This ppt contains all information about epidemiology of Diptheria. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
In this presentation there is complete content regarding its causes, pathophysiology, clinical manifestations, diagnostic evaluations and managements that can be done.
First of all as we know that otitis media is a disease condition related to ear infection and inflammations.
This ppt contains all information about epidemiology of Diptheria. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
In this presentation there is complete content regarding its causes, pathophysiology, clinical manifestations, diagnostic evaluations and managements that can be done.
First of all as we know that otitis media is a disease condition related to ear infection and inflammations.
The information about Tetanus is a basic content intended to share Students of Graduate and postgraduate in Life Sciences.
The up loader has no Commercial interests
Clostridium tetani (tetanus) - causes, symptoms, diagnosis, treatment, pathology. Tetanus is a toxin-mediated disease. The infectious agent of the disease is a neurotoxin produced by gram positive-anaerobic spore-forming organisms, Clostridium tetani. Movement of our voluntary muscles is controlled by our central nervous system. This animation describes the process of infection with Clostridium tetani and how the toxin it releases interrupts nervous control of our muscles, leading to tetanus. This loss of muscle control causes the convulsive muscle spasms typical of tetanus, which are so severe they can cause bone fractures and dislocations.infection of tetanus occurs when bacteria contaminates the wound and produce the exotoxin. The contaminated-wounds with deep puncture trauma and devitalized tissue, are at high risk for developing tetanus.
There is no person to person transmission for tetanus.
Three overlapping clinical pictures are shown, which are generalized, neonatal, and localized.
Complications include laryngospasm, fractures, arrhythmias, nosocomial-hospitalizations. Heroin users are at increased risk of tetanus.
Tetanus an neurological disease characterized by an acute onset of hypertonia, painful muscular contractions (usually of the muscles of the jaw and neck), and generalized muscle spasms without other apparent medical causes.
Tetanus in orthopedics and overview.pptxPratikSilwal4
Tetanos : Greek word: to stretch
• First described by Hippocrates & Susruta
• Neurological disease characterized by:
Acute onset of hypertonia
Painful muscular contractions (usually of
the muscles of the jaw and neck)
Generalized muscle spasms without other apparent medical causes
• Only vaccine preventable disease that is infectious but not contagious
3
CAUSATIVE AGENT
• Caused by CLOSTRIDIUM TETANI • Anaerobic
• Motile
• Gram positive bacilli
• Oval, colourless, terminal spores: tennis racket or drumstick shape
• It is found worldwide in soil, in inanimate environment, in animal faeces & occasionally human faeces.
4
Clostridium tetani Gram Stain
Round terminal spores give cells a “drumstick” or “tennis racket” appearance
5
EPIDEMIOLOGY
• Tetanus is an international health problem, as spores are ubiquitous. The disease occurs almost exclusively in persons who are unvaccinated or inadequately immunized
• Entirely preventable disease by immunization
• Tetanus occurs worldwide but is more common in hot, damp climates with soil rich in organic matter
6
EPIDEMIOLOGY IN NEPAL
• Tetanus is the major cause of morbidity and mortality in Nepal
• To control tetanus government of Nepal has introduced EPI in 1979 which
significantly reduced the burden of VPDs including tetanus
• Different programs like maternal and neonatal tetanus elimination program, safe motherhood program, tetanus toxoid (TT) campaign, training to birth attendants, health education etc. are being conducted by GON
• NT has been eliminated in Nepal since 2005. Now Nepal is aiming at controlling tetanus and sustaining NT elimination status
• According to the latest WHO data published in 2018 Tetanus Deaths in Nepal reached 251 or 0.15% of total deaths. The age adjusted Death Rate is 1.06 per 100,000 of population ranks Nepal #36 in the world.
7
STUDY CONDUCTED AT BPKIHS
• Over 22 months period from 2003 to 2005, there were 19 cases of pediatric tetanus and 5 cases of NT
• During the fiscal year 2006/2007, Morbidity at age 20-49= 43.2% of cases, Pediatric tetanus= 26.3% cases
8
TRANSMISSION
• Tetanus is not transmitted from person to person.
• Spores are introduced into wounds through trauma, surgeries and
injections, or chronic skin lesions and infections:
• Incubation period: 3 days to 3 weeks (median 7 days) ( Depends upon the site of injury)
9
• Shorter incubation periods (<7 days) along with delays in seeking treatment are associated with fatal outcomes.
• Outbreaks of tetanus related to injuries associated with natural disasters such as earthquakes and tsunamis have been documented
10
HOST FACTORS
• Age: active age (5-40 years), New born baby, Female during delivery or abortion
• Sex: Higher incidence in males than females
• Occupation: Agricultural workers are at higher risk
• Rural-Urban difference: Incidence in urban areas is much lower than in rural areas
• Immunity: Herd immunity does not protect the individual
• Environmenta
A brief discussion of a very common bacterial infection presenting as fever and skin rash following skin infection or use of tampons. Affecting adults especially women. Very helpful for medical students, ER doctors, dermatologists, nurses. References from dermatology textbook Rooks.
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2. OBJECTIVES
At the completion of the class will be able to :-
• Define tetanus
• Explain epidemiology
• Describe cause
• Enumerate sign and symptoms
• Explain pathophysiology
• Describe complication and management and nursing
management.
3. INTRODUCTION
• An acute disease induced by the
exotoxin of clostridium tetani
and clinically characterized by
muscle rigidity which persists
throughout illness due to rigidity
of muscle of neck and face
,difficulty in opening the
mouth,it is also called lockjaw.
4. EPIDEMIOLOGY
Agent factor:
• Agent- cl.tetani is a gram-positive,anaerobic,spore-
bearing organism.
• Reservoir of infection: soil and dust, found in
intestine of many animals-cattle, horses,goats and
sheep and are excreted in their feces, this spores
survive for years in nature.
5. Host factor:
• Age-5-40 years
• Sex-incidence more in male than female.
• Occupation-agricultural workers.
• Rural –urban defferences: the incidence is much lower in
urban then rural
• Immunity: no age is immune unless protected by previous
immunization.2 injection of tetanus toxoid is highly effective
and lasts for several year.
6. ENVIRONOENTAL AND SOCIAL
FACTORS:
• Tetanus is a positive environmental hazard.its
occurance depends upon man’sphysical and
ecological surroundings.
• MODE OF TRANSMISSION:Infection is acquired by
contamination of wound with tetanus spores.
• Injuries
• Accidents
• Trivial pin pricks
7. Cont…
• Skin abrasion
• Puncture wound
• Burn
• Human bites
• Animal bites and stings
• Unsterile surgery
• Incubation period-6-10 days
• But it may vary from one day to months also.
8. Causes
• Spores of the bacteria that cause tetanus, Clostridium tetani, are found in
soil, dust and animal feces.
• When they enter a deep flesh wound, spores grow into bacteria that can
produce a powerful toxin, tetanospasmin, which impairs the nerves that
control your muscles (motor neurons).
• The toxin can cause muscle stiffness and spasms — the major signs of
tetanus.
• Nearly all cases of tetanus occur in people who have never been
vaccinated or adults who haven't kept up with their 10-year booster shots.
• You can't catch tetanus from a person who has it.
9. RISK FACTOR
• Failure to get vaccinated or to keep up to date with
booster shots against tetanus
• An injury that lets tetanus spores into the wound
• A foreign body, such as a nail or splinter
11. CILNICAL MENIFESTATION
Signs and symptoms of tetanus
appear anytime from a few days
to several weeks after tetanus
bacteria enter your body through
a wound.
The average incubation period is
seven to 10 days.
12. TYPE
According to the cause of disease tetanus is
• TRAUMATIC
• PUERPERAL
• OTOGENIC
• IDIOPATHIC
• TETANUS NEONATORUM
13. DIAGNOSTIC TEST
Laboratory Studies
• Blood counts and blood chemical findings are unremarkable. Laboratory studies
may demonstrate a moderate peripheral leukocytosis.
• A lumbar puncture is not necessary for diagnosis. Cerebrospinal fluid (CSF)
findings are normal, except for an increased opening pressure, especially during
spasms.
• Serum muscle enzyme levels (eg, creatine kinase, aldolase) may be elevated.
• An assay for antitoxin levels is not readily available. However, a serum antitoxin
level of 0.01 IU/mL or higher is generally considered protective, making the
diagnosis of tetanus less likely (though rare cases have been reported to occur
despite the presence of protective antitoxin levels)
14. Cont…
• Wounds should be cultured
• Spatula Test
• Imaging studies of the head and spine reveal
no abnormalities.
18. • Children should be provided active immunity through DPT
vaccination according to the immunization schedule.
• Pregnant women should be given two injections of tetanus
toxoid.
• In unvaccinated persons, if there are wound or open injuries,
tetanus immunoglobulin should be given within 72 hours.
• Any open wound should be washed with 3% hydrogen peroxide
(H2O2) and dressed with clean dressing.
• Aseptic is used in surgical procedure and delivery. Personal
hygiene should also be taken care.
19. TREATMENT
Mild cases of tetanus can be treated
with:
• tetanus immunoglobuli (TIG), also
called tetanus antibodies or tetanus
antitoxin.
• It can be given as I.Vor I.M.
• metronidazole IV for 10 days
• diazepamoral
20. OTHER TREATMENT
Medications
• Antitoxin. Your doctor may give you a tetanus antitoxin, such as tetanus immune
globulin. However, the antitoxin can neutralize only toxin that hasn't yet bonded to
nerve tissue.
• Antibiotics
• Vaccine
• Sedatives. Doctors generally use powerful sedatives to control muscle spasms.
• Other drugs. Other medications, such as magnesium sulfate and certain beta
blockers, might be used to regulate involuntary muscle activity, such as your
heartbeat and breathing. Morphine might be used for this purpose as well as
sedation.
21. Supportive therapies
• Severe tetanus infection often requires a long stay
in an intensive care setting. Since sedatives can
inhibit breathing, you might temporarily need a
ventilator.
22. • History of present illness: a severe injury, burns
and inadequate immunization.
• Respiratory System: dyspnea, cyanosis and
asphyxia due to respiratory muscle contraction.
• Cardiovascular System : dysrhythmias,
tachycardia, hypertension and bleeding, initially
the body temperature 38-40 ° C or febrile up to
the terminal 43-44 ° C.
• Neurologic System: irritability (early),
weakness, convulsions (late), paralysis of one or
several nerves of the brain.
Nursing management
23. Cont….
• Urinary System : urinary retention (bladder distension
and urine output does not exist / oliguria)
• Digestive System: constipation due to no bowel
movements.
• Integument and muskuloskletal System: pain, tingling
at the site of injury, sweating, initially trismus, muscle
spasms face with increasing contraction eyebrows,
risus sardonicus, stiff muscles and difficulty
swallowing.
• If this continues there will be the status of general
convulsions and seizures.