This document discusses vectorial analysis of electrocardiograms. It explains that the instantaneous mean vector represents the average direction of electrical flow in the heart at a moment in time, which is usually downward. Vector direction is measured in degrees relative to a zero reference point. The mean QRS vector during ventricular depolarization is typically around +59 degrees. Different electrocardiogram leads are analyzed by drawing perpendicular projections of the heart's vector onto the axis of each lead to determine the recorded potential. This vectorial approach is used to analyze the potentials seen in the three standard limb leads during the QRS complex.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
The electrocardiogram(ECG) provides a graphic depiction of the electric forces generated by the heart . The ECG graph appear as a series of deflections and waves produced by each cardiac cycle.
During activation of the myocardium, electrical forces or action potentials are propagated in various directions. These electrical forces can be picked up from the surface of the body by means of electrodes and recorded in the form of an electrocardiogram.
Electricity and Electromagnetism (experimental study)Raboon Redar
You’ll understand the way to calculate and measure resistance in parallel and series circuits by knowing two of the three values of voltage, current, or resistance. In this experiment, there are 3 resistors, 1 power supply and wires you need for connecting resistors to each other, then to power supply. You can measure each resistor by an ohmmeter, voltages by voltmeter and currents by amperemeter (ammeter), while all of them can be measured by a multimeter. Use a multimeter for measuring resistance for better accuracy.
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A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
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Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
3. „ INSTANTANEOUS MEAN VECTOR
Current flows in all directions. Mean direction of flow of
electrical potential at one instance is known as
instantaneous mean vector or instantaneous summated
vector
Though the potential travels in all directions, the
potential flowing downwards (from base to apex of the
heart) is much greater in magnitude than the potential
flowing in other directions.
Thus, the mean direction of flow of electrical potential in
this instance is downwards.
4. DIRECTION OF VECTOR IN TERMS OF
DEGREES
Direction of current flow is always from negative point towards the positive point.
When the electrical potential flows in a horizontal plane from right side towards
left side of the heart, the degree of vector is zero.This is known as Zero
Reference Point.
In a normal heart, the average direction
of the during spread of the depolarization
wave through the ventricles, called the
Mean QRS Vector is about +59 degrees,
which is shown by vector A.
5. Axis for Standard Bipolar Lead
and Unipolar Limb Lead
Each lead is actually a pair of electrodes connected to the
body on opposite sides of the heart, and the direction from
negative electrode to positive electrode is called the
“Axis” of the lead.
The axis of lead I is 0 degrees.
The axis of lead II is +60 degrees.
lead III has an axis of +120 degrees.
6. Potentials Recorded
in Different Leads
To determine how much of the voltage in vector A will be
recorded in lead I, a line perpendicular to the axis of lead
I is drawn from the tip of vector A to the lead I axis.
This results in Projected Vector (B) is drawn along the
lead I axis.
7. when the heart vector has almost exactly the same axis as
the lead axis, essentially the entire voltage of the vector will
be recorded.
when the vector in the heart is in a direction almost
perpendicular to the axis of the lead, the voltage recorded in
the electrocardiogram of this lead is very low.
.
8. Analysis of Potentials in the Three Standard
Bipolar Limb Leads
To determine the potential recorded for each one of the three
standard bipolar limb leads, perpendicular lines (the dashed
lines) are drawn from the tip of vector A to the three lines
representing the axes of the three different standard leads.
The projected vector B depicts the potential recorded at that
instant in lead I, projected vector C depicts the potential in
lead II, and projected vector D depicts the potential in lead III.
