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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2970
A Review of Lung Cancer Detection and Segmentation on CT Scan
Anuja J1, Smitha Vas P2
1MTECH Scholar, Department of CSE, LBS Institute of Technology for Women, TVM, Kerala, India
2Assistant Professor, Department of CSE, LBS Institute of Technology for Women, TVM, Kerala, India
---------------------------------------------------------------------***----------------------------------------------------------------------
Abstract - Lung cancer in an abnormal pulmonary cell
growth. The most prevalent form of tumor is Non-Small Cell
Lung Cancer, which details about 85%. Small Cell Lung
Cancer is more aggressive than NSCLC. Lung tumor detection
is a challenge task, due to its lung nodule size in CT scan. CT
pictures are a very efficient instrument for determining lung
tumor development. However, it is a challenging method to
accurately segment the lung tumor image. CT image are
generally more susceptible to detecting the lung tumor when
the disease starts. An extensivelungtumorsegmentationstudy
is conducted in this article.
Key Words: Lung cancer, Classification, Segmentation,
Nodule Extraction and Dynamic programming.
1. INTRODUCTION
Lung cancer is the deadliest of all cancers in the world. Lung
cancer is mainly preventable; in roads have a beneficial
impact in decreasing cigarette smoking, although other
exposures to the environmental put individuals at risk.
Advances in understanding this illness lead to fresh
diagnostic and treatment methods. In2015,global burdenof
disease analysis by the world health organization projects
1,676,000 lung cancer fatalities. It predicts that this toll will
continue to increase to 2,279,000 fatalities in 2030. In the
United States, an estimated 159,390 people (70,490 females
and 88,900 males) died of lung cancer in 2009 more
fatalities than mixed breast, colon, pancreatic and prostate
cancers. Lung cancer is a modern-day illness. Lung cancer
was uncommon at the turn of the 20th century, representing
less than 0.5% of all malignancies. Although many patient’s
area symptomatic, lung cancer symptoms typically include
persistent cough, trouble breathing, blood coughing, and
chest pain. Advanced disease patients often experience
weight loss, fatigue, or chest pain. The assessment of this
patient included diagnostic studies usually conducted in an
assessment of lung cancer with the aim of determining the
phase of cancer. Staging forecasts and affects therapy.
2. TYPES OF LUNG CANCER
SCLC and NSCLC are the two types of lung cancer. This
classification is based on the tumor cells’ microscopic
appearance.
2.1 SCLC
SCLC are the most aggressive cancer than all other cancer
types. SCLC accounts about 20%. Smoking are the main
cause of SCLC cancers and only 1%ofthesecancersoccurred
in non-smokers.
2.2 NSCLC
NSCLC are the most common lung cancers. It accounting for
about 80%. Based on types of cell, NSCLC are divided into
three types: Adenocarcinomas are the most commonly seen
type of NSCLC, accounting up to 50%. This type of cancers
observed in smokers as well as non-smokers.
Bronchioloalveolar carcinoma is develops at lung’s multiple
sites along the alveolar walls. It is a subtype of
adenocarcinoma. Squamous cell carcinomas are also known
as epidermoid carcinomas, squamous cell cancers. Thistype
of cancer is seen in patient quite common. It accounts about
30%. It found at central chest area in the bronchi. Large cell
carcinomas are the least prevalent form of NSCLC.
2.3 BRONCHIAL CARCINOIDS
Bronchial carcinoids are small types it varies from 3 to 4 cm
or less, it accounts up to 5 %. These types of lung cancer
occur people under 40 years of age.
3. FACTORS AFFECTING LUNG CANCER
Many variables influence the risk of lung cancer, buttobacco
smoking was the single biggest factor contributing to the
drastic increase in the rate of lung cancer. Tobacco smoking
is not one of the biggest risk variables for lung cancer. Non-
smokers account for an estimated 15% of pulmonary
cancers in females in the United States and a much larger
10% of pulmonary cancers in females in Asia. There have
been definitions of a number of occupational carcinogens,
including asbestos, benzopyrene, arsenic, chromium and
nickel. High radiation doses improve the risk of lung cancer.
Radon and its degradation product are linked with lung
cancer in miner sex posed to elevated concentrations of
radon gas and are of concern due to potential national
exposure. Other variables known to affect the risk of lung
cancer include air pollution, other lung diseases such as
COPD and interstitial lung disease, and exposure to tobacco
smoke in the environment. Diet was also involved. Lastly,
genetic sensitivity also plays apart in lung cancer. At many
points in the cumulative steps leading to lung cancer,
genetically determined host variables may be essential,
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2971
including the danger of nicotine dependency, carcinogenic
metabolic detoxification, carcinogens activation, and DNA
damage and repair procedures.
4. PREVENTION AND TREATMENT OF LUNG
CANCER
Most risk factors for lung cancer can be altered and can
therefore be minimized or eliminated. Smoking cigarettes,
occupational exposures, exposure to radon and smoke from
the environment can all be decreased. Stopping cigarettesat
any era will reduce the risk of lung cancer. Although it never
reaches the level of an on smoker, the danger of lung cancer
in a person who stops smoking declines with longer
abstinence. Initiatives in the Community and public health
progressively restrict second hand smoke exposure. Lung
cancer treatment is usually driven by phase, although
individual variables, such as general health and coexisting
medical circumstances, are crucial. Complete surgical
removal is the best therapy, but only in early stage illness
patients. Chemotherapy is useful in most disease phases,
although in only a minority of patients it and radiation
therapy are curative. Palliative therapy can enhance quality
and often life span. A multidisciplinary strategy involving
medical, surgical and social support facilities usually
provides the highest possible care.
5. LITERATURE SURVEY
In [1] Medical image analysis moves from planar picture
visual analysis to computerized quantitative analysis of
volumetricpictures.Highperformancecomputingcapacityis
essential in order to manage the additional computation
required for volumetric pictures.
In [2] For hard copies such as print outstandpictures,analog
or visual image processing methods can be used. During the
use of these visual methods, image analysts use different
interpretation fundamental. Association is another
significant instrument for visual methods in picture
processing. Analysts therefore use a mixture of private
information and collateral information to process images.
In [3] Digital processing methods assist with the use of
computers to manipulate digital images. As raw satellite
platform image sensor information includes deficiencies. To
overcome such faults and get data originality, and undergo
different processing stages. The three general stages to be
undertaken by all kinds of data using digital technology are
pre-processing, improvement and display, extraction of
information.
In [4] We deal directly with the picture pixels in temporal
domain methods. To obtain the required improvement, the
pixel values are manipulated. The pictureisfirsttransmitted
to the frequency domain in frequency domain techniques. It
implies first, the image's Fourier Transform is calculated.All
enhancement operations are performed on the image
transformation of Fourier and then the transformation of
Inverse Fourier is performed to obtain the resulting image.
These improvement activities are done to alter the
brightness of the picture, contrast, or gray levels
distribution. As a result, the output image's pixel value
(intensities) will be modified according to the
transformation function applied to the input values.
In [5] The component of structure is a matrix consisting of
0's and 1's, where neighbors are called the 1's. The value of
each pixel in the output image is set by comparing the
corresponding pixel with its neighbors in the input image.
Dilation is to add pixels to the object borders in a picture,
while erosion is to remove pixels at the limits of objects.The
number of pixels added or even withdrawn from the picture
structure relies on the size and shape of the structuring
element used to process the picture. The situation of any
specified pixel in the output picture can be determined in
these morphological activities (dilution and erosion) by
applying a rule to the studied pixel and its neighbors in the
input picture.
In [6] Threshold is one of the commonly used image
segmentation techniques. It is helpful to discriminate from
the background in the foreground. The graylevel picturecan
be transformed into a binary image by selecting an
appropriate threshold value T. The binary image must
contain the data needed regarding the position and shape of
the objects of concern.
In [7] Otsu is an automatic segmentation techniquebasedon
region choice of thresholds. Another way to achieve
comparable outcomes is to set the limit to attempttotighten
each cluster as closely as possible, thereby minimizing their
overlap. We can't alter the distributions, of course, but we
can adjust where we separate them (the threshold). By
adjusting the limit one way, we improve the distribution of
one.
In [8] Another well-known method for identifying optimum
contours in pictures is dynamic programming. This method
is extended to a 3D surface detection method by several
techniques. A set of 2D dynamic programming iterations is
applied to consecutive slices along the third dimension.
In [9] The writers suggested transforming the 3D spherical
lung volume into the scheme of 2D polar coordinates.
In [10] [11] [12] Proposed a Region growth for pulmonary
tissue detection. In [13] combining the growing region with
morphological closure and in [14] succeed in filling the big
indentation created by blood vessels that could not be
removed by threshold.
In [15] suggested an adaptive region widening system on a
blurred connectivity map based on a previously segmented
image.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072
© 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2972
In [16] conducted SVM to classify the vector function of the
nodule. In [17] also used it to classify volumetric lungcancer
based on the machine learning concept. In [18] provided a
computational solution to using Support Vector Machines to
classify lengthy nodules in the frequency domain. In [19]
order to improve the precision of a lung tumour
classification scheme and suggested a fresh weighted SVM
classifier.
In [20] who created a knowledge based, fully automated
technique for segmenting CT volumetric chest pictures,
initially designed Fuzzy laws. The technique uses a modular
architecture composed of an anatomical model, routines for
image processing and an inference engine.
6. CONCLUSION
Early detection of cancer and research into alternatives for
early detection play essential roles for human health.
Computer tomography images (CT) are commonly used in
radio therapy planning as they provide electronic densities
of interesting tissues that are compulsory for proper
calculation. In addition, the excellent spatial resolution and
contrast between soft and hard tissues enable accurate
delineation of the goal. Compared to X Ray and MRI, CT
methods are also preferred. In the use of CT, image
processing methods have begun to become common. In this
paper, several automated methods of pancreatic tumor
segmentation have been evaluated. In order to provide
insight into different techniques, the methods and future
difficulties are discussed.
REFERENCES
[1] S. K., Jolesz, F. A., & Kikinis, R. “A high-performance
computing approach to the registration of medical
imaging data”. Parallel Computing, 24(9), 1345-1368,
1998.
[2] Sharma, D. “Identifying lung cancer using image
processing Techniques”. ICCTAI (pp. 115-120), 2011.
[3] Faye, I., Malik, A. S., & Shoaib, M. “Lung nodule detection
using `multi-resolution analysis”. CME (pp. 457-461),
May 2013.
[4] Gonzalez R.C. “Digital Image Processing”. Upper Saddle
River: Prentice Hall, 2001.
[5] Woods. “Digital Image Processing”. New York: CRC
Press, 2004.
[6] Jain. “Fundamentals of digital image processing”. 1989.
Prentice-Hall.
[7] Zhang, L. “Research on image segmentationbasedonthe
improved Otsu algorithm”. 2nd IHMSC (pp. 228-231),
August 2010.
[8] E. Song and R. Ji. “Segmentation of lung nodules in
computed tomography images using dynamic
programming and multi-direction fusion technique”,
ACAD RADIOL, Vol. 16, No. 6, pp. 678688, 2009.
[9] R. Engelmann and Q. Li. “Segmentation of pulmonary
nodules in three-dimensional CT images by use of a
spiral scanning technique”, Med. Phys., Vol. 34, No. 12,
pp. 46784689, 2007.
[10] P. Aggarwal and R. Vig. “Semantic and Content-Based
Medical Image Retrieval for Lung Cancer Diagnosiswith
the Inclusion of Expert Knowledge and Proven
Pathology”, In proc. of the IEEE 2nd ICIIP, pp. 346-351,
2013.
[11] A.-Z. Kouzani and E.-J. Hu. “Automated detectionoflung
nodules in computed tomography images: a review”,
MACH VISION APPL, Vol. 23, pp. 151163, 2012.
[12] R. Sammouda. “Identification of Lung Cancer Based on
Shape and Color”, In proc. of the 4th ICISP, June 30-July
2, 2010.
[13] D.-T. Lin. “Lung nodules identification rules extraction
with neural fuzzy network”, In Proc. of the 9th IEEE
(ICONIP), Vol. 4, pp. 2049-2053, Singapore, 18-22
Nov.2002.
[14] C.-R. Yan and, W.-T. Chen. “Autonomous detection of
pulmonary nodules on CT images with a neural
network-based fuzzy system”, Computerized Medical
Imaging & Graphics., Vol. 29, pp. 447-458, 2005.
[15] H. Amin, M.-V. Casique and X. Ye. “Segmentation of
pulmonary nodules in thoracic CT scans: A region
growing approach”, IEEE Transaction on Medical
Imaging, Vol. 27, pp. 467480, 2008.
[16] B.-V. Ginneken. “Supervised probabilistic segmentation
of pulmonary nodules in CT scans”, 9th MICCAI
Conference, Berlin, 2006.
[17] G.-Q. Wei, J. Qian and A.-K. Jain. “Learning-based
Pulmonary Nodule Detection from Multi-slice CT Data”,
18th International Congress and Exhibition, Chicago,
2004.
[18] O. Villegas. “Lung Nodule Classification in CT Thorax
Images using Support Vector Machines”, 12th ICAI, pp.
277-283, Mexico 2013.
[19] T.-A. Cheema and H.-F. Zafar.“DetectionofLungTumour
in CE CT Images by using Weighted Support Vector
Machines”, 10th IBCAST, pp. 113-116, 2013.
[20] M.-F. McNitt-Gray and N.-J. Mankovich. “Method for
segmenting chest CT image data using an anatomical
model: preliminary results”, IEEE Transaction on
Medical Imaging, vol. 16, No. 6, pp. 828839, 1997.

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IRJET- A Review of Lung Cancer Detection and Segmentation on CT Scan

  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2970 A Review of Lung Cancer Detection and Segmentation on CT Scan Anuja J1, Smitha Vas P2 1MTECH Scholar, Department of CSE, LBS Institute of Technology for Women, TVM, Kerala, India 2Assistant Professor, Department of CSE, LBS Institute of Technology for Women, TVM, Kerala, India ---------------------------------------------------------------------***---------------------------------------------------------------------- Abstract - Lung cancer in an abnormal pulmonary cell growth. The most prevalent form of tumor is Non-Small Cell Lung Cancer, which details about 85%. Small Cell Lung Cancer is more aggressive than NSCLC. Lung tumor detection is a challenge task, due to its lung nodule size in CT scan. CT pictures are a very efficient instrument for determining lung tumor development. However, it is a challenging method to accurately segment the lung tumor image. CT image are generally more susceptible to detecting the lung tumor when the disease starts. An extensivelungtumorsegmentationstudy is conducted in this article. Key Words: Lung cancer, Classification, Segmentation, Nodule Extraction and Dynamic programming. 1. INTRODUCTION Lung cancer is the deadliest of all cancers in the world. Lung cancer is mainly preventable; in roads have a beneficial impact in decreasing cigarette smoking, although other exposures to the environmental put individuals at risk. Advances in understanding this illness lead to fresh diagnostic and treatment methods. In2015,global burdenof disease analysis by the world health organization projects 1,676,000 lung cancer fatalities. It predicts that this toll will continue to increase to 2,279,000 fatalities in 2030. In the United States, an estimated 159,390 people (70,490 females and 88,900 males) died of lung cancer in 2009 more fatalities than mixed breast, colon, pancreatic and prostate cancers. Lung cancer is a modern-day illness. Lung cancer was uncommon at the turn of the 20th century, representing less than 0.5% of all malignancies. Although many patient’s area symptomatic, lung cancer symptoms typically include persistent cough, trouble breathing, blood coughing, and chest pain. Advanced disease patients often experience weight loss, fatigue, or chest pain. The assessment of this patient included diagnostic studies usually conducted in an assessment of lung cancer with the aim of determining the phase of cancer. Staging forecasts and affects therapy. 2. TYPES OF LUNG CANCER SCLC and NSCLC are the two types of lung cancer. This classification is based on the tumor cells’ microscopic appearance. 2.1 SCLC SCLC are the most aggressive cancer than all other cancer types. SCLC accounts about 20%. Smoking are the main cause of SCLC cancers and only 1%ofthesecancersoccurred in non-smokers. 2.2 NSCLC NSCLC are the most common lung cancers. It accounting for about 80%. Based on types of cell, NSCLC are divided into three types: Adenocarcinomas are the most commonly seen type of NSCLC, accounting up to 50%. This type of cancers observed in smokers as well as non-smokers. Bronchioloalveolar carcinoma is develops at lung’s multiple sites along the alveolar walls. It is a subtype of adenocarcinoma. Squamous cell carcinomas are also known as epidermoid carcinomas, squamous cell cancers. Thistype of cancer is seen in patient quite common. It accounts about 30%. It found at central chest area in the bronchi. Large cell carcinomas are the least prevalent form of NSCLC. 2.3 BRONCHIAL CARCINOIDS Bronchial carcinoids are small types it varies from 3 to 4 cm or less, it accounts up to 5 %. These types of lung cancer occur people under 40 years of age. 3. FACTORS AFFECTING LUNG CANCER Many variables influence the risk of lung cancer, buttobacco smoking was the single biggest factor contributing to the drastic increase in the rate of lung cancer. Tobacco smoking is not one of the biggest risk variables for lung cancer. Non- smokers account for an estimated 15% of pulmonary cancers in females in the United States and a much larger 10% of pulmonary cancers in females in Asia. There have been definitions of a number of occupational carcinogens, including asbestos, benzopyrene, arsenic, chromium and nickel. High radiation doses improve the risk of lung cancer. Radon and its degradation product are linked with lung cancer in miner sex posed to elevated concentrations of radon gas and are of concern due to potential national exposure. Other variables known to affect the risk of lung cancer include air pollution, other lung diseases such as COPD and interstitial lung disease, and exposure to tobacco smoke in the environment. Diet was also involved. Lastly, genetic sensitivity also plays apart in lung cancer. At many points in the cumulative steps leading to lung cancer, genetically determined host variables may be essential,
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2971 including the danger of nicotine dependency, carcinogenic metabolic detoxification, carcinogens activation, and DNA damage and repair procedures. 4. PREVENTION AND TREATMENT OF LUNG CANCER Most risk factors for lung cancer can be altered and can therefore be minimized or eliminated. Smoking cigarettes, occupational exposures, exposure to radon and smoke from the environment can all be decreased. Stopping cigarettesat any era will reduce the risk of lung cancer. Although it never reaches the level of an on smoker, the danger of lung cancer in a person who stops smoking declines with longer abstinence. Initiatives in the Community and public health progressively restrict second hand smoke exposure. Lung cancer treatment is usually driven by phase, although individual variables, such as general health and coexisting medical circumstances, are crucial. Complete surgical removal is the best therapy, but only in early stage illness patients. Chemotherapy is useful in most disease phases, although in only a minority of patients it and radiation therapy are curative. Palliative therapy can enhance quality and often life span. A multidisciplinary strategy involving medical, surgical and social support facilities usually provides the highest possible care. 5. LITERATURE SURVEY In [1] Medical image analysis moves from planar picture visual analysis to computerized quantitative analysis of volumetricpictures.Highperformancecomputingcapacityis essential in order to manage the additional computation required for volumetric pictures. In [2] For hard copies such as print outstandpictures,analog or visual image processing methods can be used. During the use of these visual methods, image analysts use different interpretation fundamental. Association is another significant instrument for visual methods in picture processing. Analysts therefore use a mixture of private information and collateral information to process images. In [3] Digital processing methods assist with the use of computers to manipulate digital images. As raw satellite platform image sensor information includes deficiencies. To overcome such faults and get data originality, and undergo different processing stages. The three general stages to be undertaken by all kinds of data using digital technology are pre-processing, improvement and display, extraction of information. In [4] We deal directly with the picture pixels in temporal domain methods. To obtain the required improvement, the pixel values are manipulated. The pictureisfirsttransmitted to the frequency domain in frequency domain techniques. It implies first, the image's Fourier Transform is calculated.All enhancement operations are performed on the image transformation of Fourier and then the transformation of Inverse Fourier is performed to obtain the resulting image. These improvement activities are done to alter the brightness of the picture, contrast, or gray levels distribution. As a result, the output image's pixel value (intensities) will be modified according to the transformation function applied to the input values. In [5] The component of structure is a matrix consisting of 0's and 1's, where neighbors are called the 1's. The value of each pixel in the output image is set by comparing the corresponding pixel with its neighbors in the input image. Dilation is to add pixels to the object borders in a picture, while erosion is to remove pixels at the limits of objects.The number of pixels added or even withdrawn from the picture structure relies on the size and shape of the structuring element used to process the picture. The situation of any specified pixel in the output picture can be determined in these morphological activities (dilution and erosion) by applying a rule to the studied pixel and its neighbors in the input picture. In [6] Threshold is one of the commonly used image segmentation techniques. It is helpful to discriminate from the background in the foreground. The graylevel picturecan be transformed into a binary image by selecting an appropriate threshold value T. The binary image must contain the data needed regarding the position and shape of the objects of concern. In [7] Otsu is an automatic segmentation techniquebasedon region choice of thresholds. Another way to achieve comparable outcomes is to set the limit to attempttotighten each cluster as closely as possible, thereby minimizing their overlap. We can't alter the distributions, of course, but we can adjust where we separate them (the threshold). By adjusting the limit one way, we improve the distribution of one. In [8] Another well-known method for identifying optimum contours in pictures is dynamic programming. This method is extended to a 3D surface detection method by several techniques. A set of 2D dynamic programming iterations is applied to consecutive slices along the third dimension. In [9] The writers suggested transforming the 3D spherical lung volume into the scheme of 2D polar coordinates. In [10] [11] [12] Proposed a Region growth for pulmonary tissue detection. In [13] combining the growing region with morphological closure and in [14] succeed in filling the big indentation created by blood vessels that could not be removed by threshold. In [15] suggested an adaptive region widening system on a blurred connectivity map based on a previously segmented image.
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 06 | June 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.211 | ISO 9001:2008 Certified Journal | Page 2972 In [16] conducted SVM to classify the vector function of the nodule. In [17] also used it to classify volumetric lungcancer based on the machine learning concept. In [18] provided a computational solution to using Support Vector Machines to classify lengthy nodules in the frequency domain. In [19] order to improve the precision of a lung tumour classification scheme and suggested a fresh weighted SVM classifier. In [20] who created a knowledge based, fully automated technique for segmenting CT volumetric chest pictures, initially designed Fuzzy laws. The technique uses a modular architecture composed of an anatomical model, routines for image processing and an inference engine. 6. CONCLUSION Early detection of cancer and research into alternatives for early detection play essential roles for human health. Computer tomography images (CT) are commonly used in radio therapy planning as they provide electronic densities of interesting tissues that are compulsory for proper calculation. In addition, the excellent spatial resolution and contrast between soft and hard tissues enable accurate delineation of the goal. Compared to X Ray and MRI, CT methods are also preferred. In the use of CT, image processing methods have begun to become common. In this paper, several automated methods of pancreatic tumor segmentation have been evaluated. In order to provide insight into different techniques, the methods and future difficulties are discussed. REFERENCES [1] S. K., Jolesz, F. A., & Kikinis, R. “A high-performance computing approach to the registration of medical imaging data”. Parallel Computing, 24(9), 1345-1368, 1998. [2] Sharma, D. “Identifying lung cancer using image processing Techniques”. ICCTAI (pp. 115-120), 2011. [3] Faye, I., Malik, A. S., & Shoaib, M. “Lung nodule detection using `multi-resolution analysis”. CME (pp. 457-461), May 2013. [4] Gonzalez R.C. “Digital Image Processing”. Upper Saddle River: Prentice Hall, 2001. [5] Woods. “Digital Image Processing”. New York: CRC Press, 2004. [6] Jain. “Fundamentals of digital image processing”. 1989. Prentice-Hall. [7] Zhang, L. “Research on image segmentationbasedonthe improved Otsu algorithm”. 2nd IHMSC (pp. 228-231), August 2010. [8] E. Song and R. Ji. “Segmentation of lung nodules in computed tomography images using dynamic programming and multi-direction fusion technique”, ACAD RADIOL, Vol. 16, No. 6, pp. 678688, 2009. [9] R. Engelmann and Q. Li. “Segmentation of pulmonary nodules in three-dimensional CT images by use of a spiral scanning technique”, Med. Phys., Vol. 34, No. 12, pp. 46784689, 2007. [10] P. Aggarwal and R. Vig. “Semantic and Content-Based Medical Image Retrieval for Lung Cancer Diagnosiswith the Inclusion of Expert Knowledge and Proven Pathology”, In proc. of the IEEE 2nd ICIIP, pp. 346-351, 2013. [11] A.-Z. Kouzani and E.-J. Hu. “Automated detectionoflung nodules in computed tomography images: a review”, MACH VISION APPL, Vol. 23, pp. 151163, 2012. [12] R. Sammouda. “Identification of Lung Cancer Based on Shape and Color”, In proc. of the 4th ICISP, June 30-July 2, 2010. [13] D.-T. Lin. “Lung nodules identification rules extraction with neural fuzzy network”, In Proc. of the 9th IEEE (ICONIP), Vol. 4, pp. 2049-2053, Singapore, 18-22 Nov.2002. [14] C.-R. Yan and, W.-T. Chen. “Autonomous detection of pulmonary nodules on CT images with a neural network-based fuzzy system”, Computerized Medical Imaging & Graphics., Vol. 29, pp. 447-458, 2005. [15] H. Amin, M.-V. Casique and X. Ye. “Segmentation of pulmonary nodules in thoracic CT scans: A region growing approach”, IEEE Transaction on Medical Imaging, Vol. 27, pp. 467480, 2008. [16] B.-V. Ginneken. “Supervised probabilistic segmentation of pulmonary nodules in CT scans”, 9th MICCAI Conference, Berlin, 2006. [17] G.-Q. Wei, J. Qian and A.-K. Jain. “Learning-based Pulmonary Nodule Detection from Multi-slice CT Data”, 18th International Congress and Exhibition, Chicago, 2004. [18] O. Villegas. “Lung Nodule Classification in CT Thorax Images using Support Vector Machines”, 12th ICAI, pp. 277-283, Mexico 2013. [19] T.-A. Cheema and H.-F. Zafar.“DetectionofLungTumour in CE CT Images by using Weighted Support Vector Machines”, 10th IBCAST, pp. 113-116, 2013. [20] M.-F. McNitt-Gray and N.-J. Mankovich. “Method for segmenting chest CT image data using an anatomical model: preliminary results”, IEEE Transaction on Medical Imaging, vol. 16, No. 6, pp. 828839, 1997.