Vital signs such as body temperature, pulse rate, respiration rate, and blood pressure can detect medical problems and are commonly measured in medical settings and at home. The normal human body temperature can range from 97.8-99°F (36.5-37.2°C) and can be taken orally, rectally, in the armpit, ear, or on the forehead. The body tightly regulates its core temperature through thermoreceptors in the skin, the hypothalamus in the brain, and effectors like shivering muscles and sweating glands. Fevers, hyperthermia, and hypothermia occur when this system is disrupted and the body temperature rises or falls outside the normal
A description of how homeostasis works and how it is the theory that links structure, function and control in physiological systems. The concept of negative (and positive) feedback is explained.
A description of how homeostasis works and how it is the theory that links structure, function and control in physiological systems. The concept of negative (and positive) feedback is explained.
The female reproductive system is made up of the internal and external sex organs that function in reproduction of new offspring. In humans, the female reproductive system is immature at birth and develops to maturity at puberty to be able to produce gametes, and to carry a fetes to full term.
cerebrum, sulci and gyri of cerebrum, lobes of cerebrum, frontal lobe , parietal lobe, temporal lobe and occipital lobe, sulci and gyri presnet in each lobes, and the functional areas , of cerebrum, brodmann areas of cerebrum, borders and surfaces of cerebrum, insula,
The female reproductive system is made up of the internal and external sex organs that function in reproduction of new offspring. In humans, the female reproductive system is immature at birth and develops to maturity at puberty to be able to produce gametes, and to carry a fetes to full term.
cerebrum, sulci and gyri of cerebrum, lobes of cerebrum, frontal lobe , parietal lobe, temporal lobe and occipital lobe, sulci and gyri presnet in each lobes, and the functional areas , of cerebrum, brodmann areas of cerebrum, borders and surfaces of cerebrum, insula,
Regulation of temperature of Human bodyRanadhi Das
Homoeothermic (WARM blooded)- Humans capable of maintaining their body temperatures within narrow limits inspite of wide variations in environmental (ambient) temperature.
Poikilothermic- (Cold blooded) eg.-fish, reptiles
Neutral zone temperature/ Comfortable temperature/Critical / ambient temperature- at which there is no active heat loss and heat gain mechanism operated by body.
So it is the lowest ambient temperature at which mammals can maintain its body temperature at the basal metabolic rate.
Normally it is 27 ± 2º C
Living tissues can function optimally only within a very narrow range of temperature. Therefore accurate regulation of body temperature is a great boon: it enables the animal to be physically active all round the year, and in different geographical locations.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Vital signs are useful in detecting or monitoring medical problems. Vital signs can be
measured in a medical setting, at home, at the site of a medical emergency, or
elsewhere.
Body temperature
Pulse rate
Respiration rate (rate of breathing)
Blood pressure
3. WHAT IS BODY TEMPERATURE?
The normal body temperature of a
person varies depending on
1. sex/gender
2. recent activity
3. food and fluid consumption
4. time of day
5. Overall health
6. In women, the stage of the
menstrual cycle.
Temperature
Measurement of the amount of
heat in the body at given time.
4. BODY TEMPERATURE
Normal body temperature can range from 97.8
degrees F (or Fahrenheit, equivalent to 36.5 degrees
C, or Celsius) to 99 degrees F (37.2 degrees C) for a
healthy adult.
5. A PERSON'S BODY TEMPERATURE CAN BE TAKEN IN
ANY OF THE FOLLOWING WAYS:
1.Orally- By mouth
2.Rectally
3.Axillary
4.Tympanic- By ear
5.By skin- Forehead
6. ORAL TEMPERATURE
Temperature can be taken by
mouth using either the classic
glass thermometer, or the
more modern digital
thermometers that use an
electronic probe to measure
body temperature.
The average normal oral
temperature is 37°C
7. RECTAL TEMPERATURE
Temperatures taken
rectally (using a glass
or digital
thermometer) tend to
be 0.5 to 0.6 degrees
F higher than when
taken by mouth.
The average normal
rectal temperature is
37.05 degrees Celsius.
8. AXILLARY TEMPERATURE
Temperatures can be taken
under the armpit using a
glass or digital thermometer.
The normal axillary
temperature is usually a
degree lower than the oral
(by mouth) temperature and
rectal temperature.
Ranges: 36-36.7 degrees
Celsius
9. TYMPANIC TEMPERATURE
By ear. A special thermometer can
quickly measure the temperature
of the ear drum, which reflects the
body's core temperature (the
temperature of the internal
organs).
Normal ranges: 36.8-37.3 degrees
Celsius
Tympanic membrane, also called
eardrum, thin layer of tissue in the
human ear that receives sound
vibrations from the outer air and
transmits them to the auditory
ossicles, which are tiny bones in
the tympanic (middle-ear) cavity.
10. FOREHEAD TEMPERATURE
By skin. A special
thermometer can quickly
measure the temperature
of the skin on the
forehead.
Ranges: 36.4-36.7 degrees
Celsius
11. VARIATIONS IN BODY TEMPERATURE
HYPOTHERMIA
Hypothermia is a medical
emergency that occurs when your
body loses heat faster than it can
produce heat, causing a
dangerously low body
temperature.
Normal body temperature is
around 98.6 F (37 C). occurs as your
body temperature falls 35 and
below degrees Celsius.
HYPERTHERMIA
Hyperthermia refers to a group of heat-
related conditions characterized by an
abnormally high body temperature —
in other words, the opposite of
hypothermia. due to a failure of the
body's thermoregulatory mechanism.
hyperthermia is defined as a
temperature greater than 37.5–38.3 °C
depending on the reference used, that
occurs without a change in the body's
temperature set point. Such elevations
range from mild to extreme; body
temperatures above 40 °C can be life-
threatening.
12. PYREXIA
Fever, also known as pyrexia and
febrile response, is defined as
having a temperature above the
normal range due to an increase in
the body's temperature set point.
There is not a single agreed-upon
upper limit for normal temperature
with sources using values between
37.5 and 38.3 °C (99.5 and 100.9
°F).
The increase in set point triggers
increased muscle contractions and
causes a feeling of cold
13. PYREXIA VS HYPERTHERMIA
Typically an elevated body temperature is caused by fever,
but hyperthermia can also be the cause. ... In contrast,
hyperthermia results when hypothalamic regulation of
body temperature is overwhelmed and an uncontrolled
increase in body temperature exceeds the body's ability to
lose heat.
The most severe form of hyperthermia is heat stroke.
14. THERMOREGULATORY SYSTEM
A system responsible in maintaining normal body temperature.
Thermoregulation is a process that allows your body to maintain its
core internal temperature. All thermoregulation mechanisms are
designed to return your body to homeostasis. This is a state of
equilibrium
15. (3) THREE PRIMARY COMPONENTS OF THERMOREGULATORY
SYSTEM
1. THERMORECEPTORS-PERIPHERY(NERVE ENDINGS)
2. THERMOREGULATING CENTER-HYPOTHALAMUS
3. EFFECTOR ORGAN
16. 1. PERIPHERAL THERMORECEPTORS–FREE NERVE ENDINGS THAT RESIDE IN THE
SKIN
KRAUS CORPUSCLES
-functioning as sensory cold
receptors.
RUFFINI CORPUSLES
-functioning as sensory heat
receptors.
17. 2. THEMOREGULATING CENTER- LOCATED IN THE HYPOTHALAMUS
Muscles can also receive messages from the
thermoregulatory center of the brain (the
hypothalamus) to cause shivering. This
increases heat production as respiration is an
exothermic reaction in muscle cells. ... In this
process, triglycerides are burned into heat,
thereby increasing body temperature.
18. EFFECTOR ORGAN A MUSCLE OR GLAND THAT CONTRACTS OR SECRETES,
RESPECTIVELY, IN DIRECT RESPONSE TO NERVE IMPULSES AND REPRODUCTIVE
ORGANS, EX. FEMALE AND REPRODUCTIVE ORGANS OF MALE.
effector
Any muscle, organ etc. that can respond to a stimulus from
a nerve.
Stimuli- a thing or event that evokes a specific functional
reaction in an organ or tissue.
Stimulus is something that causes a reaction, especially
interest, excitement or energy
19.
20.
21. THERMOMETER -INSTRUMENT USED FOR MEASURING TEMPERATURE
Types
1. Digital thermometers
2. Electronic ear thermometers
3. Forehead thermometers
4. Plastic strip thermometers
5. Pacifier thermometer
6. Glass and mercury thermometers
22. DIGITAL THERMOMETERS
Digital thermometers are regarded
as the fastest and most accurate
type of thermometer. Readings are
taken from under the tongue,
from the rectum or under the
armpit. They are easily found in
local pharmacies and can be used
at home or in the hospital.
23. ELECTRONIC EAR THERMOMETERS
These use infrared technology to
get their temperature reading.
Electronic ear thermometers are
less accurate as if there is too
much wax in the ear it can give an
incorrect reading. Despite being
expensive, they are a lot easier to
use on babies and young children,
as it can be hard to get children to
sit still for long enough while
using digital thermometers.
24. FOREHEAD THERMOMETERS
These thermometers also read
heat using infrared, and are placed
on the temporal artery. Forehead
thermometers are also not as
reliable as digital thermometers
25. PLASTIC STRIP THERMOMETERS
These thermometers can detect the presence
of a fever in a patient, however, they do not
give an exact temperature reading. They
simply act as an indication that something
might be wrong. To use them, you just place
the strip on the forehead.
26. PACIFIER THERMOMETER
These thermometers are used
predominantly in babies older
than three months. They require
the baby to be still for a couple of
minutes and this can be a struggle.
This means that sometimes the
temperature can be inaccurate.
27. GLASS AND MERCURY THERMOMETERS
These thermometers are the old school way to take a
temperature. You normally would place it under your
tongue and watch the mercury rise. Once it stops, that
would be your temperature. Unfortunately, due to the
risk of mercury poisoning, this means of taking a
temperature is not a good idea and you are highly
recommended to consult with a healthcare body to
discard any you might have.
A delicate hollow glass tube with a liquid material
(Mercury) that is very sensitive to temperature change,
expands when the temperature rises and contracts when
goes down.