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NON-INVASIVE
VENTILATION
DR.SANDEEP.G.B
NARAYANA MEDICAL COLLEGE
NELLORE
VENTILATORY FAILURE is the inability of the
Respiratory system to sustain its ventilatory function,
hence needing ventilat...
NON-INVASIVE VENTILATION (NIV)
DEFINITION:Non-invasive ventilation is the delivery of
ventilatory support without the need...
HISTORY
The concept of mechanical ventilation first evolved with
negative pressure ventilation.
• 1876 - Woillez first dev...
Iron lung
• 1960 — use of invasive positive pressure
ventilation increased .
• 1980- use of noninvasive ventilation, fueled by
the d...
INVASIVE VENTILATION

NON INVASIVE VENTILATION

ADV:1. Secures airway
2. Leak free ventilation
3. Facilitates secretion re...
NON INVASIVE VENTILATION
• TECHNIQUES OF APPLICATION:Non Invasive Negative Pressure Ventilation
(NNPV)
Non Invasive Posi...
NEGATIVE PRESSURE VENTILATION
• These devices create negative pressure around the
chest wall and augment the tidal volume....
NON INVASIVE POSITIVE PRESSURE
VENTILATION
• During NIPPV, air enters the nose, mouth or both
through the interface, which...
INTERFACES
• Devices that connect ventilator tubing to the
face, allowing the entry of pressurized gas to the
upper airway...
• Types
– Nasal interfaces:• Nasal masks, nasal cannulae or nasal cushions (within
nostrils)
• There are two basic forms o...
Variable

Nasal

Oronasal

+++

++

Claustrophobia

+

++

Rebreathing

+

++

Lower CO2

+

++

Permits expectoration

++...
Helmet:– Allows prolonged
continuous
application of NIV
– Lesser complications
like skin
necrosis, gastric
distension, and...
MECHANISM OF ACTION OF NPPV
• The work of breathing equals the product of
pressure change across the lung and volume of
ga...
1. Improvement in pulmonary mechanics and
oxygenation:
– NIV augments alveolar ventilation and allows
oxygenation without ...
3. Resetting of respiratory centre ventilatory
responses to PaCO2:
– By maintaining lower nocturnal PaCO2 during sleep
by ...
CONTRAINDICATIONS
• Inability to protect airway:– CVA, comotose patients, confused agitated
patients

• Hemodynamic instab...
CONTRAINDICATIONS
• Life threatening hypoxemia
• Copious secretions
• Conditions where NIV has not been found
effective
• ...
Requirements for successful noninvasive support
1. A co-operative patient who can control their airway
and secretions with...
INDICATIONS OF NPPV
A)
1.
•
•
•
•
•
•
•
•

Acute respiratory failure
Hypercapnic acute respiratory failure
Acute exacerbat...
INDICATIONS OF NPPV
2)Hypoxemic acute respiratory failure
• Cardiogenic pulmonary edema
• Community acquired pnemonia
• AR...
NIV in weaning from mechanical
ventilation
• It serves as a bridge between invasive support
and spontaneous breathing to r...
Determinants of success for NPPV
• Synchronised breathing
with ventilator
• Dentition intact
• Lower APACHE score
• Less a...
SELECTION CRITERIA
A) ACUTE RESPIRATORY FAILURE
•
•
•
•
•

Atleast 2 of the following criteria must be present
Respiratory...
SELECTION CRITERIA
B) CHRONIC RESPIRATORY FAILURE( OBSTRUCTIVE LUNG
DISEASE)
Fatigue, Hypersomnalence, dyspnoea
ABG shows ...
When to intubate during NIV???
• No improvement in gas exchange or dyspnoea
progressively increases
• Deterioration or no ...
NIV VENTILATORS
NIV
VENTILATORS

PRESSURE
PRESET
VENTILATORS

PSV

VOLUME
PRESET
VENTILATORS

PCV
• NIV ventilators also provide bilevel ventilation.
• A higher pressure is applied when patient inspires – IPAP.
• A lower...
MODES
• Controlled mechanical ventilation:– No patient effort
– Referred as Timed mode
– Similar to PCV

• Assist control ...
• Assist mode:
– Ventilatory support to patients effort. No backup
– Referred to spont. mode
– Similar to PSV

• CPAP:
– A...
•Proportional Assist Ventilation (PAV)
• In this mode ventilator has capacity of responding rapidly
to the patients' venti...
Other Modes of Noninvasive
Ventilatory Assistance
• Diaphragm pacing.
• Glossopharyngeal breathing.
Application of NIV
1. Choose the correct interface
2. Explain therapy and its benefit to the patient in
detail . Also disc...
5. Administer oxygen at 2 liters per minute.
6. Hold the mask with hand over face. Do not fix it
7. Increase EPAP by 1-2 c...
9. when the patients efforts are triggering the
ventilator leave EPAP at this level
10. Now start increasing IPAP in incre...
13. After titrating pressure increase Oxygen to bring
SaO2 to around 90%.
14. As the settings may be different in wakefuln...
FiO2 Setting:
• Initial FiO2 is to be slightly higher than that received
prior to NIV.
• Then it is adjusted to achieve de...
Patient Monitoring:
• The most useful indicator is patient’s comfort. ABG is
useful to assess ventilatory parameters
• If ...
Drug Delivery during NIV:
• Inhaled drugs can be administered during NIV by
adding a nebulizer to the circuit.
• This can ...
• The nebulizer dose may need to be increased if the
leak port is in the mask.
• Most nebulizers are suitable, but a nebul...
ADVANTAGES OF NPPV
• Avoidance of complications
– Related to Intubation, i.e. adverse effects from induction drugs,
risk o...
• Ease of application and removal with improved patient
comfort
• Pneumothorax is very rare.
• Correction of hypoxia with ...
Disadvantages
• NIV is not appropriate for all patients and is ineffective
in those who are severely ill.
• There are prob...
Side effects
•
•
•
•
•
•
•

Air leak
Skin necrosis- particularly over bridge of nose
Retention of secretions
Gastric diste...
Problems and complications
A. PROBLEMS RELATED TO THE INTERFACE:Improperly fitting mask, excess strap tension,
claustropho...
C. Problems associated with intolerance to NIV:
– Mask intolerance
– Patient ventilator asynchrony

D. Problems associated...
E. Major complications:
– Delay in intubation and worsening of prognosis
– Major desaturation and cardiac arrest
– Aspirat...
THANK YOU
Non-invasive Ventilation
Non-invasive Ventilation
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Non-invasive Ventilation

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The presentation will help you learn the delivery of ventilation support without the need of an invasive airway.

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Non-invasive Ventilation

  1. 1. NON-INVASIVE VENTILATION DR.SANDEEP.G.B NARAYANA MEDICAL COLLEGE NELLORE
  2. 2. VENTILATORY FAILURE is the inability of the Respiratory system to sustain its ventilatory function, hence needing ventilatory support. VENTILATORY SUPPORT Invasive Non Invasive
  3. 3. NON-INVASIVE VENTILATION (NIV) DEFINITION:Non-invasive ventilation is the delivery of ventilatory support without the need for an invasive airway.
  4. 4. HISTORY The concept of mechanical ventilation first evolved with negative pressure ventilation. • 1876 - Woillez first developed a workable iron lung. • 1889 -Alexander Graham Bell designed & built a prototype of iron lung. • 1928- Drinker introduced neg-pressure ventilation & popularized the iron lung.
  5. 5. Iron lung
  6. 6. • 1960 — use of invasive positive pressure ventilation increased . • 1980- use of noninvasive ventilation, fueled by the development of PPV delivered by close fitting nasal or face masks
  7. 7. INVASIVE VENTILATION NON INVASIVE VENTILATION ADV:1. Secures airway 2. Leak free ventilation 3. Facilitates secretion removal DISADV:1. Trauma to airway 2. Esoph/Endobronchial intub. 3. Muscle relaxants required 4. Sedation needs 5. Greater incidence of VAP, tracheal stenosis, etc.. • Decreased incidence of nosocomial infections • Improves patient comfort • Minimal sedation requirement • Less painful • Accelerates weaning
  8. 8. NON INVASIVE VENTILATION • TECHNIQUES OF APPLICATION:Non Invasive Negative Pressure Ventilation (NNPV) Non Invasive Positive Pressure Ventilation (NPPV)
  9. 9. NEGATIVE PRESSURE VENTILATION • These devices create negative pressure around the chest wall and augment the tidal volume. • Devices- 1. Body ventilators 2. Iron lung
  10. 10. NON INVASIVE POSITIVE PRESSURE VENTILATION • During NIPPV, air enters the nose, mouth or both through the interface, which in turn is connected, to Positive Pressure Ventilator.
  11. 11. INTERFACES • Devices that connect ventilator tubing to the face, allowing the entry of pressurized gas to the upper airways. • Masks are usually made from a non-irritant material such as silicon rubber. • Proper fitting mask is crucial to minimize leaks, improve patient compliance and for maximum therapeutic benefit • It should have minimal dead space and a soft inflatable cuff to provide a seal with the skin.
  12. 12. • Types – Nasal interfaces:• Nasal masks, nasal cannulae or nasal cushions (within nostrils) • There are two basic forms of nasal interface tubes; nonsealing nasal interface tubes for supplemental oxygen therapy and sealing nasal interface tubes for PAP ventilation. – Oral interfaces:– Combined oral and nasal interfaces:-
  13. 13. Variable Nasal Oronasal +++ ++ Claustrophobia + ++ Rebreathing + ++ Lower CO2 + ++ Permits expectoration ++ + Permits speech ++ + Permits eating + - Functions if nose obstructed - + Comfort
  14. 14. Helmet:– Allows prolonged continuous application of NIV – Lesser complications like skin necrosis, gastric distension, and eye irritation
  15. 15. MECHANISM OF ACTION OF NPPV • The work of breathing equals the product of pressure change across the lung and volume of gas moved. • During inspiration, most of the work is done to overcome elastic recoil of the thorax and lungs, and the resistance of the airways and non-elastic tissues.
  16. 16. 1. Improvement in pulmonary mechanics and oxygenation: – NIV augments alveolar ventilation and allows oxygenation without raising the PaCO2 2. Partial unloading of respiratory muscles: – NIV reduces respiratory muscle work and diaphragmatic electromyographic activity. – This leads to TV, RR and MV. – Also overcomes the effect of intrinsic PEEP.
  17. 17. 3. Resetting of respiratory centre ventilatory responses to PaCO2: – By maintaining lower nocturnal PaCO2 during sleep by NIV, it is possible to reset the respiratory control centre to become more responsive to an increased PaCO2 by increasing the neural output to the diaphragm and other respiratory muscles. – These patients are then able to maintain a more normal PaCO2 throughout the daylight hours without the need for mechanical ventilation.
  18. 18. CONTRAINDICATIONS • Inability to protect airway:– CVA, comotose patients, confused agitated patients • Hemodynamic instability:– Recent MI, arrhythmias, high dose inotropes • Inability to fix the interface:– facial -abnormalities, burns, trauma, anamolies • Severe GI symptoms:-
  19. 19. CONTRAINDICATIONS • Life threatening hypoxemia • Copious secretions • Conditions where NIV has not been found effective • Non availability of trained medical personnel
  20. 20. Requirements for successful noninvasive support 1. A co-operative patient who can control their airway and secretions with an adequate cough reflex. The patient should be able to co-ordinate breathing with the ventilator and breathe unaided for several minutes. 2. Hemodynamically stable 3. Blood pH >7.1 and PaCO2 <92 mmHg 4. The patient should ideally show improvement in gas exchange, H.R and R.R within first two hours.
  21. 21. INDICATIONS OF NPPV A) 1. • • • • • • • • Acute respiratory failure Hypercapnic acute respiratory failure Acute exacerbation of COPD Post extubation Weaning difficulties Post surgical respiratory failure Chest wall deformities/ neuromuscular disease Cystic fibrosis Status asthmaticus Acute respiratory failure in obesity hypoventilation
  22. 22. INDICATIONS OF NPPV 2)Hypoxemic acute respiratory failure • Cardiogenic pulmonary edema • Community acquired pnemonia • ARDS • Weaning difficulties B)Chronic respiratory failure C)Immuno-compromised patients D)Do not intubate patients
  23. 23. NIV in weaning from mechanical ventilation • It serves as a bridge between invasive support and spontaneous breathing to reduce the time on invasive mechanical ventilation. • Used – As a part of early weaning strategy, when SBT fails – After conventional weaning and extubation to prevent post extubation failure – When signs of respiratory failure develop after extubation
  24. 24. Determinants of success for NPPV • Synchronised breathing with ventilator • Dentition intact • Lower APACHE score • Less air leaking • Less secretions • Good initial response to NPPV at 1-2 hrs • Correction of pH • Reduction in respiratory rate • Reduction in PaCO2 • No pneumonia • pH>7.10 • PaCO2 < 92mm Hg • Better neurologic score • Better compliance
  25. 25. SELECTION CRITERIA A) ACUTE RESPIRATORY FAILURE • • • • • Atleast 2 of the following criteria must be present Respiratory distress with dyspnoea Use of accessory muscles of respiration Abdominal paradox Respiratory rate > 25/min ABG shows pH< 7.35 or PaCO2 >45 mmHg or PaO2/FiO2 <200
  26. 26. SELECTION CRITERIA B) CHRONIC RESPIRATORY FAILURE( OBSTRUCTIVE LUNG DISEASE) Fatigue, Hypersomnalence, dyspnoea ABG shows Ph<7.35. Paco2>55 mmHg Oxygen saturation <88% for >10% monitoring time despite O2 supplementation C) THORASIC RESTRICTIVE/CEREBRAL HYPOVENTILATION DISEASES Fatigue, morning headache, hypersomnalence, nightmares, enuresis, dyspn oea ABG shows PaCo2 >45 mmHg Nocturnal SaO2 <90% for more than 5 minutes sustained
  27. 27. When to intubate during NIV??? • No improvement in gas exchange or dyspnoea progressively increases • Deterioration or no change in the mental condition of the hypercapnoeic patients • Need for airway protection • Hemodynamic instability • Fresh MI or arrhythmias • Patient unable to tolerate the mask
  28. 28. NIV VENTILATORS NIV VENTILATORS PRESSURE PRESET VENTILATORS PSV VOLUME PRESET VENTILATORS PCV
  29. 29. • NIV ventilators also provide bilevel ventilation. • A higher pressure is applied when patient inspires – IPAP. • A lower pressure is applied when patient exhales – EPAP. • The difference between IPAP and EPAP is the EFFECTIVE PRESSURE SUPPORT. • EPAP is equivalent to applying PEEP in a spontaneously breathing patient
  30. 30. MODES • Controlled mechanical ventilation:– No patient effort – Referred as Timed mode – Similar to PCV • Assist control ventilation:– Ventilatory support in response to pt. effort and backup safety rate if pt. does not trigger – Referred as spontaneous/timed (S/T) mode – Similar to PS with apnoea backup with PC breaths
  31. 31. • Assist mode: – Ventilatory support to patients effort. No backup – Referred to spont. mode – Similar to PSV • CPAP: – A constant pressure is applied to airway throughout the cycle – Used primarily to correct hypoxemia – Not a ventilatory mode – Main indication- cardiogenic pulmonary edema
  32. 32. •Proportional Assist Ventilation (PAV) • In this mode ventilator has capacity of responding rapidly to the patients' ventilatory efforts rather than pressure or volume. • By instantaneously tracking patient inspiratory flow and its integral (volume) using an in-line pneumotachograph, this mode has the capability of responding rapidly to the patient’s ventilatory effort. • By adjusting the gain on the flow and volume signals, one can select the proportion of breathing work that is to be assisted.
  33. 33. Other Modes of Noninvasive Ventilatory Assistance • Diaphragm pacing. • Glossopharyngeal breathing.
  34. 34. Application of NIV 1. Choose the correct interface 2. Explain therapy and its benefit to the patient in detail . Also discuss the possibility of intubation 3. Set the NIV ventilator to Spont or S/T mode 4. Start with very low settings. Start low IPAP of 6-8 cm H2O and EPAP of 2-4 cm H2O. The difference between IPAP and EPAP should be atleast 4 cm H2O.
  35. 35. 5. Administer oxygen at 2 liters per minute. 6. Hold the mask with hand over face. Do not fix it 7. Increase EPAP by 1-2 cm increments till all the inspiratory efforts are able to trigger the ventilator 8. If the pt. is making inspiratory effort & the ventilator is not responding, it indicates that the pt has not generated enough respiratory effort to counter auto PEEP and trigger the ventilator. Increase EPAP further till it happens. Most of the pt require EPAP of about 4 to 6 cm H2O.
  36. 36. 9. when the patients efforts are triggering the ventilator leave EPAP at this level 10. Now start increasing IPAP in increments of 1-2 cm H2O up to a maximum pressure, which the patient can tolerate without discomfort 11. In some ventilators, inspiratory time (Ti) can be set. Setting Ti at one second is reasonable 12. Now secure interface with head straps. Avoid excessive tightness
  37. 37. 13. After titrating pressure increase Oxygen to bring SaO2 to around 90%. 14. As the settings may be different in wakefulness and sleep, readjust them accordingly
  38. 38. FiO2 Setting: • Initial FiO2 is to be slightly higher than that received prior to NIV. • Then it is adjusted to achieve desired SaO2, generally above 92%. • If a patient is hypoxic while breathing 100% oxygen on a CPAP circuit, their hypoxia may not improve if they are placed onto a BiPAP circuit (in spite of the increased ventilatory assistance) because the FiO2 will drop significantly due to increased gas flow through the breathing circuit.
  39. 39. Patient Monitoring: • The most useful indicator is patient’s comfort. ABG is useful to assess ventilatory parameters • If the patient is getting increasingly tired, or ABG deteriorates despite optimal settings, then mechanical ventilation is necessary. It must be recognized early.
  40. 40. Drug Delivery during NIV: • Inhaled drugs can be administered during NIV by adding a nebulizer to the circuit. • This can be done by using a T-piece positioned as close as possible to the patient, ideally between the exhale valve and the patient to prevent fallout and loss of the drug, although this does increase the dead space. • The optimum nebulizer position during NIV is between the leak port and the mask.
  41. 41. • The nebulizer dose may need to be increased if the leak port is in the mask. • Most nebulizers are suitable, but a nebulizer that is able to work at varying angles is useful as often the ventilator circuit is unsupported, leaving the nebulizer to function on its side. • Aerosols can also be administered into the ventilator circuit using metered dose inhalers and spacer devices especially when the leak port is in the mask.
  42. 42. ADVANTAGES OF NPPV • Avoidance of complications – Related to Intubation, i.e. adverse effects from induction drugs, risk of failed intubation, risk of aspiration of gastric content and airway trauma. – Related to tracheal tube, i.e. need of sedation, risk of endobronchial intubation, difficult communication, reduced ciliary activity and more risk of ventilator associate pneumonia. – Long term complications like tracheal stenosis, sinusitis and vocal cord damage. • Preservation of airway defense mechanism • Early ventilatory support and intermittent ventilation is possible • Patient can eat, drink, communicate and cooperate with physiotherapy
  43. 43. • Ease of application and removal with improved patient comfort • Pneumothorax is very rare. • Correction of hypoxia with out worsening hypercarbia. • It can be instituted outside the ICU because of nonrequirement of muscle paralysis • Customized purpose-built machines available with different NIV modes for domestic use. • Reduction of ICU complications, hospital mortality and lesser resource consumption in comparison with conventional mechanical ventilation.
  44. 44. Disadvantages • NIV is not appropriate for all patients and is ineffective in those who are severely ill. • There are problems of air leaks, skin damage and sore from mask pressure. • NIV may increase the risk of aspiration as airway is not protected • Mask uncomfortable/claustrophobic • No direct access to bronchial tree for suction in excessive secretions • Patient ventilator asynchrony • Gastric distension
  45. 45. Side effects • • • • • • • Air leak Skin necrosis- particularly over bridge of nose Retention of secretions Gastric distension Failure to ventilate Sleep fragmentation Upper airway obstruction
  46. 46. Problems and complications A. PROBLEMS RELATED TO THE INTERFACE:Improperly fitting mask, excess strap tension, claustrophobia, pressure over nasal bridge B. PROBLEMS ASSOCIATED WITH AIRPRESSURE AND FLOW:– Air leaks- oral dryness, eye irritation – Air pressure – redness & congestion of nose & PNS – Gastric distension
  47. 47. C. Problems associated with intolerance to NIV: – Mask intolerance – Patient ventilator asynchrony D. Problems associated with failure to ventilate adequately: – Air leak – Rebreathing of CO2 – Position of exhalation valve affects dynamic dead space
  48. 48. E. Major complications: – Delay in intubation and worsening of prognosis – Major desaturation and cardiac arrest – Aspiration pneumonia – Hypotension – Pneumothorax
  49. 49. THANK YOU

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