This document discusses several classes of drugs that act as microtubule inhibitors or target microtubules, including benzimidazoles such as thiabendazole and albendazole used to treat helminthic infections. It also discusses vinca alkaloids such as vincristine, vinblastine, and vinorelbine used to treat cancers that bind to and inhibit microtubule assembly. Taxanes such as paclitaxel are also discussed which stabilize microtubules and disrupt mitosis. Monoclonal antibodies palivizumab for RSV and infliximab for Crohn's disease and their mechanisms and side effects are summarized.
DMARDs and biologics have made a huge difference in the lives of people with RA and other rheumatologic disorders. Biologics era was showed+ in the year 1998 with the FDA approval of TNF antagonist and etanercept. Biologics bring the disease under control in 4–6 weeks compared to 3–6 months taken by traditional DMARDs.
Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others .
Immunosuppressants drugs and their mechanism of action in organ transplantati...Sreedhar Reddy
immunosuppressants are drugs used to supress immune system
1)introduction and classification 2)mechanism with flow chat 3) use of immunosuppressants and adverse effects and contraindications
immunosuppressant mainly used to treat autoimmune disorder and organ transplantation
Role of biological agents in immunosuppression in Autoimmune rheumatoid arthritis and organ transplantation
inhibition of humoral and cellular immune response
DMARDs and biologics have made a huge difference in the lives of people with RA and other rheumatologic disorders. Biologics era was showed+ in the year 1998 with the FDA approval of TNF antagonist and etanercept. Biologics bring the disease under control in 4–6 weeks compared to 3–6 months taken by traditional DMARDs.
Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others .
Immunosuppressants drugs and their mechanism of action in organ transplantati...Sreedhar Reddy
immunosuppressants are drugs used to supress immune system
1)introduction and classification 2)mechanism with flow chat 3) use of immunosuppressants and adverse effects and contraindications
immunosuppressant mainly used to treat autoimmune disorder and organ transplantation
Role of biological agents in immunosuppression in Autoimmune rheumatoid arthritis and organ transplantation
inhibition of humoral and cellular immune response
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
2. 1 BENZIMIDAZOLES
are in use for the treatment of helminthic
infections
have a broad range of activity against many
nematode and cestode parasites, including
cutaneous larva migrans, trichinosis,
disseminated strongyloidiasis, and visceral
larva migrans
considered as the drug of choice for Fasciola
hepatica therapy
3. 1.1 Thiabendazole
inhibits fumarate reductase and electron
transport–associated phosphorylation in helminths
Interference with ATP generation decreases
glucose uptake and affects the energy available
for metabolism
This inhibits microtubule assembly, which is
important in a number of helminth cellular
processes, such as mitosis, transport, and motility.
shows a broad spectrum of activity against
different nematodas lumbricoides, N. americanus,
A. duodenale, E. vermicularis, S. stercoralis, and
Trichuris trichiura
4. Adverse drug reactions
Anorexia
nausea
vomiting
Drowsiness
vertigo occur in upto one-third of patients
Diarrhea, pruritus, rash, hallucinations, crystalluria,
and leukopenia are less common
shock, hyperglycemia, lymphadenopathy, and
Stevens-Johnson syndrome are rare.
Some patients report that their urine smells like
asparagus, a reaction related to excretion of the
metabolite asparagine.
5. 1.2 Albendazole
cytoplasmic microtubular degeneration, which in
turn impairs vital cellular processes and leads to
parasite death
also inhibits helminth-specific ATP generation by
fumarate reductase
given orally and is poorly and variably absorbed
(5%) because of its poor water solubility
Oral bioavailability is increased as much as five
times when the drug is given with a fatty meal
instead of on an empty stomach
Has broad spectrum of activity against intestinal
nematodes and cestodes, as well as the liver
flukes
7. 2 Vinca Alkaloids (Vincristine, Vinblastine, and
Vinorelbine)
alkaloids bind avidly to tubulin, a class of proteins that
form the mitotic spindle during cell division
regarded as phase specific in the cell cycle, some
mammalian cells are most vulnerable in the late S-
phase
Both vincristine and vinblastine are extensively bound
to tissues, and only small amounts of the drug are
distributed to the brain or CSF with nearly similar
pharmacokinetics
Vincristine is an important component of the curative
combination chemotherapy for acute lymphoblastic
leukemia, Hodgkin’s disease (the MOPP regimen),
and non-Hodgkin’s lymphomas
8. Cont …
Vinorelbine is particularly useful in the
treatment of advanced non–small cell lung
cancer and can be administered alone or in
combination with cisplatinIt
thought to interfere with mitosis in dividing
cells through a relatively specific action on
mitotic microtubules.
9. Adverse drug reaction
Neurological toxicity
bone marrow toxicity
Severe leukopenia
potent local blistering agents and will produce
tissue necrosis if extravasated.
10. 3 Taxanes (Paclitaxel)
highly complex, organic compound isolated from
the bark of the Pacific yewtree
binds to tubulin dimers and microtubulin filaments,
promoting the assembly of filaments and
preventing their depolymerization
increase in the stability of microfilaments results in
disruption of mitosis and cytotoxicity and disrupts
other normal microtubular functions, such as
axonal transport in nerve fiber
among the most active of all anticancer drugs,
with significant efficacy against carcinomas of the
breast, ovary, lung, head, and neck
11. Adverse drug reaction
Myelosuppression
Alopecia
Most patients have mild numbness and
tingling of the fingers and toes
Mild muscle and joint aching
Nausea is usually mild or absent
Severe hypersensitivity reactions may occur
Cardiovascular side effects, consisting of mild
hypotension and bradycardia, have been
noted
13. Palivizumab (Synagis)
is a humanized monoclonal antibody directed against
the highly conserved antigenic site of the F protein on
the surface of RSV
contains 95% human and 5% murine antibody
sequences and tends to have little immunogenicity in
humans
is composed of the human framework region of the
IgG-1 -chain joined to the antigen-binding regions of a
mouse monoclonal antibody
neutralizes RSV and inhibits its ability to fuse with
host cell membranes. Resistant strains of RSV have
been derived in vitro but have not been found in
clinical isolates to date.
14. Cont …
administered prophylactically as a monthly
intramuscular injection prior to and during RSV
season
half-life of palivizumab is approximately 20 days
used to prevent serious lower respiratory tract
infection due to RSV
only in high-risk children who are younger than 24
months of age and have bronchopulmonary
dysplasia or chronic lung disease that required
treatment in the previous 6 months
is also indicated for premature infants (less than
32 weeks’ gestation)
15. Adverse drug reaction
Serious adverse reactions are rare
Mild erythema and pain may occur at the
injection site
Although no anaphylactoid reactions have
been reported to date, the possibility of this
reaction exists because palivizumab is a
protein,
16. Monoclonal antibody drug for
Immunomodulating(Muromonab-(CD3))
is a mouse monoclonal antibody that is a purified IgG
used for the prevention of acute allograft rejection in kidney
and hepatic transplants and as prophylaxis in cardiac
transplantation
also used to deplete T cells in marrow from donors before
bone marrow transplantation.
alters the cell-mediated immune response by binding to the
CD3 (cluster of differentiation antigen, T3) glycoprotein on T.
Within minutes of injection, total circulating T cells are rapidly
depleted from the blood
later reappear devoid of CD3 and antigen recognition
complexes.
17. Adverse side effects
include fever
pulmonary edema,
Vomiting
Headache
anaphylaxis
18. Monoclonal antibody drug for Gastrointestinal
Disorders(Infliximab)
TNF-is an inflammatory cytokine thought to have a
contributory role in producing chronic inflammation in
various diseases, including Crohn’s disease and
rheumatoid arthritis
is a mouse–human chimeric monoclonal neutralizing
antibody to human TNF- and is considered a
biological drug
Specific indications are for the reduction of signs and
symptoms in patients with moderately to severely
active Crohn’s disease) and fistulizing Crohn’s
disease
Responses occur within 2 weeks of an infusion,
19. The most common side effects
include rash
low blood pressure
chills, and chest pain these symptoms are
generally temporary and often respond to a
decrease in infusion rate
Another side effect is increased risk of
infections
Fatal cases of tuberculosis have been
reported following infliximab therapy
increased risk of lymphoma