Enzymes have several key characteristics:
1) They speed up chemical reactions by lowering the activation energy needed.
2) They are required in minute amounts and remain unchanged after reactions.
3) They are highly specific, with each enzyme having a unique three-dimensional structure that only binds complementary substrates.
Their activity is also affected by temperature and pH - they have optimal temperatures and pH levels at which they are most active, and are deactivated outside these ranges. Some enzymes also require co-factors to function or can catalyze reversible reactions.
Active sites of the enzyme is that point where substrate molecule bind for the chemical reaction. It is generally found on the surface of enzyme and in some enzyme it is a “Pit” like structure
The active site is a three-dimensional cleft formed by groups that come from different parts of the amino acid sequence
The active site takes up a relatively small part of the total volume of an enzyme
Active sites are clefts or crevices
Substrates are bound to enzymes by multiple weak attractions.
The specificity of binding depends on the precisely defined arrangement of atoms in an active site.
Active sites of the enzyme is that point where substrate molecule bind for the chemical reaction. It is generally found on the surface of enzyme and in some enzyme it is a “Pit” like structure
The active site is a three-dimensional cleft formed by groups that come from different parts of the amino acid sequence
The active site takes up a relatively small part of the total volume of an enzyme
Active sites are clefts or crevices
Substrates are bound to enzymes by multiple weak attractions.
The specificity of binding depends on the precisely defined arrangement of atoms in an active site.
A comprehensive coverage of Enzymes including basics, mechanisms of enzyme catalysis, enzyme inhibition and clinical applications, mostly based on Stryer- Biochemistry. The slides were intended for MBBS teaching, but should benefit the students of Biochemistry and allied sciences.
Prepared in Sept 2015
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Sustainability has become an increasingly critical topic as the world recognizes the need to protect our planet and its resources for future generations. Sustainability means meeting our current needs without compromising the ability of future generations to meet theirs. It involves long-term planning and consideration of the consequences of our actions. The goal is to create strategies that ensure the long-term viability of People, Planet, and Profit.
Leading companies such as Nike, Toyota, and Siemens are prioritizing sustainable innovation in their business models, setting an example for others to follow. In this Sustainability training presentation, you will learn key concepts, principles, and practices of sustainability applicable across industries. This training aims to create awareness and educate employees, senior executives, consultants, and other key stakeholders, including investors, policymakers, and supply chain partners, on the importance and implementation of sustainability.
LEARNING OBJECTIVES
1. Develop a comprehensive understanding of the fundamental principles and concepts that form the foundation of sustainability within corporate environments.
2. Explore the sustainability implementation model, focusing on effective measures and reporting strategies to track and communicate sustainability efforts.
3. Identify and define best practices and critical success factors essential for achieving sustainability goals within organizations.
CONTENTS
1. Introduction and Key Concepts of Sustainability
2. Principles and Practices of Sustainability
3. Measures and Reporting in Sustainability
4. Sustainability Implementation & Best Practices
To download the complete presentation, visit: https://www.oeconsulting.com.sg/training-presentations
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Enterprise Excellence is Inclusive Excellence.pdfKaiNexus
Enterprise excellence and inclusive excellence are closely linked, and real-world challenges have shown that both are essential to the success of any organization. To achieve enterprise excellence, organizations must focus on improving their operations and processes while creating an inclusive environment that engages everyone. In this interactive session, the facilitator will highlight commonly established business practices and how they limit our ability to engage everyone every day. More importantly, though, participants will likely gain increased awareness of what we can do differently to maximize enterprise excellence through deliberate inclusion.
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Dr. William Harvey is a seasoned Operations Leader with extensive experience in chemical processing, manufacturing, and operations management. At Michelman, he currently oversees multiple sites, leading teams in strategic planning and coaching/practicing continuous improvement. William is set to start his eighth year of teaching at the University of Cincinnati where he teaches marketing, finance, and management. William holds various certifications in change management, quality, leadership, operational excellence, team building, and DiSC, among others.
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A Memorandum of Association (MOA) is a legal document that outlines the fundamental principles and objectives upon which a company operates. It serves as the company's charter or constitution and defines the scope of its activities. Here's a detailed note on the MOA:
Contents of Memorandum of Association:
Name Clause: This clause states the name of the company, which should end with words like "Limited" or "Ltd." for a public limited company and "Private Limited" or "Pvt. Ltd." for a private limited company.
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Registered Office Clause: It specifies the location where the company's registered office is situated. This office is where all official communications and notices are sent.
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Capital Clause: This clause specifies the authorized capital of the company, i.e., the maximum amount of share capital the company is authorized to issue. It also mentions the division of this capital into shares and their respective nominal value.
Association Clause: It simply states that the subscribers wish to form a company and agree to become members of it, in accordance with the terms of the MOA.
Importance of Memorandum of Association:
Legal Requirement: The MOA is a legal requirement for the formation of a company. It must be filed with the Registrar of Companies during the incorporation process.
Constitutional Document: It serves as the company's constitutional document, defining its scope, powers, and limitations.
Protection of Members: It protects the interests of the company's members by clearly defining the objectives and limiting their liability.
External Communication: It provides clarity to external parties, such as investors, creditors, and regulatory authorities, regarding the company's objectives and powers.
https://seribangash.com/difference-public-and-private-company-law/
Binding Authority: The company and its members are bound by the provisions of the MOA. Any action taken beyond its scope may be considered ultra vires (beyond the powers) of the company and therefore void.
Amendment of MOA:
While the MOA lays down the company's fundamental principles, it is not entirely immutable. It can be amended, but only under specific circumstances and in compliance with legal procedures. Amendments typically require shareholder
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Topic 4 chapter 5 part 2 enzymes - characteristics of enzymes
1. Topic 4: Chapter 5
EnzymesEnzymes –– Part 2Part 2
Characteristics
Characteristics
of Enzymes
of Enzymes
2. Characteristics of Enzymes?
Enzymes
1)speed up chemical reactions
2)are required in minute amounts
3)are highly specific in their action
4)are affected by temperature
5)are affected by pH
6)Some catalyse reversible reactions
7)Some require co-enzymes
8)Are inhibited by inhibitors
3. (1) Enzymes Speed up chemical reactions(1) Enzymes Speed up chemical reactions
Activation Energy
with enzyme
Activation
Energy without
enzyme
Substrate
Products:
Energy
Time
• By lowering the activation energy needed to
start the reaction.
4. (2) Enzymes are required in minute amounts(2) Enzymes are required in minute amounts
Sucrose Glucose + Fructose
• They remain chemically unchanged after
catalysing the reactions.
• The same enzyme molecules can be reused
over again.
• Therefore, only a small amount of enzyme is
required to catalyse a large number of reactions
Sucrase
Chemically unchangedChemically unchanged
5. Maltose Glucose + GlucoseMaltose Glucose + Glucose
(3) Enzymes are highly specific(3) Enzymes are highly specific
• Each chemical reaction is catalysed by its own
specific, unique enzyme.
• This is due to every enzyme’s specific 3-d
configuration.
• How the shape of an enzyme affects its function can
be explained by the “LOCK & KEY HYPOTHESIS”.
Maltase
Starch Maltose
Amylase
6. • Enzymes are proteins and each has an active site.
• Active sites are depressions on the surface of
enzyme molecules with specific shape and
specific charges.
• Active sites are formed due to the way the proteins
are folded and held together by H-bonds.
Lock &
Key
Hypothesis
Lock &
Key
Hypothesis
7. • Every active site has it’s own specific shape and
charges.
• It only allows substrates with a
COMPLEMENTARY shape and charge to bind
with it to form an Enzyme-Substrate Complex
Lock &
Key
Hypothesis
Lock &
Key
Hypothesis
Active
Sites
Substrate Enzyme-Substrate Complex Products + EnzymeSubstrate Enzyme-Substrate Complex Products + Enzyme
Enzyme
9. TheThe
LockLock
andand KeyKey
HypothesisHypothesis
• The substrate binds to a free enzyme with a
complementary active site to form the enzyme-
substrate complex
• The enzyme-substrate complex brings about the
necessary reactions
• The product separates from the enzyme, leaving
the enzyme molecule unchanged and free to
combine again with more substrate molecules
10. (4) Enzymes are affected by temperature(4) Enzymes are affected by temperature
• Enzymes can function
over a range of
temperatures.
• But all enzymes have
their own optimum
temperature.
11. Optimum temperature
• The optimum temperature is the temperature at
which the enzyme is most active, catalysing the
largest number of reactions per second.
• Different enzymes have different optimum temp.
• Example:
most enzymes in the human body
functions best at about 37-40o
C, near
body temperature.
Enzymes of thermophilic bacteria that
live in hotsprings will have very high
optimum temperatures.
12. How enzyme activity is affected by temperature
• At low temperature, enzymes are INACTIVE.
• As temperature rises, the rate of enzyme activity
increases (usually 2x as active for every 10o
C
rise).
• Enzyme reaching maximum rate of activity at OT
NOTE:
Describe the
enzyme activity with
respect to the Rate-
Temperature Graph
• Raising the temperature increases the
kinetic energy supplied to the substrate
and enzyme molecules.
• This increases the no. of collisions
between enzyme and substrate molecules.
• Increasing the rate of formation of enzyme-
substrate complex.
• Rate of formation of the products increases
up till the optimum temperature
Increasing temp up to optimum temp.
13. How enzyme activity is affected by temperature
• Beyond the optimum temperature, rate of
enzyme activity deceases.
• Until it is completely denatured by the extreme
heat
NOTE:
Describe the
enzyme activity with
respect to the Rate-
Temperature Graph
• Increase in temperature increases the
vibrations of the atoms in the enzymes.
• Beyond the OT, the vibrations are so
violent that they break the hydrogen bonds
that hold the 3-D structrure in place.
• The enzyme loses its shape and active site
• The enzyme is DENATURED.
Increasing temp beyond optimum temp.
14. (4) Enzymes are affected by pH(4) Enzymes are affected by pH
• Different enzymes have
different optimum pH.
• Enzymes are affected
by the acidity or
alkalinity of the solutions
• M indicates the optimum
pH when the rate of
reaction is the highest
15. Different enzymes have different optimum pH
• Enzymes that work best at ACIDIC conditions
Renin and Pepsin: Found in the stomach
• Enzymes that work best at ALKALINE conditions
Intestinal Enzymes
• Enzymes that work best at NEUTRAL conditions
Amylase
ExamplesExamples
17. How enzyme activity is affected by pH
At pH slightly above or below the optimumAt pH slightly above or below the optimum
• Enzyme activity reduces when the
conditions are slightly more acidic or
alkaline than the optimum pH
• Slight changes in the pH brings about reversible
changes
• Changes can be restored by bringing enzyme back to
the optimum pH
18. How enzyme activity is affected by pH
At extreme pH conditionsAt extreme pH conditions
• Enzymes are DENATURED
• Extreme changes in the pH causes:
A change in the charges at the active sites which
repels the substrate molecules, preventing them from
binding.
The irreversible alteration to the bonds that holds the
shape of the enzyme. Enzyme thus loses its original
3-D structure. The active site loses its shape.
19. (5) Some enzymes catalyze reversible reactions(5) Some enzymes catalyze reversible reactions
AA BB CC DD+ +
Reactants Products
Products Reactants
• Some enzymes catalyse both reactions until equilibrium
is reached.
• Reactions will proceed in the direction where the products
are constantly being removed
• E.g formation of glucose during photosynthesis
20. (6) Some enzymes require co-enzymes(6) Some enzymes require co-enzymes
•Some enzymes require co-enzymes to be bound
to them before they can catalyse reactions
Co-enzymes
•Small, non-protein, organic “helper” molecules
21. (7) Enzymes are inhibited by inhibitors(7) Enzymes are inhibited by inhibitors
Type 1 (Competitive)
Substrate is prevented
from binding to active site
by inhibitor
Type 1 (Competitive)
Substrate is prevented
from binding to active site
by inhibitor
Type 2 (Non-competitive)
Binding of inhibitor does not
prevent the binding of substrate
but slows down reaction speed
Type 2 (Non-competitive)
Binding of inhibitor does not
prevent the binding of substrate
but slows down reaction speed