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Stem cells……
Stem Cells
Stem Cell History
1998 - Researchers first extract stem cells from
human embryos
1999 - First Successful human transplant of
insulin-making cells from cadavers
2001 - President Bush restricts federal funding
for embryonic stem-cell research
2002 - Juvenile Diabetes Research Foundation
International creates $20 million fund-raising
effort to support stem-cell research
2002 - California ok stem cell research
2004 - Harvard researchers grow stem cells from
embryos using private funding
2004 - Ballot measure for $3 Billion bond for
stem cells
Stem Cell – Definition
Stem Cell – Definition

A cell that has the ability to
continuously divide and
differentiate (develop) into various
other kind(s) of cells/tissues
Stem Cell Characteristics

•

‘Blank cells’ (unspecialized)

• Capable of dividing and renewing
themselves for long periods of time
(proliferation and renewal)

• Have the potential to give rise to
specialized cell types (differentiation)
Kinds of Stem Cells
Embryonic stem cells
five to six-day-old embryo
Tabula rasa
Embryonic germ cells
derived from the part of a human embryo or
fetus that will ultimately produce eggs or
sperm (gametes).
Adult stem cells
undifferentiated cells found among
specialized or differentiated cells in a tissue
or organ after birth
appear to have a more restricted ability to
produce different cell types and to self-renew.
Kinds of Stem Cells
Embryonic stem cells
five to six-day-old embryo
Tabula rasa
Embryonic germ cells
derived from the part of a human embryo or fetus that
will ultimately produce eggs or sperm (gametes).
Adult stem cells
undifferentiated cells found among specialized or
differentiated cells in a tissue or organ after birth
appear to have a more restricted ability to produce
different cell types and to self-renew.
Pluripotent Stem Cells –
more potential to become any type of cell
Multipotent stem cells
•Multipoten
t stem cells
– limited in
what the
cells can
become
Embryonic Stem Cells
Adult Stem Cells
An undifferentiated cells found
among specialized or differentiated
cells in a tissue or organ after birth
Skin
Fat Cells
Bone marrow
Brain
Many other
organs & tissues
Induced Pluripotent Stem Cells
Bone Marrow

• Found in spongy bone where blood cells form
• Used to replace damaged or destroyed bone
marrow with healthy bone marrow stem cells.
• treat patients diagnosed with leukemia, aplastic
anemia, and lymphomas
• Need a greater histological immunocompatibility
Umbilical cord stem cells

•
•
•
•
•

Also Known as Wharton’s Jelly
Adult stem cells of infant origin
Less invasive than bone marrow
Greater compatibility
Less expensive
Umbilical cord stem cells
Three important functions:
1. Plasticity: Potential to change into
other cell types like nerve cells
2. Homing: To travel to the site of
tissue damage
3. Engraftment: To unite with other
tissues
Stem Cell Applications
• Tissue repair
nerve, heart, muscle, organ,
skin
• Cancers
• Autoimmune diseases
- diabetes, rheumatoid
arthritis, MS
Tissue Repair

• Regenerate spinal
cord, heart tissue or any
other major tissue in the
body.
Heart Disease

• Adult bone marrow stem cells
injected into the hearts are believed
to improve cardiac function in victims
of heart failure or heart attack
Stem cells in the adult brain:
Problems with Adult Stem Cells
Stem cells in mature skeletal muscle:
Is there power still in our stem cells?
What is stem cell research?
•Understand more about
development, aging, disease
Experimental model systems
Prevent or treat diseases and
injuries
•Cell-based therapies
Pharmaceutical development
Includes testing and drug delivery
Why is Stem Cell Research So Important
to All of Us?

• Stem cells can replace diseased or
damaged cells
• Stem cells allow us to study
development and genetics
• Stem cells can be used to test
different substances (drugs and
chemicals)
Thank you for watching
BY:- MADHULA & MADHURI 2nd B.Sc(B.G.B)

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Stem cells

  • 3. Stem Cell History 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful human transplant of insulin-making cells from cadavers 2001 - President Bush restricts federal funding for embryonic stem-cell research 2002 - Juvenile Diabetes Research Foundation International creates $20 million fund-raising effort to support stem-cell research 2002 - California ok stem cell research 2004 - Harvard researchers grow stem cells from embryos using private funding 2004 - Ballot measure for $3 Billion bond for stem cells
  • 4. Stem Cell – Definition Stem Cell – Definition A cell that has the ability to continuously divide and differentiate (develop) into various other kind(s) of cells/tissues
  • 5. Stem Cell Characteristics • ‘Blank cells’ (unspecialized) • Capable of dividing and renewing themselves for long periods of time (proliferation and renewal) • Have the potential to give rise to specialized cell types (differentiation)
  • 6. Kinds of Stem Cells Embryonic stem cells five to six-day-old embryo Tabula rasa Embryonic germ cells derived from the part of a human embryo or fetus that will ultimately produce eggs or sperm (gametes). Adult stem cells undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth appear to have a more restricted ability to produce different cell types and to self-renew.
  • 7. Kinds of Stem Cells Embryonic stem cells five to six-day-old embryo Tabula rasa Embryonic germ cells derived from the part of a human embryo or fetus that will ultimately produce eggs or sperm (gametes). Adult stem cells undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth appear to have a more restricted ability to produce different cell types and to self-renew.
  • 8. Pluripotent Stem Cells – more potential to become any type of cell
  • 9. Multipotent stem cells •Multipoten t stem cells – limited in what the cells can become
  • 11. Adult Stem Cells An undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth Skin Fat Cells Bone marrow Brain Many other organs & tissues
  • 13. Bone Marrow • Found in spongy bone where blood cells form • Used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. • treat patients diagnosed with leukemia, aplastic anemia, and lymphomas • Need a greater histological immunocompatibility
  • 14. Umbilical cord stem cells • • • • • Also Known as Wharton’s Jelly Adult stem cells of infant origin Less invasive than bone marrow Greater compatibility Less expensive
  • 15. Umbilical cord stem cells Three important functions: 1. Plasticity: Potential to change into other cell types like nerve cells 2. Homing: To travel to the site of tissue damage 3. Engraftment: To unite with other tissues
  • 16. Stem Cell Applications • Tissue repair nerve, heart, muscle, organ, skin • Cancers • Autoimmune diseases - diabetes, rheumatoid arthritis, MS
  • 17. Tissue Repair • Regenerate spinal cord, heart tissue or any other major tissue in the body.
  • 18. Heart Disease • Adult bone marrow stem cells injected into the hearts are believed to improve cardiac function in victims of heart failure or heart attack
  • 19.
  • 20. Stem cells in the adult brain:
  • 21. Problems with Adult Stem Cells
  • 22. Stem cells in mature skeletal muscle: Is there power still in our stem cells?
  • 23. What is stem cell research? •Understand more about development, aging, disease Experimental model systems Prevent or treat diseases and injuries •Cell-based therapies Pharmaceutical development Includes testing and drug delivery
  • 24. Why is Stem Cell Research So Important to All of Us? • Stem cells can replace diseased or damaged cells • Stem cells allow us to study development and genetics • Stem cells can be used to test different substances (drugs and chemicals)
  • 25. Thank you for watching BY:- MADHULA & MADHURI 2nd B.Sc(B.G.B)