Pyridine- Pharmacy-Heterocyclic chemistry- As per PCI syllabus

1. 6- Member Heterocyclic Ring
P Y R I D I N E
Dr Akhil Nagar
RCP IPER

2. Properties
1. Aromaticity
P Y R I D I N E

3. Properties
1. Aromaticity

4. Properties
2. Basicity
P Y R I D I N E

5. Properties
2. Basicity
Pyridine is more basic than pyrrole
P Y R I D I N E
113

6. Properties
2. Basicity
114

7. Properties
2. Basicity
115

8. Properties
3. Tautomerism
116

9. 123

10. Reactions
124

11. Resonating Structures:
The bond length and stability of Pyridine can be explained by the
resonating structures. Electronegative atom N produces the
deficiency of electron density in pyridine and ring carbon acquires
increased electron density. Thus nitrogen atom in pyridine causes
deactivation of the ring, contrary to pyrrole.

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C2
C3
C4
Reactions
2. Electrophilic substitution to C

13. 126
Reactions
2. Electrophilic substitution to C

14. 127
Reactions
2. Electrophilic substitution to C

15. 128
nucleophilic substitution
Reactions
3. Nucleophilic substitution
Why pyridine undergoes
reaction at 2-position.
C3
C2

16. Reactions
Alkylation of Pyridine gives 2-butylpyridine

17. Reactions
Reaction with Potassium Hydroxide

18. 129
Reactions
3. Nucleophilic substitution

19. 130
Reactions
4. Pyridine as Nucleophilic catalyst

20. 131
Reactions
5. Reduction

21. 117
Synthesis
1. Hantzsch pyridine synthesis

22. 118
Synthesis
1. Hantzsch pyridine synthesis

26. 119
Synthesis
1. Hantzsch pyridine synthesis

27. 120
Synthesis
2. The Guareschi Synthesis

28. 121
Synthesis
3. From 1,5 - Dicarbonyl Compounds

29. 132
Medicinal uses

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Medicinal uses

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Medicinal uses