Quality control charts are used to monitor analytical results and check if a method is in control. They include mean (x̅) and range (R) charts to track the internal quality control sample for in run variation. Data points outside the control limits on the charts are rejected, and successive out of control results require investigation of potential biases. Trends on the charts indicate a gradual loss of reliability, while shifts represent abrupt changes, and both require troubleshooting of the analytical system. Laboratories define criteria for rejecting data based on control chart exceedances and take corrective actions such as reanalysis or material retesting when criteria are violated.