Composition,Brand & Price

1. Use of antifungal in
poultry and ruminant

2. content
Chemical
composition
Mode of
action
Market
name
Dosage
Price

3. List of antifungal
 Drugs for systemic fungal infections
 Polyene antibiotics
 Amphotericin B
 Nystatin
 Antifungal azoles
 triazole(Fluconazole, Itraconazole)
 Imidazole( ketonazole, miconazole,econazole)
 Drugs for superficial fungal infections
 Systemic drugs
 Griseofulvin
 Iodide
 Topical drugs
 Nystatin

4. AMPHOTERICIN B
 Chemical composition
 -Amphotericin B is a polyene antifungal containing many double bonds and large
lactone ring
 Formula C47H73NO17
 Mode of action .
 Bind irreversibly to egrosterol, in disruption of membrane integrity
 And ultimately cell death
 for treatment of lesion in lungs and air sacs in poultry
 aspergillosis in poultry
 For Mastitis in cow
 Brand name
 Fungizone I.V,fungsome (50mg),
Amphotericin
 Dosage
 In poultry concentration is ranging from 0.03 to 1mcg/ml/kg
 Price. 50 -100 in PKR

5. Antifungal azoles
 -Imidazole derivatives: ketoconazole, miconazole, econazole,
clotrimazole
 -Triazole derivatives: itraconazole, fluconazole.
 Chemical composition
 Five member heterocyclic compound contain a nitrogen atom and at
least one other non carbon atom

6. Mode of action
 -Inhibition of sterol 14-alpha-demethylase, a cytochrome P450-dependent enzyme

 blockade of the synthesis of ergosterol in fungal cell membranes
 -The ultimate effect may be fungicidal or fungistatic depending on the organism and on
drug concentration
 KETONAZOLE AND ITRACONAZOLE
 for treatment of mycotic abortion in cattle
 Fusarium species growing on stored maize , barley and pelleted cereal feed that cause
infertility in ruminants
 ITRACONAZOLE and FLUCONAZOLE
 for severe candidiasis in chicken, turkey
 Crop harvested during wet seasons , some aspergillus species (A.flavus) grow on that
cause haemorrhgaic diathesis in poultry
 Brand name
 Onmel, lotrimin
 Dosage: in poultry fluconazole 50mg/5ml powder for oral suspension
 In cattle fluconazole 250mg/kg of diet
 Price. Rs 350 rupees

7. systematic antifungal
 GRISEOFULVIn
 Chemical composition(formula)
 Griseofulvin is a benzofuran derivative
 The drug is practically insoluble in water
 Mode of action
 Griseofulvin bind with mycrotubules protein result disruption of mitosis spindle formation
 The ultimate effect is fungistatic
 For dermatophyte infection treatment
 Ring worm treatment in calves
 Ring worm in cattle and horse
 Brand name
 Griseofulvin, Gris-PEG
 Dosage:
 oral suspension 125mg/5ml
 Price:
 50-256 rupees

8. Systematic antifungal
 IODIDE
 Chemical formula
 Potassium iodide (KI)and Sodium iodide(NaI)
 Mode of action
 There mode of action is not well understood
 Enhancement of immune responses against fungal has been suggest
 For treatment of actinomycosis(lump jaw) in cattle
 Market name
 Potassium iodide, sodium iodide
 Dosage
 Potassium iodide 6 to 10g/day for 7 to 10 days given orally to cattle
 Sodium iodide 70mg/kg can be given intravenously
 Price: Rs 50-85 rupees

9. TOPICAL ANTIFUNGAL DRUGS
 Nystatin
 Chemical composition
 C14H75NO17
 Mode of acion
 A polyene antifungal useful only for local candidiasis
 To treat oral or GIT candidiasis(sour crop) in poultry
 Brand name
 SALINOSE, Nistatin, fungicidin
 Dosage:
 1ml/300g added to feed twice a day for 7 days
 in the feed (220 mg/kg of diet) or drinking water (62.5–250 mg/L with sodium lauryl sulfate, a
surfactant, at 7.8–25 mg/L) for 5 days may be effective for the treatment of affected turkeys.
 Price:
 SALINOSE 12.75 rupees

10. Topical antifungal
Haloprogin
 Chemical composition
 halogenated phenolic ether
 Formula C9H4Cl3IO
 Brand name
 halotex( westwood), polik, haloprogie
 Mode of action
 The drug is fungicidal to various species of dermatophytes and candida in cattle and
in poultry
 Dosage
 In poultry 50mg/5ml
 In cattle 200mg/kg
 Price
 250-300 rupees

11. Azoles

12. Antifungal

13. feed used as antifungal
Clove: containing eugenol, a yeast killer
Ginger: anti-candida fain gingerol that support
the liver by detoxifying candida
Garlic: contain sulphric allicin act as antifungal
Coconut: contain caprylic acid and lauric
acid which kill yeast
Potassium iodide: used as antifungal in
ruminants

14. THANKS