1) Prior to 1969, athletes were advised to avoid drinking during exercise due to beliefs that it would impair performance. However, research in the 1960s-1970s suggested not drinking was "criminal folly" and could cause heat stroke.
2) In 1981, the first reported case of exercise-associated hyponatremic encephalopathy (EAHE) occurred in a female marathon runner, indicating the dangers of overdrinking during exercise.
3) Research in the 1980s-1990s definitively showed that EAHE is caused by abnormal fluid retention when athletes drink too much, not sodium deficits as was previously believed. However, guidelines continued promoting drinking "as much as tolerable."
4) More
-water balance --> body composed of about 60-70% water
-total body water-->42L, ICF --> 28L, ECF --> 14L
- water output by urine,skin,lungs,feces.
-electrolyte bALANCE , expressed as mEq/L.
-water balance --> body composed of about 60-70% water
-total body water-->42L, ICF --> 28L, ECF --> 14L
- water output by urine,skin,lungs,feces.
-electrolyte bALANCE , expressed as mEq/L.
Last year by end of the lecture Dr Medinna gave cases to solve for Fluid and electrolytes....
He had a seperate slide for the cases..
Lecture slides are taken from Schwartz Textbook of surgery....
The blood electrolytes—sodium, potassium, chloride, and bicarbonate—help regulate nerve and muscle function and maintain acid-base balance and water balance. ... Thus, having electrolytes in the right concentrations (called electrolyte balance) is important in maintaining fluid balance among the compartments
11. water balance and exercise performanceUsman Khan
This presentation is about the need and importance of water in out daily consumption especially for athletes before, after and during exercise. it also discusses its functions
A global review of the physiology of hydration in adults, detailing the water distribution in the human body, the water balance and the main recommendations for water intake.
Last year by end of the lecture Dr Medinna gave cases to solve for Fluid and electrolytes....
He had a seperate slide for the cases..
Lecture slides are taken from Schwartz Textbook of surgery....
The blood electrolytes—sodium, potassium, chloride, and bicarbonate—help regulate nerve and muscle function and maintain acid-base balance and water balance. ... Thus, having electrolytes in the right concentrations (called electrolyte balance) is important in maintaining fluid balance among the compartments
11. water balance and exercise performanceUsman Khan
This presentation is about the need and importance of water in out daily consumption especially for athletes before, after and during exercise. it also discusses its functions
A global review of the physiology of hydration in adults, detailing the water distribution in the human body, the water balance and the main recommendations for water intake.
Presentation on the topic of athletic game.Athletics is called the mother of all the games.in this presentation history of athletics is covered.technology and equipment used in athletics are also covered
Effects of Cold Water Immersion on Muscle OxygenationFernando Farias
Postexercise cold water immersion has been advocated to
athletes as a means of accelerating recovery and improving perform-
ance. Given the effects of cold water immersion on blood flflw,
evaluating in vivo changes in tissue oxygenation during cold water
immersion may help further our understanding of this recovery
modality. This study aimed to investigate the effects of cold water
immersion on muscle oxygenation and performance during repeated
bouts of fatiguing exercise in a group of healthy young adults.
The Effect of Homemade Drink on Exercise Endrance Time in Young Adult Femalesijtsrd
When exercising for a very long period of time, sweating will occur and other physiological responses such as dehydration, decrease blood glucose, increase in heart rate, loss of electrolytes, fatigue etc which will lead to a decrease in exercise performance. Hence, there is an important function of rehydrating the body with fluids (sport drinks) containing electrolytes and carbohydrates to improve exercise endurance and performance. In this study examined the effects of effect of home made fruit drink (coconut and pineapple) on exercise endurance time of young adult females, (age: 17-26 years) of their height ranges (1.53-1.74 meters), weight ranges (42-98kg) and their BMI ranges (16.41-35.25 kg/m2) jogged at designated points for 45 minutes. After the 45 minutes exercise, they rested for 10 minutes and were administered the different drinks (control 1(water), control 2 (lucozade sport drink) and test sample (home-made coconut-pineapple fruit drink)). After administering the drinks, their heart rates and blood pressures were taken and measured then they rested for 5 minutes. After a period of rest for 15 minutes in total, they continued the exercise till they were exhausted. The result indicated that the home made coconut-pineapple fruit drink observed to have an effect on the endurance time as well as the lucozade sport isotonic drink, while water was observed not to improve the endurance time. Okonkwo, C. O. J | Oguaka V.N. | Mbachu, P"The Effect of Homemade Drink on Exercise Endrance Time in Young Adult Females" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: http://www.ijtsrd.com/papers/ijtsrd10757.pdf http://www.ijtsrd.com/medicine/physiology/10757/the-effect-of-homemade-drink-on-exercise-endrance-time-in-young-adult-females/okonkwo-c-o-j
Scientific Research Studies On Ionized Alkaline Water. Physiological Effects Of Alkaline Ionized Water: Effects On Metabolites Produced By Intestinal Fermentation.
Introduction: The objective of our study was to establish to what extent isotonic drinks infl uence the results of athletes running in a half marathon (21 km). Material and Methods: The study included 40 persons who ran in a marathon. According to their fi tness level we divided them into 2 groups of 20 runners each: the trained group (athletes who run more than 30 km per week) and the non-trained group (athletes who run less than 30 km per week). We chose 10 persons from each group who consumed isotonic drinks and 10 who drank only water. During the race, the runners had to drink the same volume of liquid. In the fi rst part of our study, we asked the participants to complete
a questionnaire with 29 questions that included asking about their training level, whether they are knowledgeable about dehydration or if they had already experienced its symptoms. In the second part of the study, we took urine samples and performed body composition tests before and after the race. We measured changes in body weight, Total Body Water Percentage (TBW%) and urine specifi c weight. From
the results, we tried to estimate the extent of dehydration during the race, also taking into consideration whether the runners consumed isotonic drinks or water.
Introduction: The objective of our study was to establish to what extent isotonic drinks infl uence the results of athletes running in a half marathon (21 km). Material and Methods: The study included 40 persons who ran in a marathon. According to their fi tness level we divided them into 2 groups of 20 runners each: the trained group (athletes who run more than 30 km per week) and the non-trained group (athletes who run less than 30 km per week). We chose 10 persons from each group who consumed isotonic drinks and 10 who drank only water. During the race, the runners had to drink the same volume of liquid. In the fi rst part of our study, we asked the participants to complete a questionnaire with 29 questions that included asking about their training level, whether they are knowledgeable about dehydration or if they had already experienced its symptoms. In the second part of the study, we took urine samples and performed body composition tests before and after the race. We measured changes in body weight, Total Body Water Percentage (TBW%) and urine specifi c weight. From
the results, we tried to estimate the extent of dehydration during the race, also taking into consideration whether the runners consumed isotonic drinks or water.
Many successful ultra-endurance athletes have switched from a high-carbohydrate to a low-carbohydrate diet, but they have not previously been studied to determine the extent of metabolic adaptations. The concept that a diet high in carbohydrate is necessary for optimizing exercise performance gained credence in the late 1960s when it was discovered that muscle glycogen depletion was associated with fatigue, and that a high-carbohydrate diet-maintained muscle glycogen and performance.
Background: Body of literature are becoming pronounced that pathological condition in one organ of the body might have an effect on other distal organs owing to the fact, that the entire body metabolism is orchestrated centrally.
Pathological events occurring in an organ are likely to be extended to other organs. Pretreatment that minimize these events are presumed to be beneficial to the extended organs.
Methods: Following 30 min of ischemia and 48 h of reperfusion in the kidney, rats under anesthesia were sacrificed and blood sample collected through cardiac puncture. Serum level of troponin I, and activities of total creatine kinase (CK), mass creatine kinase (CK-MB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma –glutamyl transferase (GGT) were estimated spectrophotometrically.
Results: Serum troponin I increased to 0.031 ± 0.001 ng/ml in the ischemic group, and following pretreatment with Lmm (600mg/kg), serum level of troponin I decreased significantly to 0.021 ± 0.001 ng/ml (P<.05).><.05),><.05)><.05).
Swimming is a movement through water using
one’s limbs and usually without artificial apparatus.
Swimming is an activity that can be both useful and
recreational.
“The move is an ongoing process of falling forward and a mass dropped from a higher level drops quickly, "says Bejan.
“The swimmer that makes the biggest wave is the faster, and makes a long trunk and larger waves. Europeans have a 3% longer than the West African body, and this gives them 1.5% more speed advantage in the pool, "he completes.
A style is also known as a stroke. "Stroke" can also refer to a single completion of the sequence of body movements repeated while swimming in the given style.
Several swimming styles are suitable for recreational swimming; many recreational swimmers prefer a style that keeps their head out of the water and has an underwater arm recovery. Breaststroke, side stroke, head up front crawl and dog paddle are the most common strokes utilized in recreational swimming. The out-of-water arm recovery of freestyle or butterfly gives rise to better exploitation of the difference in resistance between air and water and thus leads to higher speed.
It is possible to swim by moving only legs without arms or only arms without legs. Such strokes may be used for special purposes, for training or exercise, or by amputees and paralytics.
"Understanding the Carbon Cycle: Processes, Human Impacts, and Strategies for...MMariSelvam4
The carbon cycle is a critical component of Earth's environmental system, governing the movement and transformation of carbon through various reservoirs, including the atmosphere, oceans, soil, and living organisms. This complex cycle involves several key processes such as photosynthesis, respiration, decomposition, and carbon sequestration, each contributing to the regulation of carbon levels on the planet.
Human activities, particularly fossil fuel combustion and deforestation, have significantly altered the natural carbon cycle, leading to increased atmospheric carbon dioxide concentrations and driving climate change. Understanding the intricacies of the carbon cycle is essential for assessing the impacts of these changes and developing effective mitigation strategies.
By studying the carbon cycle, scientists can identify carbon sources and sinks, measure carbon fluxes, and predict future trends. This knowledge is crucial for crafting policies aimed at reducing carbon emissions, enhancing carbon storage, and promoting sustainable practices. The carbon cycle's interplay with climate systems, ecosystems, and human activities underscores its importance in maintaining a stable and healthy planet.
In-depth exploration of the carbon cycle reveals the delicate balance required to sustain life and the urgent need to address anthropogenic influences. Through research, education, and policy, we can work towards restoring equilibrium in the carbon cycle and ensuring a sustainable future for generations to come.
ENVIRONMENT~ Renewable Energy Sources and their future prospects.tiwarimanvi3129
This presentation is for us to know that how our Environment need Attention for protection of our natural resources which are depleted day by day that's why we need to take time and shift our attention to renewable energy sources instead of non-renewable sources which are better and Eco-friendly for our environment. these renewable energy sources are so helpful for our planet and for every living organism which depends on environment.
WRI’s brand new “Food Service Playbook for Promoting Sustainable Food Choices” gives food service operators the very latest strategies for creating dining environments that empower consumers to choose sustainable, plant-rich dishes. This research builds off our first guide for food service, now with industry experience and insights from nearly 350 academic trials.
UNDERSTANDING WHAT GREEN WASHING IS!.pdfJulietMogola
Many companies today use green washing to lure the public into thinking they are conserving the environment but in real sense they are doing more harm. There have been such several cases from very big companies here in Kenya and also globally. This ranges from various sectors from manufacturing and goes to consumer products. Educating people on greenwashing will enable people to make better choices based on their analysis and not on what they see on marketing sites.
Presented by The Global Peatlands Assessment: Mapping, Policy, and Action at GLF Peatlands 2024 - The Global Peatlands Assessment: Mapping, Policy, and Action
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different modes of interaction between insects and plants including mutualism, commensalism, antagonism, Pairwise and diffuse coevolution, Plant defenses, how coevolution started
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Discover top strategies for effective sustainable waste management, including product removal and product destruction. Learn how to reduce, reuse, recycle, compost, implement waste segregation, and explore innovative technologies for a greener future.
Summary of the Climate and Energy Policy of Australia
Water intoxication
1. PRACTICAL GASTROENTEROLOGY • SEPTEMBER 200846
INTRODUCTION
P
rior to 1969 athletes were encouraged to avoid
drinking any fluids during exercise since it was
believed that fluid ingestion would impair exercise
performance, in particular by causing gastrointestinal
distress, the so-called “stitch.” Athletes in those years
actively followed that advice, priding themselves on
their ability to run even 26 mile (42 km) marathon races
without drinking (1). Furthermore, the rules then gov-
erning competitive distance running restricted the
amount of fluid to which athletes had access.
In 1981 the first case of exercise-associated hypona-
tremic encephalopathy (EAHE) occurred in a 46-year-old
female marathon runner in a 90 km Comrades ultrama-
rathon in South Africa. She presented with the symptoms
and signs typical of EAHE as listed in Table 1 (2).
In 1991 we provided definitive evidence that exer-
cise-associated hyponatremic encephalopathy (EAHE)
is due to abnormal fluid retention in those who over-
drink during prolonged exercise and to which a sodium
deficit plays little or no part (3). Shortly after the pub-
lication of this compelling evidence, influential sport-
ing organizations began to promote the value of
drinking “as much as tolerable” but failed to warn of
the proven dangers of overdrinking during exercise.
As a result, more than 10 documented deaths from
EAHE, an entirely preventable condition, have been
reported in the scientific literature since 1991 (4).
Water Intoxication—Considerations
for Patients, Athletes and Physicians
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #66
Timothy D. Noakes, MBChB, MD, DSc, FACSM, Pro-
fessor in the Discovery Health Chair of Exercise and
Sports Science, Director of the UCT/MRC Research
Unit for Exercise Science and Sports Medicine,
Department of Human Biology, University of Cape
Town, Sports Science Institute of South Africa, New-
lands, South Africa.
Carol Rees Parrish, R.D., M.S., Series Editor
Prior to 1969 athletes were advised to avoid drinking any fluids during exercise. But
beginning in the 1970’s, the idea gained credence that not to drink during exercise was
“criminal folly” that could lead to dehydration-induced heat stroke. As a result athletes
were advised to drink “beyond thirst” by ingesting “as much as tolerable” during exer-
cise. The clinical sequelae of this advice became apparent in 1981 when the first
reported case of exercise-associated hyponatremic encephalopathy in a female runner
during a 90 km ultramarathon foot race in South Africa was reported. This article
reviews exercise-associated hyponatremia (EAH) and exercise-associated hyponatremic
encephalopathy (EAHE) and provides safe guidelines for hydration during exercise.
Timothy D. Noakes
(continued on page 48)
2. PRACTICAL GASTROENTEROLOGY • SEPTEMBER 200848
There is no historical evidence that the absence of
regular drinking during exercise produced any adverse
consequences. The first purported case of heat injury in
a marathon runner who did not drink during competi-
tion—Jim Peters in the 1954 Commonwealth (Empire)
Games marathon in Vancouver—may not have been
due to heat stroke (5). Instead, a series of publications
in the 1960’s showed that marathon runners who drank
little or nothing seemed to do rather well, often winning
races despite finishing with advanced grades of “dehy-
dration” and high core body temperatures (6–8). This
outcome might be expected if humans evolved their
modern form specifically because of a superior capac-
ity to run prolonged distances in (dry) heat with little or
no fluid replacement (9–11).
HUMANS EVOLVED AS RUNNERS ABLE TO
EXERCISE FOR PROLONGED PERIODS IN DRY
HEAT WITH MINIMAL FLUID REPLACEMENT
This novel theory first proposed in the early 1900’s
(12,13) holds that humans evolved our particular biolog-
ical features including long legs and short arms; relative
hairlessness associated with an unmatched ability to lose
heat by sweating; strong core abdominal muscles; and the
capacity to rotate the upper and lower bodies in opposite
directions, because all these adaptations gave early
humans an evolutionary advantage over other non-sweat-
ing mammals with whom we shared the hot African
savannah more than 2 million years ago. Thus, it
is proposed that our early hominid ancestors dis-
covered that they could capture non-sweating
mammals, especially swifter antelope, by chasing
them in the mid-day heat. Profuse sweating
allowed early hominids to safely regulate their
body temperatures as they chased these antelope
for many hours in midday heat. Provided they
could chase the antelope for long enough in suffi-
ciently hot conditions, the antelope’s brain tem-
perature would finally become too high causing it
to seek shade and to stop running. There the tem-
porarily paralyzed animal could be more easily
dispatched even by hunters, who as recently as
100,000 years ago, lacked more modern imple-
ments like spears and knives. The theory is that
the high energy diet provided by these antelope
allowed the rapid growth of the human brain and hence
the development of Homo sapien.
Naturally the best hunters would be those who were
neither overcome by thirst nor incapacitated by the loss
of a large volume of body water caused by the heavy
sweating during the three-to-six hours required for a suc-
cessful hunt (11). Like all the great runners of the past
(1), the most successful hunters would have drunk little
since carrying water would have impeded their progress
and reduced their probability of success whilst hunting.
PROMOTION OF THE CONTRARY BELIEF
THAT HUMANS ARE POORLY ADAPTED
TO EXERCISE IN THE HEAT
Two separate events that happened between 1965 and
1969 led to a contrary perception that humans are
poorly adapted for exercise in the heat and are at risk
of death from heat stroke if they sweat profusely and
do not drink copious amounts of fluid during exercise
thereby developing “dangerous dehydration.”
First was the development of the world’s first
sports drink at the University of Florida, beginning in
1965. The drink was developed by a renal physician, Dr
Robert Cade, who was certain that fluid ingestion dur-
ing exercise would prevent the development of “heat”
illness including heat stroke and heat cramps during
exercise. But the drink became an overnight commer-
cial success especially in the United States, because of
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #66
Water Intoxication
(continued from page 46)
Table 1.
Diagnostic features of exercise-associated hyponatremia (EAH)
and hyponatremic encephalopathy (EAHE)
EAH EAHE
Symptoms
Nausea Headache
Vomiting Altered level of consciousness
Unexplained fatigue Coma
Impaired exercise performance Convulsion/Seizure
Signs and clinical findings
Evidence for weight gain Evidence of weight gain
Serum [Na+] <135 mmol/L Serum [Na+] <130 mmol/L
Cerebral edema
Pulmonary edema
3. its alleged capacity to enhance the performance of
American football teams, first collegiate and later pro-
fessional, in the fourth quarter of football matches (14).
Second, a group of South African researchers
showed an apparently causal relationship between
fluid ingestion during exercise, the prevention of
“dehydration” and lower body temperatures in athletes
competing in a series of 20 mile (32 km) running races
(15). These researchers concluded that athletes who do
not drink sufficient fluids during marathon running are
at risk of developing heat stroke and that the interna-
tional ruling then in place which restricted fluid avail-
ability during marathon running was “criminal folly.”
Together these concepts led to the idea that athletes
needed to drink “as much as tolerable” during exercise
in order to maximize their performance and to insure
that they do not die from heat stroke (16,17). Skillful
marketing (18,19) soon led to the universal acceptance
that not to drink “as much as tolerable” during exercise
was extremely unwise. Soon it became the accepted
truism that any weight loss during exercise is detrimen-
tal to both health and performance (16,17).
The defining event which invited a re-assessment
of this new “truth” occurred on June 1, 1981 when an
athlete competing in the 56 mile (90 km) Comrades
Marathon in South Africa was admitted to hospital in
an unconscious state having developed a grand mal
epileptic seizure. Her serum sodium concentration on
hospital admission was 115 mmol/L confirming a
diagnosis of EAHE. She regained consciousness after
two-days and was released from hospital four-days
later. Subsequent investigation over the next two years
uncovered three additional cases of EAH and EAHE in
South African ultra-endurance athletes. Their case
reports were subsequently published in 1985 in a paper
entitled “Water intoxication: A possible complication
during endurance exercise” (2). In time the term EAH
would supercede that of water intoxication (20). The
paper drew the following conclusion: “The etiology of
this condition appears to be voluntary hyperhydration
with hypotonic solutions combined with moderate
sweat sodium chloride losses . . . advice (on fluid
replacement) should be tempered with the proviso that
the intake of hypotonic fluids in excess of that required
to balance sweat and urine losses . . . may be haz-
ardous in some individuals.”
In 1988, to evaluate this novel theory, PhD student
Anthony Irving hospitalized eight Comrades Marathon
runners with exercise-associated hyponatremic
encephalopathy (EAHE) in order to study their fluid and
sodium balance during recovery (3). He showed that all
athletes had drunk to excess during the race gaining
between two-to-six kilograms (four-to-12 pounds).
However, there was no evidence that subjects with
EAHE had incurred a greater sodium deficit than had
control runners who completed these races with normal
serum sodium concentrations. Thus we concluded that
EAH “results for fluid retention in subjects who ingest
abnormally large fluid volumes during prolonged exer-
cise” since this study found “that each of eight subjects
who collapsed with the hyponatremia of exercise (mean
plasma sodium concentration 122.4 ± 2.2 mM) were
fluid overloaded by an amount ranging from 1.22 to
5.92 liters. These fluid volumes are conservative
because no allowance was made for insensible water
losses during recovery” and that “sodium chloride
losses alone cannot explain the hyponatremia of exer-
cise” (3). The key findings are presented in Figure 1.
Our finding that subjects with EAHE did not have
a larger sodium deficit than controls is historically
important because this evidence has essentially been
ignored. Instead, theoretical arguments without exper-
imental support (21–23) were advanced to explain why
some might develop EAH or EAHE as the result of
unreplaced sodium deficits incurred during prolonged
exercise. However, no study has yet been able to doc-
ument a sodium deficit in patients with EAH or EAHE
whereas many studies have either confirmed our orig-
inal finding (24–28) or shown that sodium chloride
ingestion during exercise does not influence the serum
sodium concentration in those who do not overcon-
sume fluids during exercise (29,30). Since EAH and
EAHE are due to abnormal fluid retention, only drinks
containing sodium at a concentration well in excess of
that found in blood (>140 mmol/L) would theoreti-
cally play some role in the prevention of these condi-
tions (31). In reality, such drinks are unpalatable and
likely to induce nausea and vomiting.
Unfortunately, our original findings had little prac-
tical impact. For 10 years after the publication of our
original paper, a number of influential organizations
produced drinking guidelines which promoted the con-
PRACTICAL GASTROENTEROLOGY • SEPTEMBER 2008 49
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #66
Water Intoxication
4. PRACTICAL GASTROENTEROLOGY • SEPTEMBER 200850
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #66
Water Intoxication
cept that only if athletes drank “as much as tolerable”
could they exercise safely (16,17,32,33). These guide-
lines failed to emphasize the established finding that
the overconsumption of sodium-poor fluids during
exercise could have fatal consequences (18).
This danger was first acknowledged only after the
2002 Boston Marathon at which the next two critical
events occurred. First Cynthia Lucero died as a result
of drinking too much of an electrolyte-containing
sports drink during the race (34). Second, residents
from the Children’s Hospital at Harvard Medical
School chose that particular race to study the factors
associated with EAH and EAHE in runners in that spe-
cific race (28). That study found that 13% of the stud-
ied runners developed EAH. This compares with the
absence of a single case ever of EAH in 42 km
marathons in South Africa and New Zealand (19).
The authors proved that the same four risk factors
previously surmised (4,35) predicted the risk of EAH
during the marathon race:
• Substantial weight gain (odds ratio, 4.2)
• Consumption of more than 3 liters of fluids during
the race, consumption of fluids every mile, a racing
time of >4:00 hours (odds ratio, 7.4)
• Female sex
• Low body-mass index
In 2005 the First International Consensus Confer-
ence on EAH concluded that EAH is caused by exces-
sive fluid consumption to which a sodium deficit plays
little if any role (20). A subsequent collaborative
research paper combining this information (36) con-
cluded that 3 factors cause EAH:
1. Voluntary overdrinking caused almost certainly by
behavioral conditioning in those who have been
instructed to drink “as much as tolerable” in order “to
stay ahead of thirst” during exercise.
2. A failure to suppress the secretion of ADH in the
face of increased total body water content—the syn-
drome of Inappropriate ADH secretion (SIADH).
3. Relocation of internal sodium stores. There is grow-
ing evidence that the sodium present in the body is
not located only in the extra-cellular compartment.
Rather it seems that there may be a substantial
amount of sodium stored in an osmotically-inactivate
form (Na) within certain cells. Extracellular sodium
may then be added to that store in the process of
inactivation of osmotically-active sodium (Na+).
Alternatively, osmotically inactive sodium may be
activated and added to that already present in osmot-
ically-active form in the extracellular fluid.
We also found that approximately 70% of athletes
who gain weight during exercise (because they both
over-drink and fail appropriately to suppress ADH
secretion) do not develop EAH (36). Since these ath-
letes could not have ingested enough sodium during
exercise to maintain the serum sodium concentration
in the face of a large increase in total body water, they
(continued on page 52)
Figure 1. The study of Irving, et al (3) compared sodium
chloride (middle panel) and fluid (right panel) balance in ath-
letes who finished the 90 km Comrades Marathon with either
normal or reduced (EAH and EAHE) serum sodium chloride
concentrations (left panel).
Whereas sodium chloride losses (middle panel) were the
same in both groups of athletes, athletes who maintained
their serum sodium concentrations during the race lost
about two litres of fluid. In contrast, athletes who developed
EAH or EAHE during the Comrades Marathon finished with a
fluid excess that ranged from two-to-six litres.
Thus this study conclusively established already in 1991
that EAH and EAHE is due to fluid retention to which a
sodium chloride deficit plays little if any role. In 2005 the
International Consensus Conference on EAH (20) confirmed
that this conclusion is correct.
5. PRACTICAL GASTROENTEROLOGY • SEPTEMBER 200852
must have relocated Na+ from an internal body store.
Alternatively abnormal osmotic inactivation of extra-
cellular Na+ could worsen EAH in those who over-
drink during exercise and who fail appropriately to
suppress ADH secretion.
The point is that the development of the condition
will occur only in those who are pre-disposed because
(i) they fail appropriately to suppress ADH secretion in
response to overdrinking resulting in an expansion of
the total body water and (ii) they are either unable to
mobilize Na+ from internal stores of osmotically-inac-
tive Na or (iii) they inactivate osmotically-active cir-
culating Na+ present in the extracellular space, storing
it as Na in an intracellular site.
It therefore follows that the real etiology of EAH
can only be studied in persons who exhibit all these
abnormalities. For example, attempting to show that
sodium ingestion can prevent EAH by studying sub-
jects who are not predisposed to its development
because they lack these biological variants, will not
likely uncover the truth.
PRACTICAL CONSIDERATIONS
1. EAH is an iatrogenic disease caused by the promotion
of a false physiology. Humans are highly adapted for
exercise in the heat and do not need to drink to excess
to optimize their performance during exercise. Nor is
there any evidence that high rates of fluid ingestion
are required to prevent ill health during exercise.
When athletes drank little during exercise, they did
not develop EAH and EAHE. Only after the intro-
duction of the drinking guidelines which encouraged
athletes to drink “as much as tolerable” in order to
prevent a novel medical disease—“dehydration”—
and to optimize athletic performance, did the preva-
lence of EAH and EAHE suddenly increase.
2. EAHE is not a benign condition. At least 10 deaths
from the condition have been described in the sci-
entific literature (4). All these deaths were foresee-
able and preventable.
3. Not everyone who overdrinks during exercise will
develop EAH or EAHE. Rather it appears that only
those with genetic variants which cause (i) the
oversecretion of ADH even when they are overhy-
drated, (ii) the relocation of extracellular Na+ to an
intracellular osmotically-inactive Na store or (iii)
the inability to activate the reverse process in the
face of a large increase in total body water, are at
risk of developing EAH and EAHE.
4. Prevention of EAH and EAHE is simple. It requires
only that athletes drink according to thirst before,
during and after exercise.
5. Some patients with EAH or EAHE have died
because of inappropriate treatment—specifically
the provision of hypotonic or isotonic intravenous
fluids in large volumes—for the treatment of
“dehydration.” Yet these athletes were overhy-
drated because they had drunk to excess during
exercise and had retained that fluid because of
SIADH. Fluid restriction, not the provision of iso-
tonic or hypotonic NaCl solutions in large volumes,
is the basis for the safe treatment of EAHE.
6. A fatal outcome can be prevented by a high level of
clinical suspicion. It requires clinicians to under-
stand that an altered level of consciousness is NOT
caused by the mild levels of “dehydration” experi-
enced by athletes competing in modern athletic
events (36) in which fluid is readily available dur-
ing exercise. Typically, an altered level of con-
sciousness in athletes in whom there is no other
obvious cause (such as cardiac arrest or a cere-
brovascular accident) will be due to either heat-
stroke or EAHE. Heatstroke can be excluded by the
measurement of a rectal temperature less than about
41°C in which case EAHE becomes the most likely
diagnosis in athletes who do not exhibit other overt
clinical signs indicating intracerebral or cardiovas-
cular pathology. EAHE often presents initially as
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Water Intoxication
(continued from page 50)
Table 2.
Key factors in the prevention of EAH and
of fatal outcomes in EAHE
1. Teach athletes to drink according to the dictates of
thirst before, during and after exercise.
2. Physicians treating collapsed athletes with an altered
level of consciousness should not infuse any fluids
intravenously until a diagnosis of EAHE has been
excluded.
3. Once a diagnosis of EAHE has been established only
hypertonic (3% or greater) saline solutions should be
used for intravenous therapy.
6. confusion and withdrawal, similar to that seen in
persons with mild head injury (concussion).
7. Treatment is simple and life-saving. The key is that
no fluids with a NaCl concentration less than 3%
(i.e. hypertonic saline) should be used. For severe
cases of EAH, 3%–5% NaCl solutions given intra-
venously at slow rates are life saving (20).
The adoption of these guidelines has minimized
the incidence of EAH and its potential fatal complica-
tion, EAHE, in New Zealand and South Africa.
SUMMARY
There is and never was a need for EAH or EAHE to
occur. There is no need ever for a fatal outcome. Deaths
are always due to lack of awareness on the part of ath-
letes, their coaches, their doctors, race organizers and
powerful commercial interests, all of which have con-
spired to encourage overdrinking during exercise. The
knowledge deficit extends to those emergency ambu-
lance personnel and emergency care physicians who
believe that “dehydration” can cause an altered level of
consciousness including the development of coma and
who, as a result, have treated overhydrated athletes suf-
fering from EAH and EAHE, with the rapid infusion of
large volumes of iso- or hypotonic NaCl solutions. The
only effect of such treatment is acutely to increase
intracerebral pressure, with the production of cerebellar
coning, respiratory arrest and brain death. I
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