Sulfonamides were the first effective antimicrobial agents against bacterial infections but resistance has limited their use. They work by inhibiting the bacterial enzyme involved in folate synthesis. Sulfonamides are classified based on duration of action and include sulfadiazine and sulfamethoxazole. Resistance can develop via decreased drug uptake, decreased enzyme affinity, or increased PABA synthesis. Cotrimoxazole is a fixed dose combination of trimethoprim and sulfamethoxazole that has synergistic antibacterial effects and lower resistance due to sequential folate pathway inhibition. It is commonly used to treat urinary tract, respiratory, and gastrointestinal infections.
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
1. chemotherapy principles and problems JagirPatel3
The objective of chemotherapy is to study and to apply the drugs that have highly selective toxicity to the pathogenic microorganisms in the host body and have no or less toxicity to the host, so as to prevent and cure infective diseases caused by pathogens
Anthelmintics | B.Pharm 3rd year 2nd Sem | Medicinal Chemistry-III | History, Classification, Structures & Synthesis of anthelmintics, Synthesis of Diethylcarbamazine citrate, Synthesis of Mebendazole
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
The current slide include the pharmacology og cephalosporins.
Contents
Introduction to Cephalosporins
Classification of Cephalosporins
Cefazolin
Cephalexin
Cefuroxime
Cefuroxime axetil
Cefotaxime
Cefixime
Cefpodoxime proxetil
Cefepime
Adverse effects of Cephalosporins
Uses of Cephalosporins
The fixed dose combination of trimethoprim and sulfamethoxazole is called cotrimoxazole.
Adverse Drug Reaction, Spectrum, Resistance and Use of Cotrimoxazole.
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
1. chemotherapy principles and problems JagirPatel3
The objective of chemotherapy is to study and to apply the drugs that have highly selective toxicity to the pathogenic microorganisms in the host body and have no or less toxicity to the host, so as to prevent and cure infective diseases caused by pathogens
Anthelmintics | B.Pharm 3rd year 2nd Sem | Medicinal Chemistry-III | History, Classification, Structures & Synthesis of anthelmintics, Synthesis of Diethylcarbamazine citrate, Synthesis of Mebendazole
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
The current slide include the pharmacology og cephalosporins.
Contents
Introduction to Cephalosporins
Classification of Cephalosporins
Cefazolin
Cephalexin
Cefuroxime
Cefuroxime axetil
Cefotaxime
Cefixime
Cefpodoxime proxetil
Cefepime
Adverse effects of Cephalosporins
Uses of Cephalosporins
The fixed dose combination of trimethoprim and sulfamethoxazole is called cotrimoxazole.
Adverse Drug Reaction, Spectrum, Resistance and Use of Cotrimoxazole.
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Sulphonamide and cotrimoxazole pptx-Dr.Jibachha SahDr. Jibachha Sah
Lecturer notes on veterinary pharmacology and toxicology for B.V.Sc & A.H Seventh semester student for educational purpose.This lecturer notes will be useful for all the veterinary students.Plesae send your comments,jibachhashah@gmail.com,mob.9845024121
Sulphonamides and their combination with trimethoprim - by Dr.Jibachha SahDr. Jibachha Sah
Sulphonamides and their combination with trimethoprim is lecturer notes on Veterinary Pharmacology & Toxicology(Chemotherapy) for B.V.Sc & A.H students of veterinary college.
Sulfonamides (sulphonamides) are a group of man-made (synthetic) medicines that contain the sulfonamide chemical group. They may also be called sulfa drugs. Many people use the term sulfonamide imprecisely to refer only to antibiotics that have a sulfonamide functional group in their chemical structure.
Sulphonamides Pharmacology For Pharmacy studentsMalay Pandya
This is the PowerPoint presentation of the Antimicrobial drug - SULPHOANMIDE.
Sulphonamide is the first antimicrobial agent
It Can be employed for suppressive therapy of chronic urinary tract infection, streptococcal pharyngitis and gum infection.
Combined with trimethoprim (cotrimoxazole) sulfamethoxazole is used for many bacterial infections.
This will be useful to all Pharmacy Student ...
This ppt deals with the sulfonamide group of drugs with classification, mechanism, spectrum, resistance, uses and adverse effects discussed in detail. It also discusses in detail about Cotrimoxazole
3. prophylactic use of Anti-microbial agentsJagirPatel3
Prophylactic: A preventive measure. The word comes from the Greek for "an advance guard," an apt term for a measure taken to fend off a disease or another unwanted consequence
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. Sulfonamides
• They were the first AMAs effective against pyogenic bacterial infections
• Due to development of resistance the and availability of more safer
drugs their current utility is limited
• Except used in combination with Trimethoprim as Cotrimoxazole or
pyrimethamine
3. Classification
• Short acting: Sulfadiazine, sulfacetamide, Sulfadimidine, Sulfisoxazole
• Intermediate acting: Sulphamethaxazole, sulfadoxine, sulfamoxole
• Long acting: sulphamthoxypyridazine, sulfadimethoxine,
sulphamthoxypyrazine
• Special purpose: sulfacetamide, sulfadiazine, sulfasalazine
4. Anti Bacterial spectrum
• The sulfonamides are broad-spectrum antimicrobials
• effective against gram-positive and some gram negative organisms of
the Enterobacteriaceae.
• Good activity against Escherichia coli,
• Moderate activity against Proteus mirabilis and Enterobacter spp.
• Poor activity against in Proteus and Klebsiella spp.
• No Inhibitory activity against Pseudomonas aeruginosa and Serratia
spp. They are also effective against Chlamydia spp.,
5. Folate synthesis
Folate (“dihydrofolate”, “FH2”, “folic acid”, “vitamin B9”) is a cofactor (methyl-
group donor) in the synthesis of purines and pyrimidines used for DNA and RNA
synthesis
• Humans are not able to synthesize folate themselves, and exclusively rely on
absorption of folate from the GI tract
• Mammalian cells in contrast use folate receptors and folate carries in the plasma
membrane to scavenge the intact vitamin which is fundamental difference b/w
pathogen and mammalian cell which makes DHFR inhibitors an ideal target
• Folate is only active in the tetrahydrofolate (FH4) form, thus both humans and
bacteria need to activate folate to utilize it synthesis and activation of folate is
done in 3 steps
7. Cont…
• Sulfonamides are synthetic structural analogues of PABA and act by
displacing PABA from its binding site on dihydropteroate synthetase, thus
inhibiting bacterial synthesis of folate this leads to an inability of the bacteria to
synthesize DNA and RNA and following inability for them to divide however,
bacteria are still able to survive without dividing, thus sulfonamides are only
bacteriostatic
• Since humans do not synthesize their own folate, sulfonamides leave DNA
and RNA synthesis in human cells untouched
8. Resistance
• Bacteria may develop resistance to sulfonamides by plasmid transfer
and/or chromosomal mutations
• - this resistance may occur by 3 separate mechanisms
MECHANISM DESCRIPTION
DECREASED UPTAKE Due to decreased permeability of
the bacterial cell envelope to
sulfonamides
DECREASED AFFINITY Due to structural alterations
of dihydropteroate synthetase
(folate synthase enzymes)
INCREASED DISPLACEMENT Due to increased synthesis of
PABA and adopt alternative
pathway for folate synthesis
9. Sulphadiazine prototype
• SULFADIAZINE, sulphadoxine, sulfomethaxazole
• General information
• Administered orally and/or IV, may cross the blood-brain barrier may
cross the placental barrier
• Medical uses
• Treatment of cystitis due to escherichia and/or proteus Infection
• Treatment of chlamydia
• Trachoma
• lymphogranuloma due to chlamydia infection
10. Pharmacokinetics
• Absorption: completely absorbed from G.I.T.
• Plasma protein binding about 10 to 95% more the protein binding
longer the action
• Distribution: wildly distributed plasma, CSF, and placenta
• Excretion : they are mainly excreted by the kidney through
glomerular filtration
• Both renal tubular secretion and reabsorption occurs
• The lipid soluble members are reabsorbed hence long posses long
action
11. Cont.…
• Side effects
• Headache, nausea and vomiting, hepatitis
• Bone marrow depression: leading to thrombocytopenia
• Granulocytopenia
• Methemoglobinemia, hemolytic anemia (if glucose-6-phosphate deficiency)
• kernicterus (in infants)
• Urolitihasis (“crystalluria”) Due to poor solubility in the low pH of the renal
tubules and following crystal formation)
• hypersensitivity reactions leading to skin rashes and/or
• Angioedema
12. LONG-ACTING SULFONAMIDES
• SULFAMETHOXYDIAZINE
• Side effects Same as sulfadiazine, except for urolithiasis (due to higher solubility
at low pH,
• Hypersensitivity reactions
• leading to skin rashes, angioedema and/or stevens johnson syndrome
• Drug- drug Interactions
• They inhibit the metabolism possibly display protein binding sites of phenytoin,
tolbutamide, and warfarin
• Use:
• Rarely used alone
• In chronic UTI and Gum infection
13. Dihydrofolate reductase inhibitors
• Dihydrofolate reductase inhibitors are structural analogues of folate and
act by competitively inhibiting dihydrofolate reductase.
• Since humans need to activate folate as well, dihydrofolate reductase
inhibitors also affect DNA and RNA synthesis in human cells (!) however,
dihydrofolate reductase inhibitors have a much stronger affinity for
bacterial dihydrofolate reductase, thus affecting human cells to a much
smaller extent
• Mechanism of resistance: due to structural alterations of dihydrofolate
reductase
14. Pyrimethamine
• General information
• Administered orally, may cross the blood-brain barrier
• Medical uses
• Treatment of malaria due to plasmodium falciparum and/or
• plasmodium malariae, & or plasmodium vivax, and plasmodium ovale
infection
• Treatment of malaria due to plasmodium falciparum infection then
administered in conjunction with mefloquine
15. • Side effects
• nausea and vomiting, folate deficiency leading to, macrocytic
hyperchromatic, anemia, leukocytopenia and/or thrombocytopenia
• Hypersensitivity reactions leading to skin rashes
16. Trimethoprim
• Medical uses
• Treatment of cystitis due to escherichia and/or proteus Infection
• Treatment of pneumonia due to streptococcus and/or Haemophilus
infection
• Mechanism and other side effects are same as pyrimethamine
17. combinations
• Pyrimethamine + Sulfadiazine
• General information this particular combination is chosen due to similar
pharmacokinetics of the 2 active compounds administered orally and/or IV
may cross the blood-brain barrier
• USE
• Toxoplasmosis due to toxoplasma infection
• Malaria due to
• plasmodium falciparum, malariae, vivax and ovale and/or with aminoquinoline
18. Cotrimoxazole
• The fixed dose combination (1:5 according to WHO)
• Trimethoprim + Sulamethoxazole = Cotrimoxazole
• Both drug interfere in same metabolic pathway produces sequential
blockage
• The combination produces supra-additive effect
• Sufomethaxazole inhibits folate synthetase and trimethoprim inhibits
folate reductase
19. Cont.…
• Both drugs match closely
• They have similar half life
• Optimum synergistic effect at (20:1 suphamethaxazole:trimethoprim) in
plasma and tissues
• Advantage of combination:
• Individually both are bacteriostatic but combination is bactericidal
• Chances of bacterial resistance are reduced
20. Pharmacokinetics
• Oral and parenteral use: well absorbed orally
• Widely distributed in various organs and tissues including CSF and
sputum
• Metabolized in liver excreted in urine
• Dose reduction is needed in case of renal insufficiency
21. Adverse effect
• Dermatologic: skin rash
• G.I.T.: nausea, vomiting
• Hematologic: megaloblastic anemia, leukopenia, thrombocytopenia
• Patients with HIV: rashes, drug induced fever, diarrhea
• Drug interactions:
• Trimethoprim + warfarin: prolonged prothrombin time
• Plasma half life of phenytoin increases
22. Cotrimoxazole uses
• UTI: due to grm –ve organism like E.coli , Proteus sp.
• Can be given for chronic recurrent UTI in women's
• Small doses thrice weakly for long term prophylaxis in recurrent UTI
• Male: for bacterial prostatitis as it is concentrated in prostatic tissue
• Bacterial Respiratory tract infections:
• Acute and chronic bronchitis due to H.influenza and S.Pneumoniae
23. Cont..
• Bacterial diarrhoeas: due to Shigella, E.coli, and salmonella sp.
• Typhoid fever: it may also be effective with fluoroquinolones
• Chancroid: caused by H. Ducreyi Cotrimoxazole is equally effective
compared to drug of choice Azithromycin