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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 576
Design of Radial Pulse Detector
Miss. Dengale B. B.1, Dr. K. B. Kale2, Prof. C. R. Shah3, Miss. Thombare M.A.4
1,4PG Scholar, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India
2Dr. Professor, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India
3Assistant Professor, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India
---------------------------------------------------------------------***---------------------------------------------------------------------
Abstract -Ayurvedic and other ancient alternative medical
sciences viz. Chinese, Korean, Yunani etc. practitioners
throughout world have been using pulse diagnosis to diagnose
the disease and the organ at by feeling the palpations at their
close yet precise positions of the radial artery. In this paper,
there is consideration of some technical and clinical issues to
achieve the development of a pulse diagnosticdeviceaccording
to various fields of study: literature studies, sensors,amplifiers,
systems, physical quantity studies, and make estimated design
of system. This device should be appropriate both technically
and in terms of Indian Ayurvedic medicine. The purpose of this
project is to help medical practitioner to diagnose different
diseases in accordance with changes in various parameters of
pulse signal of radial artery. These parameters are calculated
by using different sensors. We have pointed out someproblems
occurred in previous methods of pulse diagnosisandhavetried
to overcome them. And we have proposed a new method for
radial pulse diagnosis.
Key Words: Radial artery, Pulse diagnosis, Pressure
Sensors,
1. INTRODUCTION
From the past decades, pulse diagnosis was done
from the three precise locations on the wrist at the radial
artery, like vata, pitta, and kapha. This science was very
important in theTraditional Ayurveda & Chinese. Thesignals
obtained from these locations are not only due to the
contraction and relaxation of blood vessel but also a result of
movement of blood through the artery and change in their
diameter. [1]
1.1 What is Pulse Examination?
Pulse Examination is an ancient ayurvedictechnique
of diagnosis through the pulse. It can accurately diagnose
physical, mental and emotional imbalances as well as
diseases. The pulse, when examined, reveals both physical &
mental characteristics of the patient.
1.2 History of Radial Pulse Diagnosis:
The science of Ayurveda is depends on three pulse
signals, which are vata, pitta and kapha. In Traditional
Chinese Medicine these radial artery named ascun, guan and
chi respectively. But the basic for these systems are same.
The Pulse experts using their better experience and skill feel
this signal by means of diagnosis of disease. [1]
The different waveforms obtained from vata, pitta
and kapha pulses have shape as that of movement of cobra,
frog and swan respectively as shown in fig. 1[1]
below.
Fig. 1 Shapes of waveform of vata, pitta and kapha pulses
[1]
These pulses are felt at specific position on the wrist of
the patient: vata on index finger, pitta on middle finger and
kapha on the ring finger. The Pulse experts feel them by
placing their hand in a specific orientation on the patient’s
wrist, as shown in Fig. 2 [1]
Fig. 2 Location of fingers on wrist to feel vata, pitta and
kapha pulses [1]
Also, the analysis of hollow organs and semi-solid
organs is done by feeling the natureof pulse atthedeepand
superficial layers of the wrist radial artery by applying
external pressure. The location of organ pulses on both
hand is as shown in Fig. 3[1]
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 577
Fig. 3 Location of organ pulses [1]
1.3 Development in Analysis Technology:
For this old technique ofradialpulseanalysisthereis
a requirementof yearsof experience and knowledge and can
vary from person to person. Thus the recent trend follows to
replicate this system in terms of a device which will be smart
enough to diagnose disease by capturing the signals from
wrist using various types of sensors like pressure sensors,
temperature sensors etc.
[1]
2. OBJECTIVES
The problem statement indicates the need of
development of pulse analysis technique to diagnose the
disease. In ancient technology of radial pulse diagnosis i.e.
Palpation method requires good yogic powers like mind
concentration and many years of experience in pulse
diagnosis. Also the pulse signal of radial artery varies person
to person and makes the diagnosis of disease difficult. So the
main aim of this project is to study about location of organ
pulses, to select different types of sensors used to calculate
different parameters of pulse signals by using ECU. The
objectives of this project are asbelow:
1) To help the medical practitioners for diagnosing the
various diseases accurately and precisely.
2) To reduce the time required for checking the pulse
signal for diagnosis of disease.
3) To store the pulse variation data for diseases other
than heart disease such as pitta, vatta, diabetics,
asthma etc. for further treatment on it.
3. METHODOLOGY
1) Study of basics of radial pulsediagnosis.
2) Study of location of organ pulses.
3) Designing of model of ECU (Electronic Control Unit)
to display different waveforms.
4) Selection of suitable sensors.
5) Designing and Analysis of sensors.
6) Selection of other components of ECU.
7) Construction of ECU.
8) Evaluation of expected results & Experimental
results.
4. PULSE DIAGNOSIS
4.1 Characteristics of Pulse:
Rate: - Normal pulse rates at rest, in beatsperminute(BPM).
Volume: - The degree of expansion displayed by artery
during diastolic and systolic state is called volume.
Table-1: Characteristics of pulses
[2]
newbor
n (from
0–
3
months
)
Infants
(from
3–6
months
)
Infants
(from
6–12
months
)
Child-
ren
(from 1
– 10
years)
Children
over age
10 years
& adults,
including
seniors
well-
trained
adult
athletes
100-150 90-120 80-120 70-130 60-100 40-60
Force: - It is the approximate measure of the systolic
pressure.
(Systolic Pressure: The top no. refers to amount of pressure
in your arteriesduring contractionof yourheartmuscle.=60
mm of Hg to 220 mm of Hg
Diastolic Pressure: The bottom no. refers to your B.P. when
yourheart is between beats. = 30mmof Hgto120mmofHg)
Rhythm: - A normal pulse is regular in rhythm and force. It
indicateswhether the beats are equidistantornot.Twotypes
of rhythms are
1. Regularly irregular
2. Irregularlyirregular
4.2 Effect of Various Diseases on Pulse:
Pulse plays an important role in the diagnosis of the disease.
Pulse alters in every disease and at different stages of the
same disease. In allthemedical scienceslotmanydescription
is found on this topic. Few examples are:-
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 578
Table-2: Effect of Various diseases on Pulse
[2]
5. ESTIMATED DESIGN
5.1 Components of System:
1. Input:
Pressure Sensors are required for picking up the radial
pulses from the wrist. The physical fundamentals of sensors
determinethedimensions ofmeasured signalandcalculating
the pulse rate.
2. Amplifier:
An amplifier takes a relatively small signal and increases
its magnitude. For instance, the signal coming from pressure
sensors does not have enough strength to give clear
information of physical parameters of pulse and can’t read
by operator. But put an amplifier between input and output
and the pulse waveform can be read.
3. Filter:
Electronic filters are circuits which perform signal
processing functions, specifically to remove unwanted
frequency components from the signal, to enhance wanted
ones, or both.
4. A/D Converter:
In electronics, an analog-to-digital converter is a system
that converts an analog signal, such as a pressure picked up
by a pressure sensors into a digital signal. An ADC may also
provide an isolated measurement such as an electronic
device that converts an input analog signal to a digital
number proportional to the magnitude of the signals.
5. Signal Processor:
Digital signal processing algorithms typically require a
large number of mathematical operations to be performed
quickly and repeatedly on a series of data samples. Signals
are constantly converted from analog to digital, manipulated
digitally, and then converted back to analog form.
6. D/A Converter:
In electronics, a digital-to-analog converter is a device that
converts a digital signal into an analog signal.
7. Output:
A display device is an output device for presentation of
information in visual form.
6. SELECTION OF SYSTEM COMPONENTS
6.1 Sensor Selection:
In this projectwe are presentinghigh sensitivesensordesign
for acquiring the three pulses from the radial artery along
with a method of validating the sensor with a standard
procedure.
[9]
1. Three principal pulsesare felt in the wrist region
along the radial artery. The place for feelingthepulse
is on the lateral aspect of the right forearm, 2cm up
from wrist.
2. Based on the dominant pulse among the three
and direction in which pulse motion is felt, we can
identify our 350 different diseaseconditions.
3. Healthy human subjects have three pulse
amplitudes in the ratio of 4:2:1 respectively.
4. However ratio is to follow seasonal variations
and changes with parameters as time of day,
temperature and humidity of the skin.
5. The right arm of male subjects and left arm of
female is used to read the pulse.
By considering the above points there are different
sensors present for pulse diagnosis. As many years ago
infrared optical sensors have been used for cardiovascular
pulse detection. But infrared sensors can’t measure the
pressure directly and also harmful to our body and
expensive. Another one is Strain Gauge differential pressure
sensor used in system where pressure cuff wrapped around
the wrist and then pressure modulation in cuff caused by
Malaria Slow pulse.
Sunstroke Rapid full pulse
Perforated Peptic
ulcers
Strong pulse increasing steadily
Hepatic disease Rapid pulse.
Goiter Slow pulse.
Bronchial Asthma
Small, Rapid, Irregular and
intermittent pulse.
Typhoid Slow compared to other febrile
conditions, infrequent, slow pulse
during post febrile conditions
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 579
pressure pulse was measured. But strain gauge pressure
sensors are unable to provide lower range of pressure, also
sensitive to environmental changes and contain long term
drift
[8]
.
Recently piezoelectric sensors used for measuring pulse
pressure directly in whichmechanical stimulusgeneratedby
pulse is converted into electrical signal. But in recent
technology piezoelectric sensors are present with pressure
sensitive material like Electro-Mechanical Film (EMFi) and
Polyvinylidenefluoride (PVDF) for pulse detection in radial
artery. The base material of EMFi is inexpensive which is
applicable for large area sensors but piezoelectric sensors
contain fluoride which is toxic substance therefore use ofit is
avoided inmedical purpose. In PVDF material its sensitivity
to force related to length and width i.e. area of membrane.
This property of it creates many versatile applications for
material.
From above discussion we observe that the piezoe
Electric sensor with PVDF membrane is suitable for
our system hence we select it as input to our system
Fig. 3 Pressure sensor with a PVDF membrane.
6.2 Design of PVDF based Pulse Sensor:
In PVDF material its sensitivity to force related to length
and width i.e. area of membrane. The length of membrane
decided based on following:
 The mean diameter of right and left radial artery was
2.35 ± 0.49 mm and 2.29 ± 0.48 mm respectively and
including sheath it will come up to 3mm-5mm.
 The length of PVDF membrane is depends on age,
height to weight ratio of the person. And mean value of
length is 25mm.
 The length should be less than the distance between
two tendons between which artery passes. This
changes person to person from 45mm to 55mm hence
length restricted to 50mm.
 The breadth based on placing of sensor. Since sensor
are placed at three points where we require the three
pulses are at a distance of 12.5mm center to center
hence breath should be up to 20mm.
 High-quality Invitrolon PVDF membrane with0.45µm
thicknessisparticularly suited for high sensitivityand
low background immunoblotting.
Fig. 4 Design of Pulse Sensor [9]
6.3 Sensitivity Analysis for the Sensor:
Sensor is considered as a simply supported beam as
shown in fig. 5[9]
Fig. 5 Model of our sensor for sensitivity analysis
[9]
Here P is load applied on PVDF at center which is
pressure acting over the area of artery.
Thepiezoelectric elementusedforconvertingmechanical
motionof pulse to electrical signalsmaybethoughtascharge
generator. Mechanical deformation generates a charge and
this charge appears as voltage to amplifier.
Voltage, E = Q/C Volt………………. (i)
The magnitude and polarity of the induced surface charges
are proportional to magnitude and direction of applied
force, F. Polarityof induced chargesdependsondirectionof
applied force.
Charge, Q = d × F Coulomb…………….. (ii)
Where,
d = charge sensitivityof PVDFmembrane C/N(Constantfor
given material)
pC/N …………. (a)
d = -34pC/N for PVDF material
F = Applied force
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 580
F = p × aNewton ………… (b)
(p = Pressure applied by radial pulse in N/m2, a = area of
radial pulse = πr2, m2)
By taking the values of‘d’ and ‘F’ we get value of charge,
Q = -6.8 coulomb to -45.56 coulomb.
6.4 Pulse Measuring System:
Development of a signal conditioning unit to improve
quality of signals such as amplification, filtering, common
mode rejection is generated by PVDF sensor. This unit
consists of amplifier, filter, A/D and D/A converter etc.
The components of system are selected for the above
range of charge from standard parts available in market.
7. CONCLUSION AND FUTURE WORK
We have a lot of proven records in ancient literature that
there is not a single disease in the human body which cannot
be diagnosed by examining the pulse. However, ancient
medical practitioners had to totallyrelyupon yearsofclinical
experience in order to come to any conclusive diagnosis.
Clinicians today have limited examination of the pulse to its
rate, rhythm and volume by virtueof whichtheyhardlycome
to a concrete diagnosis based upon pulse alone. Iftherecould
be a system by which the radial pulse could be critically
examined just like the ancient Ayurveda practitioners and
others, it could be one of the most useful tools in the field of
non-invasive modern medical diagnosis of disease.
Thus there is need of development of system which has
potential to objectively measure and display the changes
occurring in the radial artery in accordance with ayurvedic
principles without having to undergo subjective
interpretations.The sensorsused in such systemareselected
and design in this paper whichhelptoselectothercomponent
of ECU.Future research will concentrate on thedevelopment
of system, vibration analysis of three pulses and diagnosis of
disease like using improve version of equipment. And will
hope that developing technique should help the medical
practitioners to diagnose disease accurately and precisely.
8. REFFERENCES
1. Prajkta Kallurkar1, Shiru Sharma, Kaplesh Patil and
Neeraj Sharma ‘Nadi Diagnosis Techniques’,
International Journal Of Public Mental Health And
Neurosciences ISSN: 2394-4668, Published jointly by
Azyme Biosciences (P) Ltd.
2. Dr Gupta Vikas, DR Sodhi Danisha, DR Gupta Nidhi,
‘Conceptual Study on Nadi Vigyana’ Valley International
Journals , Volume 3, Issue 2, 1547-1552
3. C. Narayanan, A. Dinesh Kumar & S. Priyadharshini &S.
Revathy, ‘Cardiac Disorder Diagnosis Through Nadi
(Pulse) Using Piezoelectric Sensors’, International
Journal of Multidisciplinary Research and Modern
Education (IJMRME), Volume I, Issue I, 2015
4. Aniruddha Joshi, Anand Kulkarni, SharatChandran,V.K.
Jayaraman and B. D. Kulkarni, ’Nadi Tarangini: A Pulse
Based Diagnostic System’ Cité International, Lyon,
France August 23-26, 2007.
5. Karen Bilton, Leon Hammer & Chris
Zaslawski,‘Contemporary Chinese Pulse Diagnosis: A
modern interpretation of an Ancient and Traditional
Method’, Journal of Acupuncture and Meridian Studies
2013;6(5):227-233
6. Abhinav, Meghna Sareen, Mahendra Kumar, Jaya-shree
Santhosh, Ashok Salhan, Sneh Anand, ‘ Nadi Yantra –a
robust system design to capturethe signals from the
radial artery for assessment of the automatic nervous
system non-invasively’, J. Biomedical Science and
Engineering, 2009, 2, 471-479
7. Hyunho Kim, Jong Yeol Kim, Young-Jae Park & Young-
Bae Park, ‘Development Of Pulse Diagnostic Devices In
Korea’, Integrative Medicine Research, 2, 2013, 7-17
8. Steven McLellan, Christina Liese, Melissa Andrews,
Mona Boudreaux, G. Faye Boudreaux, Eugene Chabot,
and Ying Sun ‘A Microprocessor-Based Wrist Pulse
Simulator for Pulse Diagnosis in Traditional Chinese
Medicine’ Department of Electrical, Computer, and
Biomedical Engineering University of Rhode Island,
Kingston, RI 02881- 0805 USA.
9. S. Mahesh, M. Manivannan, T. Anandan, ‘Three Radial
Artery Pulse Sensor Design for Siddha Based Disease
Diagnosis’, IIT, Madras.

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Design of Radial Pulse Detector

  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 576 Design of Radial Pulse Detector Miss. Dengale B. B.1, Dr. K. B. Kale2, Prof. C. R. Shah3, Miss. Thombare M.A.4 1,4PG Scholar, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India 2Dr. Professor, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India 3Assistant Professor, Dept. of Mechanical Engineering, DVVP COE, Ahmednagar, Maharashtra, India ---------------------------------------------------------------------***--------------------------------------------------------------------- Abstract -Ayurvedic and other ancient alternative medical sciences viz. Chinese, Korean, Yunani etc. practitioners throughout world have been using pulse diagnosis to diagnose the disease and the organ at by feeling the palpations at their close yet precise positions of the radial artery. In this paper, there is consideration of some technical and clinical issues to achieve the development of a pulse diagnosticdeviceaccording to various fields of study: literature studies, sensors,amplifiers, systems, physical quantity studies, and make estimated design of system. This device should be appropriate both technically and in terms of Indian Ayurvedic medicine. The purpose of this project is to help medical practitioner to diagnose different diseases in accordance with changes in various parameters of pulse signal of radial artery. These parameters are calculated by using different sensors. We have pointed out someproblems occurred in previous methods of pulse diagnosisandhavetried to overcome them. And we have proposed a new method for radial pulse diagnosis. Key Words: Radial artery, Pulse diagnosis, Pressure Sensors, 1. INTRODUCTION From the past decades, pulse diagnosis was done from the three precise locations on the wrist at the radial artery, like vata, pitta, and kapha. This science was very important in theTraditional Ayurveda & Chinese. Thesignals obtained from these locations are not only due to the contraction and relaxation of blood vessel but also a result of movement of blood through the artery and change in their diameter. [1] 1.1 What is Pulse Examination? Pulse Examination is an ancient ayurvedictechnique of diagnosis through the pulse. It can accurately diagnose physical, mental and emotional imbalances as well as diseases. The pulse, when examined, reveals both physical & mental characteristics of the patient. 1.2 History of Radial Pulse Diagnosis: The science of Ayurveda is depends on three pulse signals, which are vata, pitta and kapha. In Traditional Chinese Medicine these radial artery named ascun, guan and chi respectively. But the basic for these systems are same. The Pulse experts using their better experience and skill feel this signal by means of diagnosis of disease. [1] The different waveforms obtained from vata, pitta and kapha pulses have shape as that of movement of cobra, frog and swan respectively as shown in fig. 1[1] below. Fig. 1 Shapes of waveform of vata, pitta and kapha pulses [1] These pulses are felt at specific position on the wrist of the patient: vata on index finger, pitta on middle finger and kapha on the ring finger. The Pulse experts feel them by placing their hand in a specific orientation on the patient’s wrist, as shown in Fig. 2 [1] Fig. 2 Location of fingers on wrist to feel vata, pitta and kapha pulses [1] Also, the analysis of hollow organs and semi-solid organs is done by feeling the natureof pulse atthedeepand superficial layers of the wrist radial artery by applying external pressure. The location of organ pulses on both hand is as shown in Fig. 3[1]
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 577 Fig. 3 Location of organ pulses [1] 1.3 Development in Analysis Technology: For this old technique ofradialpulseanalysisthereis a requirementof yearsof experience and knowledge and can vary from person to person. Thus the recent trend follows to replicate this system in terms of a device which will be smart enough to diagnose disease by capturing the signals from wrist using various types of sensors like pressure sensors, temperature sensors etc. [1] 2. OBJECTIVES The problem statement indicates the need of development of pulse analysis technique to diagnose the disease. In ancient technology of radial pulse diagnosis i.e. Palpation method requires good yogic powers like mind concentration and many years of experience in pulse diagnosis. Also the pulse signal of radial artery varies person to person and makes the diagnosis of disease difficult. So the main aim of this project is to study about location of organ pulses, to select different types of sensors used to calculate different parameters of pulse signals by using ECU. The objectives of this project are asbelow: 1) To help the medical practitioners for diagnosing the various diseases accurately and precisely. 2) To reduce the time required for checking the pulse signal for diagnosis of disease. 3) To store the pulse variation data for diseases other than heart disease such as pitta, vatta, diabetics, asthma etc. for further treatment on it. 3. METHODOLOGY 1) Study of basics of radial pulsediagnosis. 2) Study of location of organ pulses. 3) Designing of model of ECU (Electronic Control Unit) to display different waveforms. 4) Selection of suitable sensors. 5) Designing and Analysis of sensors. 6) Selection of other components of ECU. 7) Construction of ECU. 8) Evaluation of expected results & Experimental results. 4. PULSE DIAGNOSIS 4.1 Characteristics of Pulse: Rate: - Normal pulse rates at rest, in beatsperminute(BPM). Volume: - The degree of expansion displayed by artery during diastolic and systolic state is called volume. Table-1: Characteristics of pulses [2] newbor n (from 0– 3 months ) Infants (from 3–6 months ) Infants (from 6–12 months ) Child- ren (from 1 – 10 years) Children over age 10 years & adults, including seniors well- trained adult athletes 100-150 90-120 80-120 70-130 60-100 40-60 Force: - It is the approximate measure of the systolic pressure. (Systolic Pressure: The top no. refers to amount of pressure in your arteriesduring contractionof yourheartmuscle.=60 mm of Hg to 220 mm of Hg Diastolic Pressure: The bottom no. refers to your B.P. when yourheart is between beats. = 30mmof Hgto120mmofHg) Rhythm: - A normal pulse is regular in rhythm and force. It indicateswhether the beats are equidistantornot.Twotypes of rhythms are 1. Regularly irregular 2. Irregularlyirregular 4.2 Effect of Various Diseases on Pulse: Pulse plays an important role in the diagnosis of the disease. Pulse alters in every disease and at different stages of the same disease. In allthemedical scienceslotmanydescription is found on this topic. Few examples are:-
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 578 Table-2: Effect of Various diseases on Pulse [2] 5. ESTIMATED DESIGN 5.1 Components of System: 1. Input: Pressure Sensors are required for picking up the radial pulses from the wrist. The physical fundamentals of sensors determinethedimensions ofmeasured signalandcalculating the pulse rate. 2. Amplifier: An amplifier takes a relatively small signal and increases its magnitude. For instance, the signal coming from pressure sensors does not have enough strength to give clear information of physical parameters of pulse and can’t read by operator. But put an amplifier between input and output and the pulse waveform can be read. 3. Filter: Electronic filters are circuits which perform signal processing functions, specifically to remove unwanted frequency components from the signal, to enhance wanted ones, or both. 4. A/D Converter: In electronics, an analog-to-digital converter is a system that converts an analog signal, such as a pressure picked up by a pressure sensors into a digital signal. An ADC may also provide an isolated measurement such as an electronic device that converts an input analog signal to a digital number proportional to the magnitude of the signals. 5. Signal Processor: Digital signal processing algorithms typically require a large number of mathematical operations to be performed quickly and repeatedly on a series of data samples. Signals are constantly converted from analog to digital, manipulated digitally, and then converted back to analog form. 6. D/A Converter: In electronics, a digital-to-analog converter is a device that converts a digital signal into an analog signal. 7. Output: A display device is an output device for presentation of information in visual form. 6. SELECTION OF SYSTEM COMPONENTS 6.1 Sensor Selection: In this projectwe are presentinghigh sensitivesensordesign for acquiring the three pulses from the radial artery along with a method of validating the sensor with a standard procedure. [9] 1. Three principal pulsesare felt in the wrist region along the radial artery. The place for feelingthepulse is on the lateral aspect of the right forearm, 2cm up from wrist. 2. Based on the dominant pulse among the three and direction in which pulse motion is felt, we can identify our 350 different diseaseconditions. 3. Healthy human subjects have three pulse amplitudes in the ratio of 4:2:1 respectively. 4. However ratio is to follow seasonal variations and changes with parameters as time of day, temperature and humidity of the skin. 5. The right arm of male subjects and left arm of female is used to read the pulse. By considering the above points there are different sensors present for pulse diagnosis. As many years ago infrared optical sensors have been used for cardiovascular pulse detection. But infrared sensors can’t measure the pressure directly and also harmful to our body and expensive. Another one is Strain Gauge differential pressure sensor used in system where pressure cuff wrapped around the wrist and then pressure modulation in cuff caused by Malaria Slow pulse. Sunstroke Rapid full pulse Perforated Peptic ulcers Strong pulse increasing steadily Hepatic disease Rapid pulse. Goiter Slow pulse. Bronchial Asthma Small, Rapid, Irregular and intermittent pulse. Typhoid Slow compared to other febrile conditions, infrequent, slow pulse during post febrile conditions
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 579 pressure pulse was measured. But strain gauge pressure sensors are unable to provide lower range of pressure, also sensitive to environmental changes and contain long term drift [8] . Recently piezoelectric sensors used for measuring pulse pressure directly in whichmechanical stimulusgeneratedby pulse is converted into electrical signal. But in recent technology piezoelectric sensors are present with pressure sensitive material like Electro-Mechanical Film (EMFi) and Polyvinylidenefluoride (PVDF) for pulse detection in radial artery. The base material of EMFi is inexpensive which is applicable for large area sensors but piezoelectric sensors contain fluoride which is toxic substance therefore use ofit is avoided inmedical purpose. In PVDF material its sensitivity to force related to length and width i.e. area of membrane. This property of it creates many versatile applications for material. From above discussion we observe that the piezoe Electric sensor with PVDF membrane is suitable for our system hence we select it as input to our system Fig. 3 Pressure sensor with a PVDF membrane. 6.2 Design of PVDF based Pulse Sensor: In PVDF material its sensitivity to force related to length and width i.e. area of membrane. The length of membrane decided based on following:  The mean diameter of right and left radial artery was 2.35 ± 0.49 mm and 2.29 ± 0.48 mm respectively and including sheath it will come up to 3mm-5mm.  The length of PVDF membrane is depends on age, height to weight ratio of the person. And mean value of length is 25mm.  The length should be less than the distance between two tendons between which artery passes. This changes person to person from 45mm to 55mm hence length restricted to 50mm.  The breadth based on placing of sensor. Since sensor are placed at three points where we require the three pulses are at a distance of 12.5mm center to center hence breath should be up to 20mm.  High-quality Invitrolon PVDF membrane with0.45µm thicknessisparticularly suited for high sensitivityand low background immunoblotting. Fig. 4 Design of Pulse Sensor [9] 6.3 Sensitivity Analysis for the Sensor: Sensor is considered as a simply supported beam as shown in fig. 5[9] Fig. 5 Model of our sensor for sensitivity analysis [9] Here P is load applied on PVDF at center which is pressure acting over the area of artery. Thepiezoelectric elementusedforconvertingmechanical motionof pulse to electrical signalsmaybethoughtascharge generator. Mechanical deformation generates a charge and this charge appears as voltage to amplifier. Voltage, E = Q/C Volt………………. (i) The magnitude and polarity of the induced surface charges are proportional to magnitude and direction of applied force, F. Polarityof induced chargesdependsondirectionof applied force. Charge, Q = d × F Coulomb…………….. (ii) Where, d = charge sensitivityof PVDFmembrane C/N(Constantfor given material) pC/N …………. (a) d = -34pC/N for PVDF material F = Applied force
  • 5. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 04 Issue: 12 | Dec-2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 580 F = p × aNewton ………… (b) (p = Pressure applied by radial pulse in N/m2, a = area of radial pulse = πr2, m2) By taking the values of‘d’ and ‘F’ we get value of charge, Q = -6.8 coulomb to -45.56 coulomb. 6.4 Pulse Measuring System: Development of a signal conditioning unit to improve quality of signals such as amplification, filtering, common mode rejection is generated by PVDF sensor. This unit consists of amplifier, filter, A/D and D/A converter etc. The components of system are selected for the above range of charge from standard parts available in market. 7. CONCLUSION AND FUTURE WORK We have a lot of proven records in ancient literature that there is not a single disease in the human body which cannot be diagnosed by examining the pulse. However, ancient medical practitioners had to totallyrelyupon yearsofclinical experience in order to come to any conclusive diagnosis. Clinicians today have limited examination of the pulse to its rate, rhythm and volume by virtueof whichtheyhardlycome to a concrete diagnosis based upon pulse alone. Iftherecould be a system by which the radial pulse could be critically examined just like the ancient Ayurveda practitioners and others, it could be one of the most useful tools in the field of non-invasive modern medical diagnosis of disease. Thus there is need of development of system which has potential to objectively measure and display the changes occurring in the radial artery in accordance with ayurvedic principles without having to undergo subjective interpretations.The sensorsused in such systemareselected and design in this paper whichhelptoselectothercomponent of ECU.Future research will concentrate on thedevelopment of system, vibration analysis of three pulses and diagnosis of disease like using improve version of equipment. And will hope that developing technique should help the medical practitioners to diagnose disease accurately and precisely. 8. REFFERENCES 1. Prajkta Kallurkar1, Shiru Sharma, Kaplesh Patil and Neeraj Sharma ‘Nadi Diagnosis Techniques’, International Journal Of Public Mental Health And Neurosciences ISSN: 2394-4668, Published jointly by Azyme Biosciences (P) Ltd. 2. Dr Gupta Vikas, DR Sodhi Danisha, DR Gupta Nidhi, ‘Conceptual Study on Nadi Vigyana’ Valley International Journals , Volume 3, Issue 2, 1547-1552 3. C. Narayanan, A. Dinesh Kumar & S. Priyadharshini &S. Revathy, ‘Cardiac Disorder Diagnosis Through Nadi (Pulse) Using Piezoelectric Sensors’, International Journal of Multidisciplinary Research and Modern Education (IJMRME), Volume I, Issue I, 2015 4. Aniruddha Joshi, Anand Kulkarni, SharatChandran,V.K. Jayaraman and B. D. Kulkarni, ’Nadi Tarangini: A Pulse Based Diagnostic System’ Cité International, Lyon, France August 23-26, 2007. 5. Karen Bilton, Leon Hammer & Chris Zaslawski,‘Contemporary Chinese Pulse Diagnosis: A modern interpretation of an Ancient and Traditional Method’, Journal of Acupuncture and Meridian Studies 2013;6(5):227-233 6. Abhinav, Meghna Sareen, Mahendra Kumar, Jaya-shree Santhosh, Ashok Salhan, Sneh Anand, ‘ Nadi Yantra –a robust system design to capturethe signals from the radial artery for assessment of the automatic nervous system non-invasively’, J. Biomedical Science and Engineering, 2009, 2, 471-479 7. Hyunho Kim, Jong Yeol Kim, Young-Jae Park & Young- Bae Park, ‘Development Of Pulse Diagnostic Devices In Korea’, Integrative Medicine Research, 2, 2013, 7-17 8. Steven McLellan, Christina Liese, Melissa Andrews, Mona Boudreaux, G. Faye Boudreaux, Eugene Chabot, and Ying Sun ‘A Microprocessor-Based Wrist Pulse Simulator for Pulse Diagnosis in Traditional Chinese Medicine’ Department of Electrical, Computer, and Biomedical Engineering University of Rhode Island, Kingston, RI 02881- 0805 USA. 9. S. Mahesh, M. Manivannan, T. Anandan, ‘Three Radial Artery Pulse Sensor Design for Siddha Based Disease Diagnosis’, IIT, Madras.