2. Nanoparticles are solid, colloidal particles ranging 10-
1000nm, consisting of macromolecular materials in which
active ingredient is dissolved/ entrapped/ encapsulated/
absorbed/ attached.
4. Semisynthetic polymers:
• Pseudolatexes/ artificial latexes obtained form
dispersion of preformed polymers.
Ex: pseudo latexes of ethylcellulose, CAP etc.,
• These are used in preparation of nanocapsules.
41. Specific surface Sarptometer
Surface charge &
eletrophoretic
mobility
Laser Doppler Anemometry & Velocimetry
Surface
hydrophobicity
Hydrophobic interaction chromatography, 2-
phase partition, adsorption of hydrophobic
radiolabelled or fluorescent probes & conact
angle measurement.
Density Helium or air using a gas Pycnometer.
Molecular weight Gel permeation chromatography using refractive
index detector.
Chemical analysis X-ray photo electron spectroscopy
Protein adsorption 2D- PAGE (Polyacrylamide Gel Electrophoresis)
Biodegradation Nephelometer
42. In-vitro drug release:
1. side-by-side diffusion cells with artificial/ biological
membrane
2. Dialysis bag diffusion technique
3. Reverse dialysis sac technique
4. Ultracentrifugation
5. Centrifugal ultra filtration technique.