This document summarizes information about sulphonamides, a class of antibiotic drugs. It discusses the history of sulphonamides dating back to their discovery in 1935. It also covers the chemistry, mechanisms of action, spectrum of activity, resistance, interactions, uses and adverse effects of various sulphonamide drugs including co-trimoxazole, silver sulphadiazine, and dapsone. The document is intended to provide an overview of sulphonamides for educational purposes.
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
Antibacterials- sulphonamides, cotrimoxazole, Quinolones and fluoroquinolones...pharma zone
Antibacterials- sulphonamides, cotrimoxazole, Quinolones and fluoroquinolones, nitroimidazoles, Beta lactam antibiotics According to Pharmacology II dental syllabus,
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
Antibacterials- sulphonamides, cotrimoxazole, Quinolones and fluoroquinolones...pharma zone
Antibacterials- sulphonamides, cotrimoxazole, Quinolones and fluoroquinolones, nitroimidazoles, Beta lactam antibiotics According to Pharmacology II dental syllabus,
Sulphonamides and their combination with trimethoprim - by Dr.Jibachha SahDr. Jibachha Sah
Sulphonamides and their combination with trimethoprim is lecturer notes on Veterinary Pharmacology & Toxicology(Chemotherapy) for B.V.Sc & A.H students of veterinary college.
Sulphonamide and cotrimoxazole pptx-Dr.Jibachha SahDr. Jibachha Sah
Lecturer notes on veterinary pharmacology and toxicology for B.V.Sc & A.H Seventh semester student for educational purpose.This lecturer notes will be useful for all the veterinary students.Plesae send your comments,jibachhashah@gmail.com,mob.9845024121
Sulfonamides
Are similar to p-aminobenzoic acid (PABA)
Sulfonamides with varying physical, chemical, pharmacologic, & antibacterial properties are produced by attaching substituents to amido group (–SO2–NH–R) or to amino group (–NH2) of sulfanilamide nucleus.
Trimethoprim & trimethoprim+ sulfamethoxazole mixtures
Trimethoprim
Its a trimethoxybenzylpyrimidine
Mechanism of action
Selectively inhibits bacterial dihydrofolic acid reductase that converts dihydrofolic acid to tetrahydrofolic acid
Presentation gives details of Sulphonamides, its medicinal Chemistry and pharmacology , useful for the undergraduate and postgraduate students of Pharmacy , Medicinal Chemistry, Pharmaceutical Chemistry, Pharmacology, Medicine, Nursing and allied Health Sciences. Undergraduate and Postgraduate Course work
Sulfonamides (sulphonamides) are a group of man-made (synthetic) medicines that contain the sulfonamide chemical group. They may also be called sulfa drugs. Many people use the term sulfonamide imprecisely to refer only to antibiotics that have a sulfonamide functional group in their chemical structure.
Sulphonamides, MOA, SAR, History of development, Nomenclature of the Sulfonamides, Classification, Spectrum of Action of the Sulfonamides,Structure Activity Relationship, Reducing Toxicity, Cotrimoxazole
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. SULPHONAMIDES.
• HISTORY: Sulfonamides (U.S) : Sulphonamides (U.K)
• History Gerhard Domagk 1935- developed sulfa from the prod
drug azo dye, Prontosil (used to treat streptococcal infection in
mice.
• He got Nobel Prize for medicine in 1939).
DR WAF JUNE 2021 2
3. GENERAL FEATURES.
• Defined as “SULFA-related group of antibiotics, that are
derived from sulphanilamide, which are able to prevent the
multiplication of bacteria”
• Mainly, they are derivatives of PRONTOSIL RED (A dye) •
Inactive in nature • Becomes active in-vivo……
DR WAF JUNE 2021 3
5. Chemistry
• White crystalline powder, insoluble in water, soluble in alkaline
PH
● Sodium salts are soluble in water
● Weak organic acids.
● Pka 4.99 to 8.56 (used to indicate the strength of an acid)
● Parenteral preparations are alkaline- care should be taken
while administration through iv route to prevent perivascular
damage I/m and S/C preparations should be properly buffered.
● Sulfacetamide- neutral preparation for ophthalmic use.
DR WAF JUNE 2021 5
6. CLASSIFICATION OF
SULPHONAMIDES:
• BASED ON SITE OF ACTION:
• 1. For general infections: - Sulphanilamide - Sulphadiazine -
Sulphamethoxazole - Sulphadoxine - Sulphapyridine -
Sulphamethocine - Sulphathiazole
• 2. For intestinal infections: - Pthalyl Sulphathiazole - Succinyl
Sulphathiazole - Sulphasalazine
• 3. For Dermatitis: - Dapsone - Solapsone
DR WAF JUNE 2021 6
7. • 4. For local infections: - Sulphacetamide sodium - Mafenide
sodium - Silver Sulphadiazine
• 5. For UTI (Urinary Tract Infections): - Sulphadiazine -
Sulphacetamide sodium
DR WAF JUNE 2021 7
8. Based on duration of action.
• Short acting sulfonamides (4-8 hours) - Sulfadiazine
● Intermediate acting sulfonamides (8-12 hours)-
Sulfamethoxazole, Sulfamoxole
● Long acting sulfonamide (approx 7 days)- Sulfadoxine,
sulfamethopyrazine
● Special purpose sulfonamide- Sulfacetamide sod,
sulfasalazine, mafenide, silver sulfadiazine ( Burns)
DR WAF JUNE 2021 8
9. Mode Of Action.
• Under normal conditions (in bacteria): Pteridine combines with
PABA (Para-amino benzoic acid) in the presence of enzyme
Dihydropteroate synthetase which forms Dihydropteroic acid (a)
• Glutamate gets added to (a) and forms DHFA (dihydro folic acid)
DHFA, in the presence of Dihydrofolate reductase enzyme gets
converted to THFA (Tetrahydrofolic acid) THFA forms Thymidylic
acid DNA and genetic bases (purine, pyrimidine, thymidine etc. )
are formed
• Sulphonamides block the enzyme Dihydropteroate synthetase
thus Pteridine cannot combine with PABA Thus Dihydropteroic acid
is not formed
DR WAF JUNE 2021 9
11. • Sulphonamides are bacteriostatic in nature • Thus, their anti-
bacterial efficacy is just 20-30%
• Thus, they are used in combination with Trimethoprim (Di-
amino pyrimidine) as
• Co trimoxazole (sulphamethoxazole+trimethoprim
DR WAF JUNE 2021 11
12. ANTI-BACTERIAL SPECTRUM OF
SULPHONAMIDES:
• Sulphonamides are primarily Bacteriostatic against Gram
positive and Gram negative organisms
• Organisms that are sensitive to sulphonamides include:
- Streptococcus pyogenes
– Calymmobacterium granulomatis
- Haemophilus influenzae
- Vibrio cholera
- Staphylococcus aureus
- Meningococci - E.coli - Toxoplasma - Shigella - Actinomyces…
DR WAF JUNE 2021 12
13. SULPHONAMIDE RESISTANCE:
• Organisms that are resistant to sulphonamides include: -
Staphylococcus aureus - E.Coli - Meningococci - Streptococcus
viridans - Gonococci - Anaerobes • Mechanisms of resistance
include:
• 1. Production of increased amounts of PABA
• 2. Mutants contain folate synthase enzyme shows less affinity
for sulphonamides
• 3. Bacteria adopt alternative pathway for folate metabolism
• Usually Cross resistance is observed for microbes within
sulphonamides.
DR WAF JUNE 2021 13
14. ADVERSE DRUG REACTIONS OF
SULPHONAMIDES:
• Nausea
• Vomiting
• Epigastric pain
• Crystalluria
• Hypersensitivity reactions: - Urticaria - Drug fever - Rashes
• Photosensitivity
• Stevens-Johnson syndrome
DR WAF JUNE 2021 14
15. PHARMCOKINETICS.
●Rapid and complete absorption from GIT
● Widely distributed, cross BBB & placenta
● Metabolism in liver, non-microsomal, acetylation at N4
● Glomerular filtration, less soluble in acidic urine --> crystalluria (
take plenty of water to aid in elimination)
● Contraindicated in near term females and neonates
DR WAF JUNE 2021 15
16. PRINCIPLES TO BE FOLLOWED IN
SULPHONAMIDE
• Start therapy at early stage of infection
● Ineffective in chronic cases
● In severe infection administer by iv route
● Administer adequate quantity of drinking water during therapy
● Alkalinisation of urine prevents crystalluria
● Treatment should not exceed seven days
● If no favourable response within four to five days, discontinue the
therapy
● Treatment continued 48 hours after remission to prevent recurrence
for some cases
● Immune response of the host should be well maintained
DR WAF JUNE 2021 16
17. Drug interaction.
• PABA antagonizes sulfonamides
● Calcium and antacids inhibits absorption
● Pus and tissue debris - rich in thymidine and purines so
bacterial requirement of FA is less.
● Synergistic with diaminopyrimidines - Trimethoprim,
ormethoprim,
● Sulfonamides + chlortetracycline act as Growth promoter
prevent clostridial ET.
DR WAF JUNE 2021 17
18. CO-TRIMOXAZOLE. (Septrin)
• Introduction:
• Cotrimoxazole is the combination of two drugs i.e. Sulphamethoxazole and
Trimethoprim
• Co-trimoxazole mixture contains 5 parts of sulphamethoxazole and 1 part of
trimethoprim.
• These two drugs produce overtly similar effects; will sometimes produce
increased effects when used concurrently.
• Sulphonamides block the biosynthesis of folic acid from p-amino benzoic acid.
• Trimethoprim inhibits the enzyme folate reductase and blocks the conversion of
folic acid to tetrahydofolic acid (THF).
• THF is the form required for coenzyme synthesis.
• Combination of Sulphamethoxazole and Trimethoprim by synergism produces
bactericidal effect
DR WAF JUNE 2021 18
19. COTRIMOXAZOLE/TRIMETHOPRIM
• Eg.Trimethoprim, ormetoprim,Pyrimethamine
● Weak organic bases, Pka7.6 accumulate in acidic urine, milk and
ruminal fluid
● Trimethoprim- poorly soluble in water
● Fixed dose combination of sulfamethoxazole + trimethoprim(Co-
trimoxazole)
● Readily absorbed after oral administration except in ruminants –
trapped and undergo microbial degradation.
● 30 % to 60% protein bound, widely distributed in tissues including
prostate. Partly metabolized in liver and excreted in urine by
glomerular filtration and tubular secretion.
DR WAF JUNE 2021 19
20. MECHANISM OF ACTION.
• Selectively inhibits bacterial dihydrofolate reductase
• Wide distribution, crosses BBB & placenta
• Partly metabolized in liver excreted in urine
• DOSE of co- trimoxazole: •20 mg (trimethoprim) + 100 mg
(sulphamethoxazole) : paediatric tablet bd.
• •160 mg (trimethoprim) + 800 mg (sulphamethoxazole): for
adults, bid
DR WAF JUNE 2021 20
22. CO-TRIMOXAZOLE
Use:
1. It is as anti microbial agent.
2. It is mainly used in treatment of;
Urinary tract infection
Upper and Lower respiratory infection (URTI and LRTI)
Skin and wound infections
Septicemias
DR WAF JUNE 2021 22
23. SULPHADOXINE,
SULPHAMETHOPYRAZINE:
• Ultra-long acting compounds (Due to increased plasma protein
binding, and slow renal excretion)
• - Half-life: 5-9 days
• - Uses: Above drugs + PYRIMETHAMINE ( Fansidar &
Metakelvin)
• treatment of Plasmodium falciparum associated malaria
• . Pne-umocystis jiroveci pneumonia in AIDS patients
• c. Toxoplasmosis
• ADRs: serious cutaneous reactions thus not much used…
DR WAF JUNE 2021 23
24. SILVER SULPHADIAZINE:
• Active against most bacteria and fungi
• - Anti-microbial action is attributed to slow release of SILVER ions…
• - USES:
• 1. Preventing infection of burnt surfaces
• 2. Chronic ulcers
• ADR:
• 1. Itching
• 2. Burning sensation
• - DOSE: 1% cream
DR WAF JUNE 2021 24