Dokumen tersebut membahas tentang jenis-jenis lemak dalam tubuh, fungsi dan peran lemak dalam tubuh, jenis-jenis kolesterol dan lipoprotein serta profil lipid yang sehat.
3. 1.BAHAN PEMBENTUK HORMON STEROID SPT
ESTROGEN, PROGESTERON, TESTOSTERON
2.MEMBANTU MEMBENTUK PRO VIT D
3.MEMBENTUK MEMBRAN SEL
4. Fungsi Lemak
• Sumber energi terbesar
• Pelindung organ penting, spt organ perut,
pantat
• Pengangkut vitamin: A, D, E dan K
• Nutrisi esensial: As linoleat dan linolenat
• Jenis yg ditimbun di bawah kulit:Trigliserid
• Waktu muda langsing, sekarang langsung
• Dulu bau parfum, sekarang bau ….
19. Kasus Kolesterol
• Banyak makan lemak, kolesterol tinggiwajar.
• Sudah kurus, tidak banyak makan yg
enak berlemak, tetapi kolesterol tinggi,
rugi double porsi ini terjadi karena
sumber kolesterol tidak hanya exogen
tetapi juga endogen di hati.
29. An Overview of Cholesterol Metabolism
Dietary
intake
Biliary
Excretion
Large Intestine
Liver
Reverse
Cholesterol
Transport
Intestine
Small Intestine
Exogenous
pathway
LDL-C
Extra-hepatic
tissues
Extra-hepatic
Extra-hepatic
tissues
tissues
HDL-C
Endogenous
pathway
Excretion
Rifai, Handbook of Lipoprotein Testing,
30.
31. Fungsi HDL vs LDL
Ilustrasi
• HDL: -Mengangkut butir lemak dari arteri
perifer spt arteri koroner dan arteri di
otak ke tempat penyimpanannya di hepar
-Ibarat pasukan pembersih sampah
• LDL: -Mengangkut butir lemak dari hepar
ke arteri perifer spt arteri koroner dan
arteri di otak
-Ibarat pasukan provokator
Seperti yang Prof/dokter ketahui, fungsi Hati/hepar sangatlah penting diantaranya untuk : metabolisme lemak, karbohidrat & protein, metabolisme obat-obatan, serta detoksifikasi racun & toksin
Tetapi berbagai faktor perusak hepar dapat mengurangi fungsi hati. Faktor-faktor perusak hepar itu diantaranya :
Pemakaian obat-obat yang hepatotoksik seperti Antibiotika, analgesik antipiretik, dan obat Anti Tuberkulosis
Penggunaan Nerkoba dan Alkohol yang berlebihan
Infeksi mikroorganisme patologis seperti virus hepatitis, aflatoksin
Blood fats, or lipids, include several types of cholesterol and triglycerides. Cholesterol is a fat-like substance which is transported around the body in a protein package, the main ones being LDL and HDL Triglycerides are basically fats in the blood.
High blood fats or lipids are caused by a combination of genetics and lifestyle factors. LDL cholesterol and total cholesterol are most directly related to heart disease risk.
Blood lipids should be checked at least every 5 years after the age of 20. If heart disease is present, they should be tested more often.
Lipoprotein particles have historically been segregated into groups based on common physical size, density, core cholesterol and triglyceride content, and what surface lipoproteins are attached. The most common class groupings appear above.
Each lipoprotein class is composed of a continuum of individual lipoprotein particles which span a defined range of size or density.
Traditional lipid panels determine the amount of cholesterol or triglyceride carried by all particles within a lipoprotein class. While this approach allows for generalizations about the lipoproteins involved in lipid transport, it does not allow for quantification of the number or size of individual lipoprotein particles present.
This slide shows a normal artery without any restriction of blood flow. The white dot indicates cholesterol.
Deposits of fatty substances and cholesterol build up in the inner lining of an artery. This build-up, called plaque, can partially block the blood flow through an artery.
If the artery becomes totally blocked, it can cause a stroke or heart attack.
Hardening of the arteries occurs normally as we get older, but occurs at an earlier age and to a greater degree with high blood fat levels, smoking, high blood pressure, and certain diseases like diabetes.