Ebola Hemorrhagic Fever

1. By : Balbeer SinghSZABIST, Karachi

2. Background
• Ebola virus disease (EVD)
first appeared in 1976 in
2 simultaneous
outbreaks.
 one in Nzara, Sudan and
 the other in Yambuku,
Democratic Republic of
Congo.
 The current outbreak in
west Africa, (first cases
notified in March 2014),
is the largest and most
complex Ebola outbreak

4. Structure of Ebola Virus

5. Structure of Ebola Virus
• Single-stranded, linear, non-segmented
• Filamentous - shape of “U” or “6”
• Coiled, toroid, or branched
• 19 kb length,60-80 nm in diameter
• Negative-sense enveloped RNA (3’ to 5’
direction)
• “Spikes” appearance

6. • Ebola viruses are mainly
found in primates in Africa
and possibly the Philippines
• Ebola is a rare but deadly
virus that causes bleeding
inside and outside the body.
• As the virus spreads through
the body it damages the
immune system and organs

7. • Ultimately, it causes
levels of blood-clotting
cells to drop.
• This leads to severe,
uncontrollable bleeding.
• Ebola virus, kills up to
90% of people who are
infected.

8. • As the disease gets worse,
it causes bleeding inside
the body as well as from
the eyes, ears, and nose.
• Some people will vomit or
cough up blood, have
bloody diarrhea, and get a
rash.

12. Transmission
• It spreads to people by contact with the skin or
bodily fluids of an infected animal
• like a monkey Or fruit bat
• Then it moves from person to person the same
way.
• Those who care for a sick person
• or bury someone who has died from the disease
often get it.
• Other ways to get Ebola include touching
contaminated needles or surfaces.

13. Transmission

15. Who is at Most Risk
of Getting Ebola
• Health care providers caring for Ebola patients
and the family and friends in close contact
with Ebola patients are at the highest risk of
getting sick.
• Because they may come in contact with the
blood or body fluids of sick patients.
• People also can become sick with Ebola after
coming in contact with infected wildlife.

16. • Sometimes it's hard to
tell if a person has Ebola
from the symptoms
alone.
• Tests of blood and
tissues also can diagnose
Ebola.
How Is Ebola Virus Diagnosed?

17. Treatment
• No specific treatment available but
experimental ones are
• Frequent dehydration and oral rehydration
with solutions containing electrolytes or
intravenous fluids.
• Maintaining oxygen status and blood pressure
• Replacing lost blood
• Treating other infections if they occur

18. Vaccine for Ebola
• No licensed vaccine for EVD is available.
Several vaccines are being tested, but none
are available for clinical use.

21. Thank
YOu