An brief introduction to Synchrotron for the students of Biological Sciences Basics of Synchrotron

2. Synchrotron: A Reality
Zahra Naz
PhD/HEC scholar (2018)
School of Biological Sciences,
University of the Punjab, Lahore

3. Contents to be Presented…!
• Importance
• Introduction
• History
• Principle
• Locations
• Parts
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• How It Works..???
• Samples & Outputs
• Reported Biomolecules
• Opportunities for Us…
• Glimpses
• Controlling Bodies
CONTENTS TO BE PRESENTED…!

4. APPLICATIONS
Chemistry
Material
Sciences
Biological
Sciences
Physics
Medical
Sciences
Archeology
Drug
Discovery
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5. “An extremely powerful source of X-rays
produced by high energy electrons which
circulate in an electro-magnetic field”
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What is it…??WHAT IS IT…??

6. https://www.esrf.eu/about/synchrotron-science/history-synchrotron
1895: W.C. Röntgen; X-rays 1947: Elder and co-workers; Synchrotron X-rays
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HISTORY

7. “A synchrotron machine accelerates electrons to emit extremely high
energy X-rays and allows them to change direction periodically. The
resulting X-rays are emitted as dozens of thin beams, each directed
toward a beamline next to the accelerator.”
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OPERATING PRINCIPLE

8. http://www.spring8.or.jp/en/links/sr_facilities/
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LOCATIONS
Japan
USA Switzerland
Denmark
Jordan
United
KingdomAustralia
Russia Italy
Sweden

9. Electron gun
Linear accelerator (Linac)
Booster ring
Storage ring
Beamlines
End station
https://byjus.com/physics/synchrotron/
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PARTS OF A SYNCHROTRON

10. How it works?
International symposium on contemporary physics, Islamabad, Pakistan
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HOW IT WORKS?

11. SAMPLES
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Plaisier, INSC, 2018

12. Hamza et al., 2012
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OUTPUTS

13. • Macromolecular crystallography (structure)
• Non-crystalline diffraction (size and shape)
• Circular dichroism
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SCOPE FOR BIOLOGISTS
Energy (synchrotron radiations) = 2.9 - 6.0 GeV
• Infrared micro-spectroscopy
• X-ray crystallography
• Medical diagnosis

14. RNA Polymerase II (2001)Potassium channel (2004)
Multi-drug transporter AcrB
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Structures of Biomolecules Using Synchrotron Radiations

15. Opportunities for Pakistanis
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Rule the world!

16. OFFERS…!
• Research collaborations & fellowships e.g. CERN fellowships
• Staff training program
• Exchange program
• Building user capacity in the local science and technology
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17. How to get your Beam Line?
1. Plan your work
2. Determine the need for synchrotron radiations
3. Become a registered user
4. Contact the relevant person
5. Specify your work and time duration
6. Appointment for using a beam line
7. Check for funding
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18. GLIMPSES OF WORLD’S FAMOUS SYNCHROTRONS
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19. Lead shielded hutches Energy generation Working station
Synchrotron-Light for Experimental Science and Applications in
the Middle East (SESAME)
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20. European Synchrotron Radiation Facility (ESRF)
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Capillary sample spinner Power diffractometer
Andy, INSC, 2018

21. Elettra Sincrotrone, Trieste
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X-Ray Absorption Fine Structure (XAFS)
Working bench for X-Ray diffraction
Sample fixing stage

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CONTROLLING BODIES

23. Persons to Be Contacted to Use a Beamline
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Dr. Giuliana, Elletra
Dr. Jaspier, Elletra

24. • http://www.iop.org/publications/iop/2011/page_47511.html
• https://www.elettra.trieste.it.html
• https://www.photon-production.co.jp/en/index_e.htm
• hyperphysics.phy-astr.gsu.edu/hbase/Particles/synch.html
• https://home.cern/
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USEFUL LINKS

25. Light is a messenger, carrying a story
about the form of the object …
(Lawrence Bragg, 1928)
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Thank You