What is Pyridoxine? Functions of Pyridoxine Sources of Pyridoxine RDA of Biotin, Toxicity of Pyridoxine Causes of B6 deficiency Clinical features of B6 deficiency Diagnosis and treatment

1. 1
:: B-6 ::
[ PYRIDOXINE ]

2. • It is water soluble and Heat stable vitamin.
• Present in three chemical forms : Pyridoxine,
pyridoxal, pyridoxamine. Collectively B6.
• The animal sources contain pyridoxine and
plant sources contain other two.
:: B-6 :: [ PYRIDOXINE ]

3. FUNCTIONS : ( B-6, Pyridoxine ) :
• Pyridoxine requires for many processes.
1. Nutrient metabolism : amino acid, Fatty
acid, Carbohydrate , lipid, also covert
tryptophan to niacin.
2. Hemoglobin synthesis : formation of RBC
3. Neurological functions : Neurotransmitter
systhesis
4. helps for Immune system functioning.

4. • Foods rich in vitamin B6 are :
1. Green gvegetables, spinach, cauliflower,
celary, sprouts, Fruits
2. Liver, meat, eggs, fish. Milk
3. Grains, cereals, seeds, yeast
4. Also produced by bacteria in GI tract
4
SOURCES ( B-6 Pyridoxine) :

5. RDA OF B-6 Pyridoxine:
• 0.5 – 1.5 mg/day children
ARIA report 2008, 2016
• RDA (Recommanded daily allowance ) OF B-6 :
Overdosage of Vitamin B-6 :
• Toxicity : damage nerves, sensory neuropathy
• 1- 1.7 mg/day for adults
• 1.9 - 2 mg / pregnant /lactation

6. 6
:: CAUSES : DEFICIENCY : B-6 ::
• Low intake : malnutrition
• Reduced absorption : Celiac disease,
Imflammatory bowel disease (crohn’s
disease), GI surgeries
• Increased utilization : Pregnancy,
hyperthyrodism,
• Increase losses : Hemodialysis, renal failure
• Medications : Isoniazid, Hydralazine,
Penicilliamine, Corticosteroids

7. 7
:: CLINICAL FEATURES : B-6 ::
• Neurological : seizures, Peripheral neuropathy
• Interumentary : Dermatitis, Glossitis, chelitis
• Hematological : Anemia (microcytic,
hypochromic)
• Psychiatric : depression, altered mental status
in adults

8. 8
:: Deficiency : Clinical Features : B-6 ::
Seborrheic Dermatitis Peripheral Neuropathy
• Absorption of B6 : absorption in small intestine (jejunum),
Metabolized to active from in liver and Excreted in urine
from kidney

9. 9
:: TREATMENT ::
• Identify risk factors, underlying causes
• B-6 Supplementation :
• Oral pyridoxine vitamin- B6
• 50-100 mg / day
• Diagnosis : Clinical features , Serum
pyridoxal Phosphate test