The document discusses superdisintegrants, substances added to pharmaceutical formulations to facilitate the rapid disintegration of tablets and capsules for better drug absorption. It covers their selection, methods of addition, advantages, disadvantages, ideal characteristics, types, and applications in fast-dissolving and orally disintegrating tablets. Superdisintegrants are essential for improving patient compliance and enhancing the efficacy of solid dosage forms.

1. PRESENTED BY
DISHA P.WANKHEDE
B PHARM IV YEAR SEM VII
UNDER THE GUIDANCE
MR NANDKISHOR B.DESHMUKH
M PHARM ( DEPARTMENT OF PHARMACEUTICS)
SHRADDHA INSTITUTE OF PHARMACY,
KONDALA ZAMBRE, WASHIM. 444505
Superdisintegranting Agent Used in Pharmaceutical
Formulation

2. Chapter No. Title
1 Introduction
2 Seletion of superdisintegrants
3 Method of addition
4 Advantages and disadvantages
5 Ideal charaterstics
6 Types
7 Application
8 Conclusion
9 reference

3. Disintegrants are substances or a mixture of substances added to
the drug formulations that facilitate the dispersion or breakup of
tablets and contents of capsules into smaller particles for quick
dissolution.
Superdisintegrants are those substances that the faster
disintegration with a smaller quantity in contrast to disintegrants.
Eg Ispaghula husk mucilage (plantago ovata )
Xanthan gum
Gellan gum

4. Selection of superdisintegrants
The ideal disintegrant should have -
 Poor solubility.
 Poor gel formation.
 Good hydration capacity.
 Good molding and flow properties.
 It should also be compatible with the other excipients and have
desirable tableting Properties
 Quantity of disintegrates present in preparation.
 Tablet hardness.
 Kind of addition and mixing.

5. Methods of addition
 There are three methods of incorporating
disintegrating agents into the tablet.
 1. Internal addition
 In the wet granulation method the disintegrant is added to other
excipients before wetting the powder with the granulating fluid.
Thereby the disintegrant is incorporated within the granules. In
the dry granulation method the disintegrant is added to other
excipients before compressing the powder between the rollers

6.  2. External addition
 In both wet and dry granulation methods the super disintegrant is
added to the granules during dry mixing before compression.
3.Internal and External addition
 In both wet and dry granulation methods the super disintegrant is
added to the granules during dry mixing before compression

7. Advantages
1. Rapid disintegration and absorption of drug which
will produce quickly on set of action.
2. Quick absorption from the GIT improves patient
compliance
3. Effective in both hydrophilic and hydrophobic
formulations.
4. Provides good mechanical strength to the tablet
5. For easy packing and transportation.

8. Disadvantages
1. Expensive.
2. Time-consuming and fragile.
3. More sensitive and hygroscopic .
4. Unsuitable for water-sensitive drugs.

9. IDEAL CHARACTERSTICS
1. They should not require water or other liquid at the time of
administration.
2. It should easily disintegrate and dissolve.
3. It should Mask or overcome the unacceptable taste of drugs.
4. They should have high drug loading.
5. They should have a pleasant feel in their mouths.
6. Ease of administration for patients who are mentally ill
disabled and uncooperative.
7. It should produce rapid disintegration.
8. It should produce good molding and flow properties.
9. It should have poor water solubility.

10. Types
1.Natural super disintegrants
These are biologically originating and commonly used in tablet
formulation which increases disintegration of tablet
Eg. Ispaghula husk mucilage (plantago ovata) , Xanthan gum
2.Synthetic super disintegrants
These are primarily used in tablet formulation to increases the
rate of drug integraton which improve dissolution and
solubility
Eg. Modified starch , Modified celluloses (croscarmellose
sodium)
3.Co- processed superdisintegrants
These are improved super disintegrants to satisfy the need of
tablet formulation with desired end effects
Eg. ludipress, starlac

11. Application
1. Superdisintegrating agents widely used in the
formulation of fast dissolving tablets.
2. It used in orally disintegrating tablets.
3. It enhances patient compliances and conviences.
4. It used to improve the efficacy of solid dosage form.

12. Conclusion
Superdisintegrants can be use in both tabletand capsule to
produce fast disintegration . These are essential for the oral
dissolving tablet.disintegrant expand and dissolve when the
tablet to break napart in digestive system for absorbption. They
ensure that when the tablet in contact with water it rapidly
break down into smaller for the better dissolution .

13. Reference
 Ingram j.t. & lowenthal w (1966) mechanism of action of
starch as a tablet disintegrant. Journal of pharmaceutical
sciences 55(6) 614–617. Https://doi.org/10.1002/jps.
2600550617.
 Ferrero c. Muñoz n. Velasco m. V. Muñoz-ruiz a. &
jiménez-castellanos r. (1997). Disintegrating efficiency of
croscarmellose sodium in a direct compression
formulation. International journal of
pharmaceutics147(1)11– 21.https://doi.org/10.1016/s0378-
5173(96)04784-

14. THANK YOU