The electrocardiogram(ECG) provides a graphic depiction of the electric forces generated by the heart . The ECG graph appear as a series of deflections and waves produced by each cardiac cycle.
During activation of the myocardium, electrical forces or action potentials are propagated in various directions. These electrical forces can be picked up from the surface of the body by means of electrodes and recorded in the form of an electrocardiogram.
This document provides an overview of the basics of electrocardiography (ECG). It discusses the principles of cardiac activation and repolarization that underlie the ECG. It describes the components of an ECG machine and how it detects cardiac electrical signals. It explains the standard 12-lead ECG system and the orientation and views of the heart provided by each lead. Key waves, intervals, and parameters measured from the ECG are defined. The roles of cardiac anatomy and physiology in generating the ECG are also outlined.
This document provides information about electrocardiography (ECG) including the aims, objectives, ECG grid, leads, Einthoven's triangle, normal waveforms, intervals, axis, and interpretation. The key points are:
1. The ECG grid represents time (horizontal axis) and voltage (vertical axis) with small and large boxes corresponding to time and voltage increments.
2. There are 12 leads that detect electrical activity from different perspectives including limb leads (I, II, III), augmented limb leads (aVR, aVL, aVF), and precordial leads (V1-V6).
3. Normal waves include the P wave (atrial depolarization), Q
An electrocardiogram (ECG or EKG) is a graphic recording of the electrical activity of the heart over time captured by electrodes placed on the skin. The ECG depicts the heart's electrical conduction system and can be used to diagnose cardiac conditions like arrhythmias, ischemia, infarction, and others. An ECG records the P wave from atrial depolarization, the QRS complex from ventricular depolarization, and the ST-T wave from ventricular repolarization. The standard 12-lead ECG uses limb leads and precordial leads positioned on the torso to measure the heart's electrical activity from different angles.
The document provides information about electrocardiograms (ECGs). It discusses the history of ECGs, what an ECG is, how ECGs work, the components of a normal ECG tracing including waves, segments, and intervals, abnormalities that can be detected on ECGs, and the different leads used in ECGs. Specifically, it explains that an ECG is a graphic representation of the electrical activity of the heart, the P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the T wave represents ventricular repolarization. It also discusses the clinical uses of ECGs to assess cardiac conditions.
The topic is about heart related diseases and how it can be cured.what are the diseases and what are the treatments and methods. You should view it.it may be helpful to you people.
This document provides an overview of electrocardiography (ECG) and myocardial infarctions (MIs). It discusses the basics of ECG formation, electrode placement, lead types, normal ECG components and intervals. It describes how to interpret rate, rhythm, axis, waves and intervals. Abnormal findings indicating MIs such as ST elevation and pathological Q waves are also outlined. The document concludes with descriptions of STEMI and NSTEMI treatment including thrombolytics, angioplasty and medical management.
The document discusses the basics of electrocardiography (ECG). It describes what an ECG is, how it is recorded, the ECG grid, and the normal waves, complexes, intervals and segments seen on an ECG. Specifically, it explains the P wave, QRS complex, T wave, and other components and their significance in assessing electrical conduction through the heart. The conductive system of the heart is also summarized, describing how impulses originate in the sinoatrial node and are conducted to initiate coordinated contractions.
The document provides an overview of electrocardiography (ECG/EKG) including:
1. ECG records the electrical activity of the heart over time using skin electrodes and provides information on heart rate, rhythm, tissue activation, and damage.
2. Key aspects of the ECG waveform include the P wave, QRS complex, and T wave which represent atrial depolarization, ventricular depolarization, and ventricular repolarization, respectively.
3. The standard 12-lead ECG consists of 3 bipolar limb leads, 3 augmented unipolar limb leads, and 6 precordial leads which provide different views of the heart's electrical activity.
This document provides an overview of the basics of electrocardiography (ECG). It discusses the principles of cardiac activation and repolarization that underlie the ECG. It describes the components of an ECG machine and how it detects cardiac electrical signals. It explains the standard 12-lead ECG system and the orientation and views of the heart provided by each lead. Key waves, intervals, and parameters measured from the ECG are defined. The roles of cardiac anatomy and physiology in generating the ECG are also outlined.
This document provides information about electrocardiography (ECG) including the aims, objectives, ECG grid, leads, Einthoven's triangle, normal waveforms, intervals, axis, and interpretation. The key points are:
1. The ECG grid represents time (horizontal axis) and voltage (vertical axis) with small and large boxes corresponding to time and voltage increments.
2. There are 12 leads that detect electrical activity from different perspectives including limb leads (I, II, III), augmented limb leads (aVR, aVL, aVF), and precordial leads (V1-V6).
3. Normal waves include the P wave (atrial depolarization), Q
An electrocardiogram (ECG or EKG) is a graphic recording of the electrical activity of the heart over time captured by electrodes placed on the skin. The ECG depicts the heart's electrical conduction system and can be used to diagnose cardiac conditions like arrhythmias, ischemia, infarction, and others. An ECG records the P wave from atrial depolarization, the QRS complex from ventricular depolarization, and the ST-T wave from ventricular repolarization. The standard 12-lead ECG uses limb leads and precordial leads positioned on the torso to measure the heart's electrical activity from different angles.
The document provides information about electrocardiograms (ECGs). It discusses the history of ECGs, what an ECG is, how ECGs work, the components of a normal ECG tracing including waves, segments, and intervals, abnormalities that can be detected on ECGs, and the different leads used in ECGs. Specifically, it explains that an ECG is a graphic representation of the electrical activity of the heart, the P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the T wave represents ventricular repolarization. It also discusses the clinical uses of ECGs to assess cardiac conditions.
The topic is about heart related diseases and how it can be cured.what are the diseases and what are the treatments and methods. You should view it.it may be helpful to you people.
This document provides an overview of electrocardiography (ECG) and myocardial infarctions (MIs). It discusses the basics of ECG formation, electrode placement, lead types, normal ECG components and intervals. It describes how to interpret rate, rhythm, axis, waves and intervals. Abnormal findings indicating MIs such as ST elevation and pathological Q waves are also outlined. The document concludes with descriptions of STEMI and NSTEMI treatment including thrombolytics, angioplasty and medical management.
The document discusses the basics of electrocardiography (ECG). It describes what an ECG is, how it is recorded, the ECG grid, and the normal waves, complexes, intervals and segments seen on an ECG. Specifically, it explains the P wave, QRS complex, T wave, and other components and their significance in assessing electrical conduction through the heart. The conductive system of the heart is also summarized, describing how impulses originate in the sinoatrial node and are conducted to initiate coordinated contractions.
The document provides an overview of electrocardiography (ECG/EKG) including:
1. ECG records the electrical activity of the heart over time using skin electrodes and provides information on heart rate, rhythm, tissue activation, and damage.
2. Key aspects of the ECG waveform include the P wave, QRS complex, and T wave which represent atrial depolarization, ventricular depolarization, and ventricular repolarization, respectively.
3. The standard 12-lead ECG consists of 3 bipolar limb leads, 3 augmented unipolar limb leads, and 6 precordial leads which provide different views of the heart's electrical activity.
An ECG provides a graphical representation of the electrical activity of the heart. It displays deflections and waves that correspond to different stages of the cardiac cycle. Key aspects of an ECG include P, QRS, and T waves that represent atrial depolarization, ventricular depolarization, and ventricular repolarization, respectively. Normal ECG values include a PR interval of 120-200ms and a QT interval of 350-430ms. ECGs are useful for identifying arrhythmias, chamber size abnormalities, and monitoring conditions like myocardial infarction.
Electrocardiography involves recording the electrical activity of the heart over time using skin electrodes. An ECG machine produces a graph called an electrocardiogram. ECGs can be used to identify arrhythmias, ischemia, chamber hypertrophy, and other cardiac conditions. The document discusses the history of ECG machines, basic heart anatomy, ECG calibration, waveforms, and how to interpret rate and rhythm.
(1) An ECG records and displays the electrical activity of the heart over time using electrodes placed on the skin. It is used to evaluate cardiac rate, rhythm, and detect any abnormalities. (2) Key aspects of an ECG include the P wave, QRS complex, T wave, and intervals between them like the PR and QT. Together these provide information on depolarization and repolarization of the heart's chambers. (3) A standard 12-lead ECG positions 10 electrodes on the limbs and chest to measure electrical activity from multiple angles and identify any damage or disease.
The document discusses the normal electrocardiogram (ECG). It explains that the ECG records and graphs the electrical activity of the heart over time. The conducting system of the heart initiates and coordinates the contractions of the cardiac chambers. The ECG is recorded using electrodes placed on the skin that detect voltage changes between electrode pairs, known as leads. There are 12 standard leads that provide different views of the heart's electrical activity. The ECG can be used to determine the heart rate and rhythm, detect abnormalities, diagnose conditions like myocardial infarction, and evaluate the cardiac axis.
Cells in the heart act as batteries, creating small electric potentials called biopotentials. When these biopotentials change during the heartbeat, it generates an ECG signal. ECG machines use electrodes to detect these signals from the body and amplify and filter them. The signals are comprised of the superimposed action potentials from different parts of the heart. Each ECG lead provides a different view of the heart based on which areas of the heart it is detecting signals from.
An ECG is a graph of the electrical activity of the heart over time captured through skin electrodes. It involves placing electrodes on the limbs and chest to detect the weak electrical currents produced by the heart. The ECG tracing shows waves representing the depolarization and repolarization of the atria and ventricles. It is used to diagnose cardiac arrhythmias, conduction abnormalities, ischemia, and other heart conditions. The standard 12-lead ECG provides a comprehensive view of the heart's electrical activity in multiple planes. Proper placement of electrodes and interpretation of intervals, complexes, and other ECG features can reveal important cardiac information.
The document discusses ECG leads and their axis. It explains that the 12-lead ECG places electrodes on the body in different configurations to view electrical activity from different perspectives. The 3 limb leads (I, II, III) and 3 augmented leads (aVR, aVL, aVF) use the arms and legs. The 6 precordial leads (V1-V6) are placed on the chest. Together, the 12-leads provide a multi-dimensional view of the heart's electrical activity. Each lead orientation favors visibility of certain heart regions, with limb leads viewing the inferior side and precordial leads viewing anterior-posterior activity.
An ECG is a record of the heart's electrical activity over time captured by skin electrodes. It is a diagnostic tool used to detect cardiac arrhythmias, conduction abnormalities, electrolyte disturbances, and screen for heart disease. An ECG involves placing electrodes on the skin of the limbs and chest to record the heart's electrical activity through 12 leads that detect the heart from different angles based on Einthoven's triangle. The ECG trace shows the P, QRS, and T waves that correspond to atrial depolarization, ventricular depolarization and repolarization.
An electrocardiogram (ECG) records the electrical activity of the heart. It can evaluate the heart's automaticity, conductivity, and excitability, but not contractility. The ECG is generated by ion fluxes across cell membranes during cardiac activation and recovery. It represents the vector sum of dipoles created by depolarization waves. A standard 12-lead ECG provides different views of the heart through limb and precordial leads. The P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the ST-T wave represents ventricular recovery.
An ECG is a recording of the electrical activity of the heart over time using skin electrodes. It is the gold standard for diagnosing cardiac diseases in a noninvasive manner. The ECG records the P wave from atrial depolarization, the QRS complex from ventricular depolarization and repolarization of the atria, and the T wave from ventricular repolarization. Proper electrode placement and ensuring good skin contact is important for obtaining an accurate recording. The recording is then analyzed based on heart rate, rhythm, intervals, wave amplitudes and shapes to identify any abnormalities.
The document discusses the electrical conduction system of the heart and electrocardiography. It describes:
- The sinoatrial node acts as the heart's natural pacemaker and initiates electrical impulses that travel through pathways to the atrioventricular node.
- The Purkinje fibers form a network that transmits impulses from the ventricles to contract.
- An electrocardiogram detects the heart's electrical signals using electrodes placed on the skin. It displays waves, segments, and intervals that correspond to different stages of the cardiac cycle.
- The P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the T wave represents ventricular repolarization.
This document provides an overview of electrocardiography (ECG). It discusses the basics of ECG recording and waves, types of ECG leads, vector analysis, and interpretation of normal and abnormal tracings. The objectives are to explain how ECG is recorded, discuss normal waves and intervals, describe the relationship to heart electrical axis, and differentiate normal and abnormal ECGs. Key points covered include the normal P, QRS, and T waves; types of bipolar and unipolar leads; cardiac electrical axis; and manifestations of conditions like hypertrophy, conduction blocks, and arrhythmias on ECG.
The document provides information about electrocardiograms (ECGs), including a brief history of ECG development, basic cardiac anatomy and the heart's conducting system, components of the ECG waveform, electrode placements, how to read ECG paper, and cardiac axis. It explains that the ECG is a tool that records electrical activity of the heart to assess cardiac function and identify abnormalities, traces its development back to Willem Einthoven in the 1890s, and provides details on heart structures involved in the cardiac cycle and what different parts of the ECG represent.
1) The ECG records electrical activity of the heart through electrodes placed on the skin. It represents the summation of action potentials from myocardial fibers.
2) Einthoven's triangle uses the right arm, left arm, and left leg as electrode placements approximating the heart's position in the center. These produce the standard limb leads I, II, and III in bipolar recordings.
3) Unipolar precordial leads V1-V6 are obtained by placing a exploring electrode on the chest and connecting it to limb electrodes as indifferent electrodes, producing signals between the chest and each limb.
The document provides information about electrocardiograms (ECGs):
1) It defines an ECG as the physical translation of the electrical phenomena created in the heart muscles and produced as a graph by an ECG machine.
2) It describes how ECGs can be used to identify arrhythmias, ischemia, chamber hypertrophy, and other cardiac conditions.
3) It explains the basics of heart anatomy including the four chambers and valves, and how the electrical conduction system generates and transmits electrical impulses to trigger contractions.
An electrocardiogram (ECG) records the electrical activity of the heart. Small metal electrodes are attached to the skin on the arms, legs, and chest to detect electrical impulses from the heart. The ECG machine amplifies and records these impulses, showing normal and abnormal heart rhythms and any signs of heart damage or disease. A normal ECG tracing shows the P wave, QRS complex, and T wave representing atrial and ventricular contractions and repolarizations. The ECG test takes about five minutes and is painless.
The document provides an overview of electrocardiography (ECG/EKG) including:
1. ECG records the electrical activity of the heart through surface electrodes placed on the limbs and chest. This allows visualization of the cardiac cycle.
2. A standard 12-lead ECG provides views of the heart from different angles by using 10 electrodes in specific positions.
3. The ECG tracing displays P waves, QRS complex, T waves, and intervals between these waves which correspond to different phases of cardiac depolarization and repolarization.
4. Proper placement of electrodes and understanding of the waves and intervals on the ECG tracing are essential for cardiac rhythm and condition analysis.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
Ecg1 DR NIKUNJ R SHEKHADA (MBBS,MS GEN SURG,DNB CTS SR)DR NIKUNJ SHEKHADA
This document provides an overview of electrocardiograms (ECGs). It discusses what an ECG is, the history and development of ECGs, and how to interpret different parts of the ECG including waves, intervals, axes, and patterns in various leads. Key points covered include that an ECG records electrical activity of the heart and can be used for clinical diagnosis, the normal components of an ECG (P, QRS, T waves), common intervals and their meanings (PR, QT), how depolarization spreads through the heart, and what different leads examine. The document is intended as an educational guide on understanding ECGs.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
An ECG provides a graphical representation of the electrical activity of the heart. It displays deflections and waves that correspond to different stages of the cardiac cycle. Key aspects of an ECG include P, QRS, and T waves that represent atrial depolarization, ventricular depolarization, and ventricular repolarization, respectively. Normal ECG values include a PR interval of 120-200ms and a QT interval of 350-430ms. ECGs are useful for identifying arrhythmias, chamber size abnormalities, and monitoring conditions like myocardial infarction.
Electrocardiography involves recording the electrical activity of the heart over time using skin electrodes. An ECG machine produces a graph called an electrocardiogram. ECGs can be used to identify arrhythmias, ischemia, chamber hypertrophy, and other cardiac conditions. The document discusses the history of ECG machines, basic heart anatomy, ECG calibration, waveforms, and how to interpret rate and rhythm.
(1) An ECG records and displays the electrical activity of the heart over time using electrodes placed on the skin. It is used to evaluate cardiac rate, rhythm, and detect any abnormalities. (2) Key aspects of an ECG include the P wave, QRS complex, T wave, and intervals between them like the PR and QT. Together these provide information on depolarization and repolarization of the heart's chambers. (3) A standard 12-lead ECG positions 10 electrodes on the limbs and chest to measure electrical activity from multiple angles and identify any damage or disease.
The document discusses the normal electrocardiogram (ECG). It explains that the ECG records and graphs the electrical activity of the heart over time. The conducting system of the heart initiates and coordinates the contractions of the cardiac chambers. The ECG is recorded using electrodes placed on the skin that detect voltage changes between electrode pairs, known as leads. There are 12 standard leads that provide different views of the heart's electrical activity. The ECG can be used to determine the heart rate and rhythm, detect abnormalities, diagnose conditions like myocardial infarction, and evaluate the cardiac axis.
Cells in the heart act as batteries, creating small electric potentials called biopotentials. When these biopotentials change during the heartbeat, it generates an ECG signal. ECG machines use electrodes to detect these signals from the body and amplify and filter them. The signals are comprised of the superimposed action potentials from different parts of the heart. Each ECG lead provides a different view of the heart based on which areas of the heart it is detecting signals from.
An ECG is a graph of the electrical activity of the heart over time captured through skin electrodes. It involves placing electrodes on the limbs and chest to detect the weak electrical currents produced by the heart. The ECG tracing shows waves representing the depolarization and repolarization of the atria and ventricles. It is used to diagnose cardiac arrhythmias, conduction abnormalities, ischemia, and other heart conditions. The standard 12-lead ECG provides a comprehensive view of the heart's electrical activity in multiple planes. Proper placement of electrodes and interpretation of intervals, complexes, and other ECG features can reveal important cardiac information.
The document discusses ECG leads and their axis. It explains that the 12-lead ECG places electrodes on the body in different configurations to view electrical activity from different perspectives. The 3 limb leads (I, II, III) and 3 augmented leads (aVR, aVL, aVF) use the arms and legs. The 6 precordial leads (V1-V6) are placed on the chest. Together, the 12-leads provide a multi-dimensional view of the heart's electrical activity. Each lead orientation favors visibility of certain heart regions, with limb leads viewing the inferior side and precordial leads viewing anterior-posterior activity.
An ECG is a record of the heart's electrical activity over time captured by skin electrodes. It is a diagnostic tool used to detect cardiac arrhythmias, conduction abnormalities, electrolyte disturbances, and screen for heart disease. An ECG involves placing electrodes on the skin of the limbs and chest to record the heart's electrical activity through 12 leads that detect the heart from different angles based on Einthoven's triangle. The ECG trace shows the P, QRS, and T waves that correspond to atrial depolarization, ventricular depolarization and repolarization.
An electrocardiogram (ECG) records the electrical activity of the heart. It can evaluate the heart's automaticity, conductivity, and excitability, but not contractility. The ECG is generated by ion fluxes across cell membranes during cardiac activation and recovery. It represents the vector sum of dipoles created by depolarization waves. A standard 12-lead ECG provides different views of the heart through limb and precordial leads. The P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the ST-T wave represents ventricular recovery.
An ECG is a recording of the electrical activity of the heart over time using skin electrodes. It is the gold standard for diagnosing cardiac diseases in a noninvasive manner. The ECG records the P wave from atrial depolarization, the QRS complex from ventricular depolarization and repolarization of the atria, and the T wave from ventricular repolarization. Proper electrode placement and ensuring good skin contact is important for obtaining an accurate recording. The recording is then analyzed based on heart rate, rhythm, intervals, wave amplitudes and shapes to identify any abnormalities.
The document discusses the electrical conduction system of the heart and electrocardiography. It describes:
- The sinoatrial node acts as the heart's natural pacemaker and initiates electrical impulses that travel through pathways to the atrioventricular node.
- The Purkinje fibers form a network that transmits impulses from the ventricles to contract.
- An electrocardiogram detects the heart's electrical signals using electrodes placed on the skin. It displays waves, segments, and intervals that correspond to different stages of the cardiac cycle.
- The P wave represents atrial depolarization, the QRS complex represents ventricular depolarization, and the T wave represents ventricular repolarization.
This document provides an overview of electrocardiography (ECG). It discusses the basics of ECG recording and waves, types of ECG leads, vector analysis, and interpretation of normal and abnormal tracings. The objectives are to explain how ECG is recorded, discuss normal waves and intervals, describe the relationship to heart electrical axis, and differentiate normal and abnormal ECGs. Key points covered include the normal P, QRS, and T waves; types of bipolar and unipolar leads; cardiac electrical axis; and manifestations of conditions like hypertrophy, conduction blocks, and arrhythmias on ECG.
The document provides information about electrocardiograms (ECGs), including a brief history of ECG development, basic cardiac anatomy and the heart's conducting system, components of the ECG waveform, electrode placements, how to read ECG paper, and cardiac axis. It explains that the ECG is a tool that records electrical activity of the heart to assess cardiac function and identify abnormalities, traces its development back to Willem Einthoven in the 1890s, and provides details on heart structures involved in the cardiac cycle and what different parts of the ECG represent.
1) The ECG records electrical activity of the heart through electrodes placed on the skin. It represents the summation of action potentials from myocardial fibers.
2) Einthoven's triangle uses the right arm, left arm, and left leg as electrode placements approximating the heart's position in the center. These produce the standard limb leads I, II, and III in bipolar recordings.
3) Unipolar precordial leads V1-V6 are obtained by placing a exploring electrode on the chest and connecting it to limb electrodes as indifferent electrodes, producing signals between the chest and each limb.
The document provides information about electrocardiograms (ECGs):
1) It defines an ECG as the physical translation of the electrical phenomena created in the heart muscles and produced as a graph by an ECG machine.
2) It describes how ECGs can be used to identify arrhythmias, ischemia, chamber hypertrophy, and other cardiac conditions.
3) It explains the basics of heart anatomy including the four chambers and valves, and how the electrical conduction system generates and transmits electrical impulses to trigger contractions.
An electrocardiogram (ECG) records the electrical activity of the heart. Small metal electrodes are attached to the skin on the arms, legs, and chest to detect electrical impulses from the heart. The ECG machine amplifies and records these impulses, showing normal and abnormal heart rhythms and any signs of heart damage or disease. A normal ECG tracing shows the P wave, QRS complex, and T wave representing atrial and ventricular contractions and repolarizations. The ECG test takes about five minutes and is painless.
The document provides an overview of electrocardiography (ECG/EKG) including:
1. ECG records the electrical activity of the heart through surface electrodes placed on the limbs and chest. This allows visualization of the cardiac cycle.
2. A standard 12-lead ECG provides views of the heart from different angles by using 10 electrodes in specific positions.
3. The ECG tracing displays P waves, QRS complex, T waves, and intervals between these waves which correspond to different phases of cardiac depolarization and repolarization.
4. Proper placement of electrodes and understanding of the waves and intervals on the ECG tracing are essential for cardiac rhythm and condition analysis.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
Ecg1 DR NIKUNJ R SHEKHADA (MBBS,MS GEN SURG,DNB CTS SR)DR NIKUNJ SHEKHADA
This document provides an overview of electrocardiograms (ECGs). It discusses what an ECG is, the history and development of ECGs, and how to interpret different parts of the ECG including waves, intervals, axes, and patterns in various leads. Key points covered include that an ECG records electrical activity of the heart and can be used for clinical diagnosis, the normal components of an ECG (P, QRS, T waves), common intervals and their meanings (PR, QT), how depolarization spreads through the heart, and what different leads examine. The document is intended as an educational guide on understanding ECGs.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
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- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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4. THE ELECTROCARDIOGRAM
The electrocardiogram(ECG) provides a graphic depiction of the
electric forces generated by the heart . The ECG graph appear as a
series of deflections and waves produced by each cardiac cycle.
5. THE ELECTROCARDIOGRAPHIC PAPER
The electrocardiographic recording paper is divided into small and large squares.
The small squares are 1 mm & the large squares are 5 mm
The squares form a grid which facilitates the measurement of (i) time parameters
(horizontal measurement) and (ii) deflection amplitudes (vertical measurement)
In the clinical context , the electrocardiogram is nearly always conventionally
recorded at a paper speed of 25 mm/s .
At this paper speed, five large squares represent 1 s , one large square represents
0.20 s or 1/5 of a s or 200 ms and one small square represents 0.04 s or 1/25 of a
s or 40 ms .
6. Normally , the ECG machine is standardized in such a way that a 1 mV signal
from the machine produces a 10 mm vertical deflection . In other words ,
each small square on the vertical axis represents 0.1 mV and each large
square represents 0.5 mV .
Most graph papers used for the recording of electrocardiograms have every
15 th large square ( a period of 3 s) marked by a vertical line on the upper
border . This facilitates the quick assessment of the heart rate.
7.
8.
9. THE ELECTROCARDIOGRAPH
The electrocardiograph is a sophisticated galvanometer , a sensitive electromagnet ,
which can detect and record changes in electromagnetic potential .
It has positive and negative poles.
The wire extensions from these poles have electrodes at each end ; a positive
electrode at the end of the extension from the positive pole and the negative
electrode at the end of the extension from the negative pole . The paired
electrodes together constitute an electrocardiographic lead.
when the paired electrodes are oriented in any particular direction , the theoretical
straight line joining the electrodes is known as the axis of that lead or the lead
axis.
A lead so placed will detect and transmit any changes in electric potential which
occur between in electrodes.
10.
11. THE ELECTRICAL FIELD OF THE HEART
The heart is situated at the centre of the electrical field which it generates.
The intensity of this electrical field diminishes algebraically with the distance from its centre.
Thus the electrical intensity recorded by an electrode diminishes rapidly when the electrode is
moved a short distance from the heart, and less as the electrode is moved still further away
from the heart .
With distances greater than 15 cm from the heart, the decrement in the intensity of the
electrical field is hardly noticeable.
Consequently ,all electrodes placed at a distance greater than 15 cm from the heart may, in an
electrical sense , be considered to be equidistant from the heart.
For example, an electrode placed at 25 cm from the heart records about the same potential as
one placed 35 cm from the heart.
12. ELECTROCARDIOGRAPHIC LEADS
During activation of the myocardium, electrical forces or action potentials
are propagated in various directions. These electrical forces can be picked up
from the surface of the body by means of electrodes and recorded in the
form of an electrocardiogram.
A pair of electrodes, that consists of a positive and a negative electrode
constitutes an electrocardiographic lead. Each lead is oriented to record
electrical forces as viewed from one aspect of the heart.
The position of these electrodes can be changed so that different leads are
obtained. The angle of electrical activity recorded changes with each lead.
Several angles of recording provide a detailed perspective the heart.
13. There are twelve conventional leads, which may be physiologically divided into
two groups depending upon their orientation to the heart
1. The frontal plane leads (limb / extremity leads) : These are oriented in
the frontal or coronal plane of the body and consist of standard leads I, II and
III and leads aVR, aVL & aVF
2. The horizontal plane leads(chest /precordial leads) : These are oriented
in the transverse or horizontal plane of the body and are formed by the
precordial leads – V1 to V6
14.
15.
16. THE LIMB LEADS
The limb leads are derived from electrodes placed on the limbs. An electrode
is placed on each of the three limbs namely right arm, left arm and left leg.
The right leg electrode acts as the grounding electrode
1. Standard limb leads—three in number
2. Augmented limb leads—three in number
STANDARD LIMB LEADS :
The standard limb leads obtain a graph of the electrical forces as recorded
between two limbs at a time. Therefore, the standard limb leads are also called
bipolar leads. In these leads, one limb carries a positive electrode and the other
limb carries a negative electrode. There are three standard limb leads
Lead I
Lead II
Lead III
17. The leads derived from these three electrodes(limb) are conventionally as
follows
1. Standard lead I – This lead is derived from the placement of the negative
electrode on the right arm and the positive electrode on the left arm.
2. Standard lead II -This lead is derived from the placement of the negative
electrode on the right arm and the positive electrode on the left leg.
3. Standard lead III -This lead is derived from the placement of the negative
electrode on the left arm and the positive electrode on the left leg.
LEAD POSITIVE
ELECTRODE
NEGATIVE
ELECTRODE
I LA RA
II LL RA
III LL LA
18.
19.
20. AUGMENTED LIMB LEADS :
The augmented limb leads obtain a graph of the electrical forces as recorded
from one limb at a time. Therefore, the augmented limb leads are also called
unipolar leads. In these leads, one limb carries a positive electrode, while a
central terminal represents the negative pole which is actually at zero
potential. There are three augmented limb leads
Lead aVR (Right arm)
Lead aVL (Left arm)
Lead aVF (Foot left).
LEAD POSITIVE ELECTRODE
aVR RA
aVL LA
aVF LL
21.
22. THE CHEST LEADS :
The chest leads are obtained from electrodes placed on the precordium in
designated areas. An electrode can be placed on six different positions on the
left side of the chest, each position representing one lead .Accordingly, there
are six chest leads namely:
Lead V1 : Over the fourth intercostal space, just to the right of sternal
border.
Lead V2 : Over the fourth intercostal space, just to the left of sternal
border.
Lead V3 : Over a point midway between V2 and V4
Lead V4 : Over the fifth intercostal space in the midclavicular line.
Lead V5 : Over the anterior axillary line, at the same level as lead V4.
Lead V6 : Over the midaxillary line, at the same level as leads V4 and V5
23.
24. Sometimes, the chest leads are obtained from electrodes placed on the right
side of the chest. The right-sided chest leads are V1R, V2R, V3R, V4R, V5R and
V6R. These leads are mirror-images of the standard left-sided chest leads.
V1R : 4th intercostal space to left of sternum.
V2R : 4th intercostal space to right of sternum.
V3R : Point mid-way between V2R and V4R.
V4R : 5th intercostal space in midclavicular line, and so on.
The right-sided chest leads are useful in cases of:
True mirror-image dextrocardia.
Acute inferior wall myocardial infarction
(to diagnose right ventricular infarction).
25.
26. DEFLECTIONS
By convention, a deflection above the baseline or isoelectric (neutral) line is a
positive deflection while one below the isoelectric line is a negative deflection
The direction of a deflection depends upon two factors namely, the direction
of spread of the electrical force and the location of the recording electrode.
In other words, an electrical impulse moving towards an electrode creates a
positive deflection while an impulse moving away from an electrode creates a
negative deflection
27.
28. The ECG graph consists of a series of deflections or waves. Each
electrocardiographic deflection has been arbitrarily assigned a letter of the
alphabet. Accordingly, a sequence of wave that represents a single cardiac
cycle is sequentially termed as P Q R S T and U
By convention, P, T and U waves are always denoted by capital letters while
the Q, R and S waves can be represented by either a capital letter or a small
letter depending upon their relative or absolute magnitude.
29. Significance of ECG Deflections
P wave : Produced by atrial depolarization.
QRS complex : Produced by ventricular depolarization.
It consists of: Q wave : First negative deflection before R wave.
R wave : First positive deflection after Q wave.
S wave : First negative deflection after R wave.
T wave : Produced by ventricular repolarization.
U wave : Produced by Purkinje repolarization
You would be wondering where is atrial repolarization. Well, it is represented by
the Ta wave which occurs just after the P wave. The Ta wave is generally not
seen on the ECG as it coincides with (lies buried in) the larger QRS complex.
30.
31.
32.
33.
34. THE DOMINANCE OF THE LEFT VENTRICLE
• The ventricles consist essentially of three muscle masses: the IVS & the free
walls of a right and left ventricles
• The LV is a dominant anatomical structure and is also the main haemodynamic
pump of the heart. The IVS consequently forms a continuum with the free wall
of the LV
• Electrocardiologically, and electrophysiologically too,the left ventricle, including
the IVS , is the dominant ventricle. The free wall of the RV plays a relatively
minor role.
• Furthermore, while the free wall of the RV constitutes the anatomical anterior
wall of the heart, the electrocardiological anterior wall of the heart is, in
effect, the interventricular septum.
• For example, an anterior wall infarction refers to infarction of the IVS and not
the free wall of the RV
• It should also be borne in mind that the electromagnetic forces generated by
the free wall of the RV are relatively minor compared with those generated by
the free wall of the LV
35.
36. NORMAL P WAVE
• The P wave is a small rounded wave produced by atrial depolarization. In
fact, it reflects the sum of right and left atrial activation,the right
preceding the left since the pacemaker is located in the right atrium.
• The P wave is normally upright in most of the ECG leads with two exceptions.
In lead aVR, it is inverted along with inversion of the QRS complex and the T
wave , since the direction of atrial activation is away from this lead .
• In lead V1, it is generally biphasic that is, upright but with a small terminal
negative deflection, representing left atrial activation in a reverse direction
• Normally , the P wave has a single peak without a gap or notch b/w right and
left atrial components. A normal P wave meets the following criteria :
- Less than 2.5mm (0.25mV) in height
- Less than 2.5mm (0.10 sec) in width
37.
38. THE POTENTIAL FORMS OF THE QRS DEFLECTIONS AND
THEIR NOMENCLATURE
• The QRS complex reflects ventricular activation or depolarization. An initial
downward deflection after the P wave is termed as Q wave.
• An initial upwards deflection after the P wave termed as R wave
• The S wave usually represents the terminal part of ventricular activation
• The relative sizes of the QRS deflections are usually reflected by uppercase
and lower case lettering: capital and small letters.
• Thus, a small initial r wave followed by a relatively large S wave is termed an rS
compex
• A complex with an R and S wave of approximately equal amplitudes is termed an
RS complex
• A large R wave followed by a relatively small s wave is termed an Rs complex
• A single wave complex that is completely positive is termed an R wave complex
39. • A small initial downwards deflection followed by a relatively tall upwards
deflection, which, in turn, is followed by a relatively large terminal downwards
deflection, is termed a qRS complex
• A complex with a relatively deep and wide initial negative deflection followed
by a small terminal positivity is labelled as Qr complex
• A complex with complete negativity is termed a QS complex
• A second positivity of the QRS complex is termed an r’-r prime - deflection
• Thus, an rS complex followed by a small terminal positivity is termed an rSr’
complex
• When this terminal sond positivity is relatively tall, the complex is termed
rSR’.
• When the deflection is completely positive and notched , it is termed an RR’
complex
40.
41. THE GENESIS OF THE QRS COMPLEX
• Activation of the ventricles begins in the left subendocardial region of the
lower third of the IVS, spreading transversely from L-> R
• It is opposed by a smaller activation force, which occurs almost synchronously
but fractionally later, and which arises in the right subendocardial region of
the IVS, spreading transversely through the septum from R-> L
• The large L->R force dominates, counteracting the smaller R->L force and
resulting in an effective vector that is directed transversely from L->R
through the lower third of the IVS. This is sometimes referred to as the
septal force or septal vector
42. • Activation of the IVS is then followed by the activation of free walls of both
ventricles. This occurs transversely from the subendocardial to the
subepicardial regions of the free walls of both ventricles.
• This may be represented, in simplified form, by a relatively large force from
R->L through the larger free wall of the LV that occurs synchronously with a
smaller opposing force that is directed from L-> R through the smaller free
wall of the RV.
• The larger R->L force of the free LV wall dominates & counteracts the smaller
L->R force of the free RV wall. This results in an effective or net resultant
vector that is directed from R->L through the free wall of the LV.
• Thus, in very oversimplified terms, activation of the ventricles may be
depicted as a small initial vector from L->R through the IVS, followed by a
larger vector from R->L through the free wall of the LV.
43.
44. THE EFFECT ON A LEFT- ORIENTATED LEAD
A lead orientated to the LV,such as lead V6,lead aVL, or standard lead I, first
senses the relatively small resultant septal vector , which is directed away
from the positive pole of such a lead resulting in a small initial download
deflection - a small q wave
This is followed by the larger resultant vector of the free left wall, which is
directed towards the positive pole of such a lead resulting in a large upward
deflection - a tall R wave
A left -orientated lead thus normally reflects a qR complex (eg.standard laed I
& leads V4,V5 and V6)
45. THE EFFECT ON A RIGHT- ORIENTATED LEAD
A lead orientated to the RV,such as lead V1 or lead V2 ,will first sensethe small
resultant septal vector , which is directed towards it, and will consequently
reflect a small initial upwards deflection - a small r wave
This is followed by the larger resultant vector of the free left wall, which is
directed away from the right orientated lead resulting in a large downwards
deflection - a S wave
A right -orientated lead thus normally reflects a rS complex (eg. leads V1 and
V2)
46.
47. THE TRANSITION ZONE
The transition zone represents the electrocardiographic zone or lead that
reflects the transition from the rS pattern (recorded by right -orientated
laed) to the qR pattern(recorded by left -orientated laed)
It commonly occurs in one or occasionally two, of the midprecordial leads-
generally lead V3 and/or lead V4
The transition pattern is usually an RS complex but, at times, the pattern
may be relatively bizarre,
48. NORMAL T WAVE
• The T wave is a large rounded wave produced by the rapid phase of ventricular
repolarization. The T wave is normally upright in most leads with certain
exceptions.
• It is invariably inverted in lead aVR along with inversion of the P wave and QRS
complex. It is often inverted in lead V1, occasionally in lead V2 V3 and
sometimes in lead LIII
• The normal T wave is taller in lead V6 than in lead V1. The amplitude of the
normal T wave does not generally exceed 5mm in the limb leads and 10mm in the
precordial leads
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59. THE EINTHOVEN TRIANGLE
• We have seen that the standard limb leads are recorded from two limbs at a
time, one carrying the positive electrode and the other,the negative electrode.
• The three standard limb leads (I,II,III) can be seen to form an equilateral
triangle with the heart at the center. This triangle is called the Einthoven
triangle
• To facilitate the graphic representation of electrical forces, the three limbs
of the Einthoven triangle can be redrawn in such a way that the three leads
they represent bisect each other and pass through a common central point.
• This produces a triaxial reference system with each axis seperated by 600
from the other,the lead polarity (+ or -) and direction remaining the same
60.
61. • We have also seen that the augmented limb leads are recorded from one limb at
a time, the limb carrying the positive electrode and the negative pole being
represented by the central point.
• The three augmented limb leads (aVR,aVL,aVF) can be seen to form another
triaxial reference system with each axis being seperated by 600 from one other
• When this triaxial system of unipolar leads is superimposed on the triaxial
system of limb leads, we can derive a hexaxial reference system with each axis
being seperated by 300 from the other.
• Note carefully that each of the six leads retain its polarity(positive and negative
poles) and orientation(lead direction).
• The hexaxial reference system concept is important in determining the major
direction of the heart’s electrical forces p
65. ELECTRICAL AXIS
• The 12 lead ECG can measure the axis of the electrical
flow of energy during the cardiac cycle.
• Cardiac cell depolarization & repolarization produces a
many small electrical currents
• Sum of these currents are called instantaneous vectors
• Average of the instantaneous vectors called mean
vector
66. MEAN ELECTRICAL AXIS
• Direction of the mean vector called the
mean electrical axis
• Axis is defined in the frontal plane only
67.
68.
69.
70.
71.
72.
73. DETERMINATION OF QRS AXIS
METHOD-1
• Find the lead with smallest or equiphasic deflection
• Determine the lead at right angles to the first lead
• See the net deflection in the second lead
• The axis is directed towards the positive or negative pole of the second
lead
74.
75.
76. METHOD-2
For rapid and easy estimation of QRS axis,just scan the direction of the
dominant deflection in leads L1 and aVF whether positive or negative. This
gives us the quadrant in which the QRS axis is located
77.
78.
79. ABNORMALITIES OF QRS AXIS
Normal QRS axis
-300 to +900
Right axis deviation
+900 to +1800
CAUSES :
- Thin tall built
- Chronic lung disease
- Pulmonary embolism
- Ostium secundum ASD
- RVH
- Lateral wall infarction
80. Left axis deviation
-300 to -900
CAUSES:
- Obese stocky built
- WPW syndrome
- Ostium primum ASD
- LVH
- IWMI
North- West QRS axis
-900 to -1800
CAUSES:
- Congenital heart disease
- Left vevtricular aneurysm
SYNONYMS: Indeterminate QRS axis, Extreme right axis deviation, NO MAN’S LAND