Ancient sites like Newgrange Passage Tomb and Stonehenge were carefully aligned with astronomical events like solstices and equinoxes, suggesting their builders had knowledge of the movement of celestial bodies. Early models of the universe placed Earth at the center, with the geocentric model proposed by Aristotle and later displaced by Copernicus' heliocentric model placing the Sun at the center. Kepler later improved on this by discovering planetary orbits were elliptical rather than circular in shape.
Earth-Like Planet with Intelligent Life? Why 400 Years?Paul H. Carr
Earth-Like Planet with Intelligent Life? Why 400 Years?
Paul H. Carr, Ph. D.
In 1584, Dominican monk Giordano Bruno envisioned the stars as "countless suns with countless earths, all rotating around their suns.” Searching for intellectual freedom, he fled his native Italy to Protestant Switzerland and Germany, but in 1600 the Roman Inquisition condemned him for heresy. He was burned at the stake.
Fast-forwarding to 1995, the Swiss astronomers Michel Mayor and Didier Queloz announced the discovery of a planet orbiting a star similar to our sun (51 Pegasi). In 2010, 500 planets had been found orbiting 421 stars. On Feb 2, 2011, NASA announced that the Kepler space telescope had identified 1200 planet candidates.
It took 400 years for telescope technology to advance and for Copernicus, Galileo, Newton, Bradley, and Foucault to establish heliocentric cosmology, culminating in today’s astrophysics with digital imaging and processing. Here is your opportunity to learn about the progress we are making towards discovering an earth-like planet with the possibility of intelligent life. Contrasting with Bruno, in 2010 Dominican Francisco Ayala, who had been president of the Sigma Xi and AAAS, won the $1.6M Templeton Prize for affirming life’s spiritual dimension.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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3. TrackingCosmologicalEvents
Solstice:
• The word comes from Latin - Sol=sun stice=stop
• Longest and shortest days of sunlight during the year.
In the Northern hemisphere the summer solstice happens around June 21 and is
the longest period of daylight. This marks the first day of summer. The winter
solstice happens around December 21 and is the shortest period of daylight. This
marks the first day of winter.
Equinox:
• The word comes from Latin - Equi=equal nox=night
• 2 Days of the year where there is equal daylight and night during the year.
In the Northern hemisphere the spring equinox happens around March 21 and the
fall equinox happens around September 21
5. NewgrangePassageTomb
The oldest site that has definite astronomical
connections is Newgrange Passage Tomb in Ireland
that dates from about 3,200 B.C.
For about 2 weeks on either side of the winter solstice,
light passes through a roof box above the
entrance passage. This incoming light causes the
entire central passageway to be illuminated. Many of the
stones that make up Newgrange are decorated with
symbols that look like the sun.
6. Stonehenge
The most famous English site for
Neolithic astronomical use
is Stonehenge. The main stones of the
site date from about 3,000 B.C.
Some people believe that the
clear alignments of the stones with the
sun and the moon allowed the Druids
who built it to predict solar and
lunar eclipses. However, most people
believe that the site had some
religious importance attached to it rather
than an astronomically predictive value.
7. MedicineWheel
The Medicine Wheel’s large
circle measures 213
feet around. The 28 spokes
radiating from its center
represent the number of days in
the lunar cycle. Six
spokes extending well beyond
the Wheel are aligned to
the horizon positions of sunrises
and sunsets on the first days of
the four seasons.
8. AncientViews
Ancient monuments had a view that put the Earth at rest in the center of the
Universe.
The Egyptians saw the sky as the arched body of the goddess Nut
The Hindus saw the sky resting on the tusks of an immense elephant
The Babylonians saw the sky as the inside of a huge bell jar
The Arabs more recently saw the sky as an immense tent.
There were many views of the Earth’s position, however very few of these
descriptions suggested that the Earth actually turned.
9. GeocentricModel
Geocentric Model: proposed by Aristotle
that Earth is at the center, surrounded by the
Sun, the Moon and the five planets known at
the time. It also had stars that were fixed to
the outermost sphere.
The geocentric model allowed early
astronomers to forecast such events as the
phases of the Moon, but it still could not
explain many other observations. For
example, why did Mars, Jupiter, and Saturn
sometimes seem to loop back opposite to
their usual movement across the sky?
10. HeliocentricModel
Heliocentric Model: proposed by
Nicholas Copernicus and had the Sun at the center,
surrounded by Earth and the other planets. It also
had stars that were fixed to the outermost sphere.
A little less than 100 years later, a new generation of
scientists—with the help of a major technological
invention, the telescope—provided solid evidence
for Copernicus’s theory. Notable among these
scientists was the renowned Galileo Galilei of Italy.
Even though Galileo’s discoveries added credibility
to the Copernican ideas, the model could still not
predict planetary motion very accurately.
11. HeliocentricModel
Heliocentric Model: proposed by
Nicholas Copernicus and had the Sun at the center,
surrounded by Earth and the other planets. It also
had stars that were fixed to the outermost sphere.
A little less than 100 years later, a new generation of
scientists—with the help of a major technological
invention, the telescope—provided solid evidence
for Copernicus’s theory. Notable among these
scientists was the renowned Galileo Galilei of Italy.
Even though Galileo’s discoveries added credibility
to the Copernican ideas, the model could still not
predict planetary motion very accurately.
12. Ellipses
A German mathematician, Johannes Kepler, came up with the next solution to the
puzzle. Using detailed observations of the movement of the planets (observations
carefully recorded by the great Danish astronomer, Tycho Brahe), Kepler discovered
what was missing from the Copernican ideas. The orbits of the planets, he realized,
were ellipses and not circles.
Ellipse: The shape in
which planets orbit.
Similar to an oval shape