This document discusses trematode infections, including their classification, life cycles, clinical manifestations, investigations, management, and prevention. It focuses on major human trematode infections caused by blood flukes (Schistosoma spp.), liver flukes (Clonorchis sinensis and Opisthorchis spp.), intestinal flukes (Fasciolopsis buski), and lung flukes (Paragonimus westermani). Symptoms vary depending on the infecting organism but can include dermatitis, abdominal pain, bloody stool, hepatosplenomegaly, cough, and pulmonary symptoms. Diagnosis involves microscopy of stool, urine, or sputum samples, serology to detect antibodies or
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
After showing this Presentation you will able to differentiate between each type of intestinal parasite in cattle.
In this Presentation we will study the life cycle of each type
And we will able to make control ,prevention and treatment of each type
Zoonotic parasite; Toxoplasma is an opportunistic pathogen.
Infects animals, cattle, birds, rodents, pigs, and sheep.
and humans.
Causes the disease Toxoplasmosis
Clonorchis sinensis
Prepared by:
Shafqat Hussain
Taxonomy
Kingdome : Animalia
Phylum : Platyhelminths
Class : Trematoda
Order : Opisthorchiida
Family : Opisthorchiidae
Genus : Clonorchis
Species : C. sinensis
Introduction
•
Clonorchis is also known as the Chinese or oriental liver fluke.
Clonorchis is a liver fluke parasite (trematode or worm) that can
infect the liver, gallbladder, and bile duct.
food born parasite
Host
Definitive Hosts
First intermediate host must always be a snail, mainly
Parafossarulus manchouricus
Life cycle
•
Clonorchis sinensis eggs are discharged in the biliary ducts and in
the stool in an embryonated state
Eggs are ingested by a suitable snail (P. manchouricus)
intermediate host
Eggs release miracidia
which go through several developmental stages (sporocysts, rediae, and
cercariae).
The cercariae are released from the snail and, after a short period
of free-swimming time in water, they come in contact and
penetrate the flesh of freshwater fish, where they encyst as
metacercariae
Infection of humans occurs by ingestion of under cooked, salted,
pickled, or smoked freshwater fish
After ingestion, the metacercariae excyst in the duodenum
and ascend the biliary tract through the ampulla of Vater
Maturation takes approximately one month. The adult flukes
(measuring 10 to 25 mm by 3 to 5 mm) reside in small and
medium sized biliary ducts.
they lay eggs in intestine
the embryonated eggs release in stool.
The eggs are embryonated and contain the larvae called miracidia.
The sporocyst resembles a hollow and simple sac.
Oftentimes, the developing rediae are visible inside the sac.
Redia - At this larval stage, it retains a very simple worm structure.
In some ways, it still resembles a sac.
Pathogenesis
Liver flukes infect the liver, gallbladder, and bile duct in humans.
inflammation in biliary epithelium
Laboratory Findings
Blood routine test: eosinophilia, anemia in severe infection
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
After showing this Presentation you will able to differentiate between each type of intestinal parasite in cattle.
In this Presentation we will study the life cycle of each type
And we will able to make control ,prevention and treatment of each type
Zoonotic parasite; Toxoplasma is an opportunistic pathogen.
Infects animals, cattle, birds, rodents, pigs, and sheep.
and humans.
Causes the disease Toxoplasmosis
Clonorchis sinensis
Prepared by:
Shafqat Hussain
Taxonomy
Kingdome : Animalia
Phylum : Platyhelminths
Class : Trematoda
Order : Opisthorchiida
Family : Opisthorchiidae
Genus : Clonorchis
Species : C. sinensis
Introduction
•
Clonorchis is also known as the Chinese or oriental liver fluke.
Clonorchis is a liver fluke parasite (trematode or worm) that can
infect the liver, gallbladder, and bile duct.
food born parasite
Host
Definitive Hosts
First intermediate host must always be a snail, mainly
Parafossarulus manchouricus
Life cycle
•
Clonorchis sinensis eggs are discharged in the biliary ducts and in
the stool in an embryonated state
Eggs are ingested by a suitable snail (P. manchouricus)
intermediate host
Eggs release miracidia
which go through several developmental stages (sporocysts, rediae, and
cercariae).
The cercariae are released from the snail and, after a short period
of free-swimming time in water, they come in contact and
penetrate the flesh of freshwater fish, where they encyst as
metacercariae
Infection of humans occurs by ingestion of under cooked, salted,
pickled, or smoked freshwater fish
After ingestion, the metacercariae excyst in the duodenum
and ascend the biliary tract through the ampulla of Vater
Maturation takes approximately one month. The adult flukes
(measuring 10 to 25 mm by 3 to 5 mm) reside in small and
medium sized biliary ducts.
they lay eggs in intestine
the embryonated eggs release in stool.
The eggs are embryonated and contain the larvae called miracidia.
The sporocyst resembles a hollow and simple sac.
Oftentimes, the developing rediae are visible inside the sac.
Redia - At this larval stage, it retains a very simple worm structure.
In some ways, it still resembles a sac.
Pathogenesis
Liver flukes infect the liver, gallbladder, and bile duct in humans.
inflammation in biliary epithelium
Laboratory Findings
Blood routine test: eosinophilia, anemia in severe infection
DISCLAIMER: No copyright infringement intended. Images are not mine and all copyrights belong to their respective owners. This pdf file is not for sale and for educational purposes only.
This is a slide presentation for MBBS students. a brief overview of hemochromatosis, an iron overload condition. overview of hemochromatosis, pathophysiology, clinical features, approach, and management
Liver transplantation; notes of DM/DNB/SpecialistsPratap Tiwari
Liver transplantation; extensive notes of DM/DNB/Specialists. This was my notes for my exam compiled from several sources, credit goes to original authors. This is just for quick revision
This is a lecture note for 5th-semester MBBS students. Lecture notes on hepatology, liver disease, and liver abscess. Introduction to a liver abscess, pyogenic liver abscess, causes, approach and management of liver abscess.
This is a lecture note for 5th semester MBBS students. Lecture notes on hepatology, liver disease, alcoholic liver disease, alcohol-related liver disease, portal hypertension, hepatic encephalopathy, and acute liver failure. Introduction to acute liver failure, causes, approach, and management of acute liver failure .
This is a lecture note for 5th semester MBBS students. Lecture notes on hepatology, liver disease, alcoholic liver disease, alcohol-related liver disease, portal hypertension, and hepatic encephalopathy. Introduction to hepatic encephalopathy, causes, differentials, approach, and management of hepatic encephalopathy .
This is a lecture note for 5th semester MBBS students. Lecture notes on hepatology, liver disease, alcoholic liver disease, alcohol-related liver disease, alcoholic hepatitis, portal hypertension, ascites. Introduction to ascites and management of ascites.
This is a lecture note for 5th semester MBBS students. Lecture notes on hepatology, liver disease, alcoholic liver disease, alcohol-related liver disease, portal hypertension, ascites. Introduction to ascites and management of ascites.
brief lecture notes for 5th sem MBBS, on portal hypertension and varices. Introduction to portal hypertension and esophageal and gastric varices and management of variceal bleeding.
Chronic liver disease, lecture presentation for 5th sem MBBS students. Introduction to chronic liver disease, notes on liver fibrosis, alcoholic hepatitis, liver histology and overview.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
3. MAJOR HUMAN TREMATODE INFECTIONS
Blood flukes Liver flukes
Schistosoma mansoni
S. Japonicum
S. Intercalatum
S. Mekongi
S. Haematobium
Clonorchis sinensis
Opisthorchis viverrini
O. Felineus
Faciola hepatica
F. gigantica
Intestinal flukes Lung flukes
Fasciolopsis buski Paragonimus westermani
5. CLINICAL MANIFESTATIONS: SCHISTOSOMIASIS
Acute manifestations
• Cercarial dermatitis (summer’s itch):is an allergic reaction caused by the
penetration of cercariae in persons who have been exposed to cercariae in
salt water or fresh water.
• Swimmer’s itch most often occurs in S .mansoni and S. japonicum.
• Manifested as petechial hemorrhage with edema and pruritus followed by
maculopapular rashes and sometimes vesicular.
• It is self limiting
6. CLINICAL MANIFESTATIONS: SCHISTOSOMIASIS
Acute manifestations
• Katayama syndrome: This syndrome is caused by high worm load and egg
antigen stimuli that result from immune complex formation and leads to a
serum sickness–like illness.
• This is the most severe form and is most common in persons with S
mansoni and S japonicum infections.
• Symptoms include high fever, chills, headache, hepatosplenomegaly,
lymphadenopathy, eosinophilia, and dysentery.
7. CLINICAL MANIFESTATIONS: SCHISTOSOMIASIS
Chronic manifestations
• Symptoms depend on the Schistosoma species that causes the infection, the
duration and severity of the infection, and the immune response of the host
to the egg antigens.
• Terminal hematuria, dysuria, and frequent urination .
• The earliest bladder sign is pseudotubercle, but, in longstanding infection,
radiography reveals nests of calcified ova (sandy patches) surrounded by
fibrous tissue in the submucosa.
8. CNS SCHISTOSOMIASIS
• Headache, seizures (both generalized and focal), myeloradiculopathy with
lower limb and back pain, paresthesia, and urinary bladder dysfunction are
the noted symptoms of CNS schistosomiasis due to S japonicum infection.
• Neuroschistosomiasis is a severe manifestation of schistosomal infection.
The neurological symptoms result from the inflammatory response of the
host to the deposition of eggs in the brain and spinal cord.
• Myelopathy is the most common neurological complication of S.
mansoni infection.
9. SUMMARY OF MANIFESTATIONS
Organisms Symptoms
Blood flukes
S. mansoni, S. japonicum Dermatitis, abdominal pain, bloody stool, peri-portal
fibrosis, hepato-splenomegaly, ascites, CNS
Schistosoma hematobium Dermatitis, urogenital cystitis, urethritis and bladder
carcinoma
Liver flukes
C. sinensis,
O. felinus, or O. viverini
Inflammation and deformation of bile duct, hepatitis,
anemia and edema
Fasciola hepatica fever, anemia, hepatobiliary manifestations (colicky pain,
jaundice), and secondary bacterial infections are present.
15. PREVENTION
• Information, education and communication on safe food practices.
• Improved sanitation, aimed at decreasing contamination of freshwater
streams with human faeces.
• Control or containment of the intermediate snail hosts.
• Preventive chemotherapy ??
• Vaccination ??
16. TREMATODES INFECTION IN NEPAL
• Includes Fasciola spp., and Schistosoma spp. (Patz et al. 2000, Dobson et
al. 2003, Mas-Coma et al. 2009)
• The highest prevalence of infection (38.3%) was recorded among snails (I.
exustus)collected from temporary ponds in chitwan.(Devkota et al 2008)
• 1.7% infection rate of Fasciola sp. larvae in Lymnaea sp. of snail from Kavre,
Nepal (Pandey 2001)
• 3.52% rate of patent trematode infections in Chitwan and Nawal parasi
districts of Nepal (Devkota et al 2008).
17. Thankyou
References:
• Harrison’s principles of internal medicine 18h ed
• Davidson Principles & Practice of medicine
• Uptodate 19.3
• Emedicine.com last update sept 2012
Respected professor,senirs n colleghes
Trematodes,flatworms or commonly called as flukes are heterogenous group of organisms that belong to the phylum platyhelmenthis.human infections with trematodes occurs in many geographic areas worldwide inclding nepal.The victim of the infections are either the travellers to the endemic areas or the habitants of that area.
today myself,rajeev shah and prakash naag are doing a combine seminar preseentation on this topic.
I will b talking about introduction,classification and clinical features regarding trematodes infections .prakaas naag will brief on its transmission and life cycle and rajeev shah will tell about its investigation,diagnosis and management.
The trematodes or flukes are estimated to include 18,000[1] to 24,000[2] species, and Nearly all trematodes are parasites of mollusks and
vertebrates.,
For clinical purposes,significant trematode infections of humans are divided according to the tissues they invade.blood ,intestinnes, lunhs and livern the biliary tree.
So thus the major trematode infections in humans can be summarised as blood flukes, liver flukes, intestinal flukes and the lung flukes.
Among the blood flukes the major ones with clinical importance are s mansoni and s hematobium.
Among the liver flukes are the clonorchis sines and faciola hepatica.
Among the intestinal flukes are fasciolopsis buski
And among the lung fluke is paragonimus westermani.
The schistosoma infections or better termed as schistosomiasis are different from the other flukes in the senese that all the other flukes are hermaphrodite ie each fluke has both male and female organs but schistosomas are digenetic means they are of separate sexes.
The other point is schistosomas enter he host body thro skin penetration while the other are ingested by the host which will be explained in setail by prakash naag.
Almost all flukes have intermediate host as snails and definitive host as humans.and
Almost all flukes are excreted in stool except the s haematobium whose ova/adults are excreted in urine and in the lung flukes it is excreted in sputum as well.
Schistosomiasis affects about 200 million people worldwide, and more than 650 million people live in endemic areas. Worldwide, more than 250 million people in 74 countries are infected.
Clonorchiasis is believed to be the third most prevalent worm parasite disease in the world. It is endemic to Japan, China, Taiwan, and South Asia and is currently infecting an estimated 30,000,000 humans.
A host cell is a living cell in which a virus reproduces.[1]
A primary host or definitive host is a host in which the parasite reaches maturity and, if possible, reproduces sexually.
A secondary host or intermediate host is a host that harbors the parasite only for a short transition period, during which (usually) some developmental stage is completed
Trematodiasis: Infestation or infection with trematodes, often caused by ingestion of inadequately cooked food.
Eggs are eliminated with feces or urine(1) . Under optimal conditions the eggs hatch and release miracidia (2), which swim and penetrate specific snail intermediate hosts(3) . The stages in the snail include 2 generations of sporocysts (4) and the production of cercariae(5) . Upon release from the snail, the infective cercariae swim, penetrate the skin of the human host(6) , and shed their forked tail, becoming schistosomulae(7) . The schistosomulae migrate through several tissues and stages to their residence in the veins (8,9 ). Adult worms in humans reside in the mesenteric venules in various locations, which at times seem to be specific for each species(10) . For instance, S. japonicum is more frequently found in the superior mesenteric veins draining the small intestine(a) , andS. mansoni occurs more often in the superior mesenteric veins draining the large intestine(b) . However, both species can occupy either location, and they are capable of moving between sites, so it is not possible to state unequivocally that one species only occurs in one location. S. haematobium most often occurs in the venous plexus of bladder(c) , but it can also be found in the rectal venules. The females (size 7 to 20 mm; males slightly smaller) deposit eggs in the small venules of the portal and perivesical systems. The eggs are moved progressively toward the lumen of the intestine (S. mansoni and S. japonicum) and of the bladder and ureters (S. haematobium), and are eliminated with feces or urine, respectively(1) . Pathology of S. mansoni and S. japonicum schistosomiasis includes: Katayama fever, presinusoidal egg granulomas, Symmers’ pipe stem periportal fibrosis, portal hypertension, and occasional embolic egg granulomas in brain or spinal cord.
Because of the large numbers of people infected worldwide, trematode infections can cause considerable morbidity.
Many of the trematode infections, such as schistosomiasis, clonorchiasis, and pulmonary paragonimiasis, can be fatal if left untreated. Infection with intestinal trematodes is rarely fatal.
No racial predisposition to trematode infections is apparent.
Most trematode infections have no sexual predisposition.
Most trematode infections affect people of all ages equally. However, with intestinal trematode infections, children are affected more severely, as are children and adolescents with schistosomiasis.
Schistosomiasis
Acute manifestations
Cercarial dermatitis, also known as swimmer's itch, is an allergic reaction caused by the penetration of cercariae in persons who have been exposed to cercariae in salt water or fresh water. Cercarial dermatitis manifests as petechial hemorrhages with edema and pruritus, followed by maculopapular rash, which may become vesicular.
Katayama syndrome corresponds to maturation of the fluke and the beginning of oviposition. This syndrome is caused by high worm load and egg antigen stimuli that result from immune complex formation and leads to a serum sickness–like illness. This is the most severe form and is most common in persons with S mansoni and S japonicum infections. Symptoms include high fever, chills, headache, hepatosplenomegaly, lymphadenopathy, eosinophilia, and dysentery.
Chronic manifestations
Symptoms depend on the Schistosoma species that causes the infection, the duration and severity of the infection, and the immune response of the host to the egg antigens.
Terminal hematuria, dysuria, and frequent urination are the main clinical symptoms of urinary schistosomiasis.
The earliest bladder sign is pseudotubercle, but, in longstanding infection, radiography reveals nests of calcified ova (sandy patches) surrounded by fibrous tissue in the submucosa.
Dysentery, diarrhea, weakness, and abdominal pain are the major symptoms of intestinal schistosomiasis.
A reaction to schistosomal eggs in the liver causes a periportal fibrotic reaction termed Symmers clay pipestem fibrosis.
Hemoptysis, palpitation, and dyspnea upon exertion are the symptoms of schistosomal cor pulmonale that develops as a complication of hepatic schistosomiasis.
Headache, seizures (both generalized and focal), myeloradiculopathy with lower limb and back pain, paresthesia, and urinary bladder dysfunction are the noted symptoms of CNS schistosomiasis due to S japonicum infection.
Neuroschistosomiasis is a severe manifestation of schistosomal infection. The neurological symptoms result from the inflammatory response of the host to the deposition of eggs in the brain and spinal cord. Myelopathy is the most common neurological complication of Smansoni infection.[
Vaccine studies for faciola hepatica in animal models have shown reduction in worm burdens and egg production of approximately 70 percent, but vaccines for human use are not yet available
Faciola hepatics : nitazoxanide, artesunate, Bithionol (in the past)
Praziquental: there is experimental evidence that praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. The drug thereby induces contraction of the parasites, resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis).
Intestinal fluke;fasciolopsiasis;bamboo shoot,water cress(sim rayo), water chestnuts(makhan)
The highest prevalence of infection (38.3%) was recorded among snails collected from temporary ponds in chitwan.
This potentially includes Fasciola spp., Schistosoma spp. and Paramphistomum spp. in Nepal
Patz et al. 2000, Dobson et al. 2003, Mas-Coma et al. 2009
Eggs are eliminated with feces or urine(1) . Under optimal conditions the eggs hatch and release miracidia (2), which swim and penetrate specific snail intermediate hosts(3) . The stages in the snail include 2 generations of sporocysts (4) and the production of cercariae(5) . Upon release from the snail, the infective cercariae swim, penetrate the skin of the human host(6) , and shed their forked tail, becoming schistosomulae(7) . The schistosomulae migrate through several tissues and stages to their residence in the veins (8,9 ). Adult worms in humans reside in the mesenteric venules in various locations, which at times seem to be specific for each species(10) . For instance, S. japonicum is more frequently found in the superior mesenteric veins draining the small intestine(a) , andS. mansoni occurs more often in the superior mesenteric veins draining the large intestine(b) . However, both species can occupy either location, and they are capable of moving between sites, so it is not possible to state unequivocally that one species only occurs in one location. S. haematobium most often occurs in the venous plexus of bladder(c) , but it can also be found in the rectal venules. The females (size 7 to 20 mm; males slightly smaller) deposit eggs in the small venules of the portal and perivesical systems. The eggs are moved progressively toward the lumen of the intestine (S. mansoni and S. japonicum) and of the bladder and ureters (S. haematobium), and are eliminated with feces or urine, respectively(1) . Pathology of S. mansoni and S. japonicum schistosomiasis includes: Katayama fever, presinusoidal egg granulomas, Symmers’ pipe stem periportal fibrosis, portal hypertension, and occasional embolic egg granulomas in brain or spinal cord.