This presentation summarizes research on mesoporous materials for drug delivery systems. Mesoporous materials were first developed in 1990 and have large surface areas and tunable pore sizes, making them useful for controlled drug release. The presentation discusses different types of nano drug delivery systems and classifications of mesoporous materials based on pore size and framework. It also outlines the sol-gel process and properties of mesoporous silica nanoparticles. Finally, potential applications are mentioned in pharmaceuticals, biomedical, chemical catalysis, and sensors.
Just basics of mesoporous materials!!The Break through came around 1992 by both Japanese and Mobil scientist on the soft template based synthesis of mesoporous materials
Synthesis and Characterization of High Quality Mesoporous Material SBA-16 wit...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Just basics of mesoporous materials!!The Break through came around 1992 by both Japanese and Mobil scientist on the soft template based synthesis of mesoporous materials
Synthesis and Characterization of High Quality Mesoporous Material SBA-16 wit...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Gas storage in metal organic frameworks(MOFs)Nitish Kumar
Gas storage in metal organic frameworks.
1. Metal organic frameworks has surface area more than 40 tennis courts per gram. So, it has high adsorption capacity.
2. Gas storage in a cylinder filled with MOFs can store much more gas than empty cylinder.
3. Apart from storage ,MOFs can also be used for Gas Separation.
MOFs are ideal candidates as gas-sensing materials and have been widely used to detect oxygen, water vapor, toxic and hazardous gases, special air pollutants, and VOCs.
metal organic framework-carbon capture and sequestrationVasiUddin Siddiqui
MOF is a porous crystal like a spunge having an enormous surface area and provide much more rooms for storage the gases preferentially hydrogen and carbon dioxide and work as storage for next generation fuel.
MOF is a new class of material with lots of opportunity for future work. It is a coordination compound. Obviously MOF is a attractive subject for a group of researcher.
Clay is a mineral, belonging to phyllosilicate category.
Chemically it consists of aluminium silicate as a principal component along with variety of other metals like magnesium, calcium, potassium and varying level of watermolecules.
Atomic configuration of clays consists of alternating ‘sheets’ of tetrahedral SiO4 and octahedral AlO6 units formed by oxygen sharing
Organoclay is the organically modified pyllosillicate,derived from a naturally occuring clay mineral.
By exchanging the original inter layer cations for organo cations (typically alkylammonium ions) an organophillic surface is generated, consisting of covalently linked organic moieties.
The lamellar structure remains analoguos to the parent phyllosilicate.
Separation of the layers due to ion exchange from the initial interlayer spacing of as little as 3 Å in the case of Na + cations to the distances in the range of 10 - 40 Å as well as the change of chemical character of the clay surface , allows the insitu polymerisation or mixing with certain polymers to obtain what is known as nano composite.
Exfoliation of MMT and Mica with multifunctional amine copolymers
Nanoparticles are particles between 1 and 100 nanometres in size with a surrounding interfacial layer. The interfacial layer is an integral part of nanoscale matter, fundamentally affecting all of its properties. The interfacial layer typically consists of ions, inorganic and organic molecules.
Gas storage in metal organic frameworks(MOFs)Nitish Kumar
Gas storage in metal organic frameworks.
1. Metal organic frameworks has surface area more than 40 tennis courts per gram. So, it has high adsorption capacity.
2. Gas storage in a cylinder filled with MOFs can store much more gas than empty cylinder.
3. Apart from storage ,MOFs can also be used for Gas Separation.
MOFs are ideal candidates as gas-sensing materials and have been widely used to detect oxygen, water vapor, toxic and hazardous gases, special air pollutants, and VOCs.
metal organic framework-carbon capture and sequestrationVasiUddin Siddiqui
MOF is a porous crystal like a spunge having an enormous surface area and provide much more rooms for storage the gases preferentially hydrogen and carbon dioxide and work as storage for next generation fuel.
MOF is a new class of material with lots of opportunity for future work. It is a coordination compound. Obviously MOF is a attractive subject for a group of researcher.
Clay is a mineral, belonging to phyllosilicate category.
Chemically it consists of aluminium silicate as a principal component along with variety of other metals like magnesium, calcium, potassium and varying level of watermolecules.
Atomic configuration of clays consists of alternating ‘sheets’ of tetrahedral SiO4 and octahedral AlO6 units formed by oxygen sharing
Organoclay is the organically modified pyllosillicate,derived from a naturally occuring clay mineral.
By exchanging the original inter layer cations for organo cations (typically alkylammonium ions) an organophillic surface is generated, consisting of covalently linked organic moieties.
The lamellar structure remains analoguos to the parent phyllosilicate.
Separation of the layers due to ion exchange from the initial interlayer spacing of as little as 3 Å in the case of Na + cations to the distances in the range of 10 - 40 Å as well as the change of chemical character of the clay surface , allows the insitu polymerisation or mixing with certain polymers to obtain what is known as nano composite.
Exfoliation of MMT and Mica with multifunctional amine copolymers
Nanoparticles are particles between 1 and 100 nanometres in size with a surrounding interfacial layer. The interfacial layer is an integral part of nanoscale matter, fundamentally affecting all of its properties. The interfacial layer typically consists of ions, inorganic and organic molecules.
Different types of methods can be used for the preparation of Magnetic Nanoparticles, their advantages and disadvantages and applications of the materials in various fields are given in the presentation
Smart materials technology enables us to adapt to environmental changes by activating its functions. Multifunctional materials, sort of smart materials, can be activated by electrical stimuli so as to produce its geometry change or property change.
The nanotechnology aided applications have the potential to change agricultural production by allowing better management and conservation of inputs of plant and animal production. Several nanotechnology applications for agricultural production for developing countries within next 10 years has been predicted (Salamanca–Buentella et al., 2005).
Nanoparticles helps in Controlling the Plant Diseases, application of agricultural fertilizers, pesticides, antibiotics, and nutrients is typically by spray or drench application to soil or plants, or through feed or injection systems to animals. In this context, nanotechnologies offer a great opportunity to develop new products against pests (Caraglia et al., 2011). Nanoscale devices are envisioned that would have the capability to detect and treat an infection, nutrient deficiency, or other health problem, long before symptoms were evident at the macro-scale. The overall goal of this Nanoparticles is to reduce the number of unnecessary problems in agriculture (Thomas et al., 2011). In the management aspects, efforts are made to increase the efficiency of applied fertilizer with the help of nano clays and zeolites and restoration of soil fertility by releasing fixed nutrients (Dongling Qiao, et al., 2016). Nanoherbicides are being developed to address the problems in perennial weed management and exhausting weed seed bank. Bioanalytical Nanosensors are utilized to detect and quantify minute amounts of contaminants like viruses bacteria, toxins bio-hazardous substances etc. in agriculture and food systems (Tothill EI, 2011).
In this way, nanotechnology can be used as an innovative tool for delivering agrochemicals safely. More research should be done on the potential adverse effects of nanomaterials on human health, crops and the environmental safety. It is a challenge to Government and private sector as they have to ensure the acceptance of Nano foods. For it to flourish, continuous funding and understanding on the part of policy makers and science administrators, along with reasonable expectations, would be crucial for this promising field.
International Conference on Fostering High Quality Clinical Research for A He...Prachi Pandey
This paper abstract presented as poster on a International Conference, Which Held of 26 November 2023. Organized by NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan , India.
Nanotechnology in cancer and its synthesisShreyaBhatt23
basic introduction to nanotechnology and the types of nanomaterials used in medical purpose. sysnthesis of nanomaterials by physical , chemical, biosynthesis, green synthesis of nanomaterials
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
1. PRESENTATION ON
MESOPOROUS MATERIAL FOR DRUG
DELIVERY SYSTEM
Supervised By:-
Mr.Arindam Chatterjee
Assistant Professor
SPS,JNU,Jaipur
Submitted By:-
Prem jeet
B.Pharm 4th year
Enrollno:-2012/00635
For the partial fulfillment of the requirement for the reward of degree of
Bachelor of Pharmacy
SCHOOL OF PHARMACEUTICAL SCIENCES,
JAIPUR NATIONAL UNIVERSITY, JAIPUR.
2. Contents
1. Introduction
2. Different types of drug delivery system
3. Classification
4. Synthesis
5. Sol-gel Process
6. Properties of MSNs
7. Applications
8. Conclusion
9. References
3. Introduction
• Mesoporous material was first came into existence in 1990 in Japan. In the year
1992 ‘Mobil’ successfully synthesizing the mesoporous material using soft
template strategy.
• Mesoporous materials are defined as natural or synthetic materials having a
pore diameter of 2-50 nm, halfway between the pore sizes that define micro-
and macroporous materials. They have a large surface area and are particularly
useful for applications in catalysis, separation, and absorption.
• The great benefits of these materials are their high surface areas and pore
volumes with tunable pore sizes and easily functionalized pore surface
properties, which allow high drug payloads and from very rapid to slow release
kinetics for controlled drug release formulations.
4. Different types of Nano
drug delivery system.
• Liposomes.
• Titanium dioxide.
• Mesoporous Silica Nanopartciles (MSNs).
• Carbon nanotubes.
• Gold and iron oxide nanoparticles.
5. Classifications
1. Depending on pore size.
A. Microporous:- <2 nm.
B. Mesoporous:- 2-50 nm.
C . Macroporous:- >50 nm.
2. Depending on building framework
A. Purely inorganic:-silica.
B. Organic inorganic hybrid:- Metal organic
framework.
C. Purely organic:-organic porous polymers.
6. Synthesis
1.Soft Template
A. Uses soft template like organic molecules.
B. Good shape , size & morphology simples.
C. Surfactants , Formation of Micelles.
D. Removal of template
7. 2.Hard Template
A. Uses inorganic material like silica carbon
etc.
B. Tedious work up , hard to get good
morphology &costly.
C. Ordered Mesoporous materials.
10. • Silica Precursors:- Organic-silica nanoparticles contain
better properties that include large surface area, low density.
There are not pH dependent.
• Organically modified precursors:-Their poor water
solubility requires additional organic solvent and alcohol and
needs extreme conditions of pH and high temperature.
11. Properties of MSNs
• Textual properties.
• Internal Structure.
• Surface Functionalization
• pH
• Temperature
• Magnetic
• Enzyme
• Light
• Chemical reaction
13. References
1.Wan, Y.; Zhao, D. Y. Chem. Rev. 2007, 107, 2821.
2.Nabanita Pal, Asim Bhaumika, ”Advances in colloid &
interface science”,189-190 (2013) 21-41 .
3.Ying Wan & Dongyuan Zhao,Chemical reviews, Volume
107,Number 7.
4. Beck, J. S.; Vartuli, J. C.; M.E L.; C.T, K.; Schmitt, K. D;
Chu, C. T. W.; Olson, D. H.; Sheppard, E. W.; McCullen,
S. B.; Higgins, J. B.; J.L, S. J. Am. Chem. Soc 1992, 114,
10834.
5. 5.Serre, C., Millang, F., Thouvenot, C., Nogues, M.,
Marsolier,G.,Louer,D., Ferey, G., (2002) J. Am. Chem.
Soc, 124, pp.13519-13526.
14. 6.Vallet-Regí, M., Doadrio, J.C., Doadrio, A.L.,
Izquierdo-Barba, I., Pérez-Pariente, J., (2004) Solid
State Ionics, 172, pp. 435-439.
7.Izquierdo-Barba, I., Martínez, A., Doadrio, A.L.,
Pérez-Pariente, J., Vallet-Regí, M., (2005) Eur. J.
Pharm. Sci, 26, pp. 365-373.
