This document compares the seismic performance of reinforced concrete (RC) frames and composite frames with irregular floor plans located in an earthquake zone. 12 models of G+10 story buildings were analyzed (6 RC and 6 composite) using ETABS software. The models had different irregular floor plan configurations including C-shaped, U-shaped, L-shaped, T-shaped, plus-shaped and hollow shapes. Response spectrum analysis was performed. Results for time period, base shear, story shear, displacements, drifts and axial forces were compared between the RC and composite frames. The composite frames showed lower time periods, displacements, drifts and axial forces compared to the RC frames, but higher base shear and story shear due to their