Mesoporous Drug Delivery System

1. PRESENTATION ON
MESOPOROUS MATERIAL FOR DRUG
DELIVERY SYSTEM
Supervised By:-
Mr.Arindam Chatterjee
Assistant Professor
SPS,JNU,Jaipur
Submitted By:-
Prem jeet
B.Pharm 4th year
Enrollno:-2012/00635
For the partial fulfillment of the requirement for the reward of degree of
Bachelor of Pharmacy
SCHOOL OF PHARMACEUTICAL SCIENCES,
JAIPUR NATIONAL UNIVERSITY, JAIPUR.

2. Contents
1. Introduction
2. Different types of drug delivery system
3. Classification
4. Synthesis
5. Sol-gel Process
6. Properties of MSNs
7. Applications
8. Conclusion
9. References

3. Introduction
• Mesoporous material was first came into existence in 1990 in Japan. In the year
1992 ‘Mobil’ successfully synthesizing the mesoporous material using soft
template strategy.
• Mesoporous materials are defined as natural or synthetic materials having a
pore diameter of 2-50 nm, halfway between the pore sizes that define micro-
and macroporous materials. They have a large surface area and are particularly
useful for applications in catalysis, separation, and absorption.
• The great benefits of these materials are their high surface areas and pore
volumes with tunable pore sizes and easily functionalized pore surface
properties, which allow high drug payloads and from very rapid to slow release
kinetics for controlled drug release formulations.

4. Different types of Nano
drug delivery system.
• Liposomes.
• Titanium dioxide.
• Mesoporous Silica Nanopartciles (MSNs).
• Carbon nanotubes.
• Gold and iron oxide nanoparticles.

5. Classifications
1. Depending on pore size.
A. Microporous:- <2 nm.
B. Mesoporous:- 2-50 nm.
C . Macroporous:- >50 nm.
2. Depending on building framework
A. Purely inorganic:-silica.
B. Organic inorganic hybrid:- Metal organic
framework.
C. Purely organic:-organic porous polymers.

6. Synthesis
1.Soft Template
A. Uses soft template like organic molecules.
B. Good shape , size & morphology simples.
C. Surfactants , Formation of Micelles.
D. Removal of template

7. 2.Hard Template
A. Uses inorganic material like silica carbon
etc.
B. Tedious work up , hard to get good
morphology &costly.
C. Ordered Mesoporous materials.

9. Sol-gel Process
TEOS :- Tetraethyl ortho silicate.
MSNs :- Mesoporous Silica Nanopartciles

10. • Silica Precursors:- Organic-silica nanoparticles contain
better properties that include large surface area, low density.
There are not pH dependent.
• Organically modified precursors:-Their poor water
solubility requires additional organic solvent and alcohol and
needs extreme conditions of pH and high temperature.

11. Properties of MSNs
• Textual properties.
• Internal Structure.
• Surface Functionalization
• pH
• Temperature
• Magnetic
• Enzyme
• Light
• Chemical reaction

12. APPLICATIONS
1. Pharmaceutical field:- Drug delivery, Therapeutic effect .
2. Environment field:-Adsorbents ,Catalysts.
3. Biomedical field:- Bone regenerations, Gene delivery.
4. Chemical catalysis:-Higher catalytic activity MCM-41 ,
Noble metal supports.
5. Nano-material preparation:- Natural nano-particles.
6. Functional devices:-Sensors ,Solar cells, Relays .

13. References
1.Wan, Y.; Zhao, D. Y. Chem. Rev. 2007, 107, 2821.
2.Nabanita Pal, Asim Bhaumika, ”Advances in colloid &
interface science”,189-190 (2013) 21-41 .
3.Ying Wan & Dongyuan Zhao,Chemical reviews, Volume
107,Number 7.
4. Beck, J. S.; Vartuli, J. C.; M.E L.; C.T, K.; Schmitt, K. D;
Chu, C. T. W.; Olson, D. H.; Sheppard, E. W.; McCullen,
S. B.; Higgins, J. B.; J.L, S. J. Am. Chem. Soc 1992, 114,
10834.
5. 5.Serre, C., Millang, F., Thouvenot, C., Nogues, M.,
Marsolier,G.,Louer,D., Ferey, G., (2002) J. Am. Chem.
Soc, 124, pp.13519-13526.

14. 6.Vallet-Regí, M., Doadrio, J.C., Doadrio, A.L.,
Izquierdo-Barba, I., Pérez-Pariente, J., (2004) Solid
State Ionics, 172, pp. 435-439.
7.Izquierdo-Barba, I., Martínez, A., Doadrio, A.L.,
Pérez-Pariente, J., Vallet-Regí, M., (2005) Eur. J.
Pharm. Sci, 26, pp. 365-373.

15. THANK YOU