Toxic epidermal necrolysis (TEN) is a rare and potentially fatal skin reaction characterized by skin tenderness, redness, and extensive shedding of the skin's outer layer. It is caused by apoptosis of skin cells triggered by certain drugs like antibiotics, NSAIDs, and anticonvulsants. TEN affects over 30% of the body surface area and has a high mortality rate of 25-35%. Treatment focuses on discontinuing the culprit drug, providing intensive wound and skin care, and supportive care in an ICU. No specific treatments have been proven effective, and corticosteroids may increase mortality risk.