Renal physiology introduction.

Renal Physiology 1 Introduction

Aims & Content of this lecture ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Renal system – important points ,[object Object],[object Object],[object Object]

The functional unit of the kidney: the nephron ,[object Object],[object Object],[object Object],[object Object],[object Object]

Glomerulus and Bowman’s capsule ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Functions of the kidneys ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The three basic renal processes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Glomerular filtration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GFR depends on diameters of afferent and efferent arterioles  GFR  GFR Glomerulus Afferent arteriole Efferent arteriole Glomerular filtrate Aff. Art. dilatation Eff. Art. dilatation Eff. Art. constriction Aff. Art. constriction Prostaglandins, Kinins, Dopamine (low dose), ANP, NO Angiotensin II (low dose) Angiotensin II blockade Ang II (high dose), Noradrenaline (Symp nerves), Endothelin, ADH, Prost. Blockade)

Peritubular reabsorption ,[object Object],[object Object],[object Object],[object Object]

Renal transport systems ,[object Object],[object Object],[object Object],[object Object]

Na + absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Glucose handling ,[object Object],[object Object],[object Object],[object Object]

Amino acid handling ,[object Object],[object Object],[object Object],[object Object],[object Object]

K + handling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

K + handling ,[object Object],[object Object]

Modulation of K + secretion Luminal factors Stimulators Inhibitors  Flow rate  [K + ]  [Na + ]  [Cl - ]  [Cl - ]  [Ca 2+ ]  [HCO 3 - ] Ba 2+ -ve luminal voltage Amiloride Selected Diuretics Peritubular Factors Stimulators Inhibitors  K + intake ,[object Object], [K + ] Adrenaline ,[object Object],Aldosterone ADH

Countercurrent Multiplier ,[object Object],[object Object],[object Object],[object Object],[object Object]

formation of hyperosmotic urine

Osmolality of fluid along nephron ,[object Object],[object Object],[object Object]

Role of urea in concentrating urine ,[object Object],[object Object],[object Object],[object Object]

Urea recycling ,[object Object],[object Object],[object Object]

Renal physiology introduction.

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Renal physiology introduction.