1) Pelvic fractures can result in severe blood loss due to injury to the internal iliac plexus of arteries and veins. They are commonly caused by road traffic accidents.
2) Pelvic stability is determined by ligamentous structures such as the ligament of the symphysis pubis, sacrospinous ligament, and anterior sacroiliac ligament.
3) Pelvic fractures are classified using either the Young-Burgess classification based on injury mechanism, or the Tile classification based on stability. The classifications help determine treatment approach and predict associated injuries.
Please find the power point on Fracture of Talus with well diagrammatic explanation from very reliable sources. If you need such a power point on different topics related with MBBS then please write it on comment section. Thank you
Please find the power point on Fracture of Talus with well diagrammatic explanation from very reliable sources. If you need such a power point on different topics related with MBBS then please write it on comment section. Thank you
Pelvic fractures can be simple or complex and can involve any part of the bony pelvis. Pelvic fractures can be fatal, and an unstable pelvis requires immediate management.
With the pandemic overclouding the whole world it has effected every strato of people including the Orthopaedic groups. This is to highlight the impact of COVID 19 on the orthopaedic in general.
Conservative management in 3 and 4 part proximal humerus fractureBipulBorthakur
Proximal humerus fracture is common in both young as well as elderly people with most of the elderly patients unable to undergo operative management. This study is to see the aspect of conservative management in proximal humerus fracture.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
3. Introduction
Fracture of pelvis account for less than 5% of skeletal injury
But particularly important due to potential risk of severe blood loss
Majority occur due to RTA and 10% of them associated with visceral injury
6. Anatomy
• Pelvic stability is determined by ligamentous structures
• Primary restraints to external rotation of hemipelvis- ligament
of symphysis, sacrospinous liagament and anterior sacroiliac
ligament.
• Rotation in saggital plane by – sacrotuberous ligament
• Vertical displacement by- all the above ligaments ( if absent
then interosseous sacroiliac, posterior sacroiliac and iliolumbar
helps )
7.
8. Clinical assessment
Should be suspected in any multiply injured patient
Multidisciplinary approach with orthopaedic surgeons, general
surgeons, and anesthesiologists is critical to optimizing outcomes.
Patient should be managed according to ATLS protocol
• Physical examination –
Vertical shear may present with shortening and external rotation of affected
limb
Unstable lateral compression – internal rotation
9. APC injury- scrotal edema in male patient
Careful neurovascular assessment (lumbosacral injury might associate)
Careful examination of skin to rule out open fracture
AP and LC compression test should be done once (as first clot is the best
clot)
Massive flank or buttock contusions - indication of significant bleeding
Perineum must be carefully inspected – rule out open fracture
Digital rectal and vaginal examination in women should be done
12. Classification
Among all classifications below mentioned classification provide
valuable information
A. Young and Burgess- based on mechanism of injury (help to
determine associated injury)
B. Tile classification – based on stability of pelvis
13. Young and Burgess
I. Anteroposterior compression (APC)
II. Lateral compression (LC)
III. Vertical Shear(VS)
IV. Combined
14.
15. APC
1.Injury results from front to front force transmission through
pelvis
2.Initially anterior structures open up & as energy increase
posterior structure injured
(anterior- symphysis pubis, posterior- sacroiliac joint )
3. Three types – APC 1, APC2 and APC3
16. 1. APC1- less than 2.5cm widening at pubic symphysis
17. • APC2- widening of symphysis pubis more than 2.5cm with
anterior widening of sacroiliac joint
• Posterior ligaments are intact
18. apc3
• Widening of symphysis pubis more than 2.5cm with
Dislocation of sacroiliac joint
19. Lateral compression
• Injuries results from the force applied and/or transmitted to
side of pelvis
• Types –
1. Lc1
2. Lc2
3. Lc3
23. Vertical shear
• Usually seen after fall from height
• Landing on one leg leading to one hemipelvis being driven up
• Complete disruption of all posterior structures
24. Combined
• This injury combined of APC,LC and VS
• Occur when individual ejected from automobile or motorcycle
25. Tile classification
• Gives accurate assessment of pelvic stability
• It decides whether surgery required or not
• Based on stability of posterior arch
• Types –
1) Type A :stable( posterior arch intact)
2) Type B: partially stable ( incomplete disruption of posterior arch)
3) Type C: unstable ( complete disruption of posterior arch )
26.
27. Type a
• A1 – fracture not involving pelvic ring ( eg- avulsion or iliac
wing fracture)
• A2 – iliac wing fracture or anterior rami fractures
• A3 – transverse sacral fracture
28. Type B
• B1 – open book injury (exteranl rotation)
• B2 – lateral compression injury( internal rotation)
• B2-1 ipsilateral anterior and posterior injuries
• B2 -2 contralateral injuries
• B3 – bilateral SIJ/sacral fractures /subluxation
29. Type c
• C1 – complete unilateral posterior disruption
• C2 – complete unilateral posterior disruption with contralateral
partial disruption
• C3 – complete bilateral posterior disruption
30. Open fracture
• 5% common
• May contaminate with vagina or rectum – complications like
osteomyelitis, deep pelvis infection, mortality
• So careful inspection to perineal area is must and digital rectal and
vaginal should be done
• Fecal contamination – may require diverting colostomy, emergency
irrigation and debridement of fracture
• If not contaminated- regular irrigation and debridement with IV
antibiotics
31.
32. • Ruptured bladder should be suspected if they can’t void urine
• Or bladder is not palpated after adequate fluid replacement
• Rupture may be intraperitoneal or extraperitoneal
• Intraperitoneal rupture associated with massive haemorrhage
• Bowel injury might occur
• Neurological examination is important ( lumbosaccral plexus
injury)
33. Radiorapic evaluation
Standard trauma series – CT chest . Us abdomen , AP view of
pelvis lateral view of CS spine
AP view of pelvis
1. Anterior lesions- pubic rami fractures and symphysis displacement
2. Sacroiliac joint and sacral fractures
3. Iliac fractures
34. Special views
1. Obturator and iliac oblique views- for suspected acetabular
fractures
2. Inlet view- taken wit patient supine wit the tube 6deree
caudally perpendicular to pelvic brim
Provides an axial view of sacrum and sacroiliac joint
3.Outlet view- patient supine wit tube directed 45 degree
cephalhead
Determination of vertical displacement of pelvis
Provides true AP view of sacrum and pubic symphysis
36. Tretment
Non operative
– Tile A without open fracture
– Ap of pubic symphysis < 2.5 cm
– Rehabilitation – protected weight bearing with crutch supported
37. Operative treatment
• Absolute indication –
1. Open fractures or associated visceral injury
2. Open book fractures or vertically unstable fractures wit
haemodynamic instability
• Relative indication –
1. Symphysis diastasis >2.5 cm
2. LLD>1.5cm
3. Rotational deformity
4. Sacral displacement >1cm
38. Operative tecniques
• Principle- convert an unstable pelvis into stable one
• Initial treatment includes- external fixation and pelvic clamps
1. External fixation – construct mounted on two pins ideally of
5mm size spaced one cm apart along anterior iliac crest
o Or single pins placed in supra-acetabular area in AP direction
o It is resuscitative fixation and can be used definitive for anterior
pelvic injuries
43. Internal fixation or reconstructive phase
1. Diastasis of pubic symphysis
– plate fixation is most commonly used
44. • Iliac win fracture – ORIF wit la screws and neutralization plate
45. • Sacral fractures and or sacroiliac dislocation – iliosacral
screw fixation or anterior sacroiliac plating
46. Post operative management
• In general early mobility is desired
• Aggressive pulmonary toilet
• Prophylaxis against thromboembolic phenomena
• Weight bearing –
1. Full weight bearing uninvolved side- within several days
2. Partial weight bearing involved side- after 6 weeks and full after 12
weeks
47. Complications
• Infections- 0-20%
• Thromboembolism – due to disruption of pelvic veins and
immobilazation
• Malunion - rare
• Nonunion – rare
• Moratality –
– APC3 – 37%
– VS-25%
– LC- head injury major cause of death