfoliative cytology for dental students Exfoliative cytology for dental students
Exfoliative cytology for dental students
 
Pigmented Cellular Naevus
 Pigmented Cellular Naevus Pigmented Cellular Naevus
Pigmented Cellular Naevus
 
Odontogenic tumors ppt
Odontogenic tumors pptOdontogenic tumors ppt
Odontogenic tumors ppt
 
"Oral Squamous Cell Carcinoma"
 "Oral Squamous Cell Carcinoma" "Oral Squamous Cell Carcinoma"
"Oral Squamous Cell Carcinoma"
 
Salivary gland tumors
Salivary gland tumorsSalivary gland tumors
Salivary gland tumors
 
Tumor of oral cavity
Tumor of oral cavityTumor of oral cavity
Tumor of oral cavity
 
Odontogenic tumors
Odontogenic tumorsOdontogenic tumors
Odontogenic tumors
 
Leukemia and oral manifestations
Leukemia and oral manifestationsLeukemia and oral manifestations
Leukemia and oral manifestations
 
Radicular cyst (maryam arbab)
Radicular cyst (maryam arbab)Radicular cyst (maryam arbab)
Radicular cyst (maryam arbab)
 
Mucocutaneous
Mucocutaneous Mucocutaneous
Mucocutaneous
 
Leukoplakia
LeukoplakiaLeukoplakia
Leukoplakia
 
Radicular cyst or Periapical cyst
Radicular cyst or Periapical cystRadicular cyst or Periapical cyst
Radicular cyst or Periapical cyst
 
Pre cancerous lesions & conditions
Pre cancerous lesions & conditionsPre cancerous lesions & conditions
Pre cancerous lesions & conditions
 
Aot,ceot
Aot,ceotAot,ceot
Aot,ceot
 
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
The so called Calcifying Odontogenic Cyst (Doctor Faris Alabeedi MSc, MMedSc,...
 

Viewers also liked

Chronic lymphoproliferative disorders
Chronic lymphoproliferative disordersChronic lymphoproliferative disorders
Chronic lymphoproliferative disorders
Veena Raja
 
Examination of lymphnodes and cervicofacial lymphadenopathy
Examination of lymphnodes and cervicofacial lymphadenopathyExamination of lymphnodes and cervicofacial lymphadenopathy
Examination of lymphnodes and cervicofacial lymphadenopathy
anusushanth
 
Disorders of salivary glands
Disorders of salivary glandsDisorders of salivary glands
Disorders of salivary glands
Ankita Varshney
 

Viewers also liked (17)

Non neoplastic ln revised
Non neoplastic ln revisedNon neoplastic ln revised
Non neoplastic ln revised
 
resultados fecha 3
resultados fecha 3resultados fecha 3
resultados fecha 3
 
Pattern of inflammatory diseases in lymph node biopsy
Pattern of inflammatory diseases in lymph node biopsyPattern of inflammatory diseases in lymph node biopsy
Pattern of inflammatory diseases in lymph node biopsy
 
Chronic lymphoproliferative disorders
Chronic lymphoproliferative disordersChronic lymphoproliferative disorders
Chronic lymphoproliferative disorders
 
Non neoplastic lymphadenopathy
Non neoplastic lymphadenopathy Non neoplastic lymphadenopathy
Non neoplastic lymphadenopathy
 
fine needle aspiration cytology by rahul raj
fine needle aspiration cytology by rahul rajfine needle aspiration cytology by rahul raj
fine needle aspiration cytology by rahul raj
 
Cervicofacial lymphadenopathy / dental implant courses
Cervicofacial lymphadenopathy / dental implant coursesCervicofacial lymphadenopathy / dental implant courses
Cervicofacial lymphadenopathy / dental implant courses
 
Eosinophils in lymph node
Eosinophils in lymph nodeEosinophils in lymph node
Eosinophils in lymph node
 
examination of lymph nodes
examination of lymph nodesexamination of lymph nodes
examination of lymph nodes
 
Prostate Cancer And Screening
Prostate Cancer And ScreeningProstate Cancer And Screening
Prostate Cancer And Screening
 
Anatomy of lymph node
Anatomy of lymph nodeAnatomy of lymph node
Anatomy of lymph node
 
Cervical lymphadenopathy
Cervical lymphadenopathyCervical lymphadenopathy
Cervical lymphadenopathy
 
WHO 2016 update on classification of Lymphoid neoplasms
WHO 2016 update on classification of Lymphoid neoplasms WHO 2016 update on classification of Lymphoid neoplasms
WHO 2016 update on classification of Lymphoid neoplasms
 
Examination of lymphnodes and cervicofacial lymphadenopathy
Examination of lymphnodes and cervicofacial lymphadenopathyExamination of lymphnodes and cervicofacial lymphadenopathy
Examination of lymphnodes and cervicofacial lymphadenopathy
 
Disorders of salivary glands
Disorders of salivary glandsDisorders of salivary glands
Disorders of salivary glands
 
Lymphadenopathy
LymphadenopathyLymphadenopathy
Lymphadenopathy
 
Salivary glands diseases
Salivary glands diseasesSalivary glands diseases
Salivary glands diseases
 

Similar to Lymphoid lesions

rct.pptx
rct.pptxrct.pptx
rct.pptx
DrPurvaPihulkar
 

Similar to Lymphoid lesions (20)

Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
 
DOC-20221229-WA0000..pptx
DOC-20221229-WA0000..pptxDOC-20221229-WA0000..pptx
DOC-20221229-WA0000..pptx
 
Wilms tumor cause management lymphoma management
Wilms tumor cause management lymphoma managementWilms tumor cause management lymphoma management
Wilms tumor cause management lymphoma management
 
lymphoma 16-3-2023 dr masoud.ppt
lymphoma 16-3-2023 dr masoud.pptlymphoma 16-3-2023 dr masoud.ppt
lymphoma 16-3-2023 dr masoud.ppt
 
lymphoma
lymphomalymphoma
lymphoma
 
lymphadenopathy_and_malignancy.ppt
lymphadenopathy_and_malignancy.pptlymphadenopathy_and_malignancy.ppt
lymphadenopathy_and_malignancy.ppt
 
Hodgkins & Non-Hodgkins Lymphomas
Hodgkins & Non-Hodgkins LymphomasHodgkins & Non-Hodgkins Lymphomas
Hodgkins & Non-Hodgkins Lymphomas
 
rct.pptx
rct.pptxrct.pptx
rct.pptx
 
hodgkin lyphoma
hodgkin lyphomahodgkin lyphoma
hodgkin lyphoma
 
hl.ppt
hl.ppthl.ppt
hl.ppt
 
Child with lymphadenopathy
Child with lymphadenopathyChild with lymphadenopathy
Child with lymphadenopathy
 
Medicine 5th year, 4th lecture/part two (Dr. Abdulla Sharief)
Medicine 5th year, 4th lecture/part two (Dr. Abdulla Sharief)Medicine 5th year, 4th lecture/part two (Dr. Abdulla Sharief)
Medicine 5th year, 4th lecture/part two (Dr. Abdulla Sharief)
 
Hodgkins lymphoma kiran
Hodgkins lymphoma   kiranHodgkins lymphoma   kiran
Hodgkins lymphoma kiran
 
Lymphoma
LymphomaLymphoma
Lymphoma
 
Oncological disorders in children
Oncological disorders in childrenOncological disorders in children
Oncological disorders in children
 
Hodgkins lymphoma
Hodgkins lymphomaHodgkins lymphoma
Hodgkins lymphoma
 
LYMPHOMA HODGKIN and Non HODGKIN By Nawsherwan Jabbary
LYMPHOMA HODGKIN and Non HODGKIN By Nawsherwan JabbaryLYMPHOMA HODGKIN and Non HODGKIN By Nawsherwan Jabbary
LYMPHOMA HODGKIN and Non HODGKIN By Nawsherwan Jabbary
 
Hodgkin’s lymphoma
Hodgkin’s lymphomaHodgkin’s lymphoma
Hodgkin’s lymphoma
 
LYMPHOMA.pptx
LYMPHOMA.pptxLYMPHOMA.pptx
LYMPHOMA.pptx
 
Non hodgkins lymphoma nandhu
Non hodgkins lymphoma nandhuNon hodgkins lymphoma nandhu
Non hodgkins lymphoma nandhu
 

More from IAU Dent

More from IAU Dent (20)

Odontogenic Infection
Odontogenic InfectionOdontogenic Infection
Odontogenic Infection
 
Odontogenic Tumors
Odontogenic TumorsOdontogenic Tumors
Odontogenic Tumors
 
Maxillofacial injuries
Maxillofacial injuriesMaxillofacial injuries
Maxillofacial injuries
 
Impacted teeth
Impacted teethImpacted teeth
Impacted teeth
 
Odontogenic Cysts
Odontogenic CystsOdontogenic Cysts
Odontogenic Cysts
 
Chronic gingivitis
Chronic gingivitisChronic gingivitis
Chronic gingivitis
 
Plaque control
Plaque controlPlaque control
Plaque control
 
8. hypotension & hypertension
8. hypotension & hypertension8. hypotension & hypertension
8. hypotension & hypertension
 
8. Prescription Writing
8. Prescription Writing8. Prescription Writing
8. Prescription Writing
 
7. Adrenocorticosteriods
7. Adrenocorticosteriods7. Adrenocorticosteriods
7. Adrenocorticosteriods
 
7.a. histamine & antihistaminics
7.a. histamine & antihistaminics7.a. histamine & antihistaminics
7.a. histamine & antihistaminics
 
8 anticancer drugs
8  anticancer drugs8  anticancer drugs
8 anticancer drugs
 
7 antibiotic-dental
7 antibiotic-dental7 antibiotic-dental
7 antibiotic-dental
 
7.b. sedative hypnotics
7.b. sedative hypnotics 7.b. sedative hypnotics
7.b. sedative hypnotics
 
6. peptic ulcer drugs 323
6. peptic ulcer drugs 3236. peptic ulcer drugs 323
6. peptic ulcer drugs 323
 
6. anti drenergic
6. anti drenergic 6. anti drenergic
6. anti drenergic
 
6 beta lactum drugs dental
6  beta lactum drugs dental6  beta lactum drugs dental
6 beta lactum drugs dental
 
4.anti colinergic
4.anti colinergic 4.anti colinergic
4.anti colinergic
 
5 aminoglycosides,macrolides, anti tb dental
5 aminoglycosides,macrolides, anti tb dental5 aminoglycosides,macrolides, anti tb dental
5 aminoglycosides,macrolides, anti tb dental
 
5. opioid analgesics
5. opioid analgesics5. opioid analgesics
5. opioid analgesics
 

Recently uploaded

CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
ocean4396
 
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
Abortion pills in Kuwait Cytotec pills in Kuwait
 
Sonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptxSonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptx
palsonia139
 

Recently uploaded (20)

Creating Accessible Public Health Communications
Creating Accessible Public Health CommunicationsCreating Accessible Public Health Communications
Creating Accessible Public Health Communications
 
VVIP Whitefield ℂall Girls 6350482085 Heat-flaring { Bangalore } Worthy Girl ...
VVIP Whitefield ℂall Girls 6350482085 Heat-flaring { Bangalore } Worthy Girl ...VVIP Whitefield ℂall Girls 6350482085 Heat-flaring { Bangalore } Worthy Girl ...
VVIP Whitefield ℂall Girls 6350482085 Heat-flaring { Bangalore } Worthy Girl ...
 
CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
CAS 110-63-4 BDO Liquid 1,4-Butanediol 1 4 BDO Warehouse Supply For Excellent...
 
Is Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptxIs Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptx
 
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
Best medicine 100% Effective&Safe Mifepristion ௵+918133066128௹Abortion pills ...
 
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
 
Case presentation on Antibody screening- how to solve 3 cell and 11 cell panel?
Case presentation on Antibody screening- how to solve 3 cell and 11 cell panel?Case presentation on Antibody screening- how to solve 3 cell and 11 cell panel?
Case presentation on Antibody screening- how to solve 3 cell and 11 cell panel?
 
Gallbladder Double-Diverticular: A Case Report المرارة مزدوجة التج: تقرير حالة
Gallbladder Double-Diverticular: A Case Report  المرارة مزدوجة التج: تقرير حالةGallbladder Double-Diverticular: A Case Report  المرارة مزدوجة التج: تقرير حالة
Gallbladder Double-Diverticular: A Case Report المرارة مزدوجة التج: تقرير حالة
 
Premium ℂall Girls In Mira Road👉 Dail ℂALL ME: 📞9004268417 📲 ℂall Richa VIP ℂ...
Premium ℂall Girls In Mira Road👉 Dail ℂALL ME: 📞9004268417 📲 ℂall Richa VIP ℂ...Premium ℂall Girls In Mira Road👉 Dail ℂALL ME: 📞9004268417 📲 ℂall Richa VIP ℂ...
Premium ℂall Girls In Mira Road👉 Dail ℂALL ME: 📞9004268417 📲 ℂall Richa VIP ℂ...
 
Cervical screening – taking care of your health flipchart (Vietnamese)
Cervical screening – taking care of your health flipchart (Vietnamese)Cervical screening – taking care of your health flipchart (Vietnamese)
Cervical screening – taking care of your health flipchart (Vietnamese)
 
The Orbit & its contents by Dr. Rabia I. Gandapore.pptx
The Orbit & its contents by Dr. Rabia I. Gandapore.pptxThe Orbit & its contents by Dr. Rabia I. Gandapore.pptx
The Orbit & its contents by Dr. Rabia I. Gandapore.pptx
 
Mgr university bsc nursing adult health previous question paper with answers
Mgr university  bsc nursing adult health previous question paper with answersMgr university  bsc nursing adult health previous question paper with answers
Mgr university bsc nursing adult health previous question paper with answers
 
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
 
Sonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptxSonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptx
 
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
 
5Cladba ADBB 5cladba buy 6cl adbb powder 5cl ADBB precursor materials
5Cladba ADBB 5cladba buy 6cl adbb powder 5cl ADBB precursor materials5Cladba ADBB 5cladba buy 6cl adbb powder 5cl ADBB precursor materials
5Cladba ADBB 5cladba buy 6cl adbb powder 5cl ADBB precursor materials
 
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best supplerCas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
 
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depthsUnveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
 
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
 
Our Hottest 💘 Surat ℂall Girls Serviℂe 💘Pasodara📱 8527049040📱450+ ℂall Girl C...
Our Hottest 💘 Surat ℂall Girls Serviℂe 💘Pasodara📱 8527049040📱450+ ℂall Girl C...Our Hottest 💘 Surat ℂall Girls Serviℂe 💘Pasodara📱 8527049040📱450+ ℂall Girl C...
Our Hottest 💘 Surat ℂall Girls Serviℂe 💘Pasodara📱 8527049040📱450+ ℂall Girl C...
 

Lymphoid lesions

  • 1. For all student: main source is (Regezi) This outline not enough for exam Lymphoid lesions  Reactive lesions • • Lymphoid hyperplasia Angiolymphoid hyperplasia • Lymphoepithelial cyst  Developmental lesions  Neoplasms:  Lymphomas • Hodgkin’s lymphomas • Non-Hodgkin’s lymphoma  Myeloma/plasmacytoma Reactive lesions *Lymphoid hyperplasia Normal lymphoid tissue in/around the oral cavity: Pharyngeal tonsils Lingual tonsils Oral tonsils Regional lymph nods and lymphoid tissue 1. LH: is a proliferation of lymphocytes without cytological atypia. 2. Mitotic figures often remain restricted to the germinal center. 3. Occasionally, it may mimic the “starry-sky” appearance Follicular lymphoid hyperplasia: is a reactive condition involving the soft tissue covering the hard palate Lymphoproliferative disease of the palate: Similar to follicular lymphoid hyperplasia but always associated with malignancy *Angiolymphoid hyperplasia with eosinophilia "Epithelioid or histiocytoid hemangioma"  Nodular subcutaneous benign disease [Aggregates of lymphocytes and eosinophils]  Regional lymphadenopathy  Blood eosinophilia ALHE Clinically  Oral mucosal involvement is rare, however, it is common in the head & neck area  If occur, labial mucosa is the common site  Predominant in males  Affect persons in all ages  1-2cm. Solitary painless mobile lesion that enlarged gradually ALHE Histopathology  Well developed lymphoid follicles containing  Proliferating and dilated capillaries germinal centers
  • 2.  Intensive infiltration of lymphocytes with eosinophils and fewer number of macrophages Treatment: Surgical excision Intralesional steroid injections might be effective *Kimura’s Disease  Similar to ALHE but without the association with regional lymphadenopathy  Different but related entity Developmental *Lymphoepithelial cyst Neoplasm Hodgkin’s Lymphomas Non-Hodgkin’s Lymphomas **Hodgkin’s Lymphomas  Affect bone or soft tissues  Painless enlargement of lymph nods or extra-nodal lymphoid tissue  Rarely affect the oral cavity  Malignant lymphoid cells  Non-neoplastic inflammatory cells  Reed-Sternberg cells Lukes-Bulter histologic classification 1. Lymphocytic predominance 2. Nodular sclerosis 3. Mixed cellularity 4. Lymphocyte depletion Ann Arbor classification  Stage I: =Involvement of single LN or single extralymphatic site  Stage II: = 2 or more LN chains  Stage III: =Positive disease in both sides of diaphragm  Stage IV: = bone marrow, liver or other extralymphatic organs Treatment and prognosis: • External radiotherapy • Chemotherapy **Non-Hodgkin’s Lymphomas  Middle-age and elderly  Gradual, asymptomatic, Focal enlargement of lymph node  Ann Arbor classification 1-Nodular lymphoma  3 subtypes: • Poorly differentiated • Mixed lymphocytic-histiocytic • Histiocytic [least favorable prognosis] 2-Diffuse lymphoma  Lymphocytic • •  Histiocytic Well-differentiated Poorly-differentiated
  • 3.  Mixed Treatment - Stage I: radiotherapy - Other stages: chemotherapy or both *Burkett's lymphoma  Non-Hodgkin’s Lymphoma  African children lymphoma  Translocation of distal part of chromosome 8 to chr. 14. • Translocation of long arm of chromosome 22 to Chr. 9. is called Philadelphia Chr. [seen in leukemia]  Highest proliferation rate in humans Clinically African American % of all childhood malignancy Mean age Race Jaw involvement 50% 6-10% 3-10 years #100 blacks Relatively common 11 years #77% whites R. uncommon Association with EBV 90% 10% Radiographically  Poorly marginated radiolucency  Cortex: expanded, eroded or perforated Histopathologically  B-cell proliferation  Nodular or diffuse proliferation  Proliferation of lymphocytes with numerous scattered macrophages [starry-sky] Treatment and prognosis  Chemotherapy  2 years survival Plasma cell neoplasms 1-Multiple myeloma 2-Solitary plasmacytoma of bone *Multiple myeloma  What is plasma cell?  May present in soft tissue or in bone [solitary or multiple]  80% of bone plasmacytomas involve head and neck region  Mean age 63 years  May be asymptomatic. In symptomatic cases: pain, swelling, expansion, numbness or mobility of teeth. Loss of weight and anemia in some cases.  Immunoglobulin components [IgG, IgA] maybe detected in serum and urine of 91% and 97% Radiographically  85% of patients have abnormal radiographic skeletal survey  Multiple well-defined radiolucent areas Histopathology  Proliferation of plasma cells Treatment and prognosis  Chemotherapy and steroids and local radiation  Most patients die of infection or renal failure
  • 4.  Mean survival is 2-5 years *Solitary plasmacytoma of bone  Mean age 50 years  Rarely affect jaw [angle of the mandible]  It may progress to multiple myeloma Radiographically  Well defined radiolucency  It may penetrate the cortical bone to the adjacent soft tissue  Peripheral blood picture is normal  Bone biopsy reveals proliferation of plasma cells producing immunoglobulin components Treatment Local radiotherapy Survival of patients is 10 years
  • 5. Metabolic and Genetic jaw diseases       Paget’s disease Hyperparathyroidism Hyperthyroidism Acromegaly Cherubism Osteopetrosis Paget’s disease Chronic progressive disease of unknown etiology  3 stages: 1. Bone resorption 2. Vascular phase 3. Osteoblastic repair Clinical Features  ≈90% >55 years of age  Rare <40 years of age  Slightly more common in men (4:3)  More common in Europe mainly in England  Site: Femora, cranium, pelvis and sternum HP: according to it’s stage, activity of osteoclast and osteoblast, diagnosable…Why?]. mosaic picture [is characteristic but not Treatment: symptomatic includes analgesics, calcitonin. Hyperparathyroidism         Etiology: unknown, neoplasm or hereditary Elevated levels of [PTH] and hypercalcimia Bone demineralization Treatment: management of the primary cause and treatment of associated problems as renal failure Excessive amount of T3 and T4 hormones Common in female between 10 to 14 years Tremor, muscle weakness palpitation, diarrhea, anxiety and loss of weight Treatment:  thyroid-suppressive drugs [Thiocarbamides]  Radioactive iodine administration  Stress or epinephrine may precipitate “thyroid storm” Acromegaly  Hypersecretion of pituitary growth hormone  Common in 4th decade  Muscle weakness, paresthesia, new periosteal bone formation, enlargement of maxilla and mandible and paranasal sinuses, hypertension  Treatment: Controlling levels of growth hormone Cherubism     Children of 5 years Hereditary Bone expansion particularly the posterior region of the mandible Cervical and submandibular lymphadenopathy are common
  • 6. Osteopetrosis  Hereditary bone condition  Generalized symmetrical increase in skeletal density and bone abnormalities  2 main types  Infantile [malignant]  Adult [benign]  Prognosis is poor, in adults is less sever  Treatment of complications Most common lesions containing large number of multinucleated giant cells are:        cherubism giant cell tumor (osteoclastoma) fibro-osseous lesions bone lesion of hyperparathyroidism hereditary hyperparathyroidism jaw tumors syndrome aneurysmal bone cyst