The coronary circulation refers to the blood vessels that supply and drain the heart. The heart receives its blood supply from two coronary arteries - the left and right coronary arteries. The left coronary artery supplies the left side of the heart including parts of the left atrium and ventricle. It branches into the anterior interventricular artery and circumflex artery. The right coronary artery supplies the right side of the heart and parts of the left side. It has branches like the right marginal artery and posterior interventricular artery. Deoxygenated blood from the heart drains into the coronary sinus and other cardiac veins before emptying into the right atrium.
This presentation is an overview of the description of the 4 stages of the cardiac cycle (atrial diastole, atrial systole, ventricular systole, ventricular diastole) as well as explaining the mechanism of the cardiac cycle.
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
This presentation is an overview of the description of the 4 stages of the cardiac cycle (atrial diastole, atrial systole, ventricular systole, ventricular diastole) as well as explaining the mechanism of the cardiac cycle.
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
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Anatomy And Physiology of Human Heart
1. ANATOMY OF THE HEART By: Dr Mohammed Faez
2. The Heart The heart is a chambered muscular organ that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system.
3. The Heart • The heart is surrounded by membrane called Pericardium.
4. The Pericardium • The pericardium is a fibroserous sac that encloses the heart and the roots of the great vessels. • The pericardium lies within the middle mediastinum.
5. The Pericardium
6. The Pericardium • Its function is to restrict excessive movements of the heart as a whole and to serve as a lubricated container in which the different parts of the heart can contract.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. The coronary circulation
• The coronary circulation refers to the
vessels that supply and drain the heart.
• Coronary arteries are named as such
due to the way they encircle the heart,
much like a crown.
• An arterial circle surrounds the heart in
coronary(AV) sulcus. From this arterial
circle an arterial loop runs in the
anterior & inferior interventricular
grooves.
4.
5. The Arterial Supply of the Heart
• The Arterial Supply of the Heart is mostly supplied
by 2 coronary arteries, which originate from the
ascending aorta immediately above the aortic valve
from the aortic sinuses.
• The coronary arteries and their branches run on the
surface of heart being located inside the
subpericardial fibrofatty tissue.
– A. Coronary arteries are vasa vasorum of the
ascending aorta.
– B. Anatomically coronary arteries are not end-arteries
but functionally they behave like end-arteries.
6. A. Like the pulmonary valve, the aortic valve has three semilunar cusps: right, posterior, and
left. Each cusp has a fibrous nodule at the midpoint of its free edge and a thin connective
tissue area, the lunule, to each side of the nodule.
B. Blood ejected from the left ventricle forces the cusps apart.
C. When the valve closes, the nodules and lunules meet in the center. The coronary arteries
arise from the right and left aortic sinuses (spaces superior to the cusps).
7. Coronary Arteries
• There are two main coronary arteries which branch
to supply the entire heart.
• They are named the left and right coronary arteries,
and arise from the left and
right aortic sinuses within the aorta.
• The aortic sinuses are small openings found within
the aorta behind the left and right flaps of
the aortic valve.
• When the heart is relaxed, the back-flow of blood
fills these valve pockets, therefore allowing blood to
enter the coronary arteries.
8. Characteristics of coronary arteries
–A. Coronary arteries are vasa vasorum of
the ascending aorta.
–B. Anatomically coronary arteries are not
end-arteries but functionally they behave
like end-arteries.
–C. The only branches of ascending aorta.
–D. The only arteries which get filled up
during diastole of heart.
15. The left coronary artery
• The left coronary artery, which is usually larger
than the right coronary artery, supplies the
major part of the heart, including
–The greater part of the left atrium,
–Left ventricle, and
–Interventricular septum.
• The left coronary artery originates from the left
posterior aortic sinus of the ascending aorta,
immediately above the aortic valve.
16. The left coronary artery course
• After arising from ascending aorta, the left coronary artery
runs forwards and to the left between the pulmonary trunk
and the left auricle.
• It then divides into an anterior interventricular and circumflex
artery.
• The anterior interventricular artery (left anterior
descending/LAD) runs downwards in the anterior
interventricular groove to the apex of the heart. It then enters
posteriorly around the apex of the heart to go into the
posterior interventricular groove to terminate by
anastomosing with the posterior interventricular artery which
is a branch of the right coronary artery.
• The circumflex artery winds around the left margin of the
heart and continues in the left posterior coronary sulcus up to
the posterior interventricular groove where it ends by
anastomosing with the right coronary artery.
17. BRANCHES AND DISTRIBUTION
• 1) Anterior interventricular artery (or left anterior
descending (LAD) artery):
It supplies :
– (a) anterior part of interventricular septum,
– (b) greater part of the left ventricle and part of right
ventricle,
– (c) a part of left bundle branch (of His)
• 2) Circumflex artery: It supplies a left marginal artery
that provides the left margin of the left ventricle up to
the apex of the heart.
• 3) Diagonal artery: It may originate directly from the
trunk of the left coronary artery.
• 4) Conus artery: It supplies the pulmonary conus.
• 5) Atrial branches: They supply the left atrium.
19. Right coronary artery
• The right coronary artery (RCA) arises from the right
aortic sinus of the ascending aorta.
• Passes to the right of the pulmonary trunk and
runs along the coronary sulcus before branching.
• Near its origin, the RCA usually gives off an
ascending sinuatrial nodal branch, which supplies
the SA node.
• The right marginal artery arises and moves along
the right and inferior border of the heart towards
the apex.
21. Right coronary artery
• The right coronary artery
is angiographically divided into
three segments:
• 1st segment:(from the origin to the first curve);
– Passes forward for a distance. i.e. between pulmonary trunk(to its
left) & right auricle(to its right).
• 2nd segment:(first curvature to a second curvature);
– Lies in the anterior part of AV groove.i.e. on sternocostal surface
between right auricle right ventricle.
• 3rdsegment:(from the second curve to the crux cordis).
– Lies in the posterior part of AV groove.
22. Right coronary artery
Branches
1. An early atrial branch passes in the groove between the right
auricle and ascending aorta.
2. The sinu-atrial nodal branch, which passes posteriorly around the
superior vena cava to supply the sinu-atrial node;
3. A right marginal branch is given off as the right coronary artery
approaches the inferior (acute) margin of the heart and continues
along this border toward the apex of the heart;
4. A small branch to the atrioventricular node before giving off its final
major branch.
5. The posterior interventricular branch, which lies in the posterior
interventricular sulcus.
23. Area supplied
• The right coronary artery supplies
– The right atrium and right ventricle,
– The sinu-atrial and atrioventricular nodes,
– The interatrial septum,
– A portion of the left atrium,
– The posteroinferior one-third of the
interventricular septum, and
– A portion of the posterior part of the left
ventricle.
24.
25. Variations of the Coronary Arteries
• In the most common right dominant pattern, present in
approximately 67% of people. The posterior interventricular
branch arises from the right coronary artery.
• In approximately 15% of hearts, left dominance the Left
Coronary Artery is dominant in that the posterior
interventricular branch is a branch of the circumflex artery.
• There is codominance in approximately 18% of people, in
which branches of both the right and left coronary arteries
give rise to branches that course in or near the posterior IV
groove.
• Approximately 4% of people have an accessory coronary
artery.
• Another point of variation relates to the arterial supply to the
sinu-atrial and atrioventricular nodes. In most cases, these
two structures are supplied by the right coronary artery.
26.
27.
28. Artery Region supplied Vein draining region
Right coronary Right atrium
SA and AV nodes
Posterior part of interventricular septum (IVS)
Small cardiac vein
Middle cardiac vein
Right marginal Right ventricle
Apex
Small cardiac vein
Middle cardiac vein
Posterior
interventricular
Right ventricle
Left ventricle
Posterior 1/3 of IVS
Left posterior ventricular
vein
Left coronary Left atrium
Left ventricle
IVS
AV bundles
Great cardiac vein
Left anterior
descending
Right ventricle
Left ventricle
Anterior 2/3 IVS
Great cardiac vein
Left marginal Left ventricle Left marginal vein
Great cardiac vein
Circumflex Left atrium
Left ventricle
Great cardiac vein
29.
30.
31. MAJOR BRANCHES OF THE LEFT AND
RIGHT CORONARY ARTERIES
Right coronary artery Left coronary artery
Right marginal artery
Anterior interventricular
artery
Posterior interventricular
artery
Circumflex artery
Sinuatrial nodal artery Diagonal artery
32. Coronary Heart Disease
• Coronary artery disease or coronary heart disease (CHD) is
a leading cause of death worldwide. It describes a
reduction in blood flow to the myocardium and has several
causes and consequences.
• CHD can result due to atherosclerosis, thrombosis, high
blood pressure, diabetes or smoking. All these factors lead
to a reduced flow of blood to the heart through physical
obstruction or changes in the vessel wall.
• Angina pectoris describes the transient pain a person may
feel on exercise as a result of lack of oxygen supplied to the
heart. This pain is felt across the chest but is quickly
resolved upon rest.
– If left untreated, angina can soon progress to more severe
consequences, such as a myocardial infarction.
36. Venous drainage of heart
• Venous blood from the heart is drained
into right atrium by the following:
• A. Coronary sinus.
• B. Anterior cardiac veins.
• C. Venae cordisminimae (Thebesian
veins).
37. Cardiac Veins
• Blood travels from the subendocardium into
the Thebesian veins, which are small tributaries
running throughout the myocardium.
• These in turn drain into larger veins that empty into
the coronary sinus.
• The coronary sinus is the main vein of the heart,
located on the posterior surface in the coronary sulcus,
which runs between the left atrium and left ventricle.
• The sinus drains into the right atrium.
• Within the right atrium, the opening of the coronary
sinus is located between the right atrioventricular
orifice and the inferior vena cava orifice.
38. CORONARY SINUS
• Tributaries: The coronary sinus gets the following tributaries:
• A. Great cardiac vein: It accompanies anterior interventricular and
circumflex arteries to join the left end of the coronary sinus.
• B. Middle cardiac vein: It accompanies the posterior interventricular artery
and joins the coronary sinus near its termination.
• C. Small cardiac vein: It accompanies the right ventricular artery in the right
posterior coronary sulcus and the right end of the coronary sinus.
• D. Posterior vein of the left ventricle: It runs on the diaphragmatic surface
of the left ventricle and joins the sinus to the left of the middle cardiac vein.
• E. Oblique vein of the left atrium (Vein of Marshall): It’s a small vein which
runs downwards on the posterior surface of the left atrium to goes into the
left end of the coronary sinus. It develops from the left common cardinal
vein (duct of Cuvier).
• F. Right marginal vein: It accompanies the marginal branch of the right
coronary artery and joins the small cardiac vein or drains directly into the
right atrium.
• G. Left marginal vein: It accompanies the marginal branch of the left
coronary artery and drains into the coronary sinus
39. VEINS OF HEART WHICH DO NOT
OPEN INTO C0RONARY SINUS
1. ANTERIOR CARDIAC VEINS
• These are series of small veins (3 or 4) which run
parallel to every other across the surface of right
ventricle to open into the right atrium.
2. VENAE CORDISMINIMAE (THEBESIAN VEINS)
• All these are extremely small veins in the walls of all
the 4 chambers of the heart. These open directly
into the respective chambers. These are most
numerous in the right atrium.