mHealth Israel_Unmet Needs and Opportunities – Farm animals

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Presentation by Avner Finger, Head, R&D, Phibro, Unmet R&D Needs and Opportunities – Farm animals. Phibro business includes Medicated Feed Additives includes Antibiotics, Anticoccidials, Antimicrobials, Bloat Control, Anthelmintics. Vaccines. Fully Licensed includes Autogenous, Poultry, Swine, Bovine, Aqua. Nutritional Specialties include Immune Modulators, DCAD Solutions, Yeast Solutions, Mycotoxin Solutions, Phytogenic Feed Additives, DFM Solutions. MVP Adjuvants. Mineral Nutrition. Ethanol Performance. Plant Science. World meat production. Disease Pressure on the Rise. Intensive livestock production. Antimicrobial resistance. Global warming. Disease vectors prevalence. Global trade and travel. Major Challenges. Animal Protein Supply. Food Safety. Zoonotic diseases. Sustainable production. Vaccines - Our Most Effective Tool. All farmed animals are vaccinated against at least several diseases. Animal vaccines are based on some of the most advanced technologies. However…We Continue to Require Real Innovation. Rapid and accurate diagnostic tools. Vaccine platforms. Mass application.

Health & Medicine

1
September 2022
ONE HEALTH
Unmet Needs and Opportunities – Farm animals

About Phibro
Medicated
Feed
Additives
• Antibiotics
• Anticoccidials
• Antimicrobials
• Bloat Control
• Anthelmintics
Vaccines
• Fully Licensed
• Autogenous
• Poultry
• Swine
• Bovine
• Aqua
Nutritional
Specialties
• Immune
Modulators
• DCAD
Solutions
• Yeast Solutions
• Mycotoxin
Solutions
• Phytogenic
Feed Additives
• DFM Solutions
MVP
Adjuvants
• Oil-in-Water
• Polymers
• Custom
• Poultry
• Swine
• Bovine
• Aqua
Mineral
Nutrition
• Trace and
Macro Minerals
• Organic Trace
Minerals
• Premixes
• Selenium Yeast
• Colorants
• Vitamin K
Ethanol
Performance
• Antimicrobials
• Cleaning
Products
• Process Aids
• Yeast
Plant Science
• Micro nutrients
• Microbial seed
treatment
• Foliar and furrow
application

Disease Pressure on the Rise
Intensive livestock production
Antimicrobial resistance
Global warming
Disease vectors prevalence
Global trade and travel
4

Major Challenges
Animal Protein Supply
- Affected by diseases – African Swine Fever
Food Safety
- Salmonella, campylobacter
Zoonotic diseases
- Avian Influenza
Sustainable production
- Carbon emissions
- Water
- Farmland
5

6
6 9/18/2022
H5
IBDV
POX
ILT IBV
NDV
H9
Cocci
APV
Salmo
nella
Mycopl
asma
AE
Reo
IBH
E
coli
IC

Vaccines
Our Most Effective Tool
All farmed animals are vaccinated against at least several diseases
Animal vaccines are based on some of the most advanced technologies:
- Inactivated vaccines
- Live attenuated vaccines
- Live viral vector vaccines
- Non-replicating vectors vaccines
- Sub-unit recombinant antigens
- DNA vaccines
- Live and inactivated bacterial vaccines
7

However…
We Continue to Require Real Innovation
Rapid and accurate diagnostic tools
- Microorganism Isolation and identification (mainly in remote areas)
- AI systems to analyze and predict
Vaccine platforms:
- Rapid switching of genes
- Highly immunogenic
- Low costs
- Regulatory pathways
Mass application
- Most vaccines still applied by injection
- Need for oral vaccine formulation for fish and poultry
- Vaccination monitoring
8

An Example of Innovation
pHi-Tech Automated Vaccination System
9

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Linearity concept of significance, standard deviation, chi square test, students T- test, ANOVA test , pharmaceutical science, statistical analysis, statistical methods, optimization technique, modern pharmaceutics, pharmaceutics, mpharm 1 unit i sem, 1 year m pharm, applications of chi square test, application of standard deviation , pharmacy, method to compare dissolution profile, statistical analysis of dissolution profile, important statical analysis, m. pharmacy, graphical representation of standard deviation, graph of chi square test, graph of T test , graph of ANOVA test ,formulation of t test, formulation of chi square test, formula of standard deviation.

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- Video recording of this lecture in English language: https://youtu.be/gnlRvJ1TTr8 - Video recording of this lecture in Arabic language: https://youtu.be/KdVvfP7JIFI - Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html - Link to NephroTube website: www.NephroTube.com - Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html

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Thoracotomy is the surgical procedure with an incision made to access the pleural space and the contents of the thoracic cavity. Given the structures to be accessed with in the cavity, different incisions have been established to easy the procedure and these incisions qualify the types of thoracotomies to be studied hereunder. PRE OP OPTIMIZATION FOR SPECIFIC FACTORS The outcome of surgical procedures is not measured only by clinical end points but also shorter stays and lower costs. Patients’ discharge is delayed commonly due to inadequate pain relief, infection, arrhythmias, prolonged air leak and debility. Many complications that occur from thoracic operations can be anticipated. An aggressive preoperative work up mitigates morbidity and shortens convalescence. APPROACH CONSIDERATIONS There are about three principles that can guides the choice of the thoracotomy incision to be used I. Adequate exposure must be achieved. The choice of incision is aided by a thorough understanding of the surface anatomy and a comprehensive review of the radiographic images that are obtained preoperatively. II. Chest-wall function and appearance should be preserved to the extent possible. This principle include non-spreading video-assisted thoracoscopic surgery (VATS) procedures, muscle-sparing techniques, avoidance of excessive rib retraction, and rib preservation when possible. III. The third principle is that closure must be meticulous and appropriate. Strict layered closure is the rule for thoracic surgical incisions. Every effort should be made to approximate the individual divided chest-wall muscles in appropriate layers; otherwise, a significant delay in the recovery of range of motion (ROM) may result. Care must be taken to avoid over approximating the ribs and to prevent an override; this will help minimize postoperative pain. POST-OPERATIVE CARE AND MONITORING

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Integrated Neuromuscular Inhibition Technique (INIT)

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mHealth Israel_Unmet Needs and Opportunities – Farm animals

1. 1 September 2022 ONE HEALTH Unmet Needs and Opportunities – Farm animals

2. About Phibro Medicated Feed Additives • Antibiotics • Anticoccidials • Antimicrobials • Bloat Control • Anthelmintics Vaccines • Fully Licensed • Autogenous • Poultry • Swine • Bovine • Aqua Nutritional Specialties • Immune Modulators • DCAD Solutions • Yeast Solutions • Mycotoxin Solutions • Phytogenic Feed Additives • DFM Solutions MVP Adjuvants • Oil-in-Water • Polymers • Custom • Poultry • Swine • Bovine • Aqua Mineral Nutrition • Trace and Macro Minerals • Organic Trace Minerals • Premixes • Selenium Yeast • Colorants • Vitamin K Ethanol Performance • Antimicrobials • Cleaning Products • Process Aids • Yeast Plant Science • Micro nutrients • Microbial seed treatment • Foliar and furrow application

3. World meat production FAOSTAT 3

4. Disease Pressure on the Rise Intensive livestock production Antimicrobial resistance Global warming Disease vectors prevalence Global trade and travel 4

5. Major Challenges Animal Protein Supply - Affected by diseases – African Swine Fever Food Safety - Salmonella, campylobacter Zoonotic diseases - Avian Influenza Sustainable production - Carbon emissions - Water - Farmland 5

6. 6 6 9/18/2022 H5 IBDV POX ILT IBV NDV H9 Cocci APV Salmo nella Mycopl asma AE Reo IBH E coli IC

7. Vaccines Our Most Effective Tool All farmed animals are vaccinated against at least several diseases Animal vaccines are based on some of the most advanced technologies: - Inactivated vaccines - Live attenuated vaccines - Live viral vector vaccines - Non-replicating vectors vaccines - Sub-unit recombinant antigens - DNA vaccines - Live and inactivated bacterial vaccines 7

8. However… We Continue to Require Real Innovation Rapid and accurate diagnostic tools - Microorganism Isolation and identification (mainly in remote areas) - AI systems to analyze and predict Vaccine platforms: - Rapid switching of genes - Highly immunogenic - Low costs - Regulatory pathways Mass application - Most vaccines still applied by injection - Need for oral vaccine formulation for fish and poultry - Vaccination monitoring 8

9. An Example of Innovation pHi-Tech Automated Vaccination System 9

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