1. Non-invasive ventilation (NIV) delivers ventilatory support without the need for an invasive airway. It has been increasingly used since the 1980s with the development of positive pressure ventilation delivered by masks. 2. NIV can be delivered via nasal or facial masks connected to ventilators. It works by partially unloading the respiratory muscles and improving oxygenation. Common indications include acute or chronic respiratory failure. 3. The main advantages of NIV are avoiding complications of invasive ventilation while preserving airway defenses and patient comfort. However, NIV may not be suitable for severely ill patients and improper fitting of masks can cause skin damage or air leaks. Patient monitoring is important to assess response and determine

1. NON INVASIVE- VENTILATION
Dr Magan Solanki
Med resident
2021
Dr Prabhat kanvaria sir
unit head
Unit H

2. • VENTILATORY FAILURE is the inability of the Respiratory
system to sustain its ventilatory function, hence needing ventilatory
support.
• VENTILATORY SUPPORT
• Invasive
• Non Invasive

3. NON-INVASIVE VENTILATION
• DEFINITION:
• Non-invasive ventilation is the delivery of ventilatory
support without the need for an invasive airway.

4. NON INVASIVE VENTILATION
• HISTORY
• The concept of mechanical ventilation first evolved with
negative pressure ventilation. •
• 1876 - Woillez first developed a workable iron lung. • 1889 -
Alexander Graham Bell designed & built a prototype of iron
lung.
• 1928- Drinker introduced neg-pressure ventilation &
popularized the iron lung.

5. IRON LUNG

6. • 1960 — use of invasive positive pressure ventilation
increased.
• 1980- use of noninvasive ventilation, fueled by the
development of PPV delivered by close fitting nasal or
face masks

7. INVASIVE VENTILATION
ADVANTAGE:
• 1. Secures airway
• 2. Leak free ventilation
• 3. Facilitates secretion removal
• DISADVANTAGE:
• 1. Trauma to airway
• 2. Esoph/Endobronchial intub.
• 3. Muscle relaxants required
• 4. Sedation needs
• 5. Greater incidence of VAP, tracheal
stenosis, etc..
NON INVASIVE VENTILATION
• Decreased incidence of nosocomial
infections
• Improves patient comfort
• Minimal sedation requirement
• Less painful • Accelerates weaning

8. NON INVASIVE VENTILATION
TECHNIQUES OF APPLICATION:
Non Invasive Negative Pressure Ventilation (NNPV)
Non Invasive Positive Pressure Ventilation (NPPV)

9. NEGATIVE PRESSURE VENTILATION
• These devices create negative pressure around the chest wall and augment
the tidal volume
• Devices-
• 1. Body ventilators
• 2. Iron lung

10. NON INVASIVE POSITIVE PRESSURE VENTILATION
During NIPPV, air enters the nose, mouth or both through the interface, which
in turn is connected, to Positive Pressure Ventilator.

11. INTERFACES
• Masks are usually made from a non-irritant material such as silicon
rubber.
• Devices that connect ventilator tubing to the face, allowing the entry
of pressurized gas to the upper airways.
• Proper fitting mask is crucial to minimize leaks, improve patient
compliance and for maximum therapeutic benefit
• It should have minimal dead space and a soft inflatable cuff to
provide a seal with the skin.

12. Types
Nasal interfaces:
• Nasal masks, nasal cannulae or nasal cushions (within nostrils)
• There are two basic forms of nasal interface tubes;
Nonsealing nasal interface tubes for supplemental oxygen
therapy
Sealing nasal interface tubes for PAP ventilation.
Oral interfaces
Combined oral and nasal interfaces:-

16. Helmet:
• Allows prolonged continuous application of NIV
• Lesser complications like skin necrosis, gastric distension, and eye
irritation

17. MECHANISM OF ACTION OF NIPPV
• The work of breathing equals the product of
pressure change across the lung and volume of gas
moved.
• During inspiration, most of the work is done to
overcome elastic recoil of the thorax and lungs, and
the resistance of the airways and non-elastic tissues.

18. 1.Improvement in pulmonary mechanics and oxygenation:
• NIV augments alveolar ventilation and allows oxygenation without
raising the PaCO2
2.Partial unloading of respiratory muscles: –
NIV reduces respiratory muscle work and diaphragmatic
electromyographic activity.
– This leads to ↑TV, ↓RR and ↑MV.
– Also overcomes the effect of intrinsic PEEP.

19. 3. Resetting of respiratory centre ventilatory responses to
PaCO2:
– By maintaining lower nocturnal PaCO2 during sleep by NIV, it is
possible to reset the respiratory control centre to become more
responsive to an increased PaCO2 by increasing the neural output to
the diaphragm and other respiratory muscles.
– These patients are then able to maintain a more normal PaCO2
throughout the daylight hours without the need for mechanical
ventilation.

20. CONTRAINDICATIONS
• Inability to protect airway:– CVA, comotose patients, confused agitated
patients
• Hemodynamic instability:– Recent MI, arrhythmias, high dose inotropes
• Inability to fix the interface:– facial -abnormalities, burns, trauma,
anamolies
• Severe GI symptoms:-
• Life threatening hypoxemia •
• Copious secretions •
• Conditions where NIV has not been found effective •
• Non availability of trained medical personnel

21. REQUIREMENTS FOR SUCCESSFUL NONINVASIVE SUPPORT
1. A co-operative patient who can control their airway and secretions
with an adequate cough reflex. The patient should be able to co-
ordinate breathing with the ventilator and breathe unaided for
several minutes.
2 Hemodynamically stable
3. Blood pH >7.1 and PaCO2 <92 mmHg
4. The patient should ideally show improvement in gas exchange, H.R
and R.R within first two hours.

22. INDICATIONS OF NIPPV
A) Acute respiratory failure
1.Hypercapnic acute respiratory failure
• Acute exacerbation of COPD
• Post extubation
• Weaning difficulties
• Post surgical respiratory failure
• Chest wall deformities/ neuromuscular disease
• Cystic fibrosis
• Status asthmaticus
• Acute respiratory failure in obesity hypoventilation

23. INDICATIONS OF NIPPV
2)Hypoxemic acute respiratory failure
• Cardiogenic pulmonary edema
• Community acquired pnemonia
• ARDS
• Weaning difficulties
B)Chronic respiratory failure
C)Immuno-compromised patients
D)Do not intubate patients

24. NIV IN WEANING FROM MECHANICAL VENTILATION
• It serves as a bridge between invasive support and
spontaneous breathing to reduce the time on invasive
mechanical ventilation
• Used
• As a part of early weaning strategy, when SBT fails
• After conventional weaning and extubation to prevent post
extubation failure
• When signs of respiratory failure develop after extubation

25. Determinants of success for NIPPV
• Synchronised breathing with
ventilator •
• Dentition intact
• Lower APACHE score
• Less air leaking
• Less secretions
• Good initial response to NPPV
at 1-2 hrs
• Correction of pH
• No pneumonia
• pH>7.10
• PaCO2 < 92mm Hg
• Better neurologic score
• Better compliance
• Reduction in PaCO2
• Reduction in respiratory rate

26. SELECTION CRITERIA
A) ACUTE RESPIRATORY FAILURE • • • • •
• Atleast 2 of the following criteria must be present
• Respiratory distress with dyspnoea
• Use of accessory muscles of respiration
• Abdominal paradox
• Respiratory rate > 25/min
• ABG shows pH< 7.35 or PaCO2 >45 mmHg or PaO2/FiO2 <200

27. SELECTION CRITERIA
B) CHRONIC RESPIRATORY FAILURE( OBSTRUCTIVE LUNG
DISEASE)
Fatigue, Hypersomnalence, dyspnoea ,ABG shows Ph<7.35. Paco2>55
mmHg, Oxygen saturation <88% for >10% monitoring time despite O2
supplementation
C) THORASIC RESTRICTIVE/CEREBRAL HYPO VENTILATION
DISEASES
Fatigue, morning headache, hypersomnalence, nightmares, enuresis, dyspn
oea, ABG shows PaCo2 >45 mmHg, Nocturnal SaO2 <90% for more than 5
minutes sustained.

28. When to intubate during NIV???
• No improvement in gas exchange or dyspnoea
progressively increases
• Deterioration or no change in the mental condition of the
hypercapnoeic patients
• Need for airway protection
• Hemodynamic instability
• Patient unable to tolerate the mask

30. • NIV ventilators also provide bilevel ventilation.
• A higher pressure is applied when patient inspires – IPAP.
• A lower pressure is applied when patient exhales – EPAP.
• The difference between IPAP and EPAP is the
EFFECTIVE PRESSURE SUPPORT.
• EPAP is equivalent to applying PEEP in a spontaneously
breathing patient
BIPAP- bilevel positive airway pressure

31. MODES
• Controlled mechanical ventilation:–
• No patient effort
• Referred as Timed mode
• Similar to PCV
• Assist control ventilation:–
• Ventilatory support in response to pt. effort and
backup safety rate if pt. does not trigger
• Referred as spontaneous/timed (S/T) mode
• Similar to PS with apnoea backup with PC breaths

32. Assist mode: –
• Ventilatory support to patients effort. No backup
• Referred to spont. mode
• Similar to PSV
CPAP: –
• A constant pressure is applied to airway throughout the cycle
• Used primarily to correct hypoxemia
• Not a ventilatory mode
• Main indication- cardiogenic pulmonary edema

33. PROPORTIONAL ASSIST VENTILATION (PAV)
• In this mode ventilator has capacity of responding rapidly to
the patients' ventilatory efforts rather than pressure or
volume.
• By instantaneously tracking patient inspiratory flow and its
integral (volume) using an in-line pneumotachograph, this
mode has the capability of responding rapidly to the patient’s
ventilatory effort.
• By adjusting the gain on the flow and volume signals, one
can select the proportion of breathing work that is to be
assisted.

34. Other Modes of Noninvasive Ventilatory Assistance
• Diaphragm pacing.
• Glossopharyngeal breathing.

35. APPLICATION OF NIV
1. Choose the correct interface
2. Explain therapy and its benefit to the patient in detail .
Also discuss the possibility of intubation
3. Set the NIV ventilator to Spont or S/T mode
4. Start with very low settings. Start low IPAP of 6-8 cm
H2O and EPAP of 2-4 cm H2O. The difference between
IPAP and EPAP should be atleast 4 cm H2O.

36. 5 . Administer oxygen at 2 liters per minute.
6. Hold the mask with hand over face. Do not fix it
7. Increase EPAP by 1-2 cm increments till all the inspiratory efforts are able
to trigger the ventilator
8. If the pt. is making inspiratory effort & the ventilator is not responding, it
indicates that the pt has not generated enough respiratory effort to counter
auto PEEP and trigger the ventilator.
9. Increase EPAP further till it happens. Most of the pt require EPAP of
about 4 to 6 cm H2O.
9. when the patients efforts are triggering the ventilator leave EPAP at this
level .

37. 10. Now start increasing IPAP in increments of 1-2 cm H2O up to a
maximum pressure, which the patient can tolerate without discomfort
11. In some ventilators, inspiratory time (Ti) can be set. Setting Ti at
one second is reasonable
12. Now secure interface with head straps. Avoid excessive tightness
13. After titrating pressure increase Oxygen to bring SaO2 to around
90%.
14. As the settings may be different in wakefulness and sleep, readjust
them accordingly

38. FiO2 Setting
• Initial FiO2 is to be slightly higher than that received prior to
NIV. •
• Then it is adjusted to achieve desired SaO2, generally above
92%. •
• If a patient is hypoxic while breathing 100% oxygen on a
CPAP circuit, their hypoxia may not improve if they are placed
onto a BiPAP circuit (in spite of the increased ventilatory
assistance) because the FiO2 will drop significantly due to
increased gas flow through the breathing circuit.

39. PATIENT MONITORING
• The most useful indicator is patient’s comfort.
• ABG is useful to assess ventilatory parameters •
• If the patient is getting increasingly tired, or ABG
deteriorates despite optimal settings, then mechanical
ventilation is necessary. It must be recognized early.

40. DRUG DELIVERY DURING NIV
• Inhaled drugs can be administered during NIV by adding a nebulizer to
the circuit.
• This can be done by using a T-piece positioned as close as possible to the
patient, ideally between the exhale valve and the patient to prevent
fallout and loss of the drug, although this does increase the dead space.
• The optimum nebulizer position during NIV is between the leak port and
the mask.

41. • The nebulizer dose may need to be increased if the leak port is in the
mask.
• Most nebulizers are suitable, but a nebulizer that is able to work at
varying angles is useful as often the ventilator circuit is unsupported,
leaving the nebulizer to function on its side.
• Aerosols can also be administered into the ventilator circuit using
metered dose inhalers and spacer devices especially when the leak
port is in the mask.

42. ADVANTAGES OF NPPV
• Avoidance of complications
–Related to Intubation, i.e. adverse effects from induction drugs, risk of failed
intubation, risk of aspiration of gastric content and airway trauma. –
-Related to tracheal tube, i.e. need of sedation, risk of endobronchial intubation,
difficult communication, reduced ciliary activity and more risk of ventilator associate
pneumonia.
–Long term complications like tracheal stenosis, sinusitis and vocal cord damage. •
• Preservation of airway defense mechanism •
• Early ventilatory support and intermittent ventilation is possible
• Patient can eat, drink, communicate and cooperate with physiotherapy

43. • Ease of application and removal with improved patient comfort
• Pneumothorax is very rare.
• Correction of hypoxia with out worsening hypercarbia.
• It can be instituted outside the ICU because of nonrequirement of muscle paralysis
• Customized purpose-built machines available with different NIV modes for domestic
use.
• Reduction of ICU complications, hospital mortality and lesser resource consumption
in comparison with conventional mechanical ventilation.

44. DISADVANTAGES
• NIV is not appropriate for all patients and is ineffective in those who
are severely ill.
• There are problems of air leaks, skin damage and sore from mask
pressure.
• NIV may increase the risk of aspiration as airway is not protected •
• Mask uncomfortable/claustrophobic
• No direct access to bronchial tree for suction in excessive secretions
• Patient ventilator asynchrony
• Gastric distension

45. SIDE EFFECTS
• Air leak
• Skin necrosis- particularly over bridge of nose
• Retention of secretions
• Gastric distension
• Failure to ventilate
• Sleep fragmentation
• Upper airway obstruction

46. COMPLICATIONS OF NIV
A. PROBLEMS RELATED TO THE INTERFACE:
• Improperly fitting mask, excess strap tension, claustrophobia, pressure over nasal
bridge
B. PROBLEMS ASSOCIATED WITH AIRPRESSURE AND FLOW:–
• Air leaks- oral dryness, eye irritation –
• Air pressure – redness & congestion of nose & PNS – Gastric distension
C. Problems associated with intolerance to NIV: –
• Mask intolerance –
• Patient ventilator asynchrony

47. D. Problems associated with failure to ventilate adequately: –
• Air leak –
• Rebreathing of CO2 –
• Position of exhalation valve affects dynamic dead space
E. Major complications: –
• Delay in intubation and worsening of prognosis –
• Major desaturation and cardiac arrest –
• Aspiration pneumonia –
• Hypotension –
• Pneumothorax